A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 83 of 660
Leher Singh · 2018 · Child Development
Abstract Prior research suggests that bilingualism may endow infants with greater phonological flexibility. This study investigated whether this flexibility facilitates word learning in additional languages (n = 96). Experiment 1 compared…
Julie Justine Benoit, Eugenie Roudaia, Taylor Johnson et al. · 2020 · PeerJ
In the past 20 years, there has been growing research interest in the association between video games and cognition. Although many studies have found that video game players are better than non-players in multiple cognitive domains, other studies failed to replicate these results. Until now, the vast majority of studies defined video game players based on the number of hours an individual spent playing video games, with relatively few studies focusing on video game expertise using performance criteria. In the current study, we sought to examine whether individuals who play video games at a pro
Tord Ranheim Sveen, Maria Viketoft, Jan Bengtsson et al. · 2025 · Nature Communications
Land abandonment is the single largest process of land-use change in the Global North driving succession and afforestation at continental scales, but assessing its impacts on soil microbial communities remains a challenge. Here, we establish a nationwide successional gradient of paired grassland and forest sites to track developments in microbial structure and functioning following land abandonment and gradual land-use change to forests. We show that microbes generally respond through threshold dynamics, leading to increasing functional but decreasing taxonomic diversity. Succession also entai
Brahim Bergougui, Said Meziane · 2025 · Sustainability
Algeria’s resource-dependent economy faces significant challenges in balancing hydrocarbon reliance with environmental sustainability, yet existing research largely overlooks the comprehensive load capacity factor (LCF) metric in favor of traditional emissions analyses. This study examines the relationships between the LCF and key economic–environmental factors in Algeria from 1980 to 2023, including total natural resource rents, energy transition, technological innovation, GDP, primary energy consumption, and urbanization. Using ARDL and DARDL econometric approaches complemented by a kernel-b
Magdalena Paplińska‐Goryca, Paulina Misiukiewicz‐Stępień, Monika Wróbel et al. · 2025 · Scientific Reports
Microplastic particles from the air are inhaled and accumulate in the lungs, potentially causing immunological reactions and airway tissue injury. This study aimed to evaluate the biological effects of polyamide fibres on nasal epithelium…
Xiaodong Huang, Xiaozhong Chen, Chong Zhao et al. · 2020 · Frontiers in Oncology
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
Pasquale F. Innominato, Abdoulaye Karaboué, C. Focan et al. · 2020 · International Journal of Cancer
The triplet combination of irinotecan, oxaliplatin and fluorouracil is an active frontline regimen in metastatic colorectal cancer, but scarce data exist on its use as salvage treatment. We aimed at assessing its safety and efficacy profiles with its circadian-based administration (chronoIFLO5) as either first- or second-line treatment, within the time-finding EORTC 05011 trial. Five-day chronoIFLO5 was administered every 3 weeks in patients with PS 0, 1 or 2. It consisted of chronomodulated irinotecan (180 mg/sqm), oxaliplatin (80 mg/sqm) and fluorouracil-leucovorin (2800 and 1200 mg/sqm, res
Melanie Nägeli, Patrick Scherler, Stephanie Witczak et al. · 2021 · Oecologia
The joint effects of interacting environmental factors on key demographic parameters can exacerbate or mitigate the separate factors' effects on population dynamics. Given ongoing changes in climate and land use, assessing interactions between weather and food availability on reproductive performance is crucial to understand and forecast population dynamics. By conducting a feeding experiment in 4 years with different weather conditions, we were able to disentangle the effects of weather, food availability and their interactions on reproductive parameters in an expanding population of the red
Dhakshana Sivayoganathan, Deivanayagam Maruthini, Julie Glanville et al. · 2011 · Human Fertility
OBJECTIVE: This study aimed to compare the spectrum of polycystic ovary syndrome (PCOS) symptoms in patients from four different specialist clinics. DESIGN: A prospective cross-sectional observational study. SETTING: The study was…
Matthew B. Lipner, Raoud Marayati, Yangmei Deng et al. · 2016 · PLoS ONE
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benef
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
Yook Kit Ow-Yeong, Ibrahim H. Yeter, Farhan Ali · 2023 · International Journal of STEM Education
Abstract Background Data literacy is increasingly important in today’s data-driven world. Students across many educational systems first formally learn about data in elementary school not as a separate subject but via the mathematics curriculum. This experience can create tensions in the priorities of learning and assessment given the presence of other foundational mathematics content domains such as numbers, algebra, measurement, and geometry. There is a need to study data literacy in comparison to these other content domains in elementary mathematics. To address this need, we developed a met
Elizabeth Y Long, Deborah L. Finke · 2014 · Environmental Entomology
Studies manipulating predator diversity and measuring the impact on herbivore abundance have found that enhancing predator species richness often increases the strength of prey suppression. This relationship may be due to mechanisms such…
Lars Gamfeldt, Helmut Hillebrand · 2011 · PLoS ONE
The study of the interrelationship between productivity and biodiversity is a major research field in ecology. Theory predicts that if essential resources are heterogeneously distributed across a metacommunity, single species may dominate productivity in individual metacommunity patches, but a mixture of species will maximize productivity across the whole metacommunity. It also predicts that a balanced supply of resources within local patches should favor species coexistence, whereas resource imbalance would favor the dominance of one species. We performed an experiment with five freshwater al
Luke Hodgson, Jo Congleton, Richard Venn et al. · 2018 · Clinical Medicine
ABSTRACT The Royal College of Physicians (RCP) recently published the National Early Warning Score 2 (NEWS2), aiming to improve safety for patients with hypercapnic respiratory failure by suggesting a separate oxygen saturation (SpO2)…
Thomas Galland, Carlos P. Carmona, Lars Götzenberger et al. · 2020 · Ecological Indicators
Functional redundancy is considered a major component of the insurance mechanism, which theoretically maintains ecosystem stability by preventing the loss of ecosystem functions with species loss. Over the past decades, examination of…
Gareth Richards, Manuel C. Gomes, T. Ventura · 2018 · Journal of Developmental Origins of Health and Disease
Foetal sex hormones can have powerful and far-reaching effects on later phenotype. However, obtaining accurate measurements is difficult for ethical reasons, and researchers often employ proxy variables to examine their effects. The…
Erkan Er, Eduardo Gómez‐Sánchez, Yannis Dimitriadis et al. · 2019 · Interactive Learning Environments
This paper presents the findings of a mixed-methods research that explored the potentials emerging from aligning learning design (LD) and learning analytics (LA) during the design of a predictive analytics solution and from involving the…
Dhayana Dallmeier, Martin G. Larson, Na Wang et al. · 2012 · Journal of the American Heart Association
Background Prior studies have reported conflicting findings with regard to the association of biomarkers in the prediction of incident type 2 diabetes. We evaluated 12 biomarkers as possible diabetes predictors in the F ramingham H eart S…
Xinwu Qian, Lijun Sun, Satish V. Ukkusuri · 2021 · Scientific Reports
Improved mobility not only contributes to more intensive human activities but also facilitates the spread of communicable disease, thus constituting a major threat to billions of urban commuters. In this study, we present a multi-city investigation of communicable diseases percolating among metro travelers. We use smart card data from three megacities in China to construct individual-level contact networks, based on which the spread of disease is modeled and studied. We observe that, though differing in urban forms, network layouts, and mobility patterns, the metro systems of the three cities
Matthew Rueben, Frank J. Bernieri, Cindy Grimm et al. · 2017
Privacy-sensitive robotics is an emerging area of HRI research. Judgments about privacy would seem to be context-dependent, but none of the promising work on contextual "frames" has focused on privacy concerns. This work studies the impact…
Joseph Rigdon, Sanjay Basu · 2019 · BMJ Open
OBJECTIVES: We aimed to test whether or not adding (1) nutrition predictor variables and/or (2) using machine learning models improves cardiovascular death prediction versus standard Cox models without nutrition predictor variables.…
Ruhul Salim, Kamrul Hassan, Sanzidur Rahman · 2019 · Applied Economics
This study aims to investigate dynamic relationships between research and development (R&D) expenditure, climate change (measured by annual rainfall and temperature variations), human capital (proxied by literacy) and total factor…
Thit Mynster Kronborg, Robert Schierwagen, Kajetan Trôst et al. · 2023 · Hepatology Communications
BACKGROUND: Patients with cirrhosis and portal hypertension face a high risk of complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce portal pressure and thus the risk of complications and mortality.…
Uğur Demirel, Handan Çam, Ramazan Ünlü · 2020 · GAZI UNIVERSITY JOURNAL OF SCIENCE
Stock market prediction in financial and commodity markets is a major challenge for speculators, investors, and companies but also profitable with an accurate prediction. Thus, obtaining accurate prediction results becomes extremely…
Simon Ruch, Flavio Jean Schmidig, Leona Knüsel et al. · 2022 · NeuroImage
Slow-wave sleep is the deep non-rapid eye-movement (NREM) sleep stage that is most relevant for the recuperative function of sleep. Its defining property is the presence of slow oscillations (<2 Hz) in the scalp electroencephalogram (EEG). Slow oscillations are generated by a synchronous back and forth between highly active UP-states and silent DOWN-states in neocortical neurons. Growing evidence suggests that closed-loop sensory stimulation targeted at UP-states of EEG-defined slow oscillations can enhance the slow oscillatory activity, increase sleep depth, and boost sleep's recuperative fun
Rafiq Hamdi, Hans Van de Vyver, Piet Termonia · 2011 · International Journal of Climatology
Abstract We explore the use of high‐resolution dynamical downscaling as a means to simulate extreme values of summer maximum surface air temperature over Belgium ( T MAX ). We use the limited area version of the ARPEGE‐IFS model, ALADIN.…
Heather N. Taussig, Sara E. Culhane, Edward F. Garrido et al. · 2012 · Child Maltreatment
Physically neglected youth are at increased risk of mental health problems, but there are few interventions that have demonstrated efficacy in reducing mental health symptoms for this vulnerable population. The Fostering Healthy Futures…