A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21770 results · page 723 of 726
Rana D, DeBaer L, Pourcyrous M · 2025 · Children (Basel, Switzerland)
Background Polysubstance use, particularly combining opioids with stimulants such as cocaine, is rising among individuals with substance use disorders. This practice aims to balance cocaine's stimulant effects with opioids' sedative…
Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity
Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…
Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…
Marin TC, Oliveira GF, Azevêdo LM et al. · 2025 · Chronobiology international
We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL…
Song Y, Hupfeld KE, Davies-Jenkins CW et al. · 2023 · Preprint
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA),…
Rigó M, Weyers S · 2024 · Children (Basel, Switzerland)
Background COVID-19 pandemic has influenced all children's motor development. We examine whether this differs by social circumstances. We hypothesise that socially disadvantaged children experienced more pronounced motor problems compared…
Bae H, Hensch TK · 2023 · Preprint
1 Neprilysin (Nep) is a membrane-bound zinc-dependent endopeptidase that cleaves a wide variety of small peptides in the body. In the brain, it has gained fame as an important endogenous degrader of amyloid beta peptide, responsible for…
Welch JE, Luo W, Ambroise KJ et al. · 2024 · Journal of psychiatric research
Depression and some other illnesses are associated with increased self-reference and negative emotion in language. Research findings on lexical patterns in Borderline Personality Disorder (BPD) have been inconsistent. We conducted two…
Boparai ES, Lee JK, Zhu S et al. · 2023 · The American journal of gastroenterology
Occult colorectal cancer (CRC) has historically driven recommendations for colectomy in patients with inflammatory bowel disease with dysplasia . We defined the contemporary risk of occult CRC at colectomy among 93 patients with…
Ishibashi HK, Sasaki E, Chiba D et al. · 2025 · Orthopaedic journal of sports medicine
Background Ramp lesions (RLs) associated with anterior cruciate ligament (ACL) injury increase knee instability. However, whether RLs should be treated surgically remains unclear. Purpose/hypothesis This study aimed to investigate the…
Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science
[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…
Beltrami FG, Mullarkey J, Spengler CM · 2026 · Frontiers in sports and active living
Introduction Whole-body exercise can attenuate postprandial glucose (PPG) excursions, one of the three main components in glucose control. Respiratory muscle endurance exercises (RMEE) based on resisted hyperpnea could offer an alternative…
Randolph C, Needlman R, Hutchinson E · 2024 · American journal of community psychology
Political engagement (PE) is associated with a sense of empowerment. PE by parents affects children's lives. This study explored parents' attitudes about inclusion of political engagement discussion in well-child care. Because voting is an…
Kambanis PE, Graver H, Palmer LP et al. · 2025 · The International journal of eating disorders
Objective Little is known about the timing of behavioral versus cognitive change in 10-session cognitive-behavioral therapy for non-underweight eating disorders (CBT-T). We aimed to: (a) evaluate the magnitude of behavioral and cognitive…
Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus
Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…
Carney BC, Travis TE, Keyloun JW et al. · 2024 · Burns : journal of the International Society for Burn Injuries
Dyschromic hypertrophic scar (HTS) is a common sequelae of burn injury, however, its mechanism has not been elucidated. This work is a histological study of these scars with a focus on rete ridges. Rete ridges are important for normal skin…
Becker LF, Sallandt GM, Rosolowsky E et al. · 2025 · Scientific reports
Response inhibition can be explained within the theory of event coding. Event file binding and reconfiguration have previously been studied in relation to various neurotransmitters. We aimed to activate the noradrenergic system through…
Shahsavari Pour A, Hosseini A, Ghomashi I et al. · 2026 · The archives of bone and joint surgery
Objectives This study aimed to compare the clinical outcomes of trans-tibial pullout repair of the medial meniscus posterior root using the lateral tibial tunnel versus the conventional medial tibial tunnel. Methods In this prospective…
Alhamdi H, Deroche E, Shatrov J et al. · 2025 · SICOT-J
Introduction The understanding of the influence of posterior tibial slope (PTS) on knee kinematics has increased. However, the PTS influence on clinical outcomes remains unclear. The study aimed to evaluate whether a significant change…
Lo MM, Black MN, McGlory C et al. · 2026 · Physiological reports
Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega-3 fatty acid (n-3) attenuates declines in muscle mass and…
Laird‐Hopkins BC, Ashe‐Jepson E, Basset Y et al. · 2023 · Global Change Biology
Climate change is a major threat to species worldwide, yet it remains uncertain whether tropical or temperate species are more vulnerable to changing temperatures. To further our understanding of this, we used a standardised field protocol…
Lande NM, Ask TF, Sætren SS et al. · 2023 · Preprint
Background: Self-efficacy, the belief in one’s ability and capacity to organize and execute actions required to achieve desired results, is associated with adolescent academic achievement and reduced risk for psychopathology. Adolescent…
Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science
The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…
Joshi I, Devine AJ, Joshi R et al. · 2023 · Scientific reports
Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes over time are difficult to quantify. The tracheal porcine pancreatic elastase…
Fujii N, Takahashi K, Kawama R et al. · 2026 · PloS one
Higher stiffness of the medial gastrocnemius (MG) has been reported to be associated with faster race time in 100-m sprint running. However, the association of muscle stiffness with spatiotemporal variables (i.e., step frequency, step…
Bastiani O, Dardani C, Burrows K et al. · 2024 · Preprint
Observational studies report prospective associations of neurodevelopmental and psychiatric traits with paediatric incontinence and constipation, but unmeasured and residual confounding may limit observational measures. Here, we use a…
· 2022 · Current developments in nutrition
Abstract Objectives To examine and compare reported food and nutrient intake in men and women who differ in cognitive restraint (CR) and disinhibition (D) scores. We hypothesize that average intake of sodium, total sugar, saturated fat,…
Pupo MR, Diepersloot EC, Wenzel MPR et al. · 2026 · JDS communications
Feeding spoiled silage with high yeast activity is commonly related to impaired lactation performance by dairy cows. However, rehydrated corn grain silage (RCGS) may be more prone to yeast proliferation and be greatly affected by high…
Yao Y, Liu SS, Jin L et al. · 2025 · Clinical and experimental dental research
Objectives Anterior disc displacement with reduction (ADDWR) and without reduction (ADDWOR) are two common clinical types of temporomandibular disorders. This study compared the levels of anxiety, depression, somatization, and jaw function…
Kjeldsted E, Ammitzbøll G, Lænkholm AV et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant…