A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 69 of 660
Ann M. Farese, Cassandra R. Brown, Cassandra P. Smith et al. · 2013 · Health Physics
The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim…
Joseph F. Sobanko, Julia Dai, Joel M. Gelfand et al. · 2018 · Dermatologic Surgery
BACKGROUND: Minimally invasive cosmetic injectable procedures are increasingly common. However, a few studies have investigated changes in psychosocial functioning following these treatments. OBJECTIVE: To assess changes in body image,…
Haijie Liu, Yang Hu, Yan Zhang et al. · 2022 · Alzheimer s Research & Therapy
BACKGROUND: Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it currently remains unclear about the consistency of MR estimates across these GWAS, GWAX, and GWAS+GWAX datasets. METHODS: Here, we first selected 162 independent educational attainment genetic variants as the potential instrumental variables (N = 405,072). We then selected one AD GWAS dataset (N = 63
Abhishek Mathur, Sharona Ross, Kenneth Luberice et al. · 2014 · The American Surgeon
Negative margins are the goal with pancreaticoduodenectomy for pancreatic adenocarcinoma. Thereby, margins are assessed intraoperatively with frozen section analysis and negative margins are pursued. This study was undertaken to determine…
David J. Cohen, Tara A. Lavelle, Ben van Hout et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To evaluate the cost-effectiveness of alternative approaches to revascularization for patients with three-vessel or left main coronary artery disease (CAD). BACKGROUND: Previous studies have demonstrated that, despite higher…
Małgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses et al. · 2017 · BMC Cancer
BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases)
Kristi McIntyre, Joyce O’Shaughnessy, Lee S. Schwartzberg et al. · 2014 · Breast Cancer Research and Treatment
Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have…
Mary Ann McColl, Celine Boyer Denis, Kate-Lin Douglas et al. · 2023 · Canadian Journal of Occupational Therapy
Background. The Canadian Occupational Performance Measure (COPM) assists occupational therapists to identify occupational performance problems using a client-centred approach. Since its first publication in 1991, there has been abundant…
Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn et al. · 2020 · Diabetologia
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From the population-representative Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) we sampled 50% and 25% of those with starting eGFR below and above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), and with median 5.1 years of follow-up. Multiplexed ELISAs and single molecule array technology were used to measure nin
Guillém López i Casasnovas, Marina Soley‐Bori · 2014 · International Journal of Environmental Research and Public Health
In times of economic crisis, most countries face the dual challenge of fighting unemployment while restraining social expenditures and closing budget deficits. The spending cuts and lack of employment affect a large number of decisions that have a direct or indirect impact on health. This impact is likely to be unevenly distributed among different groups within the population, and therefore not only health levels may be at risk, but also their distribution. The main purpose of this paper is to explore links between unemployment, economic growth, inequality, and health. We regress a measure of
Pras Pathmanathan, Gary R. Mirams, James Southern et al. · 2011 · International Journal for Numerical Methods in Biomedical Engineering
Abstract Finite element (FE) cardiac electro‐physiology solvers commonly have ionic current determined at mesh nodes but required element interiors. We consider two interpolation approaches: (i) ionic current interpolation (ICI), where nodal ionic currents are linearly interpolated into the element and (ii) state variable interpolation (SVI), where cell model state variables are interpolated instead, from which the ionic current is evaluated. We explain why SVI leads to a method which is massively more computationally demanding than ICI (more than might originally be expected), and then demons
Magdalena Łuniewska, Katarzyna Chyl, Agnieszka Dębska et al. · 2018 · Scientific Reports
The prevalence and long-term consequences of dyslexia make it crucial to look for effective and efficient ways of its therapy. Action video games (AVG) were implied as a possible remedy for difficulties in reading in Italian and English-speaking children. However, the studies examining the effectiveness of AVG application in dyslexia suffered from significant methodological weaknesses such as small sample sizes and lack of a control group with no intervention. In our study, we tested how two forms of training: based on AVG and on phonological non-action video games (PNAVG), affect reading in a
Anvar Khosravi · 2010 · American Journal of Applied Sciences
Problem statement: It is important for policy makers to find affect of monetary and fiscal policy on economic growth and to know how those impacts on growth to present a effective policies. Approach: We apply the bounds testing (ARDL) approach and to cointegration which is more appropriate for estimation in small sample studies. The data span for the study is from 1960-2006, the empirical results found a cointegration relations between Growth, monetary policy and fiscal policy in Iran. Results: The results indicated the impact of Exchange rate and inflation on growth was negative, government e
Juliana C.N. Chan, Béatrice Sauvé, Sonya Tokmakejian et al. · 2014 · Experimental and Clinical Endocrinology & Diabetes
OBJECTIVE: Hair analysis has been demonstrated to accurately reflect exposure to drug abuse, environmental toxins and exogenous hormones. We tested the feasibility of measuring cortisol and testosterone in hair of healthy and obese…
Sanjay Yadla, George M. Ghobrial, Peter G. Campbell et al. · 2015 · Journal of Neurosurgery Spine
OBJECT: Complications after spine surgery have an impact on overall outcome and health care expenditures. The increased cost of complications is due in part to associated prolonged hospital stays. The authors propose that certain…
Clarissa S. Whiting, Wouter Hoogkamer, Rodger Kram · 2021 · Journal of sport and health science/Journal of Sport and Health Science
BACKGROUND: Compared to conventional racing shoes, Nike Vaporfly 4% running shoes reduce the metabolic cost of level treadmill running by 4%. The reduction is attributed to their lightweight, highly compliant, and resilient midsole foam…
Stanisław Karkosz, Robert Szymański, Katarzyna Sanna et al. · 2023 · JMIR Formative Research
BACKGROUND: There has been an increased need to provide specialized help for people with depressive and anxiety symptoms, particularly teenagers and young adults. There is evidence from a 2-week intervention that chatbots (eg, Woebot) are effective in reducing depression and anxiety, an effect that was not detected in the control group that was provided self-help materials. Although chatbots are a promising solution, there is limited scientific evidence for the efficacy of agent-guided cognitive behavioral therapy (CBT) outside the English language, especially for highly inflected languages. O
Jared H Cooper, David L. Johnson, Margaret Phillips · 2014 · The Annals of Occupational Hygiene
PURPOSE: To assess the relative efficacy of three types of controls in reducing respirable silica exposure during artificial stone countertop cutting with a handheld circular saw. APPROACH: A handheld worm drive circular saw equipped with…
Andrew Poppe, Deanna M. Barch, Cameron S. Carter et al. · 2016 · Schizophrenia Bulletin
Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot…
Shuva Paul, Zhen Ni, Chaoxu Mu · 2019 · IEEE Transactions on Neural Networks and Learning Systems
Due to the rapidly expanding complexity of the cyber-physical power systems, the probability of a system malfunctioning and failing is increasing. Most of the existing works combining smart grid (SG) security and game theory fail to…
Saif Ullah, Abdul Majeed, József Popp · 2023 · PLoS ONE
This study aims to assess the influence of internal and external factors on the Efficiency of banks in Pakistan using the Data Envelopment Analysis Approach (DEA). Bank's Efficiency is measured through DEA Model using input and output variables. The input variable includes the number of employees, number of branches, administration expenses, non-interest expenses, and loan loss provisions. In contrast, the output variable consists of net interest income, net commissions, and total other income. This study considers the internal determinants of the bank's Efficiency as corporate governance, ent
Nicole M. Warrington, Rebecca C. Richmond, Bjarke Fenstra et al. · 2017 · International Journal of Obesity
BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to
Nikki Gillum Posnack, Rabia Idrees, Hao Ding et al. · 2015 · PLoS ONE
BACKGROUND: The pervasive nature of plastics has raised concerns about the impact of continuous exposure to plastic additives on human health. Of particular concern is the use of phthalates in the production of flexible polyvinyl chloride (PVC) products. Di-2-ethylhexyl-phthalate (DEHP) is a commonly used phthalate ester plasticizer that imparts flexibility and elasticity to PVC products. Recent epidemiological studies have reported correlations between urinary phthalate concentrations and cardiovascular disease, including an increased risk of high blood pressure and coronary risk. Yet, there
Meredith F. Campbell, Eitan Friedman, William H. Green et al. · 2017 · International Pharmacopsychiatry
Blood serotonin levels were measured in schizophrenic children, all of whom showed manifestations of illness in the first 2 years of life, and controls. Serotonin levels were higher in patients (mean = 0.267 mug/ml) than in controls (mean…
Jordan Ngu Chuan Yong, Sayyed Mahdi Ziaei, Kenneth Szulczyk · 2021 · Asian Economic and Financial Review
In this study, the volatility of two Asian stock markets, Bursa Malaysia and Singapore Exchange, is estimated. The analysis used data on daily closing prices of the indices of the respective stock markets between July 1, 2019 and August…
Nina Vaswani · 2014 · The Howard Journal of Criminal Justice
Abstract The study explored the prevalence and nature of bereavement among 33 young men who had been sentenced to a young offender institution. A bereavement had been experienced by 91% of the sample, and the rates of traumatic and…
Yuwei Chuai, Haoye Tian, Nicolas Pröllochs et al. · 2024 · Proceedings of the ACM on Human-Computer Interaction
Developing interventions that successfully reduce engagement with misinformation on social media is challenging. One intervention that has recently gained great attention is X/Twitter's Community Notes (previously known as "Birdwatch").…
Roman David · 2017 · Political Psychology
Transitional justice encompasses a variety of measures devised to overcome legacies of gross human rights violations and other historical injustices. The spread of international criminal tribunals, truth commissions, inclusive alternatives…
N Gedney, C Huntingford, E Comyn-Platt et al. · 2019 · Environmental Research Letters
Abstract Emissions from wetlands are the single largest source of the atmospheric greenhouse gas (GHG) methane (CH 4 ). This may increase in a warming climate, leading to a positive feedback on climate change. For the first time, we extend…
Seulkee Lee, Seonyoung Kang, Yeonghee Eun et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analysis on important features. Moreover, machine learning is yet to be used to predict bDMARD responses in ankylosing spondylitis (AS). Thus, in this study, machine learning was used to predict such responses in RA and AS patients. METHODS: Data were retrieved from the Korean College of Rheumatology Biologics therapy (KOBIO) registry. The number of RA and AS patients in the traini