A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Kariem Ezzat, Andrea Sturchio, Alberto J. Espay · 2022 · Biology
Protein aggregation into amyloid fibrils affects many proteins in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer. Physicochemically, amyloid formation is a phase transition process, where soluble…
Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases
Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…
Laura M. Wasielewski · 2016 · Journal of Catholic Education
The purpose of this study was to determine if students with disabilities perform comparably to students without disabilities academically at a small liberal arts college. Quantitative results were gathered through the comparison of end of semester and cumulative grade point averages for students with disabilities and students without disabilities (n=56). The t test for independent means and a 2-way analysis of variance were used to test hypotheses. Students without disabilities had significantly higher academic performances than students with disabilities as measured by grade point averages. F
Lucius S. Fekonja, Ziqian Wang, Dogu Baran Aydogan et al. · 2021 · Frontiers in Oncology
Tumors infiltrating the motor system lead to significant disability, often caused by corticospinal tract injury. The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome. However, up to 90% of white matter (WM) voxels include multiple fiber populations, which cannot be correctly described with traditional metrics such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). Here, we used a novel fixel-based along-tract analysis consisting of cons
Lukas Ernstbrunner, Torsten Pastor, Manuel Waltenspül et al. · 2021 · The American Journal of Sports Medicine
Background: The Latarjet is a successful procedure but can be associated with significant complications, including failure. Iliac crest bone grafting (ICBG) is one of the salvage options for such failure. Purpose: To analyze factors…
Sean M. Carroll, Katherine S. Xue, Christopher J. Marx · 2014 · BMC Microbiology
BACKGROUND: A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discovery in 1960, a stock of Methylobacterium extorquens AM1 ("AM1") has remained in the lab, propagated across numerous growth and storage conditions, researchers, and facilities. To explore the extent to which this lineage has diverged, we compared our own "Modern" stock of AM1 to a
Cynthia C. Griffin, Joseph Calvin Gagnon, Maggie H. Jossi et al. · 2018 · Rural Special Education Quarterly
This study examined mathematics strategy instruction that primes the common underlying structures of word problems using explicit instruction in a rural elementary classroom with fourth- and fifth-grade students with and without…
Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE
INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco
Andrew M. Penn, Maximilian B. Bibok, Viera Saly et al. · 2018 · Biomarkers
OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.METHOD: Two consecutive cohorts of ED…
Meiling Liu, Pär Anders Granhag, Sara Landström et al. · 2010 · The Open Criminology Journal
In this paper we focused on children's deception (10-12 years, Experiment 1), and adult's ability detect deception in children (Experiment 2). The self-presentational perspective By asking unanticipated questions we put the liars in the…
Shree Krishna Subburaj, Angela Stewart, Arjun Rao et al. · 2020
Modeling team phenomena from multiparty interactions inherently requires combining signals from multiple teammates, often by weighting strategies. Here, we explored the hypothesis that strategic weighting signals from individual teammates…
Michele Duarte de Menezes, Sérgio Henrique Godinho Silva, Carlos Rogério de Mello et al. · 2016 · Scientia Agricola
This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic facto
Patrick Moore, R. Justin DeRose, James N. Long et al. · 2012 · Forests
Enhancement of forest growth through silvicultural modification of stand density is one strategy for increasing carbon (C) sequestration. Using the Fire and Fuels Extension of the Forest Vegetation Simulator, the effects of even-aged, uneven-aged and no-action management scenarios on C sequestration in a southern Appalachian red spruce-Fraser fir forest were modeled. We explicitly considered C stored in standing forest stocks and the fate of forest products derived from harvesting. Over a 100-year simulation period the even-aged scenario (250 Mg C ha−1) outperformed the no-action scenario (241
J. Duguay, P. M. Biron, J. Lacey · 2022 · Water Resources Research
Abstract When rivers collide, complex three‐dimensional coherent flow structures are generated along the confluence's mixing interface. These structures mix streamborne pollutants and suspended sediment and have considerable bearing on the…
Travis M. Seale-Carlisle, Laura Mickes · 2016 · Royal Society Open Science
In the USA and the UK, many thousands of police suspects are identified by eyewitnesses every year. Unfortunately, many of those suspects are innocent, which becomes evident when they are exonerated by DNA testing, often after having been…
Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines
Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton
Bram Van Bockstaele, Elske Salemink, Susan M. Bögels et al. · 2015 · Cognition & Emotion
Although attentional bias modification (ABM) can change anxiety, recent studies failed to replicate such effects, possibly because the visual probe ABM failed to induce changes in attentional bias (AB). We investigated whether visual probe…
Noha Mahmoud Youssef, Azza Mohammed Abdelmohsen, Ahmed Atteya Ashour et al. · 2026 · PubMed
BACKGROUND: Chronic ankle instability (CAI) is a common sequence of ankle sprain. Conservative treatment of CAI is currently accepted as a primary mean of managing the condition and preventing of recurrence. OBJECTIVES: The purpose of the…
Mats Enlund, Anders Berglund, Anna Enlund et al. · 2022 · Anesthesiology
BACKGROUND: Several retrospective studies using administrative or single-center data have failed to show any difference between general anesthesia using propofol versus inhaled volatiles on long-term survival after breast cancer surgery.…
Ashwin Ramaswamy, Alvira Tyagi, Hannah Hugo et al. · 2026 · Nature Medicine
ChatGPT Health was launched in January 2026 as OpenAI's consumer health tool and has reached millions of users. Here we conducted a structured stress test of triage recommendations using 60 clinician-authored vignettes across 21 clinical domains under 16 factorial conditions, yielding 960 total responses. Performance followed an inverted U-shaped pattern, with the most dangerous failures concentrated at clinical extremes-nonurgent presentations (35%) and emergency conditions (48%). Among gold-standard emergencies, the system undertriaged 52% of cases, directing patients with diabetic ketoacido
Bonnie M. Meguid, Hilde Coffé, Ana Catalano Weeks et al. · 2025 · Comparative Political Studies
Despite their Männerparteien reputation, populist radical right (PRR) parties have recently expanded their agendas to include women’s interests. When do they embrace these interests, and what shapes their stance? We propose a theory of…
Amanda Rotella, Adam Maxwell Sparks, Sandeep Mishra et al. · 2021 · PLoS ONE
Some evidence suggests that people behave more cooperatively and generously when observed or in the presence of images of eyes (termed the 'watching eyes' effect). Eye images are thought to trigger feelings of observation, which in turn motivate people to behave more cooperatively to earn a good reputation. However, several recent studies have failed to find evidence of the eyes effect. One possibility is that inconsistent evidence in support of the eyes effect is a product of individual differences in sensitivity or susceptibility to the cue. In fact, some evidence suggests that people who ar
Kye L. McCarthy, Peter Caputi, Brin F.S. Grenyer · 2017 · Psychology and Psychotherapy: Theory, Research and Practice
Objective Significant change events are helpful moments within a psychotherapy session that have been shown in previous research to relate strongly to outcome. They are special moments and therefore provide rich data for research into…
Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
Fabrizio Stocchi, Mario Zappia, Valentina Dall’Armi et al. · 2010 · Movement Disorders
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind,…
Paweł Miotła, Katarzyna Romanek-Piva, Michał Bogusiewicz et al. · 2017 · BioMed Research International
Aim . Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n=2748) and postmenopausal (n=1705) women with uncomplicated UTI. Methods . Urinary samples (n=4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥10 5 colony forming units (CFUs)/mL. Susceptibility and resistance testing for commonly used antibiot
Min Liu, Zhiyao Wang, Huifang Shang · 2024 · Journal of Neurology
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsoni
Oriah Mioduser, Eli Goz, Tamir Tuller · 2017 · BMC Genomics
BACKGROUND: Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes. RESULTS: We demonstrated evidence of selection for distinct composition of synonymous codons in early and late vi
Nancy Hachicho, Astrid Birnbaum, Hermann J. Heipieper · 2017 · AMB Express
Planktonic cells and those grown on surfaces (or as colony biofilm) are known to show significant differences regarding growth behavior, cell physiology, gene expression and stress tolerance. In order to compare stress behavior of different growth forms, shake cultures for planktonic growth and agar plate cultivation for colony growth, were carried out with the well investigated model organism, Pseudomonas putida mt-2. Cells were exposed to sodium chloride to cause osmotic stress as one main environmental stressor bacteria have to cope with when growing in soil. Planktonic cells were more tole
Kevin G. Shim, Shane Zaidi, Jill Thompson et al. · 2017 · Molecular Therapy
Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen…