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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21770 results · page 692 of 726

Negative / Null Result ReportMedicine

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Takatori N, Uchiyama Y, Ito H et al. · 2026 · Journal of tissue viability

Background Intraoperative pressure-related skin injuries remain a concern during surgery under general anaesthesia. Although interface pressures have been evaluated in various surgical positions, sacral pressure in the beach-chair position…

View details →DOI: 10.1016/j.jtv.2026.101027
Negative / Null Result Report

Impact of co-administration of proton pump inhibitors on efficacy and safety of oral semaglutide in patients with type 2 diabetes: a single-center retrospective study

Yokoyama T, Uchino T, Yazawa Y et al. · 2026 · Preprint

Abstract Background Oral semaglutide, a glucagon-like peptide-1 receptor agonist, improves glycemic control and reduces body weight in patients with type 2 diabetes. Although proton pump inhibitors (PPIs) have been reported to slightly…

View details →DOI: 10.21203/rs.3.rs-9444720/v1
Negative / Null Result ReportMedicine

Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.

Harun AS, Shikder AHMZH, Moni SD et al. · 2026 · Journal of oral rehabilitation

Background Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain,…

View details →DOI: 10.1111/joor.70249
Negative / Null Result ReportMedicine

Source- and land-use-dependent controls on black carbon accumulation in urban soils: A comparison between an industrial city and a megacity in central China.

Zhan C, Liu S, Kang W et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Black carbon (BC) is an important component of soil organic carbon (SOC), with implications for carbon sequestration and environmental quality, yet its variability across contrasting urban systems remains insufficiently understood. This…

View details →DOI: 10.1016/j.envpol.2026.128533
Negative / Null Result ReportMedicine

Robotic versus laparoscopic rectal resection: impact on primary postoperative ileus and the role of intraoperative fluid balance: a propensity score-matched cohort study.

Urashima T, Yabuno T, Imanishi K et al. · 2026 · Surgical endoscopy

Background Few studies have directly compared the incidence of primary postoperative ileus (primary POI) between robotic surgery (RS) and laparoscopic surgery (LS) for rectal resection. Methods This retrospective cohort study included…

View details →DOI: 10.1007/s00464-026-12994-0
Negative / Null Result Report

Monarch performance and cardenolide sequestration decline on naturally derived hybrid milkweeds (Asclepias syriaca x speciosa)

Olson-Manning CF, Acharya S, Matuck L et al. · 2026 · Preprint

Abstract Plant hybridization often alters herbivore-relevant traits, yet the effects of hybrid feeding on specialist herbivores, especially those that co-opt host-plant defenses, are largely unknown. We examined how naturally derived…

View details →DOI: 10.21203/rs.3.rs-9919052/v1
Negative / Null Result ReportMedicine

Radial Versus Femoral Access for Diagnostic Coronary Angiography: Insights From a Tertiary Academic Center in Johannesburg.

Ntaka KL, Mpanya D, Adamu UG et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The radial artery is the preferred access for performing diagnostic coronary angiograms (DCA). However, data on the safety and efficacy of radial compared to femoral access in low- and middle-income countries is limited. Aims…

View details →DOI: 10.1002/ccd.70654
Negative / Null Result ReportMedicine

Staphylococcus aureus bacteremia: clinical outcomes and predictors of 28-day mortality in a tertiary-care cohort.

Gucluer Kocaoglu MN, Kahraman H, Nayman S et al. · 2026 · BMC infectious diseases

Background Staphylococcus aureus bacteremia (SAB) is associated with substantial short-term mortality, but the relative contributions of methicillin resistance, treatment adequacy, and host-related factors to outcome remain unclear. This…

View details →DOI: 10.1186/s12879-026-13847-w
Negative / Null Result ReportMedicine

The Surgical Outcomes of Brachiocephalic Vein Transection Versus Reconstruction for Locally Advanced Thymic Epithelial Tumors.

Sun J, Xiong Y, Qiu J et al. · 2026 · Annals of surgical oncology

Background Locally advanced thymic epithelial tumors (TETs) may extend into the adjacent brachiocephalic vein (BCV), creating major technical challenges for resection. While BCV reconstruction is traditionally considered after tumor…

View details →DOI: 10.1245/s10434-026-19935-0
Negative / Null Result Report

Challenging the standard: Comparison of outcomes between Laparoscopically Assisted Anorectoplasty (LAARP) and Posterior Sagittal Anorectoplasty (PSARP) in the correction of rectobulbar fistula in Pediatric Patients

Sanchez MAC, Ruiz J, Siffredi J et al. · 2026 · Preprint

Abstract Background: Posterior sagittal anorectoplasty (PSARP) remains the standard surgical approach for rectobulbar fistula in patients with anorectal malformations (ARM). Laparoscopically assisted anorectoplasty (LAARP) has emerged as…

View details →DOI: 10.21203/rs.3.rs-9556600/v1
Negative / Null Result ReportMedicine

Levels of acylated and deacylated ghrelin are elevated in unmedicated patients with major depressive disorder and obesity: a cross-sectional study.

Lis M, Miłuch T, Krupa R et al. · 2026 · Scientific reports

Major depressive disorder (MDD) frequently co-occurs with obesity, suggesting shared neuroendocrine mechanisms. Ghrelin, a hormone involved in appetite regulation, stress response, and reward processing, has been proposed as a biological…

View details →DOI: 10.1038/s41598-026-54095-x
Negative / Null Result ReportMedicine

Spinal motion restriction in the emergency healthcare setting: A cross-sectional study of knowledge, attitudes, and practices.

Oteir A, Husein M, Alhawatmeh H et al. · 2026 · International emergency nursing

Background Spinal motion restriction (SMR) remains a fundamental component of trauma care, yet its routine application has been increasingly questioned. Evidence supporting selective SMR has grown; however, limited data exist on the…

View details →DOI: 10.1016/j.ienj.2026.101857
Negative / Null Result ReportMedicine

Factors associated with mortality in pancreatic adenocarcinoma patients achieving pathologic complete response after neoadjuvant therapy.

Suraju MO, Longbottom B, Peteson JA et al. · 2026 · American journal of surgery

Introduction Factors influencing mortality among pancreatic ductal adenocarcinoma (PDAC) patients who achieve pathologic complete response (pCR) following neoadjuvant therapy have not been previously well studied. Methods Adult PDAC…

View details →DOI: 10.1016/j.amjsurg.2026.117093
Negative / Null Result ReportMedicine

Impact of Contact Lens Use on Clinical Profile and Outcomes of Fungal Keratitis: An 8-Year Retrospective Study.

Kate A, Wannapanich T, Mandell J et al. · 2026 · American journal of ophthalmology

Purpose To compare clinical characteristics, microbiological profiles, treatment strategies, and outcomes between contact lens-associated (CL) and non-contact lens-associated (non-CL) fungal keratitis. Design Retrospective, comparative…

View details →DOI: 10.1016/j.ajo.2026.06.017
Negative / Null Result ReportMedicine

Metrics and insulin variations in women with type 1 diabetes on automated insulin delivery system during strict peripartum period.

Fresa R, Napoli A, Bitterman O · 2026 · Acta diabetologica

Introduction the use of Automated Insulin Delivery (AID) systems has increased in pregnant women with type 1 diabetes (DM1). To date, little data exist regarding glucose control and insulin modifications with AID in automode during…

View details →DOI: 10.1007/s00592-026-02733-1
Negative / Null Result ReportMedicine

Changes in Patient Characteristics and Early Clinical Outcomes Among Emergency Department-Admitted Inpatients During the 2024 Medical Workforce Crisis in South Korea.

Lee YJ, Moon SW · 2026 · Journal of clinical medicine

Background/Objectives : In February 2024, a nationwide medical crisis in South Korea caused a massive withdrawal of resident physicians. We described changes in patient characteristics and early clinical outcomes among emergency department…

View details →DOI: 10.3390/jcm15124804
Negative / Null Result ReportMedicine

Associations between discrimination and mental healthcare utilization among racial and ethnic minority cancer survivors in the All of Us Research Program.

Wen YP, Brauer ER, Choi S et al. · 2026 · BMC public health

Background Cancer survivors are twice as likely to experience psychological distress, with racial and ethnic minorities reporting higher distress and healthcare needs compared to non-Hispanic White Americans. However, this group is more…

View details →DOI: 10.1186/s12889-026-28276-2
Negative / Null Result ReportMedicine

Clinical and radiographic outcomes of cannulated cancellous screw osteosynthesis with and without side-plate for nondisplaced femoral neck fractures: a multicenter propensity score-matched study.

Maeda K, Funahashi H, Tokutake K et al. · 2026 · International orthopaedics

Purpose This study aimed to evaluate postoperative outcomes, including clinical results, radiological assessments, and complications, in patients over 50 years old with nondisplaced femoral neck fractures (Garden classification I-II)…

View details →DOI: 10.1007/s00264-026-06870-8
Negative / Null Result ReportMedicine

Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.

Liu Y, Liu L, Wang J et al. · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…

View details →DOI: 10.1016/j.eprac.2026.05.034
Negative / Null Result ReportMedicine

Clinical outcomes of a Locator-bilateral segmental bar concept versus a conventional rigid bar concept for maxillary implant-supported overdentures: a retrospective cohort study.

Zheng J, Chen M, Fu J · 2026 · BMC oral health

Background This retrospective cohort study evaluated a Locator-bilateral segmental bar concept (LBSB) for maxillary implant-supported overdentures and compared it with a conventional rigid bar concept (CRB) in terms of implant survival,…

View details →DOI: 10.1186/s12903-026-08764-y
Negative / Null Result ReportMedicine

Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.

Gentile T, Vanacore S, Caputo M et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Dental anxiety represents a major challenge in paediatric dentistry and is a frequent cause of non-cooperative behaviour during dental treatment. Nitrous oxide/oxygen inhalation conscious sedation is widely used to…

View details →DOI: 10.3390/children13060812
Negative / Null Result Report

Functional Outcome and Discharge Destination in Elderly Patients with Spinal Cord Injury: A Retrospective Cohort Study Manuscript Type: Original Article

Kurz S, Habich O, Brauer K et al. · 2026 · Preprint

Abstract Purpose To evaluate whether patients aged > 75 years with spinal cord injury (SCI) benefit from specialized inpatient rehabilitation, focusing on functional outcomes and discharge destination. Methods This retrospective…

View details →DOI: 10.21203/rs.3.rs-9332195/v1