Negative / Null Result ReportOpen accessMedicine
Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects
The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…
View details →DOI: 10.3390/insects16090989 Negative / Null Result ReportMedicine
Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation
Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…
View details →DOI: 10.1080/09638288.2023.2264765 Negative / Null Result ReportOpen accessMedicine
Hoevenaar-Blom MP, Shourick J, van Dalen JW et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence. Methods We pooled data from the multidomain MAPT (Multidomain Alzheimer…
View details →DOI: 10.1002/alz.14557 Negative / Null Result ReportOpen accessMedicine
Pizarro J, Walker MC, Sheybani L · 2025 · Epilepsia
Generalized epileptiform discharges (GEDs) in idiopathic generalized epilepsy (IGE) are classically considered symmetrical in amplitude, although this has not been formally tested. This is a major knowledge gap, since asymmetry is…
View details →DOI: 10.1111/epi.18509 Negative / Null Result ReportOpen access
Ford BE, Chachra SS, Alshawi A et al. · 2024 · Preprint
ABSTRACT Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy chronically during clinical trials. The underlying…
View details →DOI: 10.1101/2024.07.24.604910 Negative / Null Result ReportOpen accessMedicine
Mogensen DG, Aanaes K, Andersen IB et al. · 2025 · The Laryngoscope
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID-19. However, the effectiveness of olfactory training in COVID-19-induced olfactory dysfunction has been studied; only a few studies…
View details →DOI: 10.1002/lary.32275 Methods Dead-EndOpen accessMedicine
Andersen E, Bohler L, Leirbakk MJ et al. · 2025 · BMC public health
Background Given the elevated prevalence and impact of overweight and the potential risk of non-communicable diseases among women of Somali background in high-income countries and recognising the potential positive impact of physical…
View details →DOI: 10.1186/s12889-025-22475-z Negative / Null Result ReportOpen accessMedicine
Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)
Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…
View details →DOI: 10.3390/pharmacy12020058 Failed Experiment ReportOpen accessMedicine
Hägglund S, Laloy E, Alvarez I et al. · 2024 · PloS one
Non-steroidal anti-inflammatory drugs (NSAID) are not recommended for use against pneumonia in humans, but are commonly utilised against bovine respiratory disease. This study aimed to determine if the use of NSAIDs in the early phase of…
View details →DOI: 10.1371/journal.pone.0309609 Failed Experiment ReportMedicine
Gallegos-Reyes MA, Antaño-Martínez AR, Alcaraz-Contreras Y et al. · 2023 · The Journal of toxicological sciences
Lead (Pb) exposure induces testicular damage and infertility. The aim of this study was to analyze and compare the therapeutic effects of antioxidants or vitamin D and calcium, which have previously been shown to reduce the toxic effects…
View details →DOI: 10.2131/jts.48.481 Negative / Null Result ReportMedicine
Boss M, Pels F, Kleinert J · 2023 · PsyCh journal
The purpose of this study was to analyze whether the social compensation of performance drops in a team setting depends on the relationship quality. Two experiments were conducted. Experiment 1: In a team-building condition, the…
View details →DOI: 10.1002/pchj.662 Negative / Null Result Report
Rivest D, Martin-Guay M · 2023 · Preprint
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
View details →DOI: 10.21203/rs.3.rs-3398528/v1 Negative / Null Result ReportOpen accessMedicine
Başeğmez M, Eryavuz A, Demirel HH · 2025 · Journal of biochemical and molecular toxicology
This study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were…
View details →DOI: 10.1002/jbt.70324 Negative / Null Result Report
Ehinger BV, Bonasch H · 2023 · Preprint
Abstract 1 Some participants consistently show large, and others small activations in Electroencephalography (EEG) and other neuroimaging studies. Similarly, decoding accuracies in Brain-Computer-Interface (BCI) vary between subjects, in…
View details →DOI: 10.1101/2023.05.21.541632 Negative / Null Result ReportOpen accessMedicine
Scott MB, Kammermeier PJ · 2024 · Pharmaceuticals (Basel, Switzerland)
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and…
View details →DOI: 10.3390/ph17091237 Negative / Null Result ReportOpen accessMedicine
Choneva M, Delchev S, Hrischev P et al. · 2024 · International journal of molecular sciences
Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study…
View details →DOI: 10.3390/ijms251810027 Negative / Null Result ReportMedicine
Ebrahimi F, Kangari H, Akbarzadeh-Bagheban A et al. · 2025 · International journal of ophthalmology
Aim To evaluate the effects of polarized and non-polarized sunglasses on visual functions, including distance and near visual acuity, phoria, stereopsis and contrast sensitivity across five spatial frequencies (1.5, 3, 6, 12, 18…
View details →DOI: 10.18240/ijo.2025.12.14 Negative / Null Result ReportOpen accessMedicine
Zeng X, Chen Y, Lin S et al. · 2026 · Frontiers in surgery
Purpose This study aimed to investigate the influence of previous percutaneous renal procedures on the outcome of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) in patients with upper urinary tract stones. Patients and methods…
View details →DOI: 10.3389/fsurg.2026.1721410 Negative / Null Result Report
Lartey NL, Nyarko ENY, Asare-Anane H et al. · 2023 · Preprint
ABSTRACT Background and aim The lack of standardization and scientific validation of the use of most plant extracts leads to toxicity problems. The stem bark extract of Annickia polycarpa has been shown to possess antioxidant,…
View details →DOI: 10.1101/2023.09.14.557718 Negative / Null Result ReportOpen accessMedicine
Kazmi S, Sanford E, Rammaha ZA et al. · 2025 · International journal of molecular sciences
Oral squamous cell carcinoma (OSCC) is marked by profound differences in survival between the localized and disseminated disease, estimated to result in a 70% and less than a 40% five-year survival rate with surgical and/or radiation…
View details →DOI: 10.3390/ijms262110651 Negative / Null Result ReportMedicine
Dicker D, Tamir O, Lieberman-Segal G et al. · 2023 · The Israel Medical Association journal : IMAJ
Background In 2019, 1 mg subcutaneous semaglutide was registered for the treatment of diabetes in Israel. Recognition of its effect on weight has led to its use as a treatment for obesity. Objectives To explore physicians' pre-therapy…
Negative / Null Result ReportMedicine
Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
View details →DOI: 10.1111/sms.14432 Negative / Null Result ReportOpen accessMedicine
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →DOI: 10.1111/head.70061 Negative / Null Result ReportOpen accessMedicine
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →DOI: 10.1186/s13014-026-02833-w Negative / Null Result ReportOpen accessMedicine
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →DOI: 10.1007/s00394-026-03994-w Negative / Null Result ReportOpen accessMedicine
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
View details →DOI: 10.3390/membranes16040115 Negative / Null Result Report
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
View details →DOI: 10.21203/rs.3.rs-3268081/v1 Negative / Null Result ReportOpen accessMedicine
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
View details →DOI: 10.3390/pathogens14020187 Negative / Null Result ReportOpen accessMedicine
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
View details →DOI: 10.1097/gme.0000000000002542 Negative / Null Result ReportOpen accessMedicine
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
View details →DOI: 10.1038/s41598-024-83465-6 