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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 670 of 725

Negative / Null Result ReportOpen accessMedicine

Assessment of β-blocker use and all-cause mortality in patients with myocardial infarction: a real-world analysis of the NHANES 1999-2018 database.

Ling W, Li H, Liu L et al. · 2025 · Open heart

Objective To evaluate the association between β-blocker use and all-cause mortality in a real-world cohort of patients with myocardial infarction (MI). Methods This study included 2308 patients with MI from the National Health and…

View details →DOI: 10.1136/openhrt-2025-003757
Negative / Null Result ReportOpen accessMedicine

Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.

Orr SL, Hershey AD, Kurowski BG et al. · 2026 · Neurology. Genetics

Background and objectives To examine the association between genetic risk of migraine and post-traumatic headache (PTH) in children. Methods This is a secondary analysis of a cohort study that recruited children aged 8-17 years within 48…

View details →DOI: 10.1212/nxg.0000000000200371
Negative / Null Result ReportOpen accessMedicine

Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis.

Cheng T, Zhang HY, Wang TR et al. · 2025 · Scientific reports

This study uses Mendelian randomization (MR) to investigate the potential causal relationships between viral infections, including Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), SARS-CoV-2, cytomegalovirus (CMV), human…

View details →DOI: 10.1038/s41598-025-08361-z
Negative / Null Result ReportOpen accessMedicine

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster-Randomised Trial.

Diarra NH, Dicko Y, Roschnik N et al. · 2025 · Maternal & child nutrition

A cluster-randomised controlled trial was conducted in 60 communities in southern Mali to evaluate the impact of micronutrient powders (MNP) combined with seasonal malaria chemoprevention (SMC) on anaemia (primary endpoint), Plasmodium…

View details →DOI: 10.1111/mcn.70033
Negative / Null Result ReportMedicine

Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.

Bierut L, Biroli P, Galama TJ et al. · 2023 · Journal Of Economic Psychology

Smoking is one of the leading causes of preventable disease and death in the U.S., and it is strongly influenced both by genetic predisposition and childhood adversity. Using polygenic indices (PGIs) of predisposition to smoking, we…

View details →DOI: 10.1016/j.joep.2023.102636
Negative / Null Result ReportOpen accessMedicine

Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.

Sumner P, Powell G, Price A et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Many people experience aversive hypersensitivity (discomfort/visual stress) to stimuli such as bright lights, striped patterns, strobing, motion, or complex visual scenes such as supermarkets. Such sensory hypersensitivity is often…

View details →DOI: 10.1162/imag.a.1136
Negative / Null Result ReportMedicine

Weight cycling and cancer risk in the Sister Study.

Stevens VL, Priest J, Wilkerson J et al. · 2026 · American journal of epidemiology

Weight cycling, when weight is repeatedly lost intentionally and then regained, may perturb biological processes that could influence cancer development. However, results from epidemiologic studies of weight cycling are mixed and provide…

View details →DOI: 10.1093/aje/kwaf191
Negative / Null Result ReportMedicine

Association of Intensive Care Unit Patient-to-Clinician Ratios with Mortality across Two U.S. Health Systems.

Gershengorn HB, Anesi GL, Liu VX et al. · 2025 · Annals of the American Thoracic Society

Rationale: The association of interprofessional team member workload with intensive care unit (ICU) outcomes is understudied. Objectives: To evaluate the association of patient-to-intensivist ratio (PIR), patient-to-respiratory therapist…

View details →DOI: 10.1513/annalsats.202501-045oc
Negative / Null Result ReportOpen accessMedicine

Outcomes of Treating Symptomatic Intracranial Stenosis With Angioplasty or Stent Placement: A Retrospective Study in a Cohort of 37 Patients.

Jaraki D, Dorn A, Eckert T et al. · 2025 · Cureus

Background Intracranial atherosclerotic disease (ICAD) is a leading cause of ischemic stroke worldwide, with endovascular interventions such as angioplasty and stenting facing scrutiny due to variable safety outcomes in prior studies.…

View details →DOI: 10.7759/cureus.91254
Negative / Null Result ReportOpen accessMedicine

Medical Practitioners' Acceptance and Use of AI-Based Clinical Decision Support Systems in Western China: A Mixed-Methods Study.

Zhu R, Huo Z, Li Y et al. · 2026 · Healthcare (Basel, Switzerland)

Background : Doctors have made increasing use of artificial intelligence-based clinical decision support systems in recent years in eastern China, but far less so in poorer western China, where hospitals with less access to specialized…

View details →DOI: 10.3390/healthcare14081096
Negative / Null Result ReportMedicine

The impact of recreational cannabis retailer allocation on emergency department visits: A natural experiment utilizing lottery design.

Bai Y, Cao P, Kim C et al. · 2025 · The International journal on drug policy

Background In October 2018, Canada legalized recreational cannabis, with Ontario distributing retailer licenses through a lottery system in 2019. This study investigates the impact of recreational cannabis retailer allocation on emergency…

View details →DOI: 10.1016/j.drugpo.2025.104708
Replication FailureOpen accessMedicine

Medication Review and Enhanced Information Transfer at Discharge of Older Patients with Polypharmacy: a Cluster-Randomized Controlled Trial in Swiss Hospitals.

Grischott T, Rachamin Y, Senn O et al. · 2023 · Journal of general internal medicine

Background Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to…

View details →DOI: 10.1007/s11606-022-07728-6
Replication FailureOpen accessMedicine

The association between early-life nutrition and palatine tonsil grading in preschool children: a cross-sectional study.

Guo G, Yan W, Zhou R et al. · 2026 · Frontiers in nutrition

Background Early-life nutritional factors play a crucial role in child health, but their association with palatine tonsil grading is not well understood. This study aimed to investigate the relationship between early-life nutrition and…

View details →DOI: 10.3389/fnut.2026.1789543
Negative / Null Result ReportOpen accessMedicine

Restricting facial mimicry does not impair emotion recognition or influence the evaluation of human affect vocalizations and instrumental sounds.

Wołoszyn K, Hohol M, Winkielman P · 2026 · Scientific reports

The embodied simulation approach predicts that restricting facial movements disrupts emotion recognition. Such effects have been reported for facial and whole-body emotional expressions, but findings remain inconsistent, and it is unclear…

View details →DOI: 10.1038/s41598-026-43390-2
Negative / Null Result ReportOpen accessMedicine

Exploring boundary conditions of goal-driven attentional capture by affective categories: the role of prioritisation in working memory.

Brown CRH · 2026 · Psychological research

When stimuli are retained in visual working memory (VWM) external stimuli which overlap with this representation capture attention when performing a visual task. It has not been determined, however, whether this mechanism can partly…

View details →DOI: 10.1007/s00426-025-02227-9
Negative / Null Result ReportOpen accessMedicine

Object relations are processed with, but not without, awareness.

Palgi S, Bester-Arest T, Faivre N et al. · 2025 · Neuroscience of consciousness

The scope of unconscious integration is widely debated. Here, we examined this question, focusing specifically on deciphering the relations between two associatively related objects, in a set of five behavioral and electrophysiological…

View details →DOI: 10.1093/nc/niaf010
Negative / Null Result ReportOpen accessMedicine

Association of reproductive and menstrual factors with the risk of breast cancer in women: a population-based study.

Song Z, Ding M, Zang Q et al. · 2025 · BMC cancer

Background Reproductive factors significantly impact the incidence of breast cancer (BC), a concerning trend. This study aims to reassess this association and provide recommendations for fertility policies to delay the onset of BC. Methods…

View details →DOI: 10.1186/s12885-025-15048-1
Negative / Null Result ReportOpen accessMedicine

Epileptic High-Frequency Oscillations in Intracranial EEG Are Not Confounded by Cognitive Tasks.

Boran E, Stieglitz L, Sarnthein J · 2021 · Frontiers in human neuroscience

Rationale : High-frequency oscillations (HFOs) in intracranial EEG (iEEG) are used to delineate the epileptogenic zone during presurgical diagnostic assessment in patients with epilepsy. HFOs are historically divided into ripples (80-250…

View details →DOI: 10.3389/fnhum.2021.613125
Negative / Null Result ReportOpen accessMedicine

Impact of Facility Criteria Revision for Rotational Atherectomy on Outcomes After PCI: A Quasi-Experimental Difference-in-Differences Study.

Aikawa T, Mori Y, Kuno T et al. · 2026 · JACC. Advances

Background In April 2020, the facility criteria for using rotational atherectomy (RA) during percutaneous coronary intervention (PCI) were updated in Japan. Board-certified PCI operators are now permitted to perform RA during PCI in…

View details →DOI: 10.1016/j.jacadv.2026.102672
Negative / Null Result ReportMedicine

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning.

Lupien SJ, Roy DC, Raymond C et al. · 2020 · Development and psychopathology

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with…

View details →DOI: 10.1017/s0954579420001431
Negative / Null Result ReportOpen accessMedicine

Risk of infectious mononucleosis is not associated with prior infection morbidity.

Rostgaard K, Kristjánsson R, Davidsson O et al. · 2025 · Frontiers in epidemiology

Background The probability of presenting with infectious mononucleosis (IM) upon primary Epstein-Barr virus infection increases dramatically at the start of puberty. Aiming to understand why that is, we assessed whether the number of…

View details →DOI: 10.3389/fepid.2025.1518559
Negative / Null Result ReportOpen accessMedicine

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.

Jackson E, Riley T, Overton PG · 2026 · PloS one

Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for…

View details →DOI: 10.1371/journal.pone.0349512