Calmangafodipir for Prevention of Oxaliplatin-Induced Peripheral Neuropathy: Two Placebo-Controlled, Randomized Phase 3 Studies (POLAR-A/POLAR-M)
Per Pfeiffer; Maryam B. Lustberg; Jacques Näsström; Stefan Carlsson; Anders Persson; Fumiko Nagahama; Guido Cavaletti; Bengt Glimelius · 2022 · JNCI Cancer Spectrum
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract
BACKGROUND: Calmangafodipir (CaM, PledOx) demonstrated efficacy in preventing patient-reported chemotherapy-induced peripheral neuropathy (CIPN) in a randomized phase 2 study in patients with metastatic colorectal cancer. The Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy (POLAR) program aimed to assess efficacy and safety of CaM in the prevention of CIPN in patients treated with oxaliplatin in adjuvant (POLAR-A, ClinicalTrials.gov.NCT04034355) or metastatic (POLAR-M, ClinicalTrials.gov.NCT03654729) settings. METHODS: Two randomized, placebo-controlled phase 3 trials investi
Abstract by Per Pfeiffer; Maryam B. Lustberg; Jacques Näsström; Stefan Carlsson; Anders Persson; Fumiko Nagahama; Guido Cavaletti; Bengt Glimelius, JNCI Cancer Spectrum (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/jncics/pkac075