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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 687 of 725

Negative / Null Result ReportMedicine

Effects of Time of Arrival on Trauma Patient Outcomes.

LaRosa SK, Stone XA, Fenninger AA et al. · 2024 · The American surgeon

Background Arriving during "off hours" to the hospital can put patients at greater risk of complications or mortality given lesser staff. Our goal was to investigate this in trauma patients with an Injury Severity Score (ISS) of >15. We…

View details →DOI: 10.1177/00031348241248694
Negative / Null Result ReportMedicine

Motor and Cognitive Sequence Tasks Exhibit Different Ramping Patterns in Parietal and Prefrontal Cortices.

Doyle H, Yewbrey R, Kornysheva K et al. · 2025 · Journal of cognitive neuroscience

Humans complete different types of sequences as a part of everyday life. These sequences can be divided into two important categories: those that are abstract, in which the steps unfold according to a rule at super-second to minute time…

View details →DOI: 10.1162/jocn_a_02349
Negative / Null Result ReportMedicine

Climatic resilience: Marine heatwaves do not influence the variations of green crab (Carcinus maenas) megalopae supply patterns to a Western Iberian estuary.

Monteiro M, Azeiteiro UM, Queiroga H · 2024 · Marine environmental research

Extreme climatic events like marine heatwaves (MHWs) are becoming more frequent, intense, and longer lasting all around the world. The consequences of these anomalously warm periods are devastating for marine ecosystems. Still, little is…

View details →DOI: 10.1016/j.marenvres.2024.106567
Negative / Null Result ReportOpen accessMedicine

Flexible Goal Adjustment Predicts Well-Being Before and After Retirement.

Viegas LM, Bermeitinger C, Greve W · 2026 · Journal of aging research

Background and objectives Retirement represents a critical life change and is accompanied by the blocking of professional goals. We assume that the individual capability to adapt goals to changed conditions has a palliative effect on…

View details →DOI: 10.1155/jare/2950011
Negative / Null Result ReportMedicine

An acute social stressor decreases reinforcing value of both high and low energy-dense food in college students in a randomized controlled trial.

McKay NJ, Horvatits EJ, Jean M et al. · 2024 · Physiology & behavior

It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge…

View details →DOI: 10.1016/j.physbeh.2024.114531
Negative / Null Result ReportOpen accessMedicine

Oxytocin administration during labor does not affect maternal serum oxytocin levels, early postpartum breastfeeding attitude and maternal attachment.

Özdemir M, Çeber Turfan E, Keskin HL · 2025 · PloS one

The goal was to investigate the effects of synthetic oxytocin administration during labor on maternal and neonatal serum oxytocin levels, early breastfeeding attitudes, and postpartum maternal attachment immediately after birth. This…

View details →DOI: 10.1371/journal.pone.0337762
Negative / Null Result ReportOpen accessMedicine

Contribution of sympathetic nervous system activation to endothelial ischemia reperfusion injury in healthy adults.

Rosenberg AJ, Young BE, Fernandez A et al. · 2025 · Physiological reports

Ischemia-reperfusion injury (IRI) describes the phenomenon through which the restoration of blood flow following prolonged ischemia exacerbates tissue damage during reperfusion. IRI can be modeled by inducing 20-min arm ischemia followed…

View details →DOI: 10.14814/phy2.70502
Negative / Null Result ReportMedicine

Greater Emotional and Psychological Well-being Are Associated With Reduced Employee Self-report Illness-Related Absenteeism: A Multi-Industry, Cross-sectional Study Conducted During COVID-19 Pandemic.

Fannin A, Hooley C, Nelson EJ · 2024 · Journal of occupational and environmental medicine

Objective The purpose of this study is to determine the relationship that emotional, psychological, and social well-being has with self-reported illness-related absenteeism. Methods This study examines the relationship between three…

View details →DOI: 10.1097/jom.0000000000003042
Negative / Null Result ReportOpen accessMedicine

A conditional process analysis of general self-esteem in student-athletes in lower secondary sport schools.

Gjesdal S, Kristensen JÅ, Saarinen M et al. · 2026 · Frontiers in psychology

Objective Specialised sport schools at the lower secondary level aim to support the holistic development of young athletes. Consequently, understanding how to influence student-athletes' self-perceptions both inside and outside of the…

View details →DOI: 10.3389/fpsyg.2026.1771557
Negative / Null Result ReportOpen accessMedicine

Effects of mindful breathing meditation on stereotype expression in two randomized controlled double-blinded trials.

Vieth E, von Stockhausen L · 2026 · PloS one

Models of stereotypes and discrimination propose the involvement of attentional control and executive functioning in successfully suppressing discriminatory behavior. A practice that has been shown to improve cognitive control, potentially…

View details →DOI: 10.1371/journal.pone.0347871
Negative / Null Result ReportOpen accessMedicine

Impact of Blood Group on Contralateral Suppression of Otoacoustic Emissions, Speech Perception in Noise, and Binaural Integration.

Ponnana S A P, Tauro JP, S NP et al. · 2026 · International archives of otorhinolaryngology

Introduction Understanding the relationship between blood groups (A, B, AB, and O) and auditory functioning can provide valuable insights into individual differences in hearing ability and potential risks for hearing loss. Objective To…

View details →DOI: 10.1055/s-0046-1819712
Negative / Null Result ReportOpen accessMedicine

Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

Lindman BR, Pibarot P, Schwartz A et al. · 2025 · Circulation

Background The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinical…

View details →DOI: 10.1161/circulationaha.125.074425
Negative / Null Result ReportMedicine

Neurocognitive Profile of Avoidant/Restrictive Food Intake Disorder: Cognitive Flexibility, Delay Discounting, and Detail Orientation.

McPherson IK, Dalton AG, Armstrong K et al. · 2026 · The International journal of eating disorders

Objective Neurocognitive deficits are well-documented across psychiatric disorders and may indicate novel treatment targets. However, empirical data on the neurocognitive profile of avoidant/restrictive food intake disorder (ARFID) are…

View details →DOI: 10.1002/eat.70077
Negative / Null Result ReportMedicine

A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats.

Sal-Sarria S, López-Taboada I, González-Pardo H et al. · 2024 · Behavioural brain research

Prolonged consumption of diets high in saturated fat and sugar has been related to obesity and overweight, which in turn are linked to cognitive impairment in both humans and rodents. This has become a current issue, especially in children…

View details →DOI: 10.1016/j.bbr.2024.115020
Negative / Null Result ReportOpen accessMedicine

Neither the number of feature dimensions nor their task relevance necessarily affect interocular grouping in binocular rivalry.

Pedziwiatr MA, Derda M, Bator W et al. · 2026 · Attention, perception & psychophysics

When one eye views half of stimulus A and half of stimulus B, and the other eye views the respective other halves, perception fluctuates. Among percepts reflecting monocular inputs (indicating typical binocular rivalry), percepts of…

View details →DOI: 10.3758/s13414-026-03265-0
Negative / Null Result ReportMedicine

Is employment status associated with baseline symptoms, engagement, and outcomes in naturalistic psychotherapy? Evaluation in a large community mental health agency.

Jiwani Z, Xie Q, Curtin JJ et al. · 2025 · Psychotherapy (Chicago, Ill.)

Employment status, an essential socioeconomic factor, may be an important driver of disparities in mental health and access to treatment. However, prior research has been inconclusive and utilized broad employment categories. The present…

View details →DOI: 10.1037/pst0000597
Negative / Null Result ReportOpen accessMedicine

Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.

Ahmad R, Zobel G, Hannaford R et al. · 2026 · Brain, behavior, & immunity - health

Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten…

View details →DOI: 10.1016/j.bbih.2026.101284
Negative / Null Result ReportMedicine

Diverse social environments and 10-year all-cause mortality in a cohort of historically excluded racial/ethnic older adults: A latent class analysis of social integration.

Flores M, Boyd SM, O'Neill RM et al. · 2025 · Annals of epidemiology

Purpose The association between social integration and mortality in older adults from historically excluded groups may not align with the patterns observed in predominately white samples. We modeled latent groups of social integration and…

View details →DOI: 10.1016/j.annepidem.2025.08.037
Negative / Null Result ReportOpen accessMedicine

Crude protein concentration in feedlot cattle growth performance, carcass merit, and nitrogen status of long-fed feedlot steers in response to dietary protein concentrations: a comparison of industry-average and reduced protein diets.

Pittaluga AM, Relling AE · 2026 · Translational animal science

Angus × SimAngus-crossbred steers ( n = 93; body weight [BW] = 342 ± 29 kg) were used in a randomized complete block design to examine the effect of feeding finishing diets with crude protein (CP) contents similar or below industry…

View details →DOI: 10.1093/tas/txag037
Negative / Null Result ReportMedicine

Dual-Energy X-Ray Absorptiometry Does Not Confirm Validity of the Craig's Test.

Clark KA, Nielsen S, Heywood T et al. · 2024 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

The Craig's test is a clinical assessment used to quantify femoral version. The validity of the Craig's test has been called into question due to instances where the test exhibits relatively poor correlation with three-dimensional imaging.…

View details →DOI: 10.1016/j.jocd.2024.101466
Negative / Null Result ReportOpen accessMedicine

Does the number of pages received per hour affect resident productivity?

Mangino A, Stenson BA, Leventhal EL et al. · 2023 · Journal of the American College of Emergency Physicians open

Background Workflow interruptions are common for emergency physicians and are shown to have downstream consequences such as patient dissatisfaction, delay in clinical response, and increase in medical error. However, the impact of passive…

View details →DOI: 10.1002/emp2.13071
Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

View details →DOI: 10.1152/ajpregu.00113.2024
Negative / Null Result ReportOpen accessMedicine

Clinical Features Associated With Fatigue in People With Fibrotic Interstitial Lung Disease: Cross-Sectional Study.

Kawachi S, Hoffman M, Holland AE · 2025 · Respirology (Carlton, Vic.)

Background and objective Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been…

View details →DOI: 10.1111/resp.70091
Negative / Null Result ReportOpen accessMedicine

Impact of cognitive behavioral therapy on attention in patients with fibromyalgia: a randomized controlled trial.

Kazemipour S, Yamin JB, Moore D et al. · 2026 · Pain reports

Introduction More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is…

View details →DOI: 10.1097/pr9.0000000000001378
Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

View details →DOI: 10.1016/j.ajcnut.2024.08.024
Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

View details →DOI: 10.1002/jts.22991