Safety Evaluation of Topical Application of Nano-Liposomal Form of Amphotericin B (SinaAmpholeish) on Healthy Volunteers: Phase I Clinical Trial
Seyed Ebrahim ESKANDARI; Alireza FIROOZ; Mansour NASSIRI-KASHANI; Mahmoud Reza JAAFARI; Amir JAVADI; Akram MIRAMIN MOHAMMADI; Ali KHAMESIPOUR · 2019 · Iranian Journal of Parasitology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: We aimed to evaluate the safety of SinaAmpholeish in a double-blind, randomized, phase 1 clinical trial in healthy human volunteers. Methods: The study was carried out in DermaLab of Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran in 2012. A topical Nano-liposomal formulation of 0.4% Amphotericin B was developed against Leishmania under trade name of SinaAmpholeish. In this randomized, double-blind, right-left, comparative, phase I clinical trial, in 2 steps; 7 and 20 healthy volunteers were recruited and applied Si
Abstract by Seyed Ebrahim ESKANDARI; Alireza FIROOZ; Mansour NASSIRI-KASHANI; Mahmoud Reza JAAFARI; Amir JAVADI; Akram MIRAMIN MOHAMMADI; Ali KHAMESIPOUR, Iranian Journal of Parasitology (2019) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Comparative field evaluation of kelambu traps, barrier screens and barrier screens with eaves for longitudinal surveillance of adult Anopheles mosquitoes in Sulawesi, Indonesia
Negative / Null Result ReportASSOCIATION BETWEEN FAS/FASL EXPRESSION AND RHEUMATOLOGICAL MANIFESTATIONS IN PATIENTS INFECTED WITH HTLV-1
Negative / Null Result ReportCharlson Comorbidity Index Based On Hospital Episode Statistics Performs Adequately In Predicting Mortality, But Its Discriminative Ability Diminishes Over Time
Negative / Null Result ReportSeroprevalence and factors associated with SARS-CoV-2 infection among healthcare workers: cross-sectional study
Negative / Null Result ReportCan Clean Delivery Kits Prevent Infections? Lessons from Traditional Birth Attendants in Nigeria
Negative / Null Result ReportIndependent and combined effect of bilirubin and smoking on the progression of chronic kidney disease
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.18502/ijpa.v14i2.1130