Negative / Null Result ReportOpen accessMedicine
Tiffany A. Greenwood, John R. Kelsoe · 2013 · PLoS ONE
The use of clinical features to define subtypes of a disorder may aid in gene identification for complex diseases. In particular, clinical subtypes of mania may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. To assess this possibility, we performed a genome-wide association study using genotype data from the Bipolar Genome Study (BiGS) and subjects that were categorized as having either irritable or elated mania during their most severe episode. A bipolar case-only analysis in the GAIN bipolar sample identified several genomic regions that differed betwe
View details →DOI: 10.1371/journal.pone.0053804Cited by 24 Negative / Null Result ReportOpen accessEnvironmental Science
Sjirk Geerts, Pieter Willem Botha, Vernon Visser et al. · 2013 · South African Journal of Botany
The legumes (Fabaceae) Genista monspessulana and Spartium junceum are major invaders in several other parts of the world, but not yet so in South Africa. We determine their current distributions in South Africa at different spatial scales, assess population structure (soil seed banks and size at reproduction) evaluate current management activities, and provide recommendations for control (including assessing the feasibility of nation-wide eradication). G. monspessulana occurs at nine localities in three quarter-degree cells, covering a total of 22.7 ha. S. junceum is much more widespread, occu
View details →DOI: 10.1016/j.sajb.2013.03.019Cited by 24 Negative / Null Result ReportMedicine
Nathalie Charlier, Andrew D. Davidson, Kai Dallmeier et al. · 2010 · Journal of General Virology
Chimeric yellow fever virus 17D (YFV-17D) and dengue virus type 2 (DENV2) carrying the surface proteins of Modoc virus (MODV), a not-known-vector (NKV) flavivirus, replicated efficiently in mammalian (Vero-B) and mosquito (C6/36) cells,…
View details →DOI: 10.1099/vir.0.019851-0Cited by 24 Failed Experiment ReportOpen accessMedicine
Pol Specenier, Jan B. Vermorken · 2012 · ISRN Oncology
The epidermal growth factor receptor (EGFR) is overexpressed in the vast majority of cases of squamous cell carcinoma of the head and neck (SCCHN). A high EGFR expression is associated with an unfavorable prognosis. Cetuximab is a chimeric human/murine IgG1 antibody which binds with high affinity to the EGFR. It is the only targeted agent which got approval for the treatment of SCCHN from the regulatory agencies of Europe and the United States, both in locoregionally advanced disease, in association with radiation, and in recurrent/metastatic disease. The outcome of trials involving other EGFR
View details →DOI: 10.5402/2012/163752Cited by 24 Negative / Null Result ReportOpen accessMedicine
Richard A. Brown, Susan E. Ramsey, Christopher W. Kahler et al. · 2011 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: A previous pilot study found positive outcomes among alcohol-dependent individuals with elevated depressive symptoms who received cognitive-behavioral treatment for depression (CBT-D; n = 19) compared with a relaxation training…
View details →DOI: 10.15288/jsad.2011.72.286Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Trisha Harjani, Melisa-Sinem Basol, Jon Roozenbeek et al. · 2023 · Journal of Trial and Error
Although the spread of misinformation is a pervasive and disruptive global problem, extant research is skewed towards “WEIRD” countries leaving questions about how to tackle misinformation in the developing world with different media and consumption patterns unanswered. We report the results of a game-based intervention against misinformation in India. The game is based on the mechanism of psychological inoculation; borrowed from the medical context, inoculation interventions aim to pre-emptively neutralize falsehoods and help audiences spot and resist misinformation strategies. Though the eff
View details →DOI: 10.36850/e12Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Ariel White, Anton Strezhnev, Christopher Lucas et al. · 2018 · Journal of Experimental Political Science
Abstract Prior research demonstrates that responses to surveys can vary depending on the race, gender, or ethnicity of the investigator asking the question. We build upon this research by empirically testing how information about…
View details →DOI: 10.1017/xps.2017.25Cited by 24 Negative / Null Result ReportOpen accessMedicine
Arthur Wickenhagen, Meaghan Flagg, Julia R. Port et al. · 2025 · Nature Communications
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential increased transmissibility and/or disease severity. To address this, we evaluate the fitness and pathogenesis of contemporary Omicron variants XBB.1.5, XBB.1.16, EG.5.1, and JN.1 in the upper (URT) and lower respiratory tract (LRT). We compare in vivo infection in Syrian hamsters with infection in primary h
View details →DOI: 10.1038/s41467-025-55938-3Cited by 24 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Ying Shen, Yuanlong Yan, Yunqiang Liu et al. · 2013 · Human Molecular Genetics
AZFc deletions cause a significant phenotypic heterogeneity with respect to spermatogenesis; however, the reason for this is poorly understood. Recently, testis-specific protein Y-encoded 1 (TSPY1) copy number variation (CNV) was…
View details →DOI: 10.1093/hmg/ddt004Cited by 24 Negative / Null Result ReportEngineering
Jongwook Choi, Yuwen Zhang · 2020 · Numerical Heat Transfer Part A Applications
The oscillatory flow and the heat transfer in two-dimensional pulsating heat pipes (PHPs) with multi-turns were simulated using OpenFOAM. The volume of fluid method was used for the phase change, and the behavior of the working fluid was…
View details →DOI: 10.1080/10407782.2020.1717202Cited by 24 Failed Experiment ReportOpen accessImmunology and Microbiology
Dillon M. Betancourt, Juan Carlos Ramos, Glen N. Barber · 2015 · Journal of Virology
UNLABELLED: Adult T cell leukemia/lymphoma (ATL) is an aggressive cancer of CD4/CD25(+) T lymphocytes, the etiological agent of which is human T-cell lymphotropic virus type 1 (HTLV-1). ATL is highly refractory to current therapies, making…
View details →DOI: 10.1128/jvi.01356-15Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eamonn P. Culligan, Julian R. Marchesi, Colin Hill et al. · 2014 · Frontiers in Microbiology
In the current study, a number of salt-tolerant clones previously isolated from a human gut metagenomic library were screened using Phenotype MicroArray (PM) technology to assess their functional capacity. PM's can be used to study gene function, pathogenicity, metabolic capacity and identify drug targets using a series of specialized microtitre plate assays, where each well of the microtitre plate contains a different set of conditions and tests a different phenotype. Cellular respiration is monitored colorimetrically by the reduction of a tetrazolium dye. One clone, SMG 9, was found to be po
View details →DOI: 10.3389/fmicb.2014.00189Cited by 24 Negative / Null Result ReportOpen accessMedicine
Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani et al. · 2021 · American Journal of Transplantation
Long-term survival after lung transplantation is limited by chronic allograft dysfunction. The aim of this study was to investigate the effect of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i)…
View details →DOI: 10.1111/ajt.16858Cited by 24 Negative / Null Result ReportMedicine
Giorgio Aicardi · 2013 · Rejuvenation Research
Despite decades of research, there is no cure for Alzheimer disease (AD), and current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. AD is associated with impaired clearance of…
View details →DOI: 10.1089/rej.2013.1497Cited by 24 Negative / Null Result ReportOpen accessNeuroscience
Ryan Smith, Claire A. Lavalley, S Taylor et al. · 2023 · Journal of Psychiatry and Neuroscience
BACKGROUND: Decision-making under approach-avoidance conflict (AAC; e.g., sacrificing quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders. Recently, we used a computational (active inference) model…
View details →DOI: 10.1503/jpn.220226Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Juliana Abagsonema Abane, Ronald Adamtey, Virceta Owusu Ayim · 2022 · Future Business Journal
Abstract There is mixed evidence that low levels of productivity at the local government level are not common with organizations with strong cultures as these are less prone to any externalities. The paper investigated the link between organizational culture and employee productivity from the perspectives of employees of the Sekondi-Takoradi Metropolitan Assembly (STMA) in Ghana. The study used the quantitative approach with descriptive and cross-sectional designs. The simple random and stratified sampling techniques were used to select 132 respondents from the STMA using a self-administered s
View details →DOI: 10.1186/s43093-022-00145-5Cited by 24 Negative / Null Result ReportOpen accessNeuroscience
Karam Khateeb, Zhaojie Yao, Viktor Kharazia et al. · 2019
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models of stroke…
View details →DOI: 10.1109/embc.2019.8857741Cited by 24 Negative / Null Result ReportOpen accessEngineering
Shane Esola, Brian Wisner, Prashanth A. Vanniamparambil et al. · 2018 · Applied Sciences
The research presented in this article aims to demonstrate how acoustic emission (AE) monitoring can be implemented in an industrial setting to assist with part qualification, as mandated by related industry standards. The combined structural and nondestructive evaluation method presented departs from the traditional pass/fail criteria used for part qualification, and contributes toward a multi-dimensional assessment by taking advantage of AE data recorded during structural testing. To demonstrate the application of this method, 16 composite fixed-wing-aircraft spars were tested using a struct
View details →DOI: 10.3390/app8091490Cited by 24 Negative / Null Result ReportOpen accessPsychology
Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →DOI: 10.3389/fpsyg.2020.575962Cited by 24 Negative / Null Result ReportOpen accessNeuroscience
María Valdés Hernández, Lucia Ballerini, Andreas Glatz et al. · 2019 · Brain Imaging and Behavior
Brain iron deposits (IDs) are indicative of microvessel dysfunction which may predispose to small vessel disease (SVD) brain damage and worsen cognition later in life. Visible perivascular spaces in the centrum semiovale (CSO-PVS) are SVD features linked with microvessel dysfunction. We examined possible associations of CSO-PVS volume and count with brain IDs and cognitive abilities in 700 community-dwelling individuals from the Lothian Birth Cohort 1936 who underwent detailed cognitive testing and multimodal brain MRI at mean age 72.7 years. Brain IDs were assessed automatically followed by m
View details →DOI: 10.1007/s11682-019-00128-1Cited by 24 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Bo Xi, Yue Shen, Kathleen H. Reilly et al. · 2012 · Clinical Endocrinology
OBJECTIVE: Recent genome-wide association studies have identified a few single nucleotide polymorphisms (SNPs), which are associated with body mass index (BMI)/obesity. This study aimed to examine the identified associations among a…
View details →DOI: 10.1111/cen.12091Cited by 24 Negative / Null Result ReportOpen accessEngineering
Suribabu Conety Ravi, Neelakantan Thurvas Renganathan, Sivakumar Perumal et al. · 2019 · Drinking water engineering and science
Abstract. Pressure-driven analysis (PDA) of water distribution networks necessitates an assessment of the supplying capacity of a network within the minimum and required pressure ranges. Pressure-deficient conditions happen due to the uncertainty of nodal demands, failure of electromechanical components, diversion of water, aging of pipes, permanent increase in the demand at certain supply nodes, fire demand, etc. As the demand-driven analysis (DDA) solves the governing equations without any bound on pressure head, it fails to replicate the real scenario, particularly when the network experien
View details →DOI: 10.5194/dwes-12-1-2019Cited by 24 Negative / Null Result ReportMedicine
Franca E. Dupuy, Adam R. Clarke, Robert J. Barry et al. · 2013 · Clinical EEG and Neuroscience
This study further investigated electroencephalogram (EEG) differences between girls with the Combined and Inattentive types of attention-deficit/hyperactivity disorder (AD/HD). We selected subjects with widely separated scores on…
View details →DOI: 10.1177/1550059413501162Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Masaru Sekijima, Hiroshi Takeda, Katsuaki Yasunaga et al. · 2010 · Journal of Radiation Research
We investigated the mechanisms by which radiofrequency (RF) fields exert their activity, and the changes in both cell proliferation and the gene expression profile in the human cell lines, A172 (glioblastoma), H4 (neuroglioma), and IMR-90…
View details →DOI: 10.1269/jrr.09126Cited by 24 Negative / Null Result ReportMedicine
Fabrizio Stocchi, Mario Zappia, Valentina Dall’Armi et al. · 2010 · Movement Disorders
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind,…
View details →DOI: 10.1002/mds.23206Cited by 24 Negative / Null Result ReportOpen accessMedicine
Paweł Miotła, Katarzyna Romanek-Piva, Michał Bogusiewicz et al. · 2017 · BioMed Research International
Aim . Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n=2748) and postmenopausal (n=1705) women with uncomplicated UTI. Methods . Urinary samples (n=4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥10 5 colony forming units (CFUs)/mL. Susceptibility and resistance testing for commonly used antibiot
View details →DOI: 10.1155/2017/4192908Cited by 24 Negative / Null Result ReportOpen accessMedicine
Min Liu, Zhiyao Wang, Huifang Shang · 2024 · Journal of Neurology
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsoni
View details →DOI: 10.1007/s00415-024-12269-5Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Oriah Mioduser, Eli Goz, Tamir Tuller · 2017 · BMC Genomics
BACKGROUND: Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes. RESULTS: We demonstrated evidence of selection for distinct composition of synonymous codons in early and late vi
View details →DOI: 10.1186/s12864-017-4248-7Cited by 24 Negative / Null Result ReportOpen accessEnvironmental Science
Nancy Hachicho, Astrid Birnbaum, Hermann J. Heipieper · 2017 · AMB Express
Planktonic cells and those grown on surfaces (or as colony biofilm) are known to show significant differences regarding growth behavior, cell physiology, gene expression and stress tolerance. In order to compare stress behavior of different growth forms, shake cultures for planktonic growth and agar plate cultivation for colony growth, were carried out with the well investigated model organism, Pseudomonas putida mt-2. Cells were exposed to sodium chloride to cause osmotic stress as one main environmental stressor bacteria have to cope with when growing in soil. Planktonic cells were more tole
View details →DOI: 10.1186/s13568-017-0371-8Cited by 24 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin G. Shim, Shane Zaidi, Jill Thompson et al. · 2017 · Molecular Therapy
Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen…
View details →DOI: 10.1016/j.ymthe.2017.01.023Cited by 24 