Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa
Song Wang; Cecilie L. Bager; M.A. Karsdal; Dimitrios Chondros; Darin Taverna; Nicholas Willumsen · 2021 · Journal of Translational Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C), and versican (VCANM) in plasma as biomarkers for predicting progression-free survival (PFS) and overall survival (OS) in patients with mPDA treated with pegvorhyaluronidase alfa, a biologic that degrades the ECM component hyaluronan (HA), in a randomized phase 2 study (HALO109-202). METHODS: HALO109-202 comprised a discovery cohort (Stage 1, n = 94) and a validation cohort (S
Abstract by Song Wang; Cecilie L. Bager; M.A. Karsdal; Dimitrios Chondros; Darin Taverna; Nicholas Willumsen, Journal of Translational Medicine (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12967-021-02701-z