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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19810 results in Negative / Null Result Report · page 118 of 661

Negative / Null Result Report

Sigma receptor type 1 knockout mice show a mild deficit in plasticity but no significant change in synaptic transmission in the CA 1 region of the hippocampus

Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry

Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…

View details →DOI: 10.1111/jnc.13695Cited by 16
Negative / Null Result Report

Empirically determined severity levels for binge-eating disorder outperform existing severity classification schemes

Lauren N. Forrest, Ross C. Jacobucci, Carlos M. Grilo · 2020 · Psychological Medicine

Abstract Background Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of…

View details →DOI: 10.1017/s0033291720002287Cited by 16
Negative / Null Result Report

Significant contributions of combustion‐related NH 3 and non‐fossil fuel NO x to elevation of nitrogen deposition in southwestern China over past five decades

Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology

Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…

View details →DOI: 10.1111/gcb.15736Cited by 16
Negative / Null Result Report

Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia

Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE

Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…

View details →DOI: 10.1371/journal.pone.0257060Cited by 16
Negative / Null Result Report

Longitudinal association between overweight years, polygenic risk and NAFLD, significant fibrosis and cirrhosis

Veeral Ajmera, Na Wang, Hanfei Xu et al. · 2023 · Alimentary Pharmacology & Therapeutics

Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated the association between overweight‐years, a cumulative exposure based on the product of the duration and severity of…

View details →DOI: 10.1111/apt.17452Cited by 16
Negative / Null Result Report

The Association of Arterial Stiffness With Significant Carotid Atherosclerosis and Carotid Plaque Vulnerability

Nikolaos P.E. Kadoglou, Konstantinos G. Moulakakis, George Mantas et al. · 2022 · Angiology

Arterial stiffness and its valid index, the cardio-ankle vascular index (CAVI), have emerged as predictors of adverse cardiovascular outcomes. We investigated the relationship of the CAVI with significant carotid stenosis (> 50%) and the…

View details →DOI: 10.1177/00033197211068936Cited by 15
Negative / Null Result Report

Find and treat or find and lose? Tuberculosis treatment outcomes among screened newly arrived asylum seekers in Germany 2002 to 2014

Anna Kuehne, Barbara Hauer, Bonita Brodhun et al. · 2018 · Eurosurveillance

Background Germany has a low tuberculosis (TB) incidence. A relevant and increasing proportion of TB cases is diagnosed among asylum seekers upon screening. Aim: We aimed to assess whether cases identified by screening asylum seekers had…

View details →DOI: 10.2807/1560-7917.es.2018.23.11.17-00042Cited by 15
Negative / Null Result Report

Nomograms confirm serum IL-6 and CRP as predictors of immune checkpoint inhibitor efficacy in unresectable hepatocellular carcinoma

Jiajia Du, Zhiyong Huang, Erlei Zhang · 2024 · Frontiers in Immunology

Background Immunotherapy based on immune checkpoint inhibitors (ICIs) has become the first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, only a small portion of patients are responsive to ICIs. It is important…

View details →DOI: 10.3389/fimmu.2024.1329634Cited by 15
Negative / Null Result Report

“The more you did, the more it made sense”: Problem‐based learning to improve early evidence‐based practice in an undergraduate physiotherapy professional programme

Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International

Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…

View details →DOI: 10.1002/pri.1774Cited by 15
Negative / Null Result Report

Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials

Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health

The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…

View details →DOI: 10.3390/ijerph19084462Cited by 15
Negative / Null Result Report

The Development of a Charcot Foot after Significant Weight Loss in People with Diabetes

Rachel Murchison, Catherine Gooday, Ketan Dhatariya · 2014 · Journal of the American Podiatric Medical Association

Medication to aid weight loss and weight loss surgery are becoming more commonly available for people with diabetes. As a result of profound weight loss, diabetes may go into remission and many biochemical and physical parameters improve.…

View details →DOI: 10.7547/0003-0538-104.5.522Cited by 15
Negative / Null Result Report

Physical activity and prenatal depression: going beyond statistical significance by assessing the impact of reliable and clinical significant change

Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine

Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…

View details →DOI: 10.1017/s0033291719003714Cited by 15
Negative / Null Result ReportOpen accessMedicine

Evaluating deep learning methods in detecting and segmenting different sizes of brain metastases on 3D post-contrast T1-weighted images

Youngjin Yoo, Pascal Ceccaldi, Siqi Liu et al. · 2021 · Journal of Medical Imaging

Purpose: We investigate the impact of various deep-learning-based methods for detecting and segmenting metastases with different lesion volume sizes on 3D brain MR images. Approach: A 2.5D U-Net and a 3D U-Net were selected. We also…

View details →DOI: 10.1117/1.jmi.8.3.037001Cited by 15
Negative / Null Result Report

Mid‐term results show no significant difference in postoperative clinical outcome, pain and range of motion between a well‐established total knee arthroplasty design and its successor: a prospective, randomized, controlled trial

Georg Hauer, Nina Hörlesberger, Sebastian Klim et al. · 2020 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to compare the clinical and functional outcome scores following total knee arthroplasty (TKA) with two different systems. The hypothesis was that there is a difference between patients…

View details →DOI: 10.1007/s00167-020-06027-zCited by 15
Negative / Null Result Report

Saline versus Saline with Blood as a Contrast Agent for Right‐to‐left Shunt Diagnosis by Transcranial Doppler: Is There a Significant Difference?

Marcos Christiano Lange, Viviane Flumignan Zétola, Élcio J Piovesan et al. · 2010 · Journal of Neuroimaging

ABSTRACT BACKGROUND AND PURPOSE Agitated saline solution (AS) is the contrast agent (CA) of choice for the diagnosis of right‐to‐left shunt (RLS). The aim of this study was to compare AS to AS with blood (ASb) in the diagnosis and…

View details →DOI: 10.1111/j.1552-6569.2010.00521.xCited by 15
Negative / Null Result ReportAgricultural and Biological Sciences

Stay cool, travel far: cold‐acclimated oriental fruit moth females have enhanced flight performance but lay fewer eggs

Aurélie Ferrer, Dominique Mazzi, Silvia Dorn · 2014 · Entomologia Experimentalis et Applicata

Abstract Acclimation to a particular environment may provide organisms with advantages in that environment. In species with multiple generations per year, acclimation may cause life‐history traits to vary with season and between…

View details →DOI: 10.1111/eea.12163Cited by 15
Negative / Null Result Report

Home-based intervention for non-Hispanic black families finds no significant difference in infant size or growth: results from the Mothers & Others randomized controlled trial

Heather M. Wasser, Amanda L. Thompson, Chirayath M. Suchindran et al. · 2020 · BMC Pediatrics

Abstract Background Non-Hispanic black (NHB) infants are twice as likely as non-Hispanic white infants to experience rapid weight gain in the first 6 months, yet few trials have targeted this population. The current study tests the…

View details →DOI: 10.1186/s12887-020-02273-9Cited by 15
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Guadalupe Nibeyro, Verónica M. Baronetto, Juan I. Folco et al. · 2023 · Frontiers in Immunology

Introduction: Identification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases. Methods: Here, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I present

View details →DOI: 10.3389/fimmu.2023.1094236Cited by 15
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Automated Analysis of Aggregated Datasets to Identify Climatic Predictors of Botrytis Bunch Rot in Wine Grapes

G.N. Hill, R.M. Beresford, KJ Evans · 2018 · Phytopathology

Botrytis bunch rot (BBR), caused by Botrytis cinerea, results in serious losses to wine-grape production in some seasons during the preharvest period. In order to predict seasons that are at risk from BBR, datasets consisting of 25…

View details →DOI: 10.1094/phyto-10-17-0357-rCited by 15
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Skill-relatedness and employment growth of firms in times of prosperity and crisis in an oil-dependent region

John-Erik Rørheim, Ron Boschma · 2021 · Environment and Planning A Economy and Space

Many studies have shed light on the positive side of relatedness, but little attention has yet been devoted to possible downsides of relatedness for firm performance in regions. We found in a case study of the oil-dependent Stavanger region in Norway that plants in industries that are skill-related to the dominant oil and gas industry showed lower employment growth than plants in other industries. This was the case both in the boom and the crisis periods, even when controlling for supply linkages to the oil and gas sector. However, we also found that plants skill-related to the oil and gas ind

View details →DOI: 10.1177/0308518x211066102Cited by 15
Negative / Null Result Report

Writing as a Tool to Demonstrate Mathematical Understanding

Christie Lynn Martin · 2015 · School Science and Mathematics

In this study, I examine how using a writers' workshop model in mathematics creates a space for students to write about their mathematical thinking and problem solving and how their writing impacts instruction. This case study of one…

View details →DOI: 10.1111/ssm.12131Cited by 15
Negative / Null Result ReportOpen accessPsychology

A Bayesian Reanalysis of a Trial of Psilocybin Versus Escitalopram for Depression

Sandeep M. Nayak, Bilal A. Bari, David B. Yaden et al. · 2022 · Psychedelic Medicine

Objectives: To perform a Bayesian reanalysis of a recent trial of psilocybin (COMP360) versus escitalopram for Major Depressive Disorder (MDD) in order to provide a more informative interpretation of the indeterminate outcome of a previous…

View details →DOI: 10.1089/psymed.2022.0002Cited by 15
Negative / Null Result ReportMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · JAIDS Journal of Acquired Immune Deficiency Syndromes

Background: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. Setting: Two urban clinics in Kigali, Rwanda. Methods: A 2-arm individual randomized controlled trial compared…

View details →DOI: 10.1097/qai.0000000000002911Cited by 15
Negative / Null Result ReportPsychology

Impact of a Student Success Course on Undergraduate Academic Outcomes

Leah D. Hoops, Shirley L. Yu, Andrea Burridge et al. · 2015 · Journal of College Reading and Learning

Both community colleges and four-year institutions offer Student Success Courses (SSCs) to promote student engagement (self-regulated learning, SRL) and performance (grades, retention, and graduation). However, little work has been done to…

View details →DOI: 10.1080/10790195.2015.1032041Cited by 15