A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
422 results in Replication Failure · page 8 of 15
Yang Y, Lv Z, Wang Z et al. · 2026 · Preprint
Abstract Objective To investigate the method and clinical efficacy evaluation of transcatheter closure of secundum atrial septal defect (ASD) in children through the femoral vein under the guidance of ultrasonic cardiogram. Method A total…
Arnaud T, Theriault N, Court DA et al. · 2026 · Preprint
Objectives Bacteriophage (phage) therapy is being explored as a strategy for clinical control of periprosthetic joint infections, addressing the challenges of antibiotic-resistant bacteria and limitations around the complete eradication of…
Josefsson ML, Uustal E, Sohlberg S et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction Anal incontinence can have a significant negative impact on quality of life. The leading cause of anal incontinence among women of child-bearing age is obstetric-related perineal injury. The objective of this study was to…
Batashvili M, Israel BH, Levy DA et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Tactile texture memory has been underexplored compared to visual and auditory memory, despite its importance in daily functioning. Prior research indicates that theta oscillations support memory consolidation across modalities, and frontal…
Rain AZ, Sundararaghavan HG, Ji K · 2025 · Preprint
Midkine (MDK) is a heparin-binding growth factor that promotes tumor growth in many cancers and may contribute to type I neurofibromatosis (NF1) tumor by stimulating Schwann cell proliferation and supporting neurofibroma growth. Here, we…
Zhang B, Shi H, Cai W et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To investigate the association between maternal hypertensive disorders of pregnancy (HDP) and childhood neurodevelopmental disorders (NDD) by Mendelian randomization (MR). Methods A two-sample MR analysis was conducted to…
Ramasubbu D, Lewney J · 2025 · Evidence-based dentistry
Design The Brushing RemInder 4 Good oral HealTh (BRIGHT) multi-centre randomized controlled trial was based in state-funded secondary schools in England, Wales and Scotland. It had two arms, aiming to assess the clinical and cost…
Wang L, Wang X, Zhang R et al. · 2025 · The American journal of clinical nutrition
Background Gestational diabetes mellitus (GDM) affects millions of females and their children. Effective dietary strategies for early prevention are controversial. Objectives This study aims to investigate whether an individualized…
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2025 · BMC cancer
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
Liñares A, Tan HJ, Muñoz F et al. · 2025 · Journal of clinical periodontology
Aim To evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites. Materials and methods In 9 beagle dogs, three…
McNee A, Vanover D, Rijal P et al. · 2023 · Frontiers in immunology
Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large animal host for influenza A, with many physiological, immunological, and…
Autio KJ, Koivisto H, Schmitz W et al. · 2024 · The Journal of nutritional biochemistry
Mitochondrial fatty acids synthesis (mtFAS) is a conserved metabolic pathway essential for mitochondrial respiration. The best characterized mtFAS product is the medium-chain fatty acid octanoate (C8) used as a substrate in the synthesis…
Chinitz L, Böhm M, Evonich R 3rd et al. · 2024 · JACC. Clinical electrophysiology
Background The autonomic nervous system plays an important role in atrial fibrillation (AF) and hypertension. Renal denervation (RDN) lowers blood pressure (BP), but its role in AF is poorly understood. Objectives The purpose of this study…
Navaneetha Krishnan S, Jaiswal A, Mohan A et al. · 2026 · Gut microbes
Increasing evidence implicates mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease (IBD), with the IBD-associated pathobiont adherent-invasive E. coli -LF82 (AIEC) promoting epithelial mitochondrial depolarization…
Lee CT, Tran D, Tsukiboshi Y et al. · 2023 · Journal of clinical periodontology
Aim This randomized controlled trial aimed to investigate the efficacy of soft-tissue augmentation (STA) with a subepithelial connective tissue graft (SCTG) or an acellular dermal matrix (ADM) on reducing tissue alterations at an immediate…
Wang Y, Zhang M, Qian N · 2026 · Preprint
Summary Forward receptive-field (RF) remapping, a mechanism for transsaccadic updating of retinal positions and perceptual stability, transiently changes cells’ eccentricities and thus could also change their RF sizes, yet few studies…
Mesquita JAC, Diniz ACS, Araujo MR et al. · 2026 · International journal of dental hygiene
Dental materials with the potential for caries progression prevention have been an attractive alternative to minimally invasive treatments. Objectives This randomized controlled split-mouth clinical trial aimed to assess, after 18 months,…
Rajendran R, Singhania S, Suthar A et al. · 2026 · Reproduction (Cambridge, England)
In brief: An excess of extracellular High-Mobility Group Box 1 protein, an alarmin, in the uterine cavity alters the proportion and phenotype of uterine immune cells. These derangements impair decidualization and adversely impact the…
Leon D, Maslivec A, Guest B et al. · 2026 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Ceramic-on-ceramic hip resurfacing arthroplasty (CoC-HRA) has been developed to eliminate metal ion concerns which have been associated with metal-on-metal hip resurfacing arthroplasty (MoM-HRA) while maintaining similar functionality. The…
Brayner B, Mason S, Karimi E et al. · 2026 · American journal of physiology. Endocrinology and metabolism
Subcutaneous adipose tissue microvascular blood flow (MBF) increases in response to insulin or a meal, with gastric inhibitory polypeptide (GIP) being a proposed mechanism. This vascular response is blunted in people with insulin…
Nissi L, Elseragy A, Wahab A et al. · 2026 · American journal of otolaryngology
Background Depth of invasion (DOI) is a well-established prognostic factor in oral cavity squamous cell carcinoma (OSCC). Incorporating DOI into the OSCC staging system has substantially refined T-classification and now informs key…
Foley E, Bockhorst JL, Beard C et al. · 2026 · Preprint
Objective: Although perspective taking is a well-established transdiagnostic feature of psychopathology, less is known about its role in treatment outcomes. The present study examined whether perspective taking frequency upon admission to…
Parisi F, Steinsbekk S, Wichstrøm L et al. · 2026 · Child development
Emotional overeating theories posit that lability/negativity and poor emotion regulation increase emotional overeating risk, yet empirical evidence is limited. This longitudinal study followed 878 Norwegian participants (50.1% girls)…
Romero-Padron MA, Fuentes-Rivera Tau L, Jorgensen A et al. · 2026 · Journal of athletic training
Context Recovery after anterior cruciate ligament reconstruction (ACLR) can lead to weight gain and reduced physical activity (PA), potentially increasing long-term health risks. Understanding the relationship between PA patterns and…
Parry YD, Briganti G · 2026 · Preprint
Wearable EEG devices such as the Zmax headband offer scalable alternatives to laboratory polysomnography (PSG) for sleep monitoring, but their real-world performance in home settings remains poorly characterised. This study presents a…
Fuse M, Rath KA, Riggs B et al. · 2026 · PloS one
Master of Science (MS) research training programs funded by organizations such as the NIH, the NSF as well as private corporations represent the potential for significant interventions for student success, especially for marginalized or…
Zournatzidis P, Luyten P, Fonagy P et al. · 2026 · Attachment & human development
Children in institutions often develop insecure attachments. Although recovery is observed in childhood and adolescence, evidence in adulthood is limited. This pre-registered study compared adoptees with institutional experience and…
Sawatpanich T, Innoi S, Chaiyamoon A et al. · 2026 · Life (Basel, Switzerland)
Morus alba L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis,…
Jeremic M, Jovanovic-Tucovic M, Martinovic T et al. · 2026 · Neurotoxicology
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of…
Abdelmenam DS, Elshahawy WM, Ahmed RK · 2026 · Odontology
This study aimed to assess the effect of incorporating sodium fluoride (NaF) into an adhesive system on the microtensile bond strength of ceramic occlusal veneers. Eighty resin-dentin sticks (~ 1 mm 2 ) were obtained from 20 upper first…