A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
403 results in Replication Failure · page 8 of 14
Aarhus M, Netteland DF, Tverdal C et al. · 2026 · Acta neurochirurgica
Purpose Traumatic brain injury (TBI) in patients ≥ 80 years poses major clinical challenges, with limited evidence to guide neurosurgical decision-making. We evaluated mortality, functional outcomes, and prognostic factors in patients…
Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…
Castillo F, Tafur M, Lin C et al. · 2026 · Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
Introduction Nondiagnostic results after thyroid fine-needle aspiration (FNA) are common and may delay diagnosis. Purpose To identify demographic and sonographic predictors of nondiagnostic cytology at repeat thyroid FNA and to report…
Rotevatn AØ, Eagan TM, McCann A et al. · 2026 · BMC pulmonary medicine
Background and aim Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This…
Soler-Blasco R, Lozano M, González-Safont L et al. · 2026 · Environmental research
Prenatal cadmium (Cd) exposure may impair placental function and disrupt biological processes relevant to foetal neurodevelopment, including oxidative stress and metal homeostasis, but epidemiological evidence linking Cd to childhood…
Eryılmaz T, Gayretli TK, Şefik SÖ et al. · 2026 · Preprint
Abstract Background Postpartum hemorrhage remains a major cause of maternal morbidity, and cesarean delivery is associated with greater blood loss than vaginal birth. This study compared prophylactic oxytocin and carbetocin for…
Fusar-Poli L, Prachason T, Brondino N et al. · 2026 · CNS spectrums
Objective Autistic traits (ATs) are associated with difficulties in social functioning, but their impact on the quantity and the quality of daily-life social interactions is not yet fully understood. Hereby, we examined the relationship…
Yiğit N, Nazlıgül AS, Ülgen NK et al. · 2026 · Geriatric orthopaedic surgery & rehabilitation
Background Distal radius fractures are common among elderly patients and frequently pose management challenges due to advanced age, multiple comorbidities, and increased anesthesia-related risks. In high-risk individuals with limited…
Rogalska E, Stenka W, Kupcewicz E et al. · 2026 · Frontiers in public health
Introduction Breast cancer is the most common malignancy among women worldwide. Mastectomy, often accompanied by breast reconstruction, plays a key role in treatment and prevention among high-risk patients; however, psychological outcomes…
Nowell S, Fantini O, Roman A et al. · 2026 · Veterinary dermatology
Fluorescent light energy (FLE; Phovia, Vetoquinol) is a photobiomodulation therapy that promotes healing and reduces inflammation. Cutaneous epitheliotropic lymphoma (CTCL) is a neoplastic skin disease with limited treatment options.…
· 2026 · Journal of cellular and molecular medicine
Retraction Z. Li and B. M. Pützer, "Spliceosomal Protein E Regulates Neoplastic Cell Growth by Modulating Expression of Cyclin E/CDK2 and G2/M Checkpoint Proteins," Journal of Cellular and Molecular Medicine 12, no. 6a (2008): 2427-2438.…
Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice
Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…
Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews
Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…
Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery
Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…
Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
Ye J, Hoàng DĐ, Liu X et al. · 2025 · Biochemical and Biophysical Research Communications
Schisandrin B (SchB), a natural lignan with reported organ-protective effects, was hypothesized to ameliorate severe acute pancreatitis (SAP). We investigated the effects of SchB (30 and 60 mg/kg) in a caerulein-induced mouse model of SAP…
Morgan W, Butler J · 2023 · BJPsych open
Aims Women from Black and minority ethnic backgrounds have been shown to experience an increased burden of common postnatal mental health conditions and higher rates of involuntary admissions. However, evidence demonstrates disparities in…
Rana D, DeBaer L, Pourcyrous M · 2025 · Children (Basel, Switzerland)
Background Polysubstance use, particularly combining opioids with stimulants such as cocaine, is rising among individuals with substance use disorders. This practice aims to balance cocaine's stimulant effects with opioids' sedative…
Whitehead NN, Kelly SA, Demes JS et al. · 2023 · Behavioural processes
Locomotor play is vigorous and seemingly purposeless behavior, commonly observed in young mammals. It can be costly in terms of energy expenditure, increased injury risk, and predator exposure. The main hypothesized benefit of locomotor…
Grethen KJ, Gómez Y, Toscano MJ · 2025 · Applied Animal Behaviour Science
As the egg-laying industry transitions from cages to cage-free housing, laying hens are increasingly housed in large groups. Cognitive limitations may impair recognition of conspecifics in such large groups, raising questions on the hens’…
Moyini AAM, Tahir M, Farah M et al. · 2025 · Preprint
Abstract This study explores the moderating role of corporate sustainability disclosure (ESG) in the relationship between board-level committees and firm performance (FP) in Sub-Saharan Africa (SSA). While prior research has extensively…
Jedinger A, Feldhausen M · 2025 · The Journal of social psychology
The study examines the impact of hostile and benevolent sexism on attitudes toward public versus private breastfeeding. According to ambivalent sexism theory, we hypothesized that hostile sexism would result in disapproval of public…
Takagi K, Saito G, Tanaka H et al. · 2025 · ESMO open
Background The REMORA trial demonstrated efficacy and safety of lenvatinib in patients previously treated for advanced thymic carcinoma. However, more data regarding its use in clinical practice are required. Methods This multicenter…
Nagpal S, Nguyen KS, Bertrand S et al. · 2025 · Cancer reports (Hoboken, N.J.)
Background Brain metastases are common in patients with lung and breast cancer and are associated with poor outcomes. While there is some intracranial activity with systemic therapies, most chemotherapies are minimally effective.…
Miller RM, Nworu C, McKee L et al. · 2020 · Applied immunohistochemistry & molecular morphology : AIMM
Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma therapies. A phase II study (Study 39; NCT01063517) designed to investigate the…
Ajam G, Daryabor G, Jazi NN et al. · 2025 · Preprint
Abstract Viruses are among the most infectious agents thought to contribute to the development of autoimmune disorders. Adenoviruses, in particular, are widely utilized for various applications, including gene therapy, vaccine vectors, and…
Heasley CK, Stefanova V, Funk C et al. · 2025 · Preprint
Background Bifidobacterium longum subspecies infantis ( B. infantis ) abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is…
Miceli MH, Dalton LM, Pasqualotto AC et al. · 2025 · Open Forum Infectious Diseases
Background Histoplasma urine antigen detection, a valuable diagnostic tool, is often used to monitor response to antifungal therapy, but persistently positive antigen values, even when the infection has resolved, often present a clinical…
Akowundu PK, Salako AO, Akinsete AM et al. · 2025 · BMC pediatrics
Background Sickle cell anaemia (SCA) is a lifelong, chronic haemolytic disorder with episodic vaso-occlusive crises (VOC) and chronic end-organ damage. Red cell dehydration during a VOC changes permeability with loss of potassium and…
Blanco JR, Albendin-Iglesias H, Negredo-Puigmal E et al. · 2025 · PloS one
Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic…