Negative / Null Result ReportOpen accessMedicine
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan et al. · 2023 · mBio
ABSTRACT Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing respiratory-deficient colonies, termed “petite.” Despite reports of clinical petite C. glabrata strains, our understanding of petite behavior in the host remains obscure. Moreover, controversies exist regarding in-host petite fitness and its clinical relevance. Herein, we employed whole-genome sequencing (WGS), dual-RNAseq, and extensive ex vivo and
View details →DOI: 10.1128/mbio.01180-23Cited by 22 Negative / Null Result Report
HELENA FORSMAN · 2021 · International Journal of Innovation Management
While innovation is an attractive path, it is also a rocky path made up of numerous challenges, even failures. This study provides new knowledge for understanding innovation failure. It seeks answers to the question: What are the perceived…
View details →DOI: 10.1142/s1363919621501048Cited by 22 Negative / Null Result Report
Joy Leopold, Jason R. Lambert, Ifeyimika O. Ogunyomi et al. · 2019 · Equality, Diversity and Inclusion: An International Journal
Purpose The purpose of this paper is to propose that #MeToo is a social movement which has been more effective in changing norms around and increasing understanding about the prevalence and destructiveness of sexual harassment than decades…
View details →DOI: 10.1108/edi-04-2019-0129Cited by 22 Negative / Null Result Report
Stephanie K. Courtney Jones, Adam J. Munn, Phillip G. Byrne · 2018 · Royal Society Open Science
Captive breeding programmes are increasingly relied upon for threatened species management. Changes in morphology can occur in captivity, often with unknown consequences for reintroductions. Few studies have examined the morphological…
View details →DOI: 10.1098/rsos.172470Cited by 22 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sergio Garnica-Galvez, Stefanie Korntner, Ioannis Skoufos et al. · 2021 · Cells
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering. Despite the significant advancements in the field, the optimal macromolecular crowder still remains elusive. Herein, the physicochemical properties of different concentrations of different molecular weights hyaluronic acid (HA) and their influence on equine adipose-derived stem cell cultures were assessed. Within the different concentrations and molecular weight HAs, the 10 mg/mL 100 kDa and 500 kDa HAs exhibited the high
View details →DOI: 10.3390/cells10040859Cited by 22 Negative / Null Result Report
Kiana Christensen, Keegan M. Melstrom · 2021 · PLOS ONE
Squamates are ideal subjects for investigating relationships between diet and dental patterns because they exhibit wide dietary diversity, marked variation in dental shape, and are taxonomically abundant. Despite this, well-established…
View details →DOI: 10.1371/journal.pone.0257427Cited by 22 Negative / Null Result ReportOpen accessMedicine
Ángel Herráiz-Adillo, Viktor H. Ahlqvist, Sara Higueras‐Fresnillo et al. · 2023 · Frontiers in Cardiovascular Medicine
Background To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods Randomly recruited participants aged 50–64 years from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According to the AHA definitions, two CVH scores were calculated: i) the LE8 score (0, worst CVH;
View details →DOI: 10.3389/fcvm.2023.1173550Cited by 22 Negative / Null Result ReportOpen accessMedicine
Antonella Ferro, Michela Campora, A. Caldara et al. · 2024 · Journal of Clinical Medicine
Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains the mainstay treatment option for hormone receptor (HR)-positive BC either in the early or in advanced setting, including different strategies, such as the suppression of estrogen production or directly blocking the ER pathway through SERMs—selective estrogen receptor modulators—or SERDs—selective estrogen receptor degraders. Nevertheless, the development of de novo or acquired endocrine resistance still remains challenging for oncologists. The use of no
View details →DOI: 10.3390/jcm13123611Cited by 22 Negative / Null Result ReportOpen accessMedicine
Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio et al. · 2023 · Cancer Research
Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with…
View details →DOI: 10.1158/0008-5472.can-22-2620Cited by 22 Negative / Null Result ReportOpen accessMedicine
Haiming Liu, Jiaohua Luo, Bobby Guillory et al. · 2020 · Oncotarget
// Haiming Liu 1 , 2 , * , Jiaohua Luo 3 , 4 , * , Bobby Guillory 3 , Ji-an Chen 3 , 5 , Pu Zang 3 , 6 , Jordan K. Yoeli 3 , Yamileth Hernandez 3 , Ian (In-gi) Lee 1 , 2 , Barbara Anderson 1 , 2 , Mackenzie Storie 1 , 2 , Alison Tewnion 1 and Jose M. Garcia 1 , 2 , 3 1 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA 2 Gerontology and Geriatric Medicine, University of Washington Department of Medicine, Seattle, WA, USA 3 Division of Endocrinology, Diabetes and Metabolism, MCL, Center for Translational Research on Inflammatory
View details →DOI: 10.18632/oncotarget.27705Cited by 22 Negative / Null Result ReportOpen accessMedicine
Maarten Korrel, Sanne Lof, Jony van Hilst et al. · 2020 · Annals of Surgical Oncology
BACKGROUND: Surgical factors, including resection of Gerota's fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique. PATIENTS AND METHODS: Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007-2015) were analyzed. Cox proportional ha
View details →DOI: 10.1245/s10434-020-08658-5Cited by 22 Negative / Null Result ReportOpen accessMedicine
Vandana Chaturvedi, Nora Lakes, Minh H. Tran et al. · 2021 · Blood
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder in which numerous cytokines are elevated, though interferon-γ (IFN-γ) is central to disease pathogenesis and a key therapeutic target. Experimental and early clinical…
View details →DOI: 10.1182/blood.2020007930Cited by 22 Negative / Null Result ReportOpen accessMedicine
Ronak G Gandhi, Camille N Kotton · 2022 · Therapeutics and Clinical Risk Management
Purpose of Review: Cytomegalovirus (CMV) infections are a common complication in solid organ (SOT) and hematopoietic stem cell transplant (HSCT) recipients, leading to increased morbidity and mortality. Currently available treatment…
View details →DOI: 10.2147/tcrm.s303052Cited by 22 Negative / Null Result ReportOpen accessMedicine
Aldina Mešić, Emahlea Jackson, Mathias Lalika et al. · 2022 · PLOS Global Public Health
The interferon (IFN) system is a potent line of defense against viral infections. IFN-based agents already tested may be of use in COVID-19 or future viral respiratory outbreaks. Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. We identified 977 articles, of which 194 were included for full-text review. Of these, we deemed 35 articles to be relevant. The use of IFN-based agents for pre-exposure prophylaxis (n = 19) and
View details →DOI: 10.1371/journal.pgph.0000231Cited by 22 Negative / Null Result ReportMedicine
Michelle Xiao, Joseph Donahue, Marc R. Safran et al. · 2020 · Arthroscopy The Journal of Arthroscopic and Related Surgery
Purpose To discern differences between the PearlDiver and MarketScan databases with regards to patient demographics, costs, reoperations, and complication rates for isolated meniscectomy. Methods We queried the PearlDiver Humana Patient…
View details →DOI: 10.1016/j.arthro.2020.09.013Cited by 22 Negative / Null Result Report
Amie Fairs, Kristof Strijkers · 2021 · PLOS ONE
The closure of cognitive psychology labs around the world due to the COVID-19 pandemic has prevented in-person testing. This has caused a particular challenge for speech production researchers, as before the pandemic there were no studies…
View details →DOI: 10.1371/journal.pone.0258908Cited by 22 Negative / Null Result ReportOpen accessMedicine
Kazuyuki Uehara, Takashi Sasayama, Daisuke Miyawaki et al. · 2012 · Radiation Oncology
BACKGROUND: The purpose of the present study was to analyze the recurrence pattern of high-grade glioma treated with a multimodal treatment approach and to evaluate whether the MIB-1 labeling index (LI) could be a useful marker for predicting the pattern of failure in glioblastoma (GB). METHODS AND MATERIALS: We evaluated histologically confirmed 131 patients with either anaplastic astrocytoma (AA) or GB. A median dose was 60 Gy. Concomitant and adjuvant chemotherapy were administered to 111 patients. MIB-1 LI was assessed by immunohistochemistry. Recurrence patterns were categorized according
View details →DOI: 10.1186/1748-717x-7-104Cited by 22 Negative / Null Result ReportOpen accessMedicine
Berna Harmse, Herculina S. Kruger · 2011 · PubMed
Low-grade systemic inflammation is emerging as a component of the metabolic syndrome. The purpose of this study was to assess the association between serum C-reactive protein (CRP), physical activity and body composition in 193 black children aged 13 to 18 years from a South African township. Demographic information and anthropometric measurements were taken, and fasting blood samples were analysed for high-sensitivity serum CRP. Body fat was measured by air displacement plethysmography. There was a trend towards higher serum CRP in the boys with a higher percentage body fat. After multiple re
View details →DOI: 10.5830/cvja-2010-005Cited by 22 Negative / Null Result Report
Marina A Pak, Dmitry N Ivankov · 2022 · Bioinformatics
Abstract Motivation Prediction of protein stability change upon mutation (ΔΔG) is crucial for facilitating protein engineering and understanding of protein folding principles. Robust prediction of protein folding free energy change…
View details →DOI: 10.1093/bioinformatics/btac515Cited by 22 Negative / Null Result Report
Sheeva Bhattarai, Tore Framstad, Jens Peter Nielsen · 2019 · Acta Veterinaria Scandinavica
Abstract Background Anemia characterized by low hemoglobin concentration (HbC) is common in indoor housed pregnant sows. Iron is essential for hemoglobin synthesis and a number of metabolic processes including DNA synthesis and regulation…
View details →DOI: 10.1186/s13028-019-0497-6Cited by 22 Negative / Null Result Report
Mylène Potier, Gilles Fromentin, Aurélie Lesdema et al. · 2010 · British Journal of Nutrition
Whether protein is the macronutrient with the strongest satiety effect remains a matter of debate because of the diversity of study designs employed. The aim of the present study was to compare the effect of different liquid preloads made…
View details →DOI: 10.1017/s0007114510002126Cited by 22 Negative / Null Result Report
John Guenther, Samuel Osborne · 2020 · The Australian Journal of Indigenous Education
Abstract Over the 10 years of ‘Closing the Gap’, several interventions designed to improve outcomes for Aboriginal and Torres Strait Islander students have been trialled. In 2014 the Australian Government announced the ‘Flexible Literacy…
View details →DOI: 10.1017/jie.2019.28Cited by 22 Negative / Null Result Report
Anne Watson, Leon A. Barmuta · 2011 · Marine and Freshwater Research
The loss of connectivity in intermittent streams can limit aquatic-invertebrate access to food resources, with different resources available in individual pools. Although leaf litter was abundant in the Macquarie River in Tasmania, stable…
View details →DOI: 10.1071/mf10298Cited by 22 Negative / Null Result Report
Michał Borys, Beata Potręć-Studzińska, Marcin Wiech et al. · 2019 · Anaesthesiology Intensive Therapy
Background Sparse data exist on the prevalence and severity of chronic postsurgical pain (CPSP) following cesarean section. Our study aimed to compare the effectiveness of transversus abdominis plane (TAP) block and…
View details →DOI: 10.5114/ait.2019.88071Cited by 22 Negative / Null Result Report
Miled El Hajji · 2018 · International Journal of Biomathematics
In this paper, I consider two species feeding on limiting substrate in a chemostat taking into account some possible effects of each species on the other one. System of differential equations is proposed as model of these effects with…
View details →DOI: 10.1142/s1793524518501115Cited by 22 Negative / Null Result Report
Benjamin Udoka Nwosu, Layana Al-Halbouni, Sadichchha Parajuli et al. · 2021 · Frontiers in Endocrinology
Importance There is no consensus on the impact of the 2020 COVID-19 pandemic lockdown on glycemic control in children and adolescents with type 1 diabetes (T1D) in the US. Aim To determine the impact of the pandemic lockdown of March 15th…
View details →DOI: 10.3389/fendo.2021.703905Cited by 22 Negative / Null Result Report
Vasilios A. Raoulis, Aristidis Zibis, Maria Dimitra Chiotelli et al. · 2021 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to compare the maximum load to failure and stiffness of three medial patella‐femoral ligament (MPFL) reconstruction techniques: (i) suture anchor fixation (SA), (ii) interference screw…
View details →DOI: 10.1007/s00167-020-06389-4Cited by 22 Negative / Null Result ReportOpen accessMedicine
Deven K. Gupta, Beth H. Shaz · 2025 · Journal of Translational Medicine
BACKGROUND: Chimeric antigen receptor T-cell (CAR T-cell) therapies have shown significant promise in treating cancers and other diseases. However, the manufacturing processes for CAR T-cell therapies exhibit considerable variability,…
View details →DOI: 10.1186/s12967-025-06400-xCited by 22 Negative / Null Result ReportOpen accessMedicine
Bruce Cree, Joseph R. Berger, Benjamin Greenberg · 2025 · CNS Drugs
B-cell depletion with CD20-targeted agents is commonly used for treatment of multiple sclerosis (MS), other autoimmune diseases, and certain hematologic malignancies. Initial apparent success with rituximab in MS and neuromyelitis optica…
View details →DOI: 10.1007/s40263-025-01182-8Cited by 22 Negative / Null Result ReportOpen accessHealth Professions
Osea Giuntella, Johannes König, Luca Stella · 2025 · Scientific Reports
This study explores the relationship between artificial intelligence (AI) and workers' well-being and health using longitudinal survey data from Germany (2000-2020). Using a measure of occupational exposure to AI, we explore an event study…
View details →DOI: 10.1038/s41598-025-98241-3Cited by 22 