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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21379 results · page 686 of 713

Negative / Null Result ReportOpen accessMedicine

Effects of smartphone cognitive behavioural therapy on social functioning in non-depressive and subthreshold depressive adults: a secondary analysis of the RESiLIENT trial.

Tajika A, Toyomoto R, Sakata M et al. · 2026 · BMJ mental health

Background Depression is a leading cause of global disability, and subthreshold cases contribute substantially to the burden. Cognitive behavioural therapy (CBT) is effective for depressive symptoms, but its impact on social functioning in…

View details →DOI: 10.1136/bmjment-2025-302303
Negative / Null Result ReportOpen accessMedicine

Curcumin and Resveratrol vs. Ferrocene-Modified Polyphenols: Role in Enhancing Protective Properties in Human Keratinocytes.

Miletić M, Kovač V, Barišić L et al. · 2025 · Pharmaceutics

Background/Objectives : Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection.…

View details →DOI: 10.3390/pharmaceutics17121511
Negative / Null Result ReportOpen accessMedicine

Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia-Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset.

Charles AL, Tetsi L, Quiring G et al. · 2026 · Muscles (Basel, Switzerland)

Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…

View details →DOI: 10.3390/muscles5010019
Negative / Null Result ReportOpen accessMedicine

Change of maternal weight gain trajectory following lifestyle interventions for gestational diabetes and its impact on abnormal infant birthweight: an observational study based on longitudinal weight measurements.

Li J, Yang C, Li K · 2026 · BMC pregnancy and childbirth

BACKGROUND: Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.…

View details →DOI: 10.1186/s12884-026-08757-3
Negative / Null Result ReportMedicine

Impact of Tourniquet Type on Outcomes in ORIF of Pediatric Distal Radius Fractures.

Conteduca J, Longo D, Casto A et al. · 2025 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

Purpose   The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis…

View details →DOI: 10.17392/1922-22-02
Negative / Null Result ReportMedicine

Failed, Inconclusive or Interrupted Trials in Multiple Sclerosis: 2020-2024 Update.

Ricigliano VA, Szejko N, Camera V et al. · 2026 · Multiple sclerosis and related disorders

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neuronal loss, with significant public health impact. Despite important therapeutic advances, major unmet needs remain, mainly in…

View details →DOI: 10.1016/j.msard.2026.107140
Negative / Null Result ReportMedicine

[Two Cases of Node-Positive Breast Cancer in Which the Oncotype DX Test Was Performed but Yielded Inconclusive Results].

Terakawa H, Kawata C, Kurokawa Y et al. · 2025 · Gan to kagaku ryoho. Cancer & chemotherapy

Oncotype DX is performed to predict prognosis and the added benefit of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, with the goal of individualizing chemotherapy decisions. Here, we report 2 cases of early- stage…

Negative / Null Result ReportMedicine

Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France.

Dravigney L, Chartier C, Grelaud P et al. · 2026 · Journal of helminthology

Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of…

View details →DOI: 10.1017/s0022149x26101746
Negative / Null Result ReportMedicine

Dietary patterns are associated with premenstrual symptoms: a cross-sectional study among women from Central Europe.

Granda D, Szmidt MK, Jarmuzek-Orska P et al. · 2026 · Scientific reports

To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are…

View details →DOI: 10.1038/s41598-026-58236-0
Methods Dead-EndMedicine

Machine learning for predicting chaotic systems.

Schötz C, White A, Gelbrecht M et al. · 2026 · Chaos (Woodbury, N.Y.)

Predicting chaotic dynamical systems is critical in many scientific fields, such as weather forecasting, but challenging due to the characteristic sensitive dependence on initial conditions. Traditional modeling approaches require…

View details →DOI: 10.1063/5.0313297
Negative / Null Result ReportMedicine

Chemical and visual compatibility of dexmedetomidine injection with parenteral medications used in neonatal intensive care settings.

De Silva DTN, Hamilton AJ, Strunk T et al. · 2026 · European journal of hospital pharmacy : science and practice

Objective To investigate the chemical and visual compatibility of dexmedetomidine injection with 44 secondary intravenous (IV) drugs and six 2-in-1 parenteral nutrition (PN) solutions used in neonatal intensive care unit settings. Methods…

View details →DOI: 10.1136/ejhpharm-2026-004995
Negative / Null Result ReportMedicine

The evaluation of Copy Number Variants in an unselected population of patients with Inherited Cardiac Conditions: The INTERACTION Study.

Giulia C, Simona M, Monia M et al. · 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Background and aims The current diagnostic approach to inherited cardiac conditions (ICCs) is primarily focused on the analysis of single-nucleotide variants (SNVs) and small insertions/deletions (InDels). However, as recommended for other…

View details →DOI: 10.1093/europace/euag150
Negative / Null Result ReportMedicine

Effects of continuous vs. intermittent transcutaneous electrical stimulation of the auriculotemporal nerve on nociceptive processing: a pilot randomized controlled double-blind crossover trial in asymptomatic volunteers.

Barone M, Guli L, Centurión J et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of the auriculotemporal nerve on nociceptive processing. Methods Twelve asymptomatic volunteers received…

View details →DOI: 10.1080/08869634.2026.2645872
Negative / Null Result Report

Real-time resolution of VP ellipsis ambiguity and processing depth

Fujita H, Yoshida M · 2026 · Preprint

In the VP ellipsis sentence “Bill liked himself, and John did too”, the second conjunct “John did too” can be interpreted in two ways: either as “John liked Bill too” (strict interpretation) or “John liked himself too” (sloppy…

View details →DOI: 10.31234/osf.io/qx85z_v1
Negative / Null Result ReportMedicine

Comparative analysis of PTH Washout and 99mTc-MIBI SPECT/CT in presurgical localization for patients with primary hyperparathyroidism.

Cieślewicz M, Szczepanek-Parulska E, Witowska A et al. · 2026 · Journal of endocrinological investigation

Purpose Our study aimed to evaluate the performance and concordance of parathyroid hormone wash-out (PTHw) and 99m Tc-MIBI+SPECT/CT (MIBI) in preoperative localization for patients with primary hyperparathyroidism (PHPT), and assess…

View details →DOI: 10.1007/s40618-026-02873-9
Negative / Null Result ReportMedicine

'White autopsies': an overview of cases with inconclusive results of post-mortem examinations in the Department of Forensic Medicine of the Jagiellonian University Medical College in Kraków, Poland.

Zwierzewicz Z, Szpakowska A, Bistroń D et al. · 2025 · Archiwum medycyny sadowej i kryminologii

The aim of the study The aim of the study was to accurately determine the incidence of white autopsies and to identify possible conditions responsible for such autopsies by means of analyzing confirmed causes of death in the same age…

View details →DOI: 10.4467/16891716amsik.25.008.22186
Negative / Null Result ReportMedicine

COMPARING THE ABILITY OF GENETIC TESTING TO PROVIDE A DEFINITIVE DIAGNOSIS IN PATIENTS WITH PERIPHERAL AND MACULAR INHERITED RETINAL DISEASE.

Dones AM, Bou Ghanem G, Kessler C et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose We performed a retrospective cross-sectional study to determine whether there is a significant difference in the percentage of patients with diagnosed inherited macular or peripheral disease who receive more definitive genetic…

View details →DOI: 10.1097/iae.0000000000004732
Negative / Null Result ReportMedicine

Robotic arm-assisted <sup>18</sup>F-FDG PET/CT-guided biopsy in febrile patients with biopsy accessible FDG-avid lesions: a single-centre experience.

Aggarwal P, Singh H, Kumar R et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose Fever of unknown origin (FUO) is a prolonged fever with unknown etiology after an extensive outpatient or inpatient workup. 18 F-Flurodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT) has shown a…

View details →DOI: 10.1007/s00259-026-07928-w
Negative / Null Result ReportMedicine

Enteral When Compared With IV Magnesium Replacement in the Critically Ill: A Noninferiority Randomized Clinical Trial.

Nguyen CD, Panganiban HP, Karahalios A et al. · 2026 · Critical care medicine

Objectives Enteral magnesium replacement may be as effective as IV replacement while being a cheaper and more environmentally sustainable intervention. The primary objective was to evaluate whether enteral magnesium is noninferior to IV…

View details →DOI: 10.1097/ccm.0000000000007174
Negative / Null Result ReportMedicine

Development and validation of a nomogram model for predicting negative/indeterminate HIV-1 antibody confirmation: a strategy to streamline the diagnostic pathway.

Liao G, Zhang S, Wei Y et al. · 2026 · BMC medical informatics and decision making

Background The standard HIV diagnostic algorithm comprises sequential serological screening, confirmatory antibody testing, and nucleic acid confirmation when necessary. This multi-step process often causes diagnostic delays, particularly…

View details →DOI: 10.1186/s12911-026-03546-6
Negative / Null Result ReportMedicine

Assessing Blood Pressure, Mental Health, and HRV Responses to Integrated Acupuncture in Hypertensive Patients: A Pilot Randomized Controlled Trial.

Singh D, Kodali PB, Sharma G et al. · 2025 · Medical acupuncture

Abstract This study aimed to investigate the effects of an integrated acupuncture (IA) protocol on blood pressure (BP), depression, anxiety, stress scores, and heart rate variability (HRV) in hypertensive patients. Abstract The study was a…

View details →DOI: 10.1089/acu.2024.0065
Negative / Null Result ReportMedicine

The VGLUT3 positive neurons of the median raphe region promote long-term spatial memory through time-dependent mechanisms.

Fazekas CL, Török B, Szabó A et al. · 2026 · Progress in neurobiology

Episodic memory and related forms of learning depend critically on the hippocampus, whose activity is regulated by brainstem inputs that remain incompletely understood. The midbrain median raphe region (MRR) is a key regulator of forebrain…

View details →DOI: 10.1016/j.pneurobio.2026.102904
Negative / Null Result ReportOpen accessMedicine

Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report.

Li SH, Niu WW, Huo XX et al. · 2025 · World journal of gastroenterology

Background Gastric mucosa-associated lymphoid tissue (MALT) lymphoma presents with various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological…

View details →DOI: 10.3748/wjg.v31.i38.111549
Negative / Null Result ReportOpen accessMedicine

Post-Traumatic Chest Wall Abscess Associated with <i>Gordonia sputi</i> in an Immunocompetent Patient: A Case Report.

Soda M, Motoyama H, Adachi T et al. · 2026 · Surgical case reports

Introduction Gordonia species are rare aerobic Gram-positive actinomycetes and opportunistic pathogens. Their clinical manifestations and optimal management remain poorly defined. Gordonia sputi is an especially uncommon cause of…

View details →DOI: 10.70352/scrj.cr.26-0054