A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21770 results · page 704 of 726
Jacobsen LM, Schatz D · 2025 · Hormone research in paediatrics
Background Type 1 diabetes (T1D) is more than an insulin-deficiency disease - it is an autoimmune disease, and the field is moving toward adopting disease-modifying immunotherapy as part of clinical care during T1D development. Summary…
Çalışkan B · 2025 · International ophthalmology
Purpose To evaluate serum lipid profiles with triglyceride-Glucose (TyG) and TG/HDL-c indices in patients with exudative type age-related macular degeneration. Methods A total of 71 participants were included in the study: 35 with…
Davidson TM, Lebreton CL, Hendricksen AEW et al. · 2023 · Gynecologic oncology
Background IGF signaling has been implicated in the pathogenesis and progression of ovarian carcinoma (OC). Single agent activity and safety of ganitumab (AMG 479), a fully human monoclonal antibody against IGF1R that blocks binding of…
O'Hara MH, Jegede O, Dickson MA et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treatment strategy in these tumors. Subprotocol Z1C of…
Taccetti G, Terlizzi V, Campana S et al. · 2024 · European journal of pediatrics
Bacterial infections of the lower airways are the main cause of mortality and morbidity in cystic fibrosis. The most frequently isolated pathogens are S. aureus and P. aeruginosa; bacterial co-infections are frequently observed. The aim of…
Schott CA, Mohning MP, Cooley JC · 2025 · Seminars in respiratory and critical care medicine
Idiopathic pulmonary fibrosis (IPF) is a rare but devastating diagnosis for patients with only two approved drug therapies. Extensive preclinical studies have identified and characterized novel pathways driving IPF pathogenesis, and…
Mosca M, Arnaud L, Askanase A et al. · 2025 · Lupus science & medicine
Objective In PAISLEY, a 48-week, phase II, randomised controlled trial that assessed deucravacitinib in patients with active SLE, all primary and secondary endpoints were met with the deucravacitinib 3 mg two times per day dose. Changes in…
Bateman RJ, Li Y, McDade EM et al. · 2025 · The Lancet. Neurology
Background Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people is unknown. The…
Hamamoto H, Suzuki Y, Takano Y et al. · 2022 · BMC surgery
Background This retrospective study aimed to compare long-term oncological outcomes between laparoscopic-assisted colectomy (LAC) with extracorporeal anastomosis (EA) and totally laparoscopic colectomy (TLC) with intracorporeal anastomosis…
Borghaei H, O'Byrne KJ, Paz-Ares L et al. · 2023 · ESMO open
Background In CheckMate 227 Part 1, first-line nivolumab plus ipilimumab prolonged overall survival (OS) in patients with metastatic non-small-cell lung cancer (NSCLC) and tumor programmed death-ligand 1 (PD-L1) expression ≥1% versus…
Cacko A, Kozyra-Pydyś E, Gawałko M et al. · 2021 · Cardiology journal
Background Among patients with an implanted cardiac implantable electronic device (CIED), ipsilateral upper extremity vein stenosis or occlusion (VSO) is observed more frequently than in the general population. However, there are no data…
Choueiri TK, Albiges L, Barthélémy P et al. · 2024 · Lancet (London, England)
Background Immune checkpoint inhibitors (ICIs) and vascular endothelial growth factor receptor tyrosine kinase inhibitors are cornerstones of first-line treatment for advanced renal cell carcinoma; however, optimal treatment sequencing…
Konno Y, Mayama M, Takehara K et al. · 2025 · Journal of gynecologic oncology
Objective This study aimed to assess the prognostic significance of para-aortic lymphadenectomy (PALX) and para-aortic lymph node metastasis in endometrial cancer (EC) patients at risk of post-operative recurrence. Methods Japanese…
Pettengell R, Długosz-Danecka M, Andorsky D et al. · 2020 · British journal of haematology
PIX306 was a phase 3, randomised, single-blind, multicentre trial conducted in adult patients with diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) grade 3 who relapsed after ≥1 rituximab-containing regimen and were not…
Tolaney SM, Sahebjam S, Le Rhun E et al. · 2020 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor-positive (HR + ) metastatic breast…
Rascol O, Tönges L, deVries T et al. · 2022 · Parkinsonism & related disorders
Background Immediate-release (IR) amantadine has been used for treatment of levodopa induced dyskinesia (LID). The immediate-release/extended-release (IR/ER) amantadine formulation OS320 (OSMOLEX ER®) contains an IR outer layer and ER core…
Takenaka Y, Maeda K, Yamada M et al. · 2026 · Behavioural brain research
Background Motor imagery (MI) improves motor performance, but standardized objective quality evaluation methods are lacking. The relationship between MI quality and actual performance improvements also remains unclear. Purpose We…
Bandaru S, Bodduluri S, Swami R et al. · 2026 · Scientific reports
ADRB2 gene polymorphisms have been widely studied for their role in influencing asthma pathophysiology. Of particular note, the Gln27Glu (+ 79 C > G, rs1042714) polymorphism, which alters the extracellular domain at the N-terminus of β 2…
Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery
ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…
Celik B, Kaya M, Emre S · 2026 · Parasite immunology
Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While the association between CSU and internal parasites has been investigated, the association of ectoparasites such as Demodex…
Vaisman TM, Koller J · 2025 · Preprint
Abstract Background: Family accommodation (FA) consists of changes in behavior or routines made by family members of people with psychological or developmental disorders, to reduce child distress associated with the disorder. Preliminary…
Bajaj JS, Kamath PS, Wong F et al. · 2026 · Clinical and molecular hepatology
Background/aims Infections with drug-resistant organisms (DROs) are associated with poor outcomes in cirrhosis. Rifaximin, widely used for hepatic encephalopathy (HE) could promote cross-resistance, but data regarding clinical impact are…
Prada-Rey N, Samal L, Rodriguez JA · 2026 · Journal of general internal medicine
Rationale & objective To describe kidney health evaluation rates in patients with type 2 diabetes mellitus overall and compare outcomes by language preference. Study design Retrospective cohort analysis. Setting & participants Adult…
Schott P, Enser K, Weiß M · 2026 · Preprint
Interpersonal emotion regulation depends not only on specific strategies, but also on the choice of regulation partner. While previous research suggests that individuals select regulation partners based on their perceived competence in…
Mahar JH, Wayda B, Weng Y et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the United States, despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data…
Liu C · 2026 · Reproductive biology and endocrinology : RB&E
Arkfeld et al. reported that AMH predicts miscarriage in non-PCOS but not in PCOS ART cycles. We raise concerns regarding the biological plausibility and data interpretation of their findings. Extremely low AMH (<1 ng/mL) is…
Wu P, Li L, An G et al. · 2026 · Ocular immunology and inflammation
Background Multiple studies have associated PTGER4 polymorphisms with susceptibility to several autoimmune diseases, particularly ankylosing spondylitis (AS)-a condition strongly linked to the onset of acute anterior uveitis (AAU). Given…
Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…
Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…
Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine
Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…