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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21385 results · page 694 of 713

Negative / Null Result ReportMedicine

Physical activity and health-related quality of life among men with prostate cancer living in remote areas of Quebec A cross-sectional, observational study.

Gendron MP, El-Haouly A · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction The majority (97.5%) of men with prostate cancer (PCa) live for at least five years after diagnosis. The health-related quality of life (HRQoL) of such men is affected by the adverse effects of treatment. Men living in remote…

View details →DOI: 10.5489/cuaj.9077
Negative / Null Result ReportMedicine

Impact of Lordosis Distribution Index on Proximal Junctional Kyphosis and Clinical Outcomes in Patients Undergoing Thoracolumbar Fusion for Degenerative Flatback Syndrome.

Park JS, Kang DH, Lee CS et al. · 2025 · Spine

Study design Retrospective study using prospectively collected data. Objective To investigate the impact of the lordosis distribution index (LDI) on proximal junctional kyphosis (PJK) and clinical outcomes in patients with degenerative…

View details →DOI: 10.1097/brs.0000000000005489
Negative / Null Result ReportMedicine

Lack of association between the length of anogenital distance and vaginal pH in women with endometriosis.

Khan KN, Fujishita A, Hiraki K et al. · 2024 · The journal of obstetrics and gynaecology research

Aim We investigated the association between the length of anogenital distance (AGD) and intra-vaginal pH, an indicator of vaginal eubiosis or dysbiosis, in women with endometriosis. Methods A prospective cohort study was performed…

View details →DOI: 10.1111/jog.16129
Negative / Null Result ReportMedicine

Academic and Pre-Medical Advising Factors Associated with Admission to the John A. Burns School of Medicine Among Premedical Students at the University of Hawai'i at Mānoa.

Hosoda KK, Shiroma KY, Lee PM et al. · 2026 · Hawai'i journal of health & social welfare

The Medical School Hotline of the University of Hawai'i John A. Burns School of Medicine was founded in 1993, by Satoru Izutu PhD (former vice-dean of UH JABSOM). It is edited by Kathleen Kihmm Connolly PhD, HJH&W Contributing Editor.…

View details →DOI: 10.62547/nugk1824
Negative / Null Result ReportMedicine

The Infrapatellar Fat Pad Fibrosis Degree Does Not Influence Postoperative Pain 6 Months Following Patellofemoral Arthroplasty.

Franco D, Leite CBG, Schmidt S et al. · 2026 · The journal of knee surgery

This retrospective study investigates whether the degree of infrapatellar fat pad (IFP) fibrosis influences postoperative pain 6 months following patellofemoral arthroplasty (PFA). Furthermore, this study explores whether sex and patellar…

View details →DOI: 10.1055/a-2693-0621
Negative / Null Result ReportMedicine

The Value of Anti-Drug Antibody Detection in Discriminating Patients from Healthy Controls and Predicting the Gross Motor Functional State in Patients with Pompe Disease.

Aziz-Ahari S, Aminian M, Rahimian A et al. · 2026 · Iranian journal of allergy, asthma, and immunology

Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection…

View details →DOI: 10.18502/ijaai.v25i2.20800
Negative / Null Result ReportMedicine

Early Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study.

Kardon A, Ren H, Gerard E et al. · 2026 · Neurocritical care

Background Headache is nearly ubiquitous in the immediate aftermath of nontraumatic, aneurysmal pattern subarachnoid hemorrhage (SAH); however, pain experiences vary significantly throughout the intensive care unit (ICU) course across…

View details →DOI: 10.1007/s12028-025-02396-w
Negative / Null Result ReportOpen accessMedicine

Radiolucent lines after robotic-assisted surface-matching kinematically aligned UKA: short-term incidence and lack of association with tibial alignment.

Itou J, Kuwasawa A, Nihei K et al. · 2026 · Archives of orthopaedic and trauma surgery

Purpose This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints.…

View details →DOI: 10.1007/s00402-026-06335-y
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Middle Cerebral Artery Diastolic Deceleration Area and Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)

Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…

View details →DOI: 10.3390/medicina62050957
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between COL1A1 rs1800012 Polymorphism and Anterior Open Bite Malocclusion in a Turkish Case-Control Cohort.

Polat T, Yılmaz ÖÖ, Önem Özbilen E et al. · 2025 · Genes

Background/objectives Anterior open bite is a multifact orial malocclusion influenced by genetic and environmental factors. Variants in the Collagen type I, alpha 1 ( COL1A1 ) gene, particularly rs1800012, have been implicated in bone…

View details →DOI: 10.3390/genes16101122
Negative / Null Result ReportMedicine

Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.

Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care

PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…

View details →DOI: 10.1177/26350106251361363
Negative / Null Result ReportMedicine

Habitual Worry, Cognitive Control, and Heart Rate Variability in Adult ADHD.

Längle A, Reyes Del Paso GA, Ettinger U et al. · 2025 · Psychophysiology

Adult attention-deficit/hyperactivity disorder (ADHD) is associated with substantial impairments in well-being and quality of life. In addition to cognitive and behavioral symptoms, emotional dysregulation characterizes the disorder. This…

View details →DOI: 10.1111/psyp.70110
Negative / Null Result ReportMedicine

Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study.

Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery

Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…

View details →DOI: 10.1016/j.avsg.2025.11.008
Negative / Null Result ReportMedicine

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection.

da Silva JC, Caetano AR, Mendonça ACDF et al. · 2025 · The journal of applied laboratory medicine

Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB…

View details →DOI: 10.1093/jalm/jfae151
Negative / Null Result ReportMedicine

Is time interval from breastfeeding cessation to frozen single euploid embryo transfer cycle associated with pregnancy outcome?

Bergin K, Leibner L, Roger S et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Prolactin (PRL) secretion during breastfeeding suppresses gonadotropin releasing hormone and ovulation. While PRL receptors are present in the endometrium, it is unknown whether transient rises in secretion during breastfeeding…

View details →DOI: 10.1002/ijgo.70418
Negative / Null Result ReportOpen accessMedicine

The relational association between multiple sexual partners and HIV testing on cervical cancer screening among women of reproductive age in Ghana: A national population-based study.

Afaya A, Awunyo W, Udeoha MA et al. · 2026 · PloS one

Background Cervical cancer screening remains vital in the early detection of precancerous lesions and promotes better treatment outcomes. Though evidence suggested multiple sexual partners and HIV infection as risk factors for cervical…

View details →DOI: 10.1371/journal.pone.0344086
Negative / Null Result Report

Carboplatin-Induced Ototoxicity in Children Treated for Retinoblastoma

Singh V, N B, Palla S et al. · 2025 · Preprint

Background: The chemotherapy regimen comprising carboplatin, vincristine, and etoposide (JOE) is commonly used to treat retinoblastoma. Carboplatin-induced ototoxicity is infrequently reported. High-frequency hearing loss may impair…

View details →DOI: 10.22541/au.174962434.47219542/v1
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Glucose Homeostasis and Immune Checkpoint Inhibitor Outcomes: A Retrospective Institutional Review.

Justice J, Burnette H, Irlmeier R et al. · 2025 · Cancers

Background/objectives Immune checkpoint inhibitors (ICIs) have revolutionized outcomes for patients with melanoma. As such, it is important to understand factors that may influence response as well as toxicity to these therapies. Impaired…

View details →DOI: 10.3390/cancers17193230
Negative / Null Result ReportMedicine

Carboplatin-Induced Ototoxicity in Children Treated for Retinoblastoma.

Singh V, Banumathy N, Palla S et al. · 2025 · Pediatric blood & cancer

Background The chemotherapy regimen comprising carboplatin, vincristine, and etoposide (JOE) is commonly used to treat retinoblastoma. Carboplatin-induced ototoxicity is infrequently reported. Extended high-frequency hearing loss may…

View details →DOI: 10.1002/pbc.31934
Negative / Null Result ReportOpen accessMedicine

Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.

Akbari T, Mach L, Hammersley DJ et al. · 2025 · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Background Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium. Objectives To…

View details →DOI: 10.1016/j.jocmr.2025.101953
Negative / Null Result ReportMedicine

High levels of the adipokines leptin and metrnl in patients with paroxysmal atrial fibrillation and obstructive sleep apnea are not associated with the severity of sleep apnea or the burden of atrial fibrillation.

Ueland T, Traaen GM, Hunt TE et al. · 2025 · Sleep medicine

Study objectives Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are highly prevalent conditions sharing multiple risk factors including obesity. Adipokines secreted from adipose tissue could modify pathways affecting atrial…

View details →DOI: 10.1016/j.sleep.2025.106862
Negative / Null Result ReportMedicine

Epigenetic alterations of serotonergic but not dopaminergic signalling in compulsive sexual behaviour disorder.

Androvičová R, Jahn K, Engel J et al. · 2026 · Behavioural brain research

Rationale The compulsive sexual behaviour disorder (CSBD) is a recent addition to the ICD-11 diagnostic manual under the chapter of impulse control disorders. Though there is a wealth of different theoretical viewpoints regarding the…

View details →DOI: 10.1016/j.bbr.2025.115872
Negative / Null Result ReportMedicine

The Characteristics of Peripheral Blood Lymphocyte Subsets in HIV-related Diffuse Large B-cell Lymphoma Patients and Their Impact on Treatment Efficacy.

Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research

Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…

View details →DOI: 10.2174/011570162x369231250818043532
Negative / Null Result ReportMedicine

Suicidal Communications in Adults with Borderline Personality Disorder: Clinical Correlates and Treatment Response to Dialectical Behavior Therapy.

Bitran AM, Kleiman EM, Rizvi SL · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Objective Suicidal communications (SCs)-also known as suicide threats or "gestures," whereby an individual verbally or behaviorally signals suicidal intent-present a serious challenge to clinicians and loved ones, who may struggle to…

View details →DOI: 10.1080/13811118.2025.2512455