Failed Experiment ReportOpen accessMedicine
Penelope‐Georgia Papayanni, D. Chasiotis, Kiriakos Koukoulias et al. · 2021 · Clinical Infectious Diseases
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an urgent need for the development of effective therapies for coronavirus disease 2019 (COVID-19). METHODS: We first tested SARS-CoV-2-specific…
View details →DOI: 10.1093/cid/ciab371Cited by 20 Negative / Null Result ReportOpen accessMedicine
Santiago Moreno, Bernardino Alcázar-Navarrete, Carlos Dueñas et al. · 2022 · Drug Design Development and Therapy
The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of antiviral agents in general and remdesivir in COVID-19 patients. This review evaluated a battery of antiviral compounds and their…
View details →DOI: 10.2147/dddt.s356951Cited by 20 Negative / Null Result ReportOpen accessMedicine
Jong Hoon Hyun, Moo Hyun Kim, Yujin Sohn et al. · 2021 · BMC Infectious Diseases
Abstract Background Coronavirus disease 2019 (COVID-19) is associated with acute respiratory distress syndrome, and corticosteroids have been considered as possible therapeutic agents for this disease. However, there is limited literature on the appropriate timing of corticosteroid administration to obtain the best possible patient outcomes. Methods This was a retrospective cohort study including patients with severe COVID-19 who received corticosteroid treatment from March 2 to June 30, 2020 in seven tertiary hospitals in South Korea. We analyzed the patient demographics, characteristics, and
View details →DOI: 10.1186/s12879-021-06221-5Cited by 20 Negative / Null Result ReportOpen accessImmunology and Microbiology
Sergio Cleto, Camila Eleutério Rodrigues, Ceila María Sant’Ana Malaque et al. · 2016 · PLoS ONE
BACKGROUND: Leptospirosis is a health problem worldwide. Its most severe form is a classic model of sepsis, provoking acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI), with associated mortality that remains unacceptably high. We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. However, the mode of clearance can also affect dialysis patient outcomes. Therefore, the objective of this study was to compare the effects of SLED with traditional (diffusive) clearance, via hemodia
View details →DOI: 10.1371/journal.pone.0160010Cited by 20 Negative / Null Result ReportOpen accessMedicine
Pierina Navarria, Federico Pessina, Stefano Tomatis et al. · 2017 · Oncotarget
// Pierina Navarria 1, * , Federico Pessina 2, * , Stefano Tomatis 1 , Riccardo Soffietti 3 , Marco Grimaldi 4 , Egesta Lopci 5 , Arturo Chiti 5, 7 , Antonella Leonetti 9 , Alessandra Casarotti 2 , Marco Rossi 2 , Luca Cozzi 1 , Anna Maria Ascolese 1 , Matteo Simonelli 6, 7 , Simona Marcheselli 8 , Armando Santoro 6, 7 , Elena Clerici 1 , Lorenzo Bello 2 and Marta Scorsetti 1, 7 1 Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 2 Neurosurgical Oncology Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 3 Consultant
View details →DOI: 10.18632/oncotarget.18809Cited by 20 Negative / Null Result ReportOpen accessMedicine
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende‐Zuma et al. · 2022 · EClinicalMedicine
Background HIV-TB treatment integration reduces mortality. Operational implementation of integrated services is challenging. This study assessed the impact of quality improvement (QI) for HIV-TB integration on mortality within primary…
View details →DOI: 10.1016/j.eclinm.2022.101298Cited by 20 Negative / Null Result ReportOpen accessMedicine
Mohan Li, Yuelun Zhang, Lijian Pei et al. · 2022 · Frontiers in Oncology
Background Effects of anesthetic interventions on cancer prognosis remain controversial. There is evidence that estrogen receptor (ER)-negative breast cancer patients have an early recurrence peak. We aimed to assess the potential benefit of regional anesthesia-analgesia versus general anesthesia regarding early recurrence in breast cancer according to ER expression. Methods Based on a multicenter randomized controlled trial (clinicaltrials.gov, NCT00418457), we included all the patients from Peking Union Medical College Hospital research center in this study. The primary outcome was breast ca
View details →DOI: 10.3389/fonc.2022.837959Cited by 20 Negative / Null Result Report
Greg Campbell, Andrew Coffey, Heather Miller et al. · 2018 · Animal Production Science
Beef cattle production is the major agricultural pursuit in the arid rangelands of Australia. Dingo predation is often considered a significant threat to production in rangeland beef herds, but there is a need for improved understanding of…
View details →DOI: 10.1071/an17008Cited by 20 Negative / Null Result ReportOpen accessMedicine
Anthony Bentley, Samantha Gillard, Michael Spino et al. · 2013 · PharmacoEconomics
BACKGROUND: Patients with β-thalassaemia major experience chronic iron overload due to regular blood transfusions. Chronic iron overload can be treated using iron-chelating therapies such as desferrioxamine (DFO), deferiprone (DFP) and…
View details →DOI: 10.1007/s40273-013-0076-zCited by 20 Negative / Null Result ReportOpen accessMedicine
Tanguy Y. Seiwert, Sara Kochanny, Kevin Wood et al. · 2020 · Cancer
BACKGROUND: Patients with cetuximab-resistant, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) have poor outcomes. This study hypothesized that dual blockade of mammalian target of rapamycin and epidermal growth factor…
View details →DOI: 10.1002/cncr.32929Cited by 20 Negative / Null Result ReportOpen accessMedicine
Laurent Chiche · 2012 · Therapeutics and Clinical Risk Management
Belimumab is the first biologic approved for patients with systemic lupus erythematosus (SLE). Belimumab is the first of a new class of drug targeting B cell-stimulating factors or their receptors to reach the market. Its target, BLyS,…
View details →DOI: 10.2147/tcrm.s19819Cited by 20 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
April R. Giles, Martin Lock, Shu‐Jen Chen et al. · 2023 · Human Gene Therapy
For successful vector-based gene therapy manufacturing, the selected adeno-associated virus (AAV) vector production system must produce vector at sufficient scale. However, concerns have arisen regarding the quality of vector produced…
View details →DOI: 10.1089/hum.2022.116Cited by 20 Negative / Null Result ReportOpen accessMedicine
Oluwamayokun Oshinowo, Renee Copeland, Yumiko Sakurai et al. · 2021 · Blood Advances
Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar. Multiple biophysical parameters integrate during clot formation, measured by bulk clot…
View details →DOI: 10.1182/bloodadvances.2020003755Cited by 20 Negative / Null Result ReportOpen accessMedicine
Malin Assarsson, Jan Söderman, Olaf Dienus et al. · 2020 · Acta Dermato Venereologica
Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial…
View details →DOI: 10.2340/00015555-3619Cited by 20 Negative / Null Result Report
Paweł Mateusz Nowak, Edyta Sekuła, Paweł Kościelniak · 2020 · Chromatographia
Abstract The choice between capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) is not easy and depends on many factors. An attempt to facilitate this choice is this work, in which both techniques have been…
View details →DOI: 10.1007/s10337-020-03933-9Cited by 20 Negative / Null Result Report
Remco van Dijk, Sem J. Aronson, Dirk R. de Waart et al. · 2017 · Scientific Reports
Abstract We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit…
View details →DOI: 10.1038/s41598-017-01602-wCited by 20 Negative / Null Result Report
Rezzy Eko Caraka, Yusra Yusra, Toni Toharudin et al. · 2021 · Sustainability
Background and objectives: The impacts of COVID-19 are like two sides of one coin. During 2020, there were many research papers that proved our environmental and climate conditions were improving due to lockdown or large-scale restriction…
View details →DOI: 10.3390/su13115946Cited by 20 Negative / Null Result Report
Nadia A. Abdelmegeed Abdelwahed, Bahadur Ali Soomro, Naimatullah Shah · 2022 · Management of Environmental Quality: An International Journal
Purpose The study investigates the intention to adopt climate change and the pro-environmental behaviours among the residents of a developing country (Pakistan) through the theory of planned behaviour (TPB). Design/methodology/approach…
View details →DOI: 10.1108/meq-10-2021-0236Cited by 20 Negative / Null Result Report
Yukari Kobayashi, Jennifer A. Tremmel, Yuhei Kobayashi et al. · 2015 · Journal of the American Heart Association
Background Although a myocardial bridge ( MB ) is often regarded as a benign coronary variant, recent studies have associated MB with focal myocardial ischemia. The physiological consequences of MB on ventricular function during stress…
View details →DOI: 10.1161/jaha.115.002496Cited by 20 Negative / Null Result Report
W. Roether, J. E. Lupton · 2011 · Ocean Science
Abstract. Observations of tritium and 3He in the Tyrrhenian Sea, 1987–2009, confirm the enhanced vertical mixing of intermediate waters into the deep waters that has been noted and associated with the Eastern Mediterranean Transient in…
View details →DOI: 10.5194/os-7-91-2011Cited by 20 Negative / Null Result ReportBusiness, Management and Accounting
Matthijs van der Loos · 2011 · Data Archiving and Networked Services (DANS)
Recent studies suggest that entrepreneurship is partly heritable, but are unable to pinpoint the specific genes involved. This thesis presents results from novel research aiming to identify genes associated with entrepreneurship using…
Negative / Null Result ReportNeuroscience
Jedidiah Siev, Shelby E. Zuckerman, Joseph J. Siev · 2018 · Social Psychology
Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to…
View details →DOI: 10.1027/1864-9335/a000349Cited by 20 Negative / Null Result ReportOpen accessMedicine
Thi Yen Loan Le, Hilda A. Pickett, Andrian Yang et al. · 2019 · Scientific Reports
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) and use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability to repair the heart after induced myocardial infarction. hTERT over-expression in PDGFRα + cardiac MSCs (hTERT + PDGFRα + cMSCs) modulates cell differentiation, proliferation, survival and angiogenesis re
View details →DOI: 10.1038/s41598-019-47022-wCited by 20 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil et al. · 2025 · Cancer Discovery
This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with…
View details →DOI: 10.1158/2159-8290.cd-24-1230Cited by 20 Negative / Null Result ReportOpen accessPsychology
Claire Linares, Anne-Laure Sellier · 2021 · PLoS ONE
A 2013 article reported two experiments suggesting that the mere presence of a cellphone (vs. a notebook) can impair the relationship quality between strangers. The purpose of the present research is twofold: (1) closely replicate this article's findings, and (2) examine whether there may be an impact of the mere presence of a phone on creativity, whether at a group- or an individual- level. In two experiments (N = 356 participants, 136 groups), we followed the original procedure in the 2013 article. In particular, groups of participants who had never seen each other before the study had a con
View details →DOI: 10.1371/journal.pone.0251451Cited by 20 Negative / Null Result ReportOpen accessMedicine
Ana C. Ruiz Pardo, John Paul Minda · 2022 · Acta Psychologica
The present study was a pre-registered direct replication of Ward et al.'s (2017) second experiment (OSF pre-registration found at: https://osf.io/5fq4r). This replication assigned both smartphone location (on desk, in pocket/bag, or outside of the testing room) and smartphone power (on, or off) for a total of six conditions. Participants completed an automated operation span (OSpan) task, a Cue-Dependent Go/No-Go task, and the smartphone attachment and dependency inventory. It was hypothesized that performance on an attention-demanding task (i.e., the OSpan task) would be worse for those in c
View details →DOI: 10.1016/j.actpsy.2022.103717Cited by 20 Negative / Null Result ReportSocial Sciences
Ben Backes, Michael Hansén · 2017 · Education Finance and Policy
Recent evidence on teacher productivity suggests that teachers meaningfully influence non-test academic student outcomes that are commonly overlooked by narrowly focusing on test scores. Despite a large number of studies investigating the…
View details →DOI: 10.1162/edfp_a_00231Cited by 20 Negative / Null Result ReportOpen accessMedicine
Lara J. Mentink, Joao Guimaraes, Myrthe Faber et al. · 2021 · NeuroImage
Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. We aimed to replicate the early findings of Filippini et al, using the APOE gene, still the principal AD risk gene, and extended this with a polygenic risk score (PRS) analysis for AD, using the Human Connectome Project dataset (HCP). We include
View details →DOI: 10.1016/j.neuroimage.2021.118304Cited by 20 Negative / Null Result ReportPsychology
Emiko J. Muraki, Penny M. Pexman · 2021 · Journal of Experimental Psychology Learning Memory and Cognition
In embodied theories of semantic representation, the processes and mechanisms of modal simulations that are engaged during semantic processing have tended to be underspecified. We investigated the possibility that motor imagery may be a…
View details →DOI: 10.1037/xlm0001039Cited by 20 Negative / Null Result ReportOpen accessDecision Sciences
J. van Wolferen, Yoel Inbar, Marcel Zeelenberg · 2013 · Judgment and Decision Making
Abstract In this paper we test two hypotheses regarding magical thinking about the perceived likelihood of future events. The first is that people believe that those who “tempt fate” by failing to take necessary precautions are more likely to suffer negative outcomes. The second is the “protection effect”, where reminding people of precautions they have taken leads them to see related risks as less likely. To this end, we describe the results from three attempted direct replications of a protection effect experiment reported in Tykocinski (2008) and two replications of a tempting fate experime
View details →DOI: 10.1017/s1930297500004496Cited by 20 