A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Jedidiah Siev, Shelby E. Zuckerman, Joseph J. Siev · 2018 · Social Psychology
Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to…
Thi Yen Loan Le, Hilda A. Pickett, Andrian Yang et al. · 2019 · Scientific Reports
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) and use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability to repair the heart after induced myocardial infarction. hTERT over-expression in PDGFRα + cardiac MSCs (hTERT + PDGFRα + cMSCs) modulates cell differentiation, proliferation, survival and angiogenesis re
Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil et al. · 2025 · Cancer Discovery
This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with…
Claire Linares, Anne-Laure Sellier · 2021 · PLoS ONE
A 2013 article reported two experiments suggesting that the mere presence of a cellphone (vs. a notebook) can impair the relationship quality between strangers. The purpose of the present research is twofold: (1) closely replicate this article's findings, and (2) examine whether there may be an impact of the mere presence of a phone on creativity, whether at a group- or an individual- level. In two experiments (N = 356 participants, 136 groups), we followed the original procedure in the 2013 article. In particular, groups of participants who had never seen each other before the study had a con
Ana C. Ruiz Pardo, John Paul Minda · 2022 · Acta Psychologica
The present study was a pre-registered direct replication of Ward et al.'s (2017) second experiment (OSF pre-registration found at: https://osf.io/5fq4r). This replication assigned both smartphone location (on desk, in pocket/bag, or outside of the testing room) and smartphone power (on, or off) for a total of six conditions. Participants completed an automated operation span (OSpan) task, a Cue-Dependent Go/No-Go task, and the smartphone attachment and dependency inventory. It was hypothesized that performance on an attention-demanding task (i.e., the OSpan task) would be worse for those in c
Ben Backes, Michael Hansén · 2017 · Education Finance and Policy
Recent evidence on teacher productivity suggests that teachers meaningfully influence non-test academic student outcomes that are commonly overlooked by narrowly focusing on test scores. Despite a large number of studies investigating the…
Lara J. Mentink, Joao Guimaraes, Myrthe Faber et al. · 2021 · NeuroImage
Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. We aimed to replicate the early findings of Filippini et al, using the APOE gene, still the principal AD risk gene, and extended this with a polygenic risk score (PRS) analysis for AD, using the Human Connectome Project dataset (HCP). We include
Emiko J. Muraki, Penny M. Pexman · 2021 · Journal of Experimental Psychology Learning Memory and Cognition
In embodied theories of semantic representation, the processes and mechanisms of modal simulations that are engaged during semantic processing have tended to be underspecified. We investigated the possibility that motor imagery may be a…
J. van Wolferen, Yoel Inbar, Marcel Zeelenberg · 2013 · Judgment and Decision Making
Abstract In this paper we test two hypotheses regarding magical thinking about the perceived likelihood of future events. The first is that people believe that those who “tempt fate” by failing to take necessary precautions are more likely to suffer negative outcomes. The second is the “protection effect”, where reminding people of precautions they have taken leads them to see related risks as less likely. To this end, we describe the results from three attempted direct replications of a protection effect experiment reported in Tykocinski (2008) and two replications of a tempting fate experime
Cristian Vasco · 2013 · Americanae (AECID Library)
Con datos de la “Encuesta de condiciones de vida (ecv) 2005-2006”, este artículo analiza el impacto de la migración internacional y las remesas en la iniciativa emprendedora en el Ecuador rural. Los resultados sugieren que ni la migración…
Ellen Bialystok · 2020 · Journal of Multilingual Theories and Practices
The controversy over whether bilingualism has consequences for mind and brain shows no sign of abating. A steady stream of research reporting both positive results supporting the claim for beneficial effects of bilingualism and null…
Seong Ki Yoo, Simon L. Cotton, Young Jin Chun et al. · 2017 · IEEE Antennas and Wireless Propagation Letters
This letter investigates the first-order characteristics of dynamic off-body communications channels at 60 GHz. In particular, we have studied signal propagation from a chest-worn millimeter-wave transmitter as an adult male walked toward and then away from a hypothetical base station. The mobile line-of-sight (LOS) and non-LOS (NLOS) channel measurements have been conducted in a diverse range of environments, including a hallway, an open office, an anechoic chamber, and an outdoor car park. In this study, we have decomposed the received signal into its path loss, large-scale, and small-scale
Lukas Klaschinski, Konrad Schnabel, Michela Schröder–Abé · 2017 · Comprehensive Results in Social Psychology
The current study attempted to replicate results by Cuddy, Wilmuth, Yap, and Carney (2015) who showed that adopting high-power poses prior to a demanding job interview improved dominant behavior and overall hireability judgments. We…
Amy K. Sheaffer, Min S. Lee, Dennis Hernandez et al. · 2011 · Antiviral Therapy
BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…
Stephanie Loomis, Man Li, Nisa M. Maruthur et al. · 2018 · Diabetes
Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide…
Shayne B. Piasta, Jessica A. R. Logan, Cynthia M. Zettler‐Greeley et al. · 2022 · Journal of Learning Disabilities
Preschool-age children identified as at risk for later reading difficulties can benefit from supplemental, small-group emergent literacy intervention. As such interventions become commercially available and marketed to preschool programs,…
Megan Willis, Andrea I. Costantino, Michael A. Nitsche et al. · 2019 · Frontiers in Neuroscience
There has been increasing interest in the utility of transcranial electrical stimulation as a tool to enhance cognitive abilities. In the domain of face perception, enhancements have been reported for both transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (tRNS) targeting the occipitotemporal cortex. In a series of two experiments, we attempted to replicate these findings for face identity perception, and extend on previous studies, to determine if similar enhancements are also observed for object and facial expression perception. In Experi
Victor Virlogeux, Rebecca E. Graff, Thomas J. Hoffmann et al. · 2015 · Cancer Epidemiology Biomarkers & Prevention
BACKGROUND: Prostate cancer incidence and mortality rates vary across populations, with African American men exhibiting the highest rates. To date, genome-wide association studies have identified 104 SNPs independently associated with…
Lei Sun, Sergey Yagoda, Baiyun Yao et al. · 2019 · Clinical Drug Investigation
BACKGROUND AND OBJECTIVE: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine…
Tamar Sofer, Leslie S. Emery, Deepti Jain et al. · 2019 · Scientific Reports
Abstract Lower extremity peripheral artery disease (PAD) burden differs by race/ethnicity. Although familial aggregation and heritability studies suggest a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-European descent populations. Genome-wide association studies (GWAS) of the ankle brachial index (ABI) and PAD (defined as an ABI < 0.90) have not been conducted in Hispanics/Latinos. We performed a GWAS of PAD and the ABI in 7,589 participants aged >45 years from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We also performed
Fabio Caraffini, Giovanni Iacca · 2020 · Mathematics
We present Stochastic Optimisation Software (SOS), a Java platform facilitating the algorithmic design process and the evaluation of metaheuristic optimisation algorithms. SOS reduces the burden of coding miscellaneous methods for dealing…
Arran T. Reader, Victoria S. Trifonova, H. Henrik Ehrsson · 2021 · European Journal of Neuroscience
Body ownership refers to the distinct sensation that our observed body belongs to us, which is believed to stem from multisensory integration. This is commonly shown through the rubber hand illusion (RHI), which induces a sense of ownership over a false limb. Whilst the RHI may interfere with object-directed action and alter motor cortical activity, it is not yet clear whether a sense of ownership over an artificial hand has functional consequences for movement production per se. As such, we performed two motion-tracking experiments (n = 117) to examine the effects of the RHI on the reaction t
Roope Lasanen, Petro Julkunen, Olavi Airaksinen et al. · 2015 · Skin Research and Technology
BACKGROUND: Topical menthol gels are used in the treatment of various pain conditions. However, the effect of the menthol concentration to skin cooling or cooling sensation is not clear. We hypothesized that increasing menthol…
Xue Zhou, Yang Xu, Jia Wang et al. · 2011 · PLoS ONE
BACKGROUND: Autism is a common, severe and highly heritable neurodevelopmental disorder in children, affecting up to 100 children per 10,000. The MET gene has been regarded as a promising candidate gene for this disorder because it is located within a replicated linkage interval, is involved in pathways affecting the development of the cerebral cortex and cerebellum in ways relevant to autism patients, and has shown significant association signals in previous studies. PRINCIPAL FINDINGS: Here, we present new ASD patient and control samples from Heilongjiang, China and use them in a case-contro
Wei Li, Laura Germine, Samuel A. Mehr et al. · 2022 · Infant and Child Development
Widespread failures of replication and generalization are, ironically, a scientific triumph, in that they confirm the fundamental metascientific theory that underlies our field. Generalizable and replicable findings require testing large…
Santiago López‐Miranda, Daniel Berdejo, Elisa Pagán et al. · 2020 · Journal of the Science of Food and Agriculture
Abstract BACKGROUND The antimicrobial activity of essential oils and their constituents has led to increasing interest in using them as natural preservative agents. However, their high sensitivity to light and oxygen, their volatility and…
Hwa Young Ahn, Hye Sook Min, Yohwan Yeo et al. · 2015 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Previous studies on the extent to which radioactive iodine (RAI) therapy for thyroid cancer increases the risk of subsequently developing breast cancer have given conflicting results. OBJECTIVE: This study aimed to evaluate the…
Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips · 2017 · Chronic Stress
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,…
Lekshmi Santhosh, Snigdha Jain, Anna K. Brady et al. · 2017 · Annals of the American Thoracic Society
RATIONALE: It is important for attending physicians to know which behaviors influence learner perceptions. To date, two studies focusing on general medicine attending physicians have been published addressing internal medicine residents'…
Àngels Colomé · 2018 · Quarterly Journal of Experimental Psychology
Larger distance effects in high math-anxious individuals (HMA) performing comparison tasks have previously been interpreted as indicating less precise magnitude representation in this population. A recent study by Dietrich, Huber, Moeller, and Klein limited the effects of math anxiety to symbolic comparison, in which they found larger distance effects for HMA, despite equivalent size effects. However, the question of whether distance effects in symbolic comparison reflect the properties of the magnitude representation or decisional processes is currently under debate. This study was designed t