A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21374 results · page 669 of 713
De Souza Mares G, Bastos Tavares MV, Danieluk MF et al. · 2025 · Preprint
Introduction: Postinfectious hyposmia gained special attention in the postpandemic era, and persistent cases are particularly difficult to treat. Many unproven therapies are used in clinical practice, including corticosteroids, with…
Jaghsi AA, Rokaya D · 2025 · European journal of dentistry
The implant impression technique plays a critical role in determining the accuracy of implant working casts. This laboratory study aimed to evaluate and compare the accuracy of working casts fabricated using four different impression…
Shin L, Mentz O, Gelfand AA et al. · 2026 · Headache
Introduction There is an unmet need for safe, evidence-based pharmacologic treatments for migraine prevention in children and adolescents. Rimegepant and atogepant, calcitonin gene-related peptide receptor antagonists (gepants), have been…
Bartels CM, Ranganathan B, Spinner M · 2025 · Journal of the American Veterinary Medical Association
Objective To prospectively evaluate a nonporous wrap's ability to prevent inadvertent perianesthetic hypothermia (IPH) in canines undergoing ovariohysterectomy. Methods All client-owned canines and felines undergoing ovariohysterectomy…
Aziz M, Leske V, Guerdile MJ et al. · 2025 · Hormone research in paediatrics
Introduction Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is a rare disorder characterized by respiratory failure, autonomic dysregulation, and endocrine abnormalities.…
Sadeghpour M, Laughter M, Rizzo SI et al. · 2026 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Background Despite evidence supporting efficacy of low-fluence Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm lasers, treatment protocols are not standardized and limited to mostly retrospective, observational,…
Wu BY, Hsu CY, Cheng YH · 2026 · Archives of physical medicine and rehabilitation
Objective To evaluate the efficacy of ultrasound-guided dextrose injection (DI) therapy for chronic anterior talofibular ligament sprain. Design A randomized, single-blinded controlled trial. Setting Participants were recruited from the…
Greco P, Costanzi F, Listorti I et al. · 2026 · Reproductive biomedicine online
Research question Can hyaluronan-enriched transfer medium (HETM) improve reproductive outcomes in frozen single euploid blastocyst transfers after preimplantation genetic testing for aneuploidy (PGT-A)? Design Retrospective analysis of 445…
Zhao P, Wang X, Zhang Q et al. · 2025 · British journal of hospital medicine (London, England : 2005)
Aims/Background Growth hormone (GH) supplementation contributes to improved reproductive and pregnancy outcomes in in vitro fertilization (IVF)-embryo transfer (ET) in polycystic ovary syndrome (PCOS) women. This study aimed to explore the…
Rosa HH, Ruppel C, Trappel ND et al. · 2026 · Medicina oral, patologia oral y cirugia bucal
Background This study evaluated the efficacy of a single 15 mg preoperative sublingual dose of melatonin in reducing anxiety as the primary outcome, and its effects on psychomotor performance, postoperative sleep quality, and early…
Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery
Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…
Graciano N, López L, Rodriguez CA et al. · 2025 · Breast cancer research and treatment
Purpose Patients with triple-negative breast cancer (TNBC) who do not achieve pathological complete response (non-pCR) after neoadjuvant chemotherapy (NACT) have a high-risk of relapse. While adjuvant capecitabine (AdjCape) has…
Graciano N, López L, Rodriguez CA et al. · 2025 · Preprint
Abstract Purpose Patients with triple-negative breast cancer (TNBC) who do not achieve pathological complete response (non-pCR) after neoadjuvant chemotherapy (NACT) have a high risk of relapse. While adjuvant capecitabine (AdjCape) has…
Apostol M, Valles T, Corlier J et al. · 2025 · Preprint
Abstract Accelerated repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for Major Depressive Disorder (MDD), with an FDA-cleared protocol utilizing 10 sessions of prolonged intermittent Theta Burst Stimulation…
Windle R, Dillon H, Heinrich A · 2026 · Ear and hearing
Objectives To determine whether normally aging older adults, fitted with hearing aids, report a benefit from, or a preference for, slow or fast-acting compression, and whether this relationship is influenced by cognitive ability, hearing…
Groothof D, Bakker SJ · 2025 · Preprint
Tolvaptan is the only approved therapy for slowing disease progression in autosomal dominant polycystic kidney disease (ADPKD). Its use necessitates a careful balance between its kidney-protective effects and the burdensome aquaretic…
Mitra S, Jain A, Ting JY et al. · 2026 · JAMA network open
Importance Wide variation exists in patent ductus arteriosus (PDA) treatment practices in extremely preterm infants (defined in this study as born before 29 weeks' gestation). Commonly used treatment strategies include use of standard-dose…
Falade AS, Redd R, Desai SH et al. · 2026 · Blood advances
Abstract Use of brentuximab vedotin (BV) and PD-1 monoclonal antibodies (mAbs) before autologous stem cell transplantation (ASCT) could impact the benefit of post-ASCT BV maintenance in relapsed/refractory (R/R) classic Hodgkin lymphoma…
Senda A, Suginaka H, Morishita K et al. · 2025 · Stroke and vascular neurology
Introduction Cerebral venous thrombosis (CVT) is a rare but serious disease. Despite anticoagulation being the cornerstone therapy, some patients experience worsening disease, necessitating alternative treatment. Endovascular treatment is…
Sandoval JL, Kiavue N, Djerroudi L et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose In patients with metastatic breast cancer, ≥5 circulating tumor cells (CTC)/7.5 mL of blood is a validated adverse prognostic marker. The STIC CTC phase III trial (N = 778, hormone receptor-positive HER2- metastatic breast cancer)…
Grossmann NC, Barmettler L, Sava M et al. · 2025 · World journal of urology
PURPOSE: To assess the effect of single-dose perioperative antibiotic prophylaxis (PAP) on surgical site infection (SSI) rates and related outcomes in elective scrotal or inguinal testicular surgery. METHODS: Retrospective cohort study of…
Das UN · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
The failed regimens for sepsis include but are not limited to steroids, antibiotic coverage for gram-negatives, and activated protein C. Reports of dramatic successes with vitamin C, its low cost and virtual absence of side effects in…
Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes
Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…
Nasrallah OG, Herrera MT, Nasr RW et al. · 2025 · Preprint
Abstract Background : Standardization of multi-parametric MRI (mp-MRI) prior to prostate biopsy and the incorporation of ultrasound fusion allowed precise and accurate targeted prostate biopsies. Random biopsies, still performed as…
Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons
Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…
Asali M, Asali G · 2026 · Advances in urology
Background Partial nephrectomy represents a nephron-sparing strategy aimed at preserving renal function while balancing increased technical complexity and potential oncological considerations. Innovations in minimally invasive surgery,…
Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist
Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…
Hara R, Watanabe S, Murase Y et al. · 2025 · Chest
Case presentation A 72-year-old man with progressive dyspnea was referred to our hospital for evaluation of diffuse lung disease. His medical history was unremarkable except for a 20-year history of smoking 20 cigarettes per day. Abnormal…
McDermott MM, Zhang D, Zhao L et al. · 2025 · Journal of the American Heart Association
Background Supervised treadmill exercise improves walking performance in people with lower extremity peripheral artery disease, but benefits are not immediate. This study identified the time course of attaining meaningful improvement in…
Humes LE, Dhar S, Singh J · 2025 · International journal of audiology
Objective To evaluate use of the Hearing Handicap Inventory for the Elderly (HHIE), and its derivatives, as hearing-aid outcome measures. Design A targeted narrative literature review identified 12 studies in the primary research…