Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
View details →DOI: 10.1038/s41598-020-68878-3Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →DOI: 10.1109/tnb.2019.2909094Cited by 24 Negative / Null Result ReportOpen accessMedicine
Yen‐Jen Chen, Hsien‐Te Chen, Horng‐Chaung Hsu · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Survival is a key factor physicians consider when selecting a treatment modality for the treatment of spinal metastases. Various assessment systems can predict length of survival and facilitate selection of the most appropriate treatment. Spinal palsy is a prognostic parameter in the Tokuhashi scoring system but not in the Tomita scoring system. A limitation of these scoring systems is that studies of them have included different tumor types. The aim of this study was to evaluate the usefulness of preoperative neurological status as a prognostic factor in non-small-cell lung cancer
View details →DOI: 10.1186/s13018-015-0291-8Cited by 24 Negative / Null Result Report
Marie R. Johnston, Nick J. Balster, Anita M. Thompson · 2020 · Water
Rain gardens are residential bioretention practices widely used to manage urban runoff, yet their design as plant-soil systems lacks understanding. We hypothesized that vegetative treatment (turfgrass, prairie, and shrubs, plus a…
View details →DOI: 10.3390/w12113151Cited by 24 Negative / Null Result Report
Andrea Riboli, Fabio Esposito, Giuseppe Coratella · 2022 · Journal of Strength & Conditioning Research
Abstract Riboli, A, Esposito, F, and Coratella, G. Small-sided games in elite football: practical solutions to replicate the 4-min match-derived maximal intensities. J Strength Cond Res 37(2): 366–374, 2023—The purpose of the study was to…
View details →DOI: 10.1519/jsc.0000000000004249Cited by 24 Negative / Null Result Report
Kye L. McCarthy, Peter Caputi, Brin F.S. Grenyer · 2017 · Psychology and Psychotherapy: Theory, Research and Practice
Objective Significant change events are helpful moments within a psychotherapy session that have been shown in previous research to relate strongly to outcome. They are special moments and therefore provide rich data for research into…
View details →DOI: 10.1111/papt.12116Cited by 24 Negative / Null Result Report
Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
View details →DOI: 10.1161/jaha.117.006304Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Song Wang, Cecilie L. Bager, M.A. Karsdal et al. · 2021 · Journal of Translational Medicine
BACKGROUND: Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C), and versican (VCANM) in plasma as biomarkers for predicting progression-free survival (PFS) and overall survival (OS) in patients with mPDA treated with pegvorhyaluronidase alfa, a biologic that degrades the ECM component hyaluronan (HA), in a randomized phase 2 study (HALO109-202). METHODS: HALO109-202 comprised a discovery cohort (Stage 1, n = 94) and a validation cohort (S
View details →DOI: 10.1186/s12967-021-02701-zCited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Oriah Mioduser, Eli Goz, Tamir Tuller · 2017 · BMC Genomics
BACKGROUND: Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes. RESULTS: We demonstrated evidence of selection for distinct composition of synonymous codons in early and late vi
View details →DOI: 10.1186/s12864-017-4248-7Cited by 24 Negative / Null Result ReportOpen accessEnvironmental Science
Nancy Hachicho, Astrid Birnbaum, Hermann J. Heipieper · 2017 · AMB Express
Planktonic cells and those grown on surfaces (or as colony biofilm) are known to show significant differences regarding growth behavior, cell physiology, gene expression and stress tolerance. In order to compare stress behavior of different growth forms, shake cultures for planktonic growth and agar plate cultivation for colony growth, were carried out with the well investigated model organism, Pseudomonas putida mt-2. Cells were exposed to sodium chloride to cause osmotic stress as one main environmental stressor bacteria have to cope with when growing in soil. Planktonic cells were more tole
View details →DOI: 10.1186/s13568-017-0371-8Cited by 24 Negative / Null Result ReportMedicine
Fabrizio Stocchi, Mario Zappia, Valentina Dall’Armi et al. · 2010 · Movement Disorders
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind,…
View details →DOI: 10.1002/mds.23206Cited by 24 Negative / Null Result ReportMedicine
Gülen Hatemi, Emire Seyahi, İzzet Fresko et al. · 2017 · PubMed
Several articles highlighting the epidemiology, pathogenesis, clinical features, treatment modalities and disease assessment of Behçet's syndrome (BS) have been published during the last year. Clinical and radiological features of lower…
Negative / Null Result ReportOpen accessMedicine
Paweł Miotła, Katarzyna Romanek-Piva, Michał Bogusiewicz et al. · 2017 · BioMed Research International
Aim . Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n=2748) and postmenopausal (n=1705) women with uncomplicated UTI. Methods . Urinary samples (n=4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥10 5 colony forming units (CFUs)/mL. Susceptibility and resistance testing for commonly used antibiot
View details →DOI: 10.1155/2017/4192908Cited by 24 Negative / Null Result ReportOpen accessMedicine
Min Liu, Zhiyao Wang, Huifang Shang · 2024 · Journal of Neurology
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsoni
View details →DOI: 10.1007/s00415-024-12269-5Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Zeng, Yukun Li, Feifei Quan et al. · 2020 · Molecular Medicine Reports
Propofol, a commonly used intravenous anesthetic agent during surgery, has relatively widespread pharmacological actions. Previous studies have reported that propofol may act as an antitumor drug in several cancer types, such as pancreatic…
View details →DOI: 10.3892/mmr.2020.11223Cited by 23 Negative / Null Result ReportOpen accessMedicine
Francesca Faustini, Nicky Dunn, Nastya Kharlamova et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-associated vasculitis (AAV) and as off-label therapy for systemic lupus erythematosus (SLE), but data on occurrence and predisposing factors to ADAs in these diseases is limited. OBJECTIVES: To elucidate the rate of occurrence, and risk factors for ADAs against rituximab in SLE and AAV. METHODS: ADAs were detected using a bridging electrochemilumi
View details →DOI: 10.1186/s13075-021-02589-6Cited by 23 Negative / Null Result Report
HAELIM PARK, PATRICK VAN HORN · 2015 · Journal of Money, Credit and Banking
We analyze the impact of contractionary monetary policy through increases in reserve requirements on bank lending. We compare the lending behavior of banks that were subject to the requirement increases in 1936–37, Federal Reserve member…
View details →DOI: 10.1111/jmcb.12235Cited by 23 Negative / Null Result ReportMedicine
Brintha K. Enestvedt, M. Brian Fennerty, A. Zaman et al. · 2011 · Alimentary Pharmacology & Therapeutics
BACKGROUND: In recent clinical trials (RCT) of bowel preparation, Golytely was more efficacious than MiraLAX. We hypothesised that there is a difference in adenoma detection between Golytely and MiraLAX. AIMS: To compare the adenoma…
View details →DOI: 10.1111/j.1365-2036.2011.04795.xCited by 23 Negative / Null Result ReportOpen accessMedicine
Mathias Roth, Christoph Holtmann, Loay Daas et al. · 2021 · Cornea
PURPOSE: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible…
View details →DOI: 10.1097/ico.0000000000002705Cited by 23 Negative / Null Result Report
Li Sian Goh · 2021 · Criminology & Public Policy
Research Summary Despite the widespread interest that de‐escalation training has attracted in law enforcement contexts over the past few years, we know little about its effectiveness in reducing use of force incidents. This study seeks to…
View details →DOI: 10.1111/1745-9133.12536Cited by 23 Negative / Null Result ReportOpen accessNeuroscience
A. V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova et al. · 2022 · International Journal of Molecular Sciences
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
View details →DOI: 10.3390/ijms23010497Cited by 23 Negative / Null Result ReportOpen accessMedicine
Nan Bi, Jun Liang, Zongmei Zhou et al. · 2019 · JAMA Network Open
Importance: Treatment of locally advanced non-small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomized clinical trial has provided evidence of a direct comparison with CCRT alone. Objective: To determine the effect of combined selective COX-2 inhibition with standard CCRT on survival among patients with unresectable stage III NSCLC. Design, Setting, and Participants: A single-center, open-label, ra
View details →DOI: 10.1001/jamanetworkopen.2019.18070Cited by 23 Negative / Null Result ReportOpen accessImmunology and Microbiology
Jayson L. Parker, Jillian Clare Köhler · 2010 · Journal of Pharmacy & Pharmaceutical Sciences
PURPOSE: To determine the risk of drug failure during clinical trial testing in Crohn's disease and determine what steps can be taken to improve outcomes. This is the first study to quantify such risk for a single disease. METHODS: Moderate to severe Crohn's disease was investigated by reviewing press releases from 1998 to June 2008. Clinical trial failure causes were classified as commercial or clinical and compared with industry expectations. The risk of failure was also reviewed based on whether the compound was a small molecule drug or a biologic. Lastly, the role of the sponsor was examin
View details →DOI: 10.18433/j39014Cited by 23 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Lulu Yu, Yang Liu, Fei Xu · 2019 · BMC Plant Biology
BACKGROUND: Hydrogen cyanide (HCN) is a small gaseous molecule that is predominantly produced as an equimolar co-product of ethylene (ET) biosynthesis in plants. The function of ET is of great concern and is well studied; however, the function of HCN is largely unknown. Similar to ET, HCN is a simple and diffusible molecule that has been shown to play a regulatory role in the control of some metabolic processes in plants. Nevertheless, it is still controversial whether HCN should be regarded as a signalling molecule, and the cross-talk between HCN and ET in gene expression regulation remains u
View details →DOI: 10.1186/s12870-019-1690-5Cited by 23 Negative / Null Result ReportOpen accessMedicine
Kennichi Kakudo · 2022 · Cancers
Histopathological diagnosis of papillary thyroid carcinomas (PTCs) is prone to significant observer variation due to different thresholds of RAS-like nuclear changes among pathologists. This gap recently widened due to a defensive attitude by Western pathologists where malpractice litigation is significant. Cases with delicate RAS-like nuclear changes are follicular adenomas when they are noninvasive, follicular carcinomas when invasive, and follicular variant PTCs when they have fully developed PTC-type nuclear features in Asian practice. The different diagnostic threshold of PTC nuclear feat
View details →DOI: 10.3390/cancers14030812Cited by 23 Negative / Null Result Report
Jianjun Liu, Zhanqing Li · 2018 · Geophysical Research Letters
Abstract Aerosol optical quantities have been widely employed as the proxy variables of cloud condensation nuclei concentration to study aerosol indirect effects (AIE). Due to the aerosol swelling effect, cloud condensation nuclei and…
View details →DOI: 10.1029/2018gl077679Cited by 23 Negative / Null Result Report
Kenneth Button · 2012 · Transportation Journal
Abstract The article examines the sustainability of the low-cost, or no-frills, airline business model. It looks at the background to the development of this managerial approach within the context of some prevailing business theories and…
View details →DOI: 10.5325/transportationj.51.2.0197Cited by 23 Negative / Null Result ReportOpen accessMedicine
Wanlong Ma, Hagop M. Kantarjian, Ke Zhang et al. · 2010 · BMC Medical Genetics
BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: We genotyped the EPO rS1617640 SNP in 189 patients with MDS, 257 with acute myeloid leukemia (AML), 106 with acute lymphoblastic leukemia, 97 with chronic lymphocytic leukemia, 353
View details →DOI: 10.1186/1471-2350-11-163Cited by 23 Negative / Null Result Report
Francisca Alves-Cardoso, Vanessa Campanacho · 2022 · Heritage
Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely…
View details →DOI: 10.3390/heritage5030085Cited by 23 Negative / Null Result Report
Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery
Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…
View details →DOI: 10.1093/neuros/nyy467Cited by 23 