Negative / Null Result ReportOpen accessMedicine
Bommersbach TJ, Saliba M, Gilman CK et al. · 2025 · JAACAP open
Objective Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for future substance use. Stimulant medication has largely failed to demonstrate protection against future substance use, but no studies have assessed whether…
View details →DOI: 10.1016/j.jaacop.2025.05.004 Negative / Null Result ReportMedicine
Wolpe N, Perrottelli A, Giuliani L et al. · 2025 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
The negative symptoms of schizophrenia can determine functional outcome in patients. Despite its clinical significance, no treatment exists to date, as numerous pharmacological and non-pharmacological clinical trials have failed to…
View details →DOI: 10.1016/j.euroneuro.2024.12.016 Negative / Null Result ReportMedicine
Imam R, Chastang KM, Olowojesiku R et al. · 2025 · The Pediatric infectious disease journal
Background Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those at low risk of mortality or…
View details →DOI: 10.1097/inf.0000000000004581 Negative / Null Result ReportMedicine
Steendam ST, Prutean N, Clybouw F et al. · 2024 · Biological psychology
Previous research suggests that the mere presence of a smartphone can detrimentally affect performance. However, other studies failed to observe such detrimental effects. A limitation of existing studies is that no indexes of (potentially…
View details →DOI: 10.1016/j.biopsycho.2024.108893 Negative / Null Result ReportOpen accessMedicine
Brenner H, Sergeev D, Heisser T et al. · 2025 · Alimentary pharmacology & therapeutics
NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with…
View details →DOI: 10.1111/apt.70231 Negative / Null Result ReportMedicine
Deng S, Hu L, Chen G et al. · 2025 · Advanced materials (Deerfield Beach, Fla.)
Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous clinical trials have failed to demonstrate synergistic effects. One of the key reasons is that conventional…
View details →DOI: 10.1002/adma.202419418 Negative / Null Result ReportOpen accessMedicine
Murillo-Olaizola A, Rodrigo-Gisbert M, Requena M et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized controlled trials of endovascular treatment (EVT) for distal and medium vessel occlusion (DMVO) stroke did not demonstrate clinical benefit over best medical therapy and suggested potential safety concerns. We…
View details →DOI: 10.1161/svin.125.002137 Negative / Null Result ReportOpen accessPhysics
M. A. G. Maia, C. N. A. Willmer, L. N. da Costa · 1997 · arXiv
We examine the H1 content of spiral galaxies in groups by using a catalog of loose groups of galaxies identified in a magnitude limited sample m < 15.7 spanning the range 8 h to 18 h in right ascension and +9 to +15 in declination. The redshift completeness of the galaxy sample is ~95%. No significant effect of H1 depletion is found, although there may be a hint that the earliest type spirals are slightly deficient.
Negative / Null Result ReportOpen accessComputer Science
N. Metwally, M. Abdel-Aty, M. Sebawe Abdalla · 2008 · arXiv
The speed of quantum computation is investigated through the time evolution of the speed of the orthogonality. The external field components for classical treatment beside the detuning and the coupling parameters for quantum treatment play important roles on the computational speed. It has been shown that the number of photons has no significant effect on the speed of computation. However, it is very sensitive to the variation in both detuning and the interaction coupling parameters.
Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessComputer Science
D. Kharzeev, H. Satz, A. Syamtomov et al. · 1996 · arXiv
We extend a recent sum rule calculation for inelastic quarkonium-hadron interactions to realistic parton distribution functions; we also include finite target-mass corrections. Both modifications are shown to have no significant effect on the resulting cross section behaviour but the performed analysis gives useful insights on the sum-rule approach in general.
Negative / Null Result ReportOpen accessComputer Science
Shaaban Khalil · 1999 · arXiv
We show that large SUSY phases have no significant effect on the relic density of the lightest supersymmetric particle (LSP). However, they are very significant for the detection rates. We emphasise that the phase of the trilinear coupling increase the direct and indirect detection rates.
Negative / Null Result ReportMedicine
Emborg C, Kothari SF, Finnerup NB et al. · 2025 · Handbook of clinical neurology
Over the past decades, a growing number of clinical trials in neurologic conditions have failed to demonstrate superiority of active treatments over placebo. A key question in this context is whether an increase in placebo response can…
View details →DOI: 10.1016/b978-0-443-29884-4.00018-2 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportOpen accessBiology (General)
Qiaoli Wang, Wenpei Wang, Yonghui Wang et al. · 2024 · Journal of Fungi
Manganese is one of the trace elements necessary for organisms to maintain normal biological activities and is also a cofactor for manganese superoxide dismutase (Mn-SOD) and manganese peroxidase (MnP). In order to find a simple and effective method to rejuvenate the degenerated V. volvacea strains, we explored the effect of the exogenous addition of MnSO 4 on the antioxidant vigour and productivity of degenerated strains of V. volvacea . The results showed that the exogenous MnSO 4 had no significant effect on the non-degenerated strain T0, but it could effectively increase the mycelial growt
View details →DOI: 10.3390/jof10120825 Negative / Null Result ReportOpen accessPhysics
D. Sarenac, O. Lailey, D. V. Garrad et al. · 2026 · arXiv
A recent proposal suggested that neutron orbital angular momentum (OAM) states could be detected via spin-polarized absorption in polarized 3He, with predicted cross-section variations linked to the neutron's OAM. We experimentally tested this hypothesis using spin-polarized neutron beams with OAM =-2 to 2, generated by fork-dislocation phase-gratings, and transmitted through a polarized 3He cell. Within statistical precision, no OAM-dependent change in the absorption cross section was observed. This null result places stringent constraints on polarized 3He-based OAM detection schemes. The abs
Negative / Null Result ReportOpen accessSpecial aspects of education
Brahma Wahyu Kurniawan, Beny Mahyudi Saputra · 2022 · Aksara
This study aims to find out about consumer satisfaction directly and indirectly in terms of the brand ambassador and e-word of mouth variables as well as purchasing decisions as a moderating variable. Using path analysis techniques and 125 people as respondents who have used online media (marketplace) to make transactions. The results obtained in this study are that there is no significant effect indirectly, but it has a significantly positive effect when viewed from the direct influence of each variable. Indicates that consumers who are respondents are not too concerned with many consideratio
View details →DOI: 10.37905/aksara.8.3.1967-1976.2022 Negative / Null Result ReportOpen accessComputer Science
Alejandro Ibarra, Andreas Rappelt · 2017 · arXiv
We present a method to calculate, without making assumptions about the local dark matter velocity distribution, the maximal and minimal number of signal events in a direct detection experiment given a set of constraints from other direct detection experiments and/or neutrino telescopes. The method also allows to determine the velocity distribution that optimizes the signal rates. We illustrate our method with three concrete applications: i) to derive a halo-independent upper limit on the cross section from a set of null results, ii) to confront in a halo-independent way a detection claim to a
Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →DOI: 10.1053/j.semtcvs.2025.01.004 Negative / Null Result ReportMedicine
Yu H, Wu L, Wang H et al. · 2026 · Animal bioscience
Objective Compared with commercial laying hens, indigenous chicken breeds generally exhibit lower reproductive performance. This study aims to elucidate the impact of abdominal fat deposition on the reproductive performance of indigenous…
View details →DOI: 10.5713/ab.250869 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Yuming ZHANG, Xuefeng MEI · 2025 · Medžiagotyra
This work investigated the adhesion performance of recycled concrete with nano-SiO2 and nano-Al2O3 and steel bars in cold environments through freeze‒thaw cycle tests and tensile tests. The results show that the nanomaterials and number of freeze-thaw cycles have no significant effect on the damage morphology of the sample, but the adhesion strength and steel bar slip of the sample are considerably affected by the nanomaterials and number of freeze-thaw cycles. After the addition of the nanomaterials, the adhesion strength increased by 10.4 % (11.2 %), and the steel slip increased, by 17.3 % (
View details →DOI: 10.5755/j02.ms.38941 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →DOI: 10.1101/2025.09.17.25336036 Negative / Null Result ReportOpen accessComputer Science
D. V. Ahluwalia, S. P. Horvath · 2010 · arXiv
In the very special relativity (VSR) proposal by Cohen and Glashow, it was pointed out that invariance under HOM(2) is both necessary and sufficient to explain the null result of the Michelson-Morely experiment. It is the quantum field theoretic demand of locality, or the requirement of P, T, CP, or CT invariance, that makes invariance under the Lorentz group a necessity. Originally it was conjectured that VSR operates at the Planck scale; we propose that the natural arena for VSR is at energies similar to the standard model, but in the dark sector. To this end we provide an ab initio spinor r
Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →DOI: 10.1007/s10120-025-01705-8 Negative / Null Result ReportOpen accessMedicine
Bowers O, Killion HJ, Kuhlman K et al. · 2026 · BMC veterinary research
BACKGROUND: This study measured phenotypic resistance of enteric Escherichia coli (E. coli) obtained from livestock and wildlife across agricultural districts within Wyoming, U.S.A., to antimicrobials used in the cattle industry. It is the…
View details →DOI: 10.1186/s12917-026-05386-y Negative / Null Result ReportOpen accessAgriculture
Yasen H. Al tahan · 2005 · Mesopotamia Journal of Agriculture
In this study a specific gravity separator has been used in order to consider the effect of three levels of: longitudinal slop angles, vibration speeds, outlets for the produce and their effect on specific weight, productivity and seed purity. The results show the longitudinal horizontal slop angle (0) surpassed significantly in recording the greatest values for all characteristics of the study. While the second vibration speed surpassed significantly in specific weight and productivity and there were no significant effect in seed purity. in the product out lets, the first out lets achieved th
View details →DOI: 10.33899/magrj.2005.36122 Negative / Null Result ReportOpen accessMedicine
Diptasree Maitra Ghosh, Dinesh Kumar, Sridhar Poosapadi Arjunan et al. · 2017 · PLoS ONE
This study has described and experimentally validated the differential electrodes surface electromyography (sEMG) model for tibialis anterior muscles during isometric contraction. This model has investigated the effect of pennation angle on the simulated sEMG signal. The results show that there is no significant effect of pennation angle in the range 0° to 20° to the single fibre action potential shape recorded on the skin surface. However, the changes with respect to pennation angle are observed in sEMG amplitude, frequency and fractal dimension. It is also observed that at different levels o
View details →DOI: 10.1371/journal.pone.0189036 Negative / Null Result ReportOpen accessPhysics
Vasco Guerra, Rodrigo de Abreu · 2005 · arXiv
In this work we show that the null result of the Michelson-Morley experiment in vacuum is deeply connected with the notion of time. It can be deduced without any mathematics only from the assumption that all good clocks can be used to measure time with the same results, independently of the machinery involved in their manufacturing. A second important assumption, intrinsic to the very notion of time, is that clocks measure time in the same way in different frames, i.e., the notion of time is the same in all inertial frames. Under this assumption, we point out that the "postulate" of constancy
Negative / Null Result ReportOpen accessMedicine
Said C, Hayward C, Stevens M et al. · 2026 · Bioengineering (Basel, Switzerland)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has failed to demonstrate mortality benefit in randomised controlled trials of cardiogenic shock. We aimed to determine whether a novel 'Hemi-ECMO' configuration, involving aortic…
View details →DOI: 10.3390/bioengineering13050499 