A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Wang F, Wang C, Wang T et al. · 2025 · Preprint
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research
Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…
Bitran AM, Kleiman EM, Rizvi SL · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research
Objective Suicidal communications (SCs)-also known as suicide threats or "gestures," whereby an individual verbally or behaviorally signals suicidal intent-present a serious challenge to clinicians and loved ones, who may struggle to…
Mehta R, Sah R · 2025 · Cerebral circulation - cognition and behavior
•SDMT drop at baseline linked to higher Fazekas (WMH) scores.•No follow-up MoCA/SDMT association after multiple correction.•Practice effects likely inflated cognitive test recovery scores.•High attrition biased against fatigue and…
Liampas I, Tsirelis D, Dastamani M et al. · 2024 · Journal of molecular neuroscience : MN
Background and objectives Data on the association between BDNF rs6265 and multiple sclerosis (MS) are scarce and heterogeneous. Materials and methods We undertook a case-control study design. Newly diagnosed individuals with MS based on…
Yin Q, Shu T, Chen Z et al. · 2025 · Preprint
Abstract Background To investigate the relationship between emotional dysregulation, as measured by the emotional go/nogo task, and the multidimensional profile of borderline personality disorder (BPD). Methods Eighty-two participants (32…
Ajam G, Daryabor G, Jazi NN et al. · 2025 · Preprint
Abstract Viruses are among the most infectious agents thought to contribute to the development of autoimmune disorders. Adenoviruses, in particular, are widely utilized for various applications, including gene therapy, vaccine vectors, and…
Heasley CK, Stefanova V, Funk C et al. · 2025 · Preprint
Background Bifidobacterium longum subspecies infantis ( B. infantis ) abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is…
Miceli MH, Dalton LM, Pasqualotto AC et al. · 2025 · Open Forum Infectious Diseases
Background Histoplasma urine antigen detection, a valuable diagnostic tool, is often used to monitor response to antifungal therapy, but persistently positive antigen values, even when the infection has resolved, often present a clinical…
McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)
Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…
Bontrager M, Worthy SJ, Leventhal L et al. · 2025 · Preprint
Summary Herbarium specimens are broadly distributed in space and time, enabling investigation of climate impacts on phenology and fitness. We reconstructed specimen “lived” climate from knowledge of germination cues and collection dates…
Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology
Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…
Christian K, Moritz C, Skelton K et al. · 2024 · Preprint
1. Reptiles are challenged with maintaining stable hydric states and viable body temperatures in a variable terrestrial environment. Reptiles can use behaviour to select favourable microhabitats as well as physiological adaptations, such…
Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports
Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…
Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…
van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
Soffer GK, Feinberg T, Kroll H et al. · 2025 · The Journal of asthma : official journal of the Association for the Care of Asthma
Objectives To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma…
Zhou C, Cui GY, Tang YH et al. · 2025 · World journal of diabetes
Background The association between ambient air pollution and glycolipid metabolic disorders (GMDs, including diabetes mellitus and dyslipidemia) is still not well understood, especially when it comes to the different effects of long-term…
Mayntz SP, Warncke S, Ladefoged LG et al. · 2025 · Journal of cardiology
Background Cardiovascular disease is a leading cause of mortality globally, with air pollution, particularly fine particulate matter (PM 2.5 ), recognized as a significant risk factor. While long-term accumulated exposure to PM 2.5 has…
Toklu E, Göknar G, Adıyeke SK · 2026 · BMC ophthalmology
BACKGROUND: Idiopathic epiretinal membrane (iERM) is a common age-related vitreoretinal disorder characterized by fibrocellular proliferation on the inner limiting membrane. Although systemic inflammation has been suggested to play a…
Schiemer C, Horswill MS, Hill A et al. · 2025 · Journal of safety research
Introduction As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors in medicinal populations.…
Yang Y, Li Z, Zhu Y et al. · 2025 · Diagnostic pathology
Background Triple-negative breast cancer (TNBC) is aggressive and has limited therapeutic options due to the absence of targeted therapies, highlighting the urgent need for prognostic biomarkers linked to cancer stemness and…
Kobayashi S · 2025 · World journal of hepatology
Carteri et al reaffirmed the value of the Child-Turcotte-Pugh score in predicting survival in patients with cirrhosis. However, the lack of association with nutritional markers warrants careful interpretation. In cirrhosis, complex…
Yigit S, Nursal AF, Celik A et al. · 2024 · Revista da Associacao Medica Brasileira (1992)
Objective Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity.…
Takanaga S, Matsumoto N, Kadowaki T et al. · 2024 · Acta medica Okayama
Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a…
Yang X, Liu W, Mao Z et al. · 2026 · GigaScience
Background Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association studies (EWAS) of preeclampsia produced inconsistent results in cord…
Alroba R, Alfakhri A, Badreldin H et al. · 2024 · Pharmacoepidemiology and drug safety
Purpose Previous research and pharmacovigilance monitoring activities have suggested a potential association between indapamide use and rhabdomyolysis. This study aims to investigate the potential causal relationship between the use of…
Barcia Aguilar C, Amengual-Gual M, Brenton JN et al. · 2024 · Seizure
Purpose Evaluate the relationship between first and second-line medication dosing and progression to refractory status epilepticus (RSE) in children. Methods This is a retrospective analysis of prospectively collected data from September…
Bhushan A, Dexter F, Brindeiro C et al. · 2026 · Anesthesiology and perioperative science
Purpose Earlier, patients developed surgical site infection for 2.0% of cases without Staphylococcus aureus transmission through anesthesia work areas, 11% with S. aureus transmitted susceptible to prophylactic antibiotic, and 18% with…
Szczuko M, Szmigiel O, Szczuko U et al. · 2026 · Journal of clinical medicine
Background : Hashimoto's thyroiditis (HT) is the result of a complex interplay between genetic, environmental, and epigenetic factors. The role of cellular and humoral immunity in the pathogenesis of the disease is well-established.…