Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo
Remco van Dijk; Sem J. Aronson; Dirk R. de Waart; Stan F. van de Graaf; Suzanne Duijst; Jurgen Seppen; Ronald Oude Elferink; Ulrich Beuers · 2017 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Abstract We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit…
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Metadata source: Crossref · DOI 10.1038/s41598-017-01602-w