Phase II Study of Palbociclib in Patients with Tumors with CDK4 or CDK6 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1C.
O'Hara MH; Jegede O; Dickson MA; DeMichele AM; Piekarz R; Gray RJ; Wang V; McShane LM · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Purpose Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treatment strategy in these tumors. Subprotocol Z1C of…
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Metadata source: Europe PMC · DOI 10.1158/1078-0432.ccr-24-0036