A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Thomas A. Buckley, James A. Diao, Cam N. Srivastava et al. · 2026 · Nature Communications
Multimodal foundation models have shown compelling but conflicting performance in medical image interpretation. However, the ways in which these models integrate and prioritize different data modalities, including images and text, remain…
David Funosas, Esther Sebastián‐González, Jon Morant et al. · 2026 · Ecological Indicators
Abstract Recent advances in machine learning have accelerated automated species detection across diverse ecological domains, enabling large-scale, non-invasive monitoring of biodiversity. In ornithological research, coupling passive acoustic monitoring (PAM) with rapidly-developing novel identification tools such as BirdNET—a deep learning–based sound recognition algorithm—offers new opportunities for surveying vocally active bird communities. Yet, BirdNET performance across diverse ecological and biogeographic contexts remains to be quantified. Here, we present the first worldwide evaluation
Iliana Medina, Alice Exnerová, Klára Daňková et al. · 2025 · Science
Natural selection has repeatedly led to the evolution of two alternative antipredator color strategies-camouflage to avoid detection and aposematism to advertise unprofitability-but we lack understanding of how ecological context favors one strategy over the other. We conducted a globally replicated predation experiment at 21 sites on six continents to test how predator community, prey community, and visual environment influenced the predation risk of 15,018 artificial paper "moth" prey with cryptic or warning coloration. Results indicated that aposematic strategies fare better in environments
Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou et al. · 2026 · European Heart Journal - Digital Health
ABSTRACT Background Timely and accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and clinically managing patients. Current workflows rely on computerized ECG interpretation tools built into ECG signal…
Wesley Myers, Kristin M. Lloyd, Jillian J. Turanovic et al. · 2018 · Journal of Contemporary Criminal Justice
There is a growing “replication crisis” in the social and behavioral sciences, where original research across a wide array of substantive areas has failed to replicate when conducted by others. This problem highlights the importance of…
Ryan Shean, Tathya Shah, Aditya Pandiarajan et al. · 2025 · Scientific Reports
The ability of large language models (LLMs) to accurately answer medical board-style questions reflects their potential to benefit medical education and real-time clinical decision-making. With the recent advance to reasoning models, the latest LLMs excel at addressing complex problems in benchmark math and science tests. This study assessed the performance of first-generation reasoning models-DeepSeek's R1 and R1-Lite, OpenAI's o1 Pro, and Grok 3-on 493 ophthalmology questions sourced from the StatPearls and EyeQuiz question banks. o1 Pro achieved the highest overall accuracy (83.4%), signifi
Bianca Brown, Botagoz Tusmagambet, Valentino Rahming et al. · 2023 · Applied Psycholinguistics
Abstract This study conceptually replicated and extended Reid, Trofimovich, and O’Brien (2019), who found that native English speakers could be biased positively (or negatively) relative to a control condition in terms of how they rate non-native English speech. Our internet-based study failed to replicate Reid et al. across a wider population sample of “native” speakers ( n = 189). Listeners did not change how they rated non-native English speech after social bias orientations and performed similarly across all five measures of speech and across age and race (Asian, Black, and Caucasian). We
Filippo Laganà, Danilo Pratticò, Marco F. Quattrone et al. · 2026 · Eng—Advances in Engineering
Defects in printed circuit boards (PCBs), if not detected promptly, may persist over time until they cause the failure of critical components. Traditional monitoring methods, which are limited to simulations or superficial measurements, obstruct predictive maintenance and real-time fault detection. To address these issues and enhance real-time diagnostics of thermal anomalies in PCBs, this work proposes an integrated system that combines infrared thermography (IRT), artificial intelligence (AI) algorithms, and Taguchi–ANOVA statistical techniques. IR thermography was employed to identify therm
Qiyao Zhang, Zhen Cao, Shangcheng Yan et al. · 2025 · Journal of Translational Medicine
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its aggressive nature and dismal prognosis, ranking as a leading cause of cancer-related mortality worldwide. Despite advancements in surgical…
Chloe Wittenberg, Ziv Epstein, Gabrielle Péloquin-Skulski et al. · 2025 · PNAS Nexus
Abstract Recent advancements in generative AI have raised widespread concern about the use of this technology to spread audio and visual misinformation. In response, there has been a major push among policymakers and technology companies to label AI-generated media appearing online. It remains unclear, however, what types of labels are most effective for this purpose. Here, we evaluate two (potentially complementary) strategies for labeling AI-generated content online: (i) a process-based approach, aimed at clarifying how content was made and (ii) a harm-based approach, aimed at highlighting c
Mboneye Anselme, Huafeng He, Chengyang Lai et al. · 2025 · Journal of Translational Medicine
In the realm of cellular biochemistry, mitochondria have been increasingly recognized for their critical role in both cellular metabolism and the etiology of various diseases. Mitochondrial transporters (MTs) are essential for maintaining…
Stijntje Dijk, Claudia Wollny, Jörg Barkhausen et al. · 2025 · JAMA
Importance: Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective: To assess the effects of…
Yasir Almuhanna · 2025 · Journal of Clinical Medicine
Wound healing is a complex and multistage process that incorporates precise cellular and molecular coordination. The presence of biofilms in chronic wounds adversely affects the wound healing process, as it prolongs the closure of the wound, thus sustaining chronic inflammation. Current data suggest that biofilms are present in almost all chronic wounds, which leads to significant challenges in diagnosis and treatment. Traditional detection methods, such as cultures and light microscopy, often fail to detect biofilms; however, sophisticated molecular and imaging techniques are constrained by t
Josef Biber, Catharina Gandor, Elvir Bećirović et al. · 2025 · Pharmacology & Therapeutics
Gene therapy is an innovative medical approach that offers new treatment options for congenital and acquired diseases by transferring, correcting, inactivating or regulating genes to supplement, replace or modify a gene function. The approval of voretigene neparvovec (Luxturna), a gene therapy for RPE65-associated retinopathy, has marked a milestone for the field of retinal gene therapy, but has also helped to accelerate the development of gene therapies for genetic diseases affecting other organs. Voretigene neparvovec is a vector based on adeno-associated virus (AAV) that delivers a function
Piers Forster, Tristram Walsh, Chris Smith et al. · 2026 · Earth system science data
Abstract. In a rapidly changing climate, evidence-based decision-making benefits from up-to-date and timely information. We track twelve key sets of indicators of the state of the climate system, closely following Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment report (AR6) methods, to produce our fourth annual publication. One of the indicators, the Earth's energy imbalance (EEI) provides a crucial integrative measure of the overall heating of the planet and the pace of climate change – this has more than doubled since the 1976–1995 period. A newly added indicator of tempera
Patrick Vermersch, Laura Airas, Thomas Berger et al. · 2025 · Frontiers in Immunology
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resident immune cells of the CNS. This review discusses the role of microglia in neuroinflammation, tissue repair, and neural homeostasis, as well as their involvement in MS and explores potential therapeutic strategies targeting microglial function. Methods: A literature search conducted in August 202
Chris M. Smith-Martin, Steven Jansen, Timothy J. Brodribb et al. · 2022 · Frontiers in Forests and Global Change
One of the most prominent changes in neotropical forests has been the increase in abundance and size of lianas. Studies suggest that lianas have more acquisitive strategies than trees, which could allow them to take advantage of water more…
Lina Caballero-Villalobos, Francisco Fajardo-Gutiérrez, Mariasole Calbi et al. · 2021 · Frontiers in Ecology and Evolution
It is predicted that climate change will strongly affect plant distributions in high elevation “sky islands” of tropical Andes. Polylepis forests are a dominant element of the treeline throughout the Andes Cordillera in South America.…
Margarida Arrobas, João V. Decker, Bruna L. Feix et al. · 2021 · Soil Use and Management
Abstract Soil conditioners, such as biochar and zeolites, may play an important role in agriculture if they increase nutrient use efficiency, in particular, that of phosphorus (P), due to the depletion of phosphate rocks from which…
Emily P. Taylor, Rachel Couper, Carolyn Maeve Butler · 2017 · Psychology and Psychotherapy Theory Research and Practice
OBJECTIVES: Perfectionism is recognized as a significant risk factor for psychopathology. Emerging research links attachment to perfectionism in adult and college-age samples. The Frost Multidimensional Perfectionism Scale (FMPS) has been…
Amy Robinson, Matthew Burgess, Sheila Webb et al. · 2022 · Cancers
There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here, we show that there is an increase in the number of bone marrow, circulating and splenic monocytes by using mouse models of breast cancer caused by the mammary epithelial expression of the polyoma middle T antigen. Cancer does not affect ratios of classical to non-classical populations of monocytes in the circulation nor does it affect their half-lives. Single cell RNA sequencing also indicates that cancer doe
Alessandra S. Souza, Theresa Thaler, Heinrich R. Liesefeld et al. · 2020 · Journal of Experimental Psychology Human Perception & Performance
Emotion is assumed to change how people process information by modulating attentional focus. Two recent studies (Spachtholz et al., 2014; Xie & Zhang, 2016) reported that self-reported negative emotion boosted the precision with which…
Lebena Varghese, Lisa M. Finkelstein · 2020 · Annals of the New York Academy of Sciences
Our current research investigated how mentors enhance protégé self-efficacy. Drawing from social comparison theory, we propose that the shared experience between mentors and protégés facilitates the ability of protégés to adopt the…
Carmine Zoccali, Francesca Mallamaci, Luca De Nicola et al. · 2023 · Clinical Kidney Journal
Resistant hypertension (RH) is linked to an increased risk of cardiovascular and renal complications. Treatment options include non-pharmacological interventions, such as lifestyle modifications, and the use of specific antihypertensive…
Hubertus Himmerich, Jörg-Egbert Wolf, Peter Zimmermann et al. · 2016 · Chinese Medical Journal
To the Editor: With great interest we read the original article of Chen et al.[1] published in the Chinese Medical Journal comparing serum concentrations of cytokines in patients of Han and Li ethnicity with posttraumatic stress disorder…
José M. Eltit, Clara Franzini‐Armstrong, Claudio F. Pérez · 2014 · Journal of Biological Chemistry
The β1a subunit is a cytoplasmic component of the dihydropyridine receptor (DHPR) complex that plays an essential role in skeletal muscle excitation-contraction (EC) coupling. Here we investigate the role of the C-terminal end of this auxiliary subunit in the functional and structural communication between the DHPR and the Ca2+ release channel (RyR1). Progressive truncation of the β1a C terminus showed that deletion of amino acid residues Gln489 to Trp503 resulted in a loss of depolarization-induced Ca2+ release, a severe reduction of L-type Ca2+ currents, and a lack of tetrad formation as eva
Mark B. Stoddard, Hui Li, Shuyi Wang et al. · 2015 · mBio
UNLABELLED: Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a "quasispecies." Transmission is generally associated with a stringent population bottleneck characterized by infection by limited numbers of "transmitted/founder" (T/F) viruses. Characterization of T/F genomes of human immunodeficiency virus type 1 (HIV-1) has been integral to studies of transmission, immunopathogenesis, and vaccine development. Here, we describe the identification of complete T/F genomes of HCV by single-genome sequencing of plasma viral RNA from a
Valentine Wanga, Charles S. Venuto, Gene D. Morse et al. · 2015 · Pharmacogenetics and Genomics
BACKGROUND: Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We carried out genomewide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first…
Klaus Grobys · 2021 · International Review of Financial Analysis
Recent research shows that the vast majority of scientific studies published in leading finance journals fails scientific replication (Hou, Xue, and Zhang, 2020; Harvey, Liu, and Zhu; 2016). This study argues that p-hacking, publication pressure and the selection bias from leading finance journals are perhaps not the underlying root cause for this issue. This study shows that standard methodologies often used in finance research are inevitably sample-specific due to the very nature of financial markets. While the consensus of earlier research postulates a rejection of the time-honored Levy hyp
Thomas Perneger, Angèle Gayet-Ageron · 2023 · JAMA
Importance Many randomized clinical trials yield statistically nonsignificant results. Such results are difficult to interpret within the dominant statistical framework. Objective To estimate the strength of evidence in favor of the null…