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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21385 results · page 693 of 713

Negative / Null Result ReportMedicine

Insufficient Evidence for Load as the Primary Cause of Nonspecific (Chronic) Low Back Pain. A Scoping Review.

de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…

View details →DOI: 10.2519/jospt.2024.11314
Negative / Null Result ReportMedicine

The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.

Xiang C, Zheng M, Li Y et al. · 2025 · Annals of vascular surgery

Background Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial…

View details →DOI: 10.1016/j.avsg.2025.01.013
Negative / Null Result ReportOpen accessMedicine

Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?

Matsuzaki S · 2026 · Reproductive medicine and biology

Background Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…

View details →DOI: 10.1002/rmb2.70041
Negative / Null Result Report

Multiple mating predicts queen reproductive output in the polygynous Neotropical trap-jaw ant, Odontomachus chelifer (Formicidae: Ponerinae)

Florindo HS, Azevedo-Silva M, Pereira-Romeiro MP et al. · 2025 · Preprint

The factors that influence the organisms’ ability to reproduce are diverse. In ants, social structure may contribute to queens’ Reproductive Output (RO), alongside environmental conditions and genetic attributes. Polygynous species like…

View details →DOI: 10.1101/2025.05.05.652256
Negative / Null Result ReportOpen accessMedicine

C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death.

Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology

Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…

View details →DOI: 10.1186/s12933-025-03028-5
Negative / Null Result ReportMedicine

Goal framing of health promotion messages in contact lens wear.

Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…

View details →DOI: 10.1016/j.clae.2025.102387
Negative / Null Result ReportMedicine

Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.

Sirirungreung A, Lee PC, Hu YH et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to…

View details →DOI: 10.1158/1055-9965.epi-25-1034
Negative / Null Result ReportMedicine

Estimation of the economic impacts and operational limitations imposed on unmanned aerial systems by poor sky conditions

Prince Czarnecki JM, Shockley JM, Wasson L et al. · 2024 · Precision Agriculture

Cloudy skies reduce image quality obtained from unmanned aerial vehicles (UAV) due to variable lighting conditions imposed on the surface. This study provides a novel approach for identifying temporal windows of opportunity that show…

View details →DOI: 10.1007/s11119-023-10055-3
Negative / Null Result ReportOpen accessMedicine

Use of oXiris<sup>®</sup> vs standard AN69ST filters in sepsis-associated acute kidney injury requiring continuous renal replacement therapy: a retrospective matched cohort study.

Yepes Gómez D, Moreno-Bedoya S, Lohle-Rueda S et al. · 2026 · Frontiers in nephrology

Background Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and carries high short-term mortality despite timely antimicrobials and organ support. Adsorptive hemofilters such as the oXiris ® membrane have…

View details →DOI: 10.3389/fneph.2026.1810007
Negative / Null Result ReportMedicine

Diverging paths: Modeling the relation between adverse effects, attitudes, perceived adherence, and treatment effect in an internet-based cognitive-behavioral intervention for obsessive-compulsive disorder.

Baumeister A, Schuurmans L, Schultz J et al. · 2025 · Behaviour research and therapy

Background and aim The efficacy of internet-based interventions (IBI) for various psychiatric disorders is widely established, but little is known about the mechanisms or possible influencing factors. One of the most prominent problems in…

View details →DOI: 10.1016/j.brat.2024.104673
Negative / Null Result ReportMedicine

Efficacy of Molding Helmet Therapy following Suturectomy for Craniosynostosis: A Single-center, Retrospective Analysis in Japan.

Kurimoto M, Nawashiro T, Nagakura M et al. · 2025 · The Journal of craniofacial surgery

Craniosynostosis limits normal cranial growth, significantly affecting the growth and development of children. This increase in intracranial pressure results in significant cosmetic and functional losses. This study investigated the…

View details →DOI: 10.1097/scs.0000000000010799
Negative / Null Result ReportOpen accessMedicine

A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus.

Mao J, Gan Y, Tan X et al. · 2025 · International journal of women's health

Objective High basophil count levels are associated with an increased risk of gestational diabetes mellitus (GDM). We used two-sample Mendelian randomisation (MR) to explore a potential causal relationship. It also aims to offer genetic…

View details →DOI: 10.2147/ijwh.s500632
Negative / Null Result ReportOpen accessMedicine

Reassessment of the Collaborative Normal-Tension Glaucoma Study: Statistical Evidence and Implications for Current Management.

Killer HE, Pircher A, Stekhoven DJ · 2026 · Ophthalmology and therapy

Introduction The Collaborative Normal-Tension Glaucoma Study (CNTGS) is frequently cited as evidence that a 30% reduction in intraocular pressure (IOP) slows progression in normal-tension glaucoma (NTG). This study re-examines the…

View details →DOI: 10.1007/s40123-025-01300-1
Failed Experiment Report

Venetoclax and azacitidine compared with intensive chemotherapy for adverse-risk acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation in first complete remission: a multicenter study of TROPHY group.

Mo X, Wen Q, Jiang C et al. · 2024 · Preprint

Abstract It was commonly accepted that adverse-risk acute myeloid leukemia patients should receive allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). In this multicenter study, we aimed to…

View details →DOI: 10.21203/rs.3.rs-5222638/v1
Negative / Null Result ReportMedicine

Developing Solutions to the Waitlist Problem for Eating Disorder Treatments.

Wade TD, Jabs M, Keegan E et al. · 2024 · The International journal of eating disorders

Objective We examine the small amount of research to date that describes and/or evaluates waitlist interventions as a precursor to treatment for an eating disorder (ED) with the intent to provide recommendations for future research that…

View details →DOI: 10.1002/eat.24310
Negative / Null Result ReportOpen accessMedicine

Are KLIC and CRIME-80 scores useful to assist decision-making initially or at the moment of repeat DAIR? - a retrospective study.

Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection

Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…

View details →DOI: 10.5194/jbji-10-403-2025
Negative / Null Result ReportMedicine

Elevational pattern of species range size of vascular plants in Changbai Mountain, China:A test of Rapo-port's rule.

Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology

Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…

View details →DOI: 10.13287/j.1001-9332.202412.001
Negative / Null Result ReportMedicine

Self-Reported Inner Speech Reflects Improvement From Language Therapy.

Stark BC, Alexander JM, Stockrahm E et al. · 2026 · American journal of speech-language pathology

Purpose This study examined the role of inner speech-defined here as the subjective experience of covert lexical access-in naming recovery following semantic feature analysis (SFA) treatment in individuals with aphasia. Specifically, it…

View details →DOI: 10.1044/2026_ajslp-25-00363