e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21770 results · page 705 of 726

Negative / Null Result ReportMedicine

The relationship between distal lumbar lordosis correction and early postoperative L1-pelvic angle changes in adult spinal deformity surgery.

de Oliveira RG, Fujii T, Younus I et al. · 2026 · Spine deformity

Purpose To evaluate the early postoperative relationship between changes in distal and proximal lumbar lordosis and the L1-pelvic angle in adult spinal deformity surgery. Methods A retrospective review was performed of 120 adult spinal…

View details →DOI: 10.1007/s43390-026-01482-z
Negative / Null Result Report

Stable episodic memory and high education do not influence the rate of Alzheimer’s disease pathology as measured by plasma p-tau217

Avelar-Pereira B, Spotorno N, Orduña Dolado A et al. · 2026 · Preprint

Alzheimer’s disease (AD) neuropathological changes can be detected with blood-based biomarkers during the long preclinical phase that precedes clinical diagnosis. Tau phosphorylated at threonine 217 (p-tau217) has been found to closely…

View details →DOI: 10.64898/2026.04.16.718397
Negative / Null Result ReportMedicine

Mobility measures and waking-day movement behaviour composition among older adults: a compositional data analysis of the McMaster Monitoring My Mobility study.

Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity

Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…

View details →DOI: 10.1186/s12966-026-01939-4
Negative / Null Result ReportMedicine

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.

Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology

Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…

View details →DOI: 10.1016/j.jacl.2026.05.221
Negative / Null Result ReportMedicine

Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.

Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology

PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…

View details →DOI: 10.1177/11206721261444772
Negative / Null Result ReportMedicine

The Lack of Association of Infant Gender with Postpartum Depression and Breastfeeding Duration.

Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…

View details →DOI: 10.1177/15568253251386877
Negative / Null Result ReportOpen accessMedicine

Three-Dimensional Speckle-Tracking Echocardiography-Derived Left Ventricular Volumes Show No Associations with Mitral Annular Plane Systolic Excursion in Healthy Adults (Findings from the MAGYAR-Healthy Study).

Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine

Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…

View details →DOI: 10.3390/jcm15103589
Negative / Null Result Report

Target Amplicon Deep Sequencing of Pfk13 gene in patients with Plasmodium falciparum malaria during the therapeutic efficacy study trials from 2020 to 2022 in Senegal

Tine A, Diallo MA, Gaye A et al. · 2026 · Preprint

Abstract Background: Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment in Africa. However, the emergence of Plasmodium falciparum artemisinin partial resistance associated with mutations in the…

View details →DOI: 10.21203/rs.3.rs-9272508/v1
Negative / Null Result ReportMedicine

Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level.

Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…

View details →DOI: 10.1002/smi.70167
Negative / Null Result ReportMedicine

Lack of association between Helicobacter pylori and pediatric atopy: Evidence from a Latin American multicenter cohort.

Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…

View details →DOI: 10.1002/jpn3.70237
Negative / Null Result ReportMedicine

Spatial Association between Air Pollution and Non-communicable Diseases and their Distribution in India.

Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…

View details →DOI: 10.4103/ijcm.ijcm_209_25
Negative / Null Result Report

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · Preprint

Abstract Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy, and to determine whether therapeutic…

View details →DOI: 10.21203/rs.3.rs-8673450/v1
Negative / Null Result ReportMedicine

The lack of association between cumulative MTX dose and liver fibrosis in PsA: a cohort study.

Kharouf F, Mehta P, Carrizo Abarza V et al. · 2025 · Rheumatology (Oxford, England)

Objectives Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic…

View details →DOI: 10.1093/rheumatology/keaf282
Negative / Null Result ReportMedicine

Quantitative assessments of ultrasound-based rotator cuff muscle quality.

Nasr AJ, Wang H, Khazzam M et al. · 2026 · PM & R : the journal of injury, function, and rehabilitation

Background Fatty infiltration and muscle atrophy strongly influence clinical outcomes in patients with rotator cuff tears. Emerging quantitative techniques integrated with brightness-mode ultrasound and shear wave elastography (SWE) have…

View details →DOI: 10.1002/pmrj.70097
Negative / Null Result ReportOpen accessMedicine

Lack of association between G6PD variants and Parkinson disease.

Chifamba LV, Parlar SC, Liu L et al. · 2026 · HGG advances

Oxidative stress has been implicated in Parkinson disease (PD). Genes involved in PD, such as PRKN, PINK1, and PARK7, contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase,…

View details →DOI: 10.1016/j.xhgg.2025.100555
Negative / Null Result Report

Lack of association between G6PD variants and Parkinson’s disease

Chifamba LV, Parlar SC, Liu L et al. · 2025 · Preprint

Oxidative stress has been implicated in Parkinson’s disease (PD). Genes involved in PD, such as PRKN, PINK1 and PARK7 , contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate…

View details →DOI: 10.1101/2025.04.23.25324774
Negative / Null Result ReportOpen accessMedicine

Optimal duration of neoadjuvant chemotherapy prior to CRS ± HIPEC for colorectal cancer: An assessment of survival and postoperative outcomes.

Bennett FJ, Oppat KM, Zaidi MY et al. · 2026 · Surgical oncology insight

Background Cytoreductive surgery (CRS) with or without heated intraperitoneal chemotherapy (HIPEC) represents a viable therapy for select patients with colorectal cancer (CRC) peritoneal metastases. Given recurrence rates, challenges…

View details →DOI: 10.1016/j.soi.2025.100210
Negative / Null Result ReportOpen accessMedicine

Weight and sleep health in OSA: exploring their link.

Beatty CJ, Landry SA, Mann DL et al. · 2026 · Frontiers in sleep

Objectives Weight loss is often recommended for individuals with obesity and OSA, however, weight loss is particularly hard for this population. This study investigates how weight and weight change are associated with sleep health in…

View details →DOI: 10.3389/frsle.2026.1828583
Negative / Null Result ReportMedicine

Differences in time to treatment and impact on overall survival in adolescents and young adults with Hodgkin lymphoma.

Cruz CA, Rodriguez ER, Thawani M et al. · 2025 · Leukemia & lymphoma

Delays in time to treatment (TTT) have been shown to affect cancer survival, yet this has not been investigated in adolescent and young adult (AYA) Hodgkin lymphoma (HL) patients. This retrospective analysis included 508 patients with TTT…

View details →DOI: 10.1080/10428194.2025.2499607
Negative / Null Result ReportMedicine

Lack of Association of Pediatric Surgical Patient Outcomes With Increased Disposable Operating Room Supply Costs.

Acker SN, Prendergast C, Inge TH et al. · 2024 · Journal of pediatric surgery

Introduction There is wide variation in the cost of disposable operating room supplies between surgeons performing the same operation at the same institution. The general relationship between variation in disposable supply cost and patient…

View details →DOI: 10.1016/j.jpedsurg.2024.03.046
Negative / Null Result ReportOpen accessMedicine

Assessment of the Association Between Whole Blood Viscosity and Coronary Artery Calcium Score.

Duyuler S, Türker Duyuler P, Kalaycı S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Whole Blood Viscosity (WBV), estimated using the De Simone formula, is a key hemodynamic parameter linked to endothelial dysfunction and atherosclerosis. Its association with significant coronary calcification,…

View details →DOI: 10.3390/medicina62010169
Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

View details →DOI: 10.1080/09603123.2024.2412118
Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

View details →DOI: 10.1136/thorax-2024-222570
Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

View details →DOI: 10.3389/fcvm.2026.1759117