Development of a Chimeric Replicon System for Phenotypic Analysis of Ns3 Protease Sequences from HCV Clinical Isolates
Amy K. Sheaffer; Min S. Lee; Dennis Hernandez; Susan Chaniewski; Fei Yu; Paul Falk; Jacques Friborg; Guangzhi Zhai · 2011 · Antiviral Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…
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Metadata source: OpenAlex · DOI 10.3851/imp1825