Negative / Null Result ReportMedicine
Jing S, Wang J, Cheng S et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
Voltage-gated sodium channels (VGSCs) are emerging therapeutic targets for cancers including neural tumors such as neuroblastomas and gliomas. BmK IT2, a neurotoxic polypeptide from the scorpion Buthus martensii Karsch, is a known…
View details →DOI: 10.1016/j.toxicon.2026.109166 Negative / Null Result ReportMedicine
Gokdemir MT, Gokdemir GS · 2026 · BMC infectious diseases
Background Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic…
View details →DOI: 10.1186/s12879-026-13542-w Negative / Null Result ReportMedicine
Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international
Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…
View details →DOI: 10.1007/s00383-026-06464-w Negative / Null Result ReportOpen accessMedicine
Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…
View details →DOI: 10.1186/s41021-026-00361-3 Negative / Null Result ReportOpen accessMedicine
Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro
Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…
View details →DOI: 10.1523/eneuro.0068-26.2026 Negative / Null Result ReportMedicine
Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…
View details →DOI: 10.1016/j.cgh.2024.05.017 Failed Experiment ReportOpen accessMedicine
Chihara Y, Takeda T, Goto Y et al. · 2022 · The oncologist
Background Osimertinib is one of the standard first-line treatments for advanced non-small cell lung cancer in patients with epidermal growth factor receptor (EGFR) mutations, because it achieves significantly longer progression-free…
View details →DOI: 10.1093/oncolo/oyac193 Failed Experiment ReportMedicine
Tsimafeyeu I, Goutnik V, Shrainer I et al. · 2023 · American journal of cancer research
About 40% of patients with non-small cell lung cancer (NSCLC) developed pleural effusions at some time during the course of their disease. Preliminary results from our Phase 2 multicentre clinical trial (Cohort 1) demonstrated the safety…
Negative / Null Result ReportOpen accessMedicine
Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist
Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…
View details →DOI: 10.1093/oncolo/oyae274 Failed Experiment ReportMedicine
Paz-Ares L, Goto Y, Wan-Teck Lim D et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Objectives Canakinumab, an interleukin-1 beta inhibitor, previously showed reduced lung cancer incidence and mortality (CANTOS). Here, we compare the efficacy/safety of canakinumab versus placebo in patients with advanced non-small cell…
View details →DOI: 10.1016/j.lungcan.2023.107451 Negative / Null Result ReportMedicine
Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment
Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…
View details →DOI: 10.1016/j.scitotenv.2026.181799 Negative / Null Result ReportMedicine
Hauptmann E MD, Whitlock R MD, Yeganeh S MD et al. · 2026 · The Journal of surgical research
Introduction Sternal-sparing left ventricular assist device (ssLVAD) insertion avoids the morbidity of median sternotomy for patients with heart failure. Obesity may present challenges in this minimal access operation. We present our…
View details →DOI: 10.1016/j.jss.2026.04.014 Negative / Null Result ReportMedicine
Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma
Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…
View details →DOI: 10.1080/02770903.2026.2644881 Negative / Null Result ReportMedicine
Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…
View details →DOI: 10.1016/j.reprotox.2025.109045 Negative / Null Result ReportMedicine
Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research
Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…
View details →DOI: 10.1016/j.bbr.2026.116225 Negative / Null Result ReportMedicine
Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports
Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…
View details →DOI: 10.1038/s41598-026-42284-7 Negative / Null Result ReportMedicine
Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science
The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…
View details →DOI: 10.3168/jds.2025-27829 Failed Experiment ReportMedicine
Kang J, Hooker D, DeBruin J et al. · 2026 · Field Crops Research.
In-season split-nitrogen (N) applications made after canopy closure in corn (Zea mays L.) are becoming more common. A better understanding of the physiological and environmental factors that influence their effectiveness is needed. The…
Failed Experiment Report
Melcher AV, Hafflett L, Tang L et al. · 2026 · Preprint
ABSTRACT Background Doxorubicin (DOX) causes sex-specific cardiotoxicity. Metabolic impairment is a well-established cardiotoxic effect of DOX treatment that can contribute to other detrimental effects such as increased reactive oxygen…
View details →DOI: 10.64898/2026.05.28.728478 Failed Experiment Report
Kitaoka Y, Whyland K, Li Z et al. · 2026 · Preprint
Abstract Background Migraine is a debilitating neurological disorder affecting ~ 15% of the global population with greater prevalence in females. Cannabinoid 1 and 2 receptor (CB1R and CB2R) agonists alleviate migraine symptoms. However,…
View details →DOI: 10.21203/rs.3.rs-8714966/v1 Negative / Null Result Report
Kalafut KC, Cormerais Y, Cissé MY et al. · 2025 · Preprint
The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, while aberrant activation is linked to human disease, including metabolic disease. Cellular…
View details →DOI: 10.1101/2025.10.01.679861 Negative / Null Result Report
Jordhani M, Ruci D, Jordhani P et al. · 2025 · Preprint
Background: Hydroxychloroquine (HCQ) is a disease-modifying antirheumatic drug used in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other autoimmune diseases. Although HCQ reduces SARS-CoV-2 replication in vitro at…
View details →DOI: 10.20944/preprints202509.1673.v1 Negative / Null Result Report
Ryan BC, Griffith KE, Geczi CN et al. · 2025 · Preprint
Stargardt disease (STGD1) is the most common inherited macular dystrophy, caused by loss-of-function mutations in ABCA4 that result in bisretinoid-containing lipofuscin accumulation in the retinal pigment epithelium (RPE), and progressive…
View details →DOI: 10.1101/2025.10.25.684461 Negative / Null Result ReportOpen accessMedicine
Caltabiano A, Voruganti A, Nesi J et al. · 2026 · JMIR serious games
Background Exposure and response prevention is a first-line intervention for obsessive-compulsive disorder (OCD), yet many individuals with contamination concerns do not access care. Virtual reality exposure-based therapy (VRET) may…
View details →DOI: 10.2196/78169 Negative / Null Result Report
Rau KK, Harrison BJ, Venkat G et al. · 2025 · Preprint
Pain resulting from tissue damage, including surgical incision, is often only partially responsive to standard treatments focusing on inflammation, suggesting additional mechanisms are involved. Tissue damage leads to expression in dorsal…
View details →DOI: 10.1101/2025.02.11.637320 Negative / Null Result Report
Heller DT, Benites NM, Amick EM et al. · 2025 · Preprint
Pre-sensory (ps), peripherally-generated spontaneous activity (SA) is important for establishing basic topography of central components of sensory pathways. However, roles for psSA in sculpting connections at the single neuron level and in…
View details →DOI: 10.1101/2025.08.28.672917 Negative / Null Result ReportMedicine
Kik OE, Zaviska F, Lesage G et al. · 2026 · Water research
This study investigated the electro-oxidation (EO) of three priority micropollutants: carbamazepine (CBZ), diuron (DIU), and perfluorooctane sulfonate (PFOS), in secondary-treated wastewater using boron-doped diamond (BDD) anodes. Although…
View details →DOI: 10.1016/j.watres.2025.125158 Negative / Null Result ReportMedicine
Bidon M, Saito T, Skjaerven KH et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)
Methylmercury (MeHg) is a pervasive neurotoxicant threatening aquatic ecosystems. Selenium (Se) has been reported to protect fish against the adverse MeHg toxicity, yet molecular investigations of their interaction in the brain remain…
View details →DOI: 10.1016/j.aquatox.2026.107706 Negative / Null Result ReportMedicine
Birsen I, Erdogan K, Ozsoy O et al. · 2026 · Tissue & cell
Inflammatory bowel disease (IBD) is a systemic condition that can also lead to extraintestinal complications, including liver damage. Disruptions in the gut-liver axis and inflammatory mediators play a key role in this process. Apelin, a…
View details →DOI: 10.1016/j.tice.2025.103276 Negative / Null Result ReportMedicine
Dai T, Dai Q, Ding Y et al. · 2026 · Neurochemical research
Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibition of histone deacetylases (HDACs) may convert microglia to a branching state and thus prevent neuroinflammation.…
View details →DOI: 10.1007/s11064-026-04688-9 