A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21379 results · page 691 of 713
Yadav R, Shukla U, Yadav U et al. · 2026 · Annals of African medicine
Background Improvement in neurological function has been reported in stroke patients after hyperbaric oxygen therapy (HBOT) administration. Although the majority of spontaneous neurological recovery occurs within the first 90 days…
Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…
Bovenberg C, Keeler JL, Cardi V et al. · 2026 · Journal of eating disorders
Background Anorexia nervosa (AN) is a severe psychiatric disorder (ED) with high mortality, marked functional impairment, and substantial phenotypical heterogeneity. Despite extensive research, treatment outcomes remain poor, and it is…
Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…
Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology
Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…
Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine
Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…
Wang J, Chen J, Zhao Y et al. · 2026 · Bone & joint research
Aims Ankle sprain (AS), a prevalent sports injury, often progresses to chronic ankle instability (CAI) and post-traumatic arthritis if inadequately treated. Despite known clinical manifestations, the molecular mechanisms driving poor…
Seok HG, Park SG · 2026 · Archives of orthopaedic and trauma surgery
INTRODUCTION: The recovery patterns following arthroscopic rotator cuff repairs are influenced by several factors, including the size of the tear and the degree of patient compliance. This study aimed to ascertain whether a correlation…
Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama
We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…
Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation
The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…
Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…
Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine
Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…
Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)
Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…
Xie E, He Y, Cao T et al. · 2026 · Preprint
Abstract Background BOPPPS, which comprises six components—Bridge-in, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary—is a student-centered structured teaching model widely applied in theoretical courses.…
Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…
Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery
Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…
Da Costa M, Seitz B, Munteanu C et al. · 2026 · Die Ophthalmologie
Background In Germany, each surgical corneal center defines individual criteria for the indications for Descemet membrane endothelial keratoplasty (DMEK). Clinical experience shows a clear discrepancy between best corrected visual activity…
Eldesoqui M, Al-Batati A, Erfan OS et al. · 2026 · Clinical anatomy (New York, N.Y.)
Generation Z has different requirements, problems, expectations, and attitudes that they bring into the educational environment. Teachers have unprecedented challenges in addressing their needs and aspirations. Gamification involves…
Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…
Metry M, Bernard S · 2026 · JAAPA : official journal of the American Academy of Physician Assistants
Abstract Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economically burdensome condition. The…
Golz C, Gerlach M, Meichtry A et al. · 2026 · Preprint
Abstract Background: Presenteeism behaviour, defined as working while ill, can negatively affect employee health and productivity. Despite its high prevalence, targeted theory-based interventions remain scarce. This study evaluated a…
Flores Rodríguez JC, Morán Ortega MJ, Jimenez Ordoñez AC et al. · 2026 · Cureus
Postbiotics, defined as non-viable microbial cells and their metabolites, have emerged as topical therapies for inflammatory dermatoses and provide more clinical benefits than live postbiotics by eliminating infection risk and stability.…
Cangemi DJ, Laitman AP, Faiman O et al. · 2026 · Annals of medicine
Introduction Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately.…
Gozde Ozdemir B, Avci F, Huseynli L et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.…
Yang J, Han Y · 2026 · Food Hydrocolloids.
The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…
Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…
Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science
Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…
Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…
Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics
Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…
Jiang Y, Ma L, Lu B et al. · 2026 · Frontiers in oncology
Pancreatic cancer continues to be one of the foremost contributors to cancer-related mortality. Erlotinib is a targeted agent that has shown a significant improvement in outcomes for advanced pancreatic cancer when administered alongside…