Abandoned HypothesisOpen accessMedicine
Yata S, Takatani Y, Sato Y et al. · 2025 · Cureus
Sodium zirconium cyclosilicate (SZC) is a novel potassium-binding agent used to treat hyperkalemia. Although SZC is generally considered safe, its efficacy and safety in critically ill patients remain unclear. We report a novel adverse…
View details →DOI: 10.7759/cureus.93726 Negative / Null Result ReportOpen accessMedicine
Draper B, Wand APF · 2025 · Current opinion in psychiatry
Purpose of review Depression and physical illnesses have long been recognized as risk factors for suicidal behaviour in late life. Qualitative studies have previously identified frailty as being an issue in late life suicidal behaviour,…
View details →DOI: 10.1097/yco.0000000000001009 Failed Experiment ReportOpen accessMedicine
McCloskey NS, Li C, Kirby LG · 2025 · Psychopharmacology
Rationale Our laboratory has demonstrated that stressors regulate the 5-HT system with consequences in behavioral models of psychiatric disorders including addiction. We have employed behavioral pharmacology methods to show that stressors…
View details →DOI: 10.1007/s00213-025-06947-z Negative / Null Result ReportOpen accessMedicine
Sieborg J, Maul JT, Wu JJ et al. · 2025 · Acta dermato-venereologica
Biosimilars are designed to be analogous to the biologic originators. However, comprehensive comparisons between biosimilars are limited and lacking for patients with psoriasis. This study's objective was to compare 1-year drug survival of…
View details →DOI: 10.2340/actadv.v105.42572 Negative / Null Result ReportMedicine
Hossain SJ, Tofail F, Mehrin SF et al. · 2023 · Pediatrics
Background and objectives Previously, in 30 Bangladeshi villages, 2 groups of children with iron-deficiency anemia (IDA) and nonanemic (NA) iron sufficiency aged 6 to 24 months participated in 2 parallel cluster randomized controlled…
View details →DOI: 10.1542/peds.2023-060221e Negative / Null Result ReportOpen accessMedicine
Bingöl G, Jesurasa S, Stroethoff M et al. · 2025 · Frontiers in cardiovascular medicine
Remote ischemic preconditioning (RIPC) has been shown in several experimental studies as an organ protective procedure against ischemic injury, but the implementation of RIPC into routine clinical practice has so far failed due to…
View details →DOI: 10.3389/fcvm.2025.1631222 Negative / Null Result ReportOpen accessMedicine
Mayer L, Lichtblau M, Furian M et al. · 2025 · Journal of the American Heart Association
Background Exposure to high altitude triggers hypoxic pulmonary vasoconstriction with a rise in pulmonary artery pressure (PAP). This may lead to symptomatic pulmonary hypertension with impaired right heart function and exercise capacity.…
View details →DOI: 10.1161/jaha.125.041941 Negative / Null Result ReportOpen accessMedicine
López-de la Rosa A, Díez-Montero C, Martínez-Plaza E et al. · 2024 · Ophthalmology and therapy
Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of…
View details →DOI: 10.1007/s40123-024-00882-6 Negative / Null Result ReportMedicine
Fitzgerald LS, Reynoso Spurrier CS, Lau NJ et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Mitochondria are key regulators of metabolism and ATP supply in skeletal muscle, while circadian rhythms influence many physiological processes. However, whether mitochondrial function is intrinsically regulated in a circadian manner in…
View details →DOI: 10.1152/ajpendo.00027.2025 Negative / Null Result ReportMedicine
Fernández-Ruiz M, Sánchez Moreno B, Santiago Almeda J et al. · 2023 · Transplant infectious disease : an official journal of the Transplantation Society
Previous studies have suggested that exposure to statins confers a protective effect in bloodstream infection (BSI) due to the anti-inflammatory and immunomodulatory properties attributed to these lipid-lowering drugs. Scarce evidence is…
View details →DOI: 10.1111/tid.14132 Negative / Null Result ReportOpen accessMedicine
Vilk Ayalon N, Omer Vilk N, Sompolinsky Y et al. · 2026 · Reproductive health
BACKGROUND: Frozen embryo transfer (FET) is widely used due to its safety and effectiveness. However, it has been associated with an increased risk of large for gestational age (LGA) infants. Proposed mechanisms include effects of embryo…
View details →DOI: 10.1186/s12978-026-02322-z Negative / Null Result ReportOpen accessMedicine
Agudelo LR, Yarmush G, Kumar S et al. · 2025 · Biology
Accelerating healing is a clinical goal in both acute and chronic non-healing skin wounds. We leveraged the public Recon database, which seeks to aggregate all of the metabolic pathways in the human body, to uncover whether increasing the…
View details →DOI: 10.3390/biology14060722 Negative / Null Result ReportMedicine
Sandoval-Alarcón S, Bäumle R, Castellucci HI · 2025 · Applied ergonomics
Dentists face various occupational demands that heighten their risk of developing work-related musculoskeletal disorders (WMSDs), including prolonged static postures, repetitive movements, unsuitable dental instruments, extended work…
View details →DOI: 10.1016/j.apergo.2025.104602 Negative / Null Result ReportOpen accessMedicine
Nimkulrat SD, Wagner MR, Waters BJ et al. · 2025 · Scientific reports
RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic β cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to β cell failure in…
View details →DOI: 10.1038/s41598-025-32403-1 Negative / Null Result ReportOpen accessMedicine
Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports
We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…
View details →DOI: 10.1038/s41598-025-21890-x Negative / Null Result ReportOpen accessMedicine
Cesanelli L, Venckunas T, Minderis P et al. · 2026 · Antioxidants (Basel, Switzerland)
Background/Objectives : This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli…
View details →DOI: 10.3390/antiox15030379 Negative / Null Result ReportOpen accessMedicine
Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology
Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…
View details →DOI: 10.1007/s00213-025-06753-7 Negative / Null Result Report
Caballero P, Prieto-Amador M, Martínez-Guitarte J · 2022 · Preprint
Abstract Pesticides are an environmental problem. The search for new pest control methods has focused on compounds with low or no toxic effects in non-target organisms. Analogs of the juvenile hormone (JH) interfere endocrine system of…
View details →DOI: 10.21203/rs.3.rs-1036012/v2 Negative / Null Result ReportMedicine
Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
View details →DOI: 10.1093/cid/ciae058 Negative / Null Result ReportOpen accessMedicine
Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)
α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…
View details →DOI: 10.5511/plantbiotechnology.24.0721b Negative / Null Result ReportOpen accessMedicine
Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health
This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…
View details →DOI: 10.3390/ijerph23050602 Negative / Null Result Report
Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
View details →DOI: 10.1101/2022.11.01.514620 Negative / Null Result ReportOpen accessMedicine
Winter AL, Peter M, Thunell E et al. · 2026 · Neural plasticity
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent…
View details →DOI: 10.1155/np/3960593 Negative / Null Result ReportMedicine
Chen P, Lv J · 2024 · Nephrology (Carlton, Vic.)
This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid…
View details →DOI: 10.1111/nep.14369 Negative / Null Result ReportMedicine
Hosier H, Lipkind HS, Rasheed H et al. · 2023 · Hypertension (Dallas, Tex. : 1979)
Background Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has been associated with preeclampsia in observational studies. We use Mendelian randomization analyses to estimate the association between lipid levels,…
View details →DOI: 10.1161/hypertensionaha.122.20426 Negative / Null Result ReportOpen accessMedicine
Richardson KE, Suo C, Albertella L et al. · 2025 · JAMA psychiatry
Importance Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training…
View details →DOI: 10.1001/jamapsychiatry.2025.2319 Negative / Null Result ReportOpen accessMedicine
da Silva NIS, de Araújo TLAC, Firmino SS et al. · 2026 · Tropical animal health and production
This study aimed to evaluate the effects of supplementing high-concentrate diets for sheep with green propolis extract (PRO) from Mimosa tenuiflora or with salinomycin (SAL) on feed intake, apparent digestibility, nitrogen balance, and…
View details →DOI: 10.1007/s11250-026-05012-x Negative / Null Result ReportOpen accessMedicine
Luzuriaga AL, Madrigal-González J, de la Cruz M et al. · 2026 · Ecology
The relationship between taxonomic and phylogenetic diversities remains underexplored. Our goal was to determine whether a causal link exists between species richness and phylogenetic diversity and to determine the direction of this…
View details →DOI: 10.1002/ecy.70361 Failed Experiment ReportOpen accessMedicine
Khasanov TA, Maleeva EE, Koshelev SG et al. · 2024 · Marine drugs
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic…
View details →DOI: 10.3390/md22090382 Negative / Null Result ReportOpen accessMedicine
Lo Verso L, Lessard M, Lauzon K et al. · 2026 · Journal of animal science
This study aimed to determine the effects of deoxynivalenol (DON) and zearalenone (ZEA) co-contamination on systemic immune responses and intestinal mucosal immunity in weaned piglets and to evaluate the mitigating ability of antioxidant…
View details →DOI: 10.1093/jas/skag080 