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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21374 results · page 671 of 713

Failed Experiment ReportMedicine

Effects of Proprioceptive Attenuation with Noisy Tendon Electrical Stimulation on Adaptation to Beyond-Real Interaction.

Ogawa M, Matsumoto K, Aoyama K et al. · 2025 · IEEE transactions on visualization and computer graphics

Virtual reality (VR) enables beyond-real interactions (BRI) that transcend physical constraints, offering effective user experiences like extending a hand to grasp distant objects. However, adapting to novel mappings of BRI often reduces…

View details →DOI: 10.1109/tvcg.2025.3549562
Failed Experiment ReportOpen accessMedicine

Testing the Ingroup Advantage in Emotion Perception from Dynamic Posed and Spontaneous Expressions.

Cong YQ, Yurdum L, Fischer A et al. · 2025 · Journal of nonverbal behavior

The ingroup advantage refers to the phenomenon of emotions being more accurately recognised when expressors and perceivers share the same cultural background. Though well-documented in studies using posed facial expressions, whether the…

View details →DOI: 10.1007/s10919-025-00492-1
Failed Experiment ReportMedicine

Cardiac vagal reactivation at the onset of muscle Metaboreflex activation is not further impaired in patients with Parkinson's disease.

Sabino-Carvalho JL, Guerrero RV, Teixeira AL et al. · 2025 · Autonomic neuroscience : basic & clinical

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by non-motor symptoms and marked altered sympathetic and parasympathetic activity. However, it is currently unclear if inappropriate autonomic adjustments are…

View details →DOI: 10.1016/j.autneu.2025.103311
Negative / Null Result ReportOpen accessMedicine

Distrusting minds, skeptical judgments? No evidence for a trust-truth link.

Bertram AM, Lalot F, van der Werff L et al. · 2025 · Frontiers in psychology

Introduction Many daily situations require rapid judgments about whether information is true or false based on limited information. Prior research has predominantly examined how statement and source characteristics influence these…

View details →DOI: 10.3389/fpsyg.2025.1626047
Negative / Null Result ReportMedicine

Mathematical modelling of carbohydrate and protein metabolism in muscle.

Alharbi BM, Williams HE, Parr T et al. · 2025 · Mathematical biosciences

We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to…

View details →DOI: 10.1016/j.mbs.2025.109455
Negative / Null Result ReportMedicine

Global and segmental longitudinal and radial strain in Takotsubo versus ST-elevation myocardial infarction.

Poller A, Jha S, Molander L et al. · 2025 · International journal of cardiology

Background It is incompletely understood why patients with takotsubo syndrome (TS) have milder symptoms and a better hemodynamic profile than patients with ST-elevation myocardial infarction (STEMI) despite similar or more extensive…

View details →DOI: 10.1016/j.ijcard.2025.133668
Negative / Null Result ReportOpen accessMedicine

The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.

Maier LE, Vanden Berg ER, Simpson L et al. · 2026 · Physiological reports

This study examined how sex influences blood flow during exercise at altitude and relative contributions of adrenergic mechanisms. Thirteen participants (8 M/5F) were tested at low and high altitude (days 3-11). Participants performed…

View details →DOI: 10.14814/phy2.70754
Negative / Null Result ReportOpen accessMedicine

Neuroinflammation PET and long-term cognition and survival in symptomatic Alzheimer's disease.

Rikken RM, Yaqub M, Coomans EM et al. · 2025 · Alzheimer's research & therapy

Background Neuroinflammation plays a key role in Alzheimer's disease (AD) pathophysiology, but it is not clear how neuroinflammation contributes to disease progression. We aim to investigate the role of neuroinflammation on longitudinal…

View details →DOI: 10.1186/s13195-025-01915-3
Negative / Null Result ReportOpen accessMedicine

Bioceramic arm garment does not increase diameter of brachial artery and blood flow-Compliance and biceps microcirculation in male recreational sports practitioners at rest: A single blinded randomized cross-over study.

Chamoux M, Rakobowchuk M, Gaston AF et al. · 2025 · Journal of sport and health science

Background Interest in clothing that reflects far infrared (FIR) radiation naturally emitted by the body during and after exercise has increased based on the assumption that this can increase arterial and venous blood flow. Indeed, in…

View details →DOI: 10.1016/j.jshs.2025.101117
Negative / Null Result ReportMedicine

Trace element and δ<sup>13</sup>C values of the banana prawn Penaeus merguiensis reveal the importance of catchment-derived resources across both estuarine and nearshore habitats.

Munroe S, O'Mara K, Kenyon R et al. · 2025 · Marine environmental research

Wet season freshwater flows deliver catchment nutrients (terrestrial and freshwater) to tropical estuaries that stimulate productivity and support consumers. However, the impact of flows on species in the adjacent nearshore is unclear. We…

View details →DOI: 10.1016/j.marenvres.2025.107028
Negative / Null Result ReportOpen accessMedicine

Visualizations during arithmetic tasks hamper performance and increase cognitive load in 9-year-olds: an fNIRS study.

Skau S, Karlsson J, Åsberg Johnels J et al. · 2026 · Frontiers in psychology

This study investigates whether visual aids increase or decrease cognitive load during arithmetic tasks in 9-year-old children, using behavioral measures and functional near-infrared spectroscopy (fNIRS). Previous research suggests mixed…

View details →DOI: 10.3389/fpsyg.2026.1722948
Negative / Null Result Report

Psychotic-like experiences and white matter microstructure: A fixel-based analysis approach with robust replication across two cohorts

Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Preprint

Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…

View details →DOI: 10.31234/osf.io/hv596_v1
Negative / Null Result ReportMedicine

Combined ketamine and psychotherapy provide no additional benefit beyond ketamine alone in treating depression or PTSD: Evidence from a help-seeking sample.

Moore TM, Walker K, Tung E et al. · 2025 · Journal of affective disorders

Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like…

View details →DOI: 10.1016/j.jad.2025.04.041
Negative / Null Result ReportOpen accessMedicine

The Effect of Flow-Controlled Ventilation on Mechanical Power in Laparoscopic Surgeries: A Comparative Analysis with Pressure Controlled Volume Guaranteed and Volume Controlled Ventilation.

Sencan A, Dundar N, Gunel B et al. · 2025 · Medeniyet medical journal

Objective To compare mechanical power (MP) levels among flow-controlled ventilation (FCV), volume-controlled ventilation (VCV), and pressure-controlled volume-guaranteed ventilation (PCV-VG) during laparoscopic surgery and to test the…

View details →DOI: 10.4274/mmj.galenos.2025.66664
Negative / Null Result ReportMedicine

Longitudinal Associations Between Cannabis Use during Pregnancy and Child Cognitive, Motor, and Language Development at 2 Years Old.

Pleau J, Tanguay N, Courtemanche Y et al. · 2025 · Maternal and child health journal

Objectives The objectives of this study are to describe cannabis use during pregnancy, identify associated factors, examine the associations between prenatal cannabis use and the cognitive, motor and language development of 2-year-old…

View details →DOI: 10.1007/s10995-025-04077-8
Negative / Null Result ReportMedicine

Special Issue Registered Report: Intentional suppression as a method to boost fear extinction.

Quaedflieg CWEM, Ashton SM, Beckers T et al. · 2025 · Journal of behavior therapy and experimental psychiatry

Fear is a universal experience and fuels our response to cope with threat. Persistent fear, after the threat is no longer present, is a central symptom seen in a number of clinical conditions. Exposure therapy, the most common treatment to…

View details →DOI: 10.1016/j.jbtep.2025.102018
Negative / Null Result Report

Age Differences in Reward Discounting in an Effortful 3D Game

van Berlo E · 2024 · Preprint

In this study, we investigated how spatial, temporal, and effort dimensions collectively influence reward discounting across different age groups. Using a 3D simulated environment, participants aged 7 to 77 chose between a nearby tree with…

View details →DOI: 10.31234/osf.io/grv5w
Negative / Null Result Report

Short Naps Improve Subsequent Learning in a High School Setting

Vidal V, Pretel MR, Capurro L et al. · 2024 · Preprint

Abstract The application of neuroscience findings in educational settings offers promising opportunities to enhance academic performance. Adolescents, particularly affected by delayed sleep patterns due to early school start times, often…

View details →DOI: 10.21203/rs.3.rs-5485881/v1
Negative / Null Result Report

Range-wide assessment of the Tasmanian devil gut microbiome

Molloy M, McLennan E, Fox S et al. · 2024 · Preprint

The gut microbiome is an important component of host health and function and is influenced by internal and external factors such as host phylogeny, age, diet, and environment. Monitoring the gut microbiome has become an increasingly…

View details →DOI: 10.22541/au.172969938.82154815/v1
Negative / Null Result ReportOpen accessMedicine

Determinants of changes in self-esteem after remission of first-episode psychosis: A study of associated cross-sectional and longitudinal factors.

Hidding M, van der Stouwe E, Rosema BS et al. · 2025 · Psychological medicine

Background Low self-esteem is an important and potentially modifiable risk factor for the development and outcome of psychotic disorders. The factors involved in low self-esteem in psychotic disorders are not yet fully understood. The…

View details →DOI: 10.1017/s0033291725102857
Negative / Null Result Report

Millisecond-scale motor coding precedes sensorimotor learning in songbirds

Pascual LMM, Vusirikala A, Nemenman IM et al. · 2024 · Preprint

The changes in neural activity that underlie motor skill acquisition during development are unknown. Juvenile songbirds learn their songs by an imitative process, and after learning adults use a millisecond-precise spike timing code to…

View details →DOI: 10.1101/2024.09.27.615500