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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 669 of 725

Negative / Null Result ReportMedicine

Exploring a Single Music Therapy Session to Reduce 22q11.2 Deletion Syndrome Child and Adolescent's Outpatient Clinic-Related Anxiety.

Broughton MC, Bunzli E, Pagel S et al. · 2026 · Journal of paediatrics and child health

Aim This study explored whether a single music therapy session could reduce 22q11.2 deletion syndrome (DS) children and adolescents' clinic-related anxiety when visiting the hospital outpatient clinic for health appointments. Methods The…

View details →DOI: 10.1111/jpc.70397
Negative / Null Result ReportMedicine

Mediating effects of depression, stigma, and self-efficacy on self-management improvement in an evidence-based epilepsy self-management program.

Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B

Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…

View details →DOI: 10.1016/j.yebeh.2026.111117
Negative / Null Result Report

Comparative chemical characterisation of chitosans and their impact on growth, faecal consistency and microbiota composition in weaned piglets

Blasio SD, Middelkoop A, Molist F et al. · 2026 · Preprint

Managing post-weaning diarrhoea (PWD) in piglets is difficult due to limits on antibiotics and zinc. Chitosan is emerging as a potential feed additive. We analysed a chito-oligosaccharide hydrochloride (COS-HCl), a low molecular weight…

View details →DOI: 10.64898/2026.03.26.714014
Negative / Null Result ReportMedicine

Relationship Between Mental Health and Protective Health Behaviors in Adolescents: A Secondary Data Analysis.

Mahat G, Zha P · 2026 · Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

Evidence highlights rising mental health concerns among youth. This study investigated the relationship between protective behaviors, including physical activity, regular breakfast, sleep, and parental monitoring, and adolescent mental…

View details →DOI: 10.1016/j.pedhc.2026.05.012
Negative / Null Result ReportMedicine

Impact of oral glucocorticoids on the effectiveness of romosozumab: the multicenter OASIS cohort study.

Yukishima T, Kobayakawa T, Hirano Y et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

This multicenter retrospective cohort compared romosozumab outcomes between oral glucocorticoid users and non-users. Bone turnover marker responses and lumbar spine bone mineral density gains were similar, whereas total hip bone mineral…

View details →DOI: 10.1007/s00198-026-08051-0
Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

View details →DOI: 10.1038/s41598-026-58855-7
Negative / Null Result ReportMedicine

Pharmacokinetics of polyethylene glycol (PEG)-capped gold nanoparticles in rats: impact of free PEG pre-administration.

Darweesh RS, Alnuaimi TM, Zayed AL et al. · 2026 · Nanotechnology

Polyethylene glycol (PEG)-capped gold nanoparticles (PEG-AuNPs) are of great interest for targeted drug delivery and targeted delivery of chemotherapy due to their biocompatibility and ability to evade detection by the immune system.…

View details →DOI: 10.1088/1361-6528/ae4fc9
Negative / Null Result ReportMedicine

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Ifrah-Tsruya H, Lev M, Polat U · 2026 · Vision research

Attention-Deficit/Hyperactivity Disorder (ADHD) is typically conceptualized as a disorder of executive control; however, accumulating evidence suggests that early sensory processing may also be atypical. The present study examined contrast…

View details →DOI: 10.1016/j.visres.2026.108867
Negative / Null Result ReportMedicine

Reliability of Noninvasive Blood Pressure Monitoring During Atrial Fibrillation Ablation Under General Anesthesia.

Schwartz J, Al-Sadawi M, Mattimore D et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To evaluate the accuracy and reliability of noninvasive blood pressure (NIBP) monitoring compared to invasive blood pressure (IBP) measurements during atrial fibrillation (AF) ablation under general anesthesia, and to determine…

View details →DOI: 10.1053/j.jvca.2026.03.003
Negative / Null Result ReportMedicine

Concomitant cholecystectomy did not significantly reduce the risk of subsequent biliary events and malignancy in treating gallstone ileus.

Su YS, Liu HY, Chen CY et al. · 2026 · Surgical endoscopy

Background This nationwide cohort study compared long-term subsequent benign biliary events and biliary tract malignancy in patients with gallstone ileus treated with or without concomitant cholecystectomy. Methods This retrospective…

View details →DOI: 10.1007/s00464-025-12536-0
Negative / Null Result ReportMedicine

Management of the Condyle in Posterior Mandibular Reconstruction: Major Clinical and Patient-Reported Outcomes.

Coleman-Belin JC, Zhang KK, Cohen Z et al. · 2026 · Journal of surgical oncology

Background and objectives Tumor involvement of the posterior mandible often requires resection of the mandibular condyle and associated soft tissue. This study explores clinical and patient-reported outcomes (PROs) associated with condyle…

View details →DOI: 10.1002/jso.70182
Methods Dead-End

Identifying Yield-Limiting Nutrients for Tef [Eragrostis Tef (Zucc.)Trotter] Across Landscape Positions in West Belesa District, Northeastern Ethiopia

Getnet H, Addis A, Ayalew B et al. · 2026 · Preprint

Abstract Landscape position affects soil fertility through nutrient redistribution caused by erosion. In Ethiopia, soil fertility maps indicate deficiencies of essential nutrients, including Nitrogen (N), phosphorus (P), potassium (K),…

View details →DOI: 10.21203/rs.3.rs-10044858/v1
Methods Dead-EndMedicine

Impact of sky view factor on multimodal physiological responses: integrating EEG, heart rate, and thermal sensation in urban landscapes.

Fan L, Li Z, Chang L et al. · 2026 · Scientific reports

Traditional thermal comfort models often fail to capture the dynamic neurophysiological complexity of outdoor human perception. This study introduces a neurophysiological approach to investigate how Sky View Factor (SVF) modulates human…

View details →DOI: 10.1038/s41598-026-58340-1
Negative / Null Result ReportMedicine

Design and Preliminary Evaluation of a Hand-Held Surgical Robot for Enhanced Intuitive Control in Laparoscopy.

Kong K, Qiang Z, Yang Y et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Background Surgical robots offer improved precision and stability for laparoscopy; nevertheless, their limited portability and high cost impede broader clinical applications. Methods This paper proposes a hand-held surgical robot with an…

View details →DOI: 10.1002/rcs.70176
Negative / Null Result ReportMedicine

EEG activities and connectivities associated with surtitle presentation during live opera viewing: an exploratory analysis of cognitive absorption.

Boasen J, Giroux F, Duchesneau MO et al. · 2026 · Scientific reports

Characterizing brain activities underlying text availability in an ecologically valid context and identifying whether aspects of these activities are influenced by one's state of cognitive absorption (CA) are important yet unexplored lines…

View details →DOI: 10.1038/s41598-026-56620-4
Negative / Null Result Report

Cusp Overlap Versus Standard Three-Cusp Technique for Self-Expanding Transcatheter Aortic Valves – A Single Center Experience

Ispas A, Brunet D, Saadi R et al. · 2026 · Preprint

Background: Conduction disturbances and the subsequent need for permanent pacemaker implantation (PPMI) remain a major limitation of transcatheter aortic valve replacement (TAVR) with self-expanding transcatheter heart valves (SE-THVs).…

View details →DOI: 10.20944/preprints202606.0545.v1
Negative / Null Result ReportMedicine

Effects of filtered vs. unfiltered TikTok videos on mood, body and facial satisfaction, and cosmetic surgery interest.

Harriger JA, Brown SA, Chung HG et al. · 2026 · Body image

This study investigated the effects of exposure to unfiltered vs. filtered idealized TikTok videos in a sample of 299 adult women, ages 18-83-years-old. Participants were randomly assigned to view idealized unfiltered, idealized filtered,…

View details →DOI: 10.1016/j.bodyim.2026.102030
Negative / Null Result ReportMedicine

Feasibility, safety and outcomes of contrast-free cardiac resynchronisation therapy device implantation: a retrospective cohort comparison.

Friedrich L, Walgenbach M, O Connor M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND: Left ventricular lead (LVL) implantation can be challenging in Cardiac Resynchronization Therapy (CRT). Therefore, contrast is commonly used to visualize the coronary venous system. However, contrast use is correlated with…

View details →DOI: 10.1007/s10840-026-02283-0
Negative / Null Result ReportMedicine

Sleep Quality in Later Life: How Does It Affect Driving Safety?

Barrett AE, Soulie B, Mimbs H et al. · 2026 · International journal of aging & human development

Drowsy driving is a major cause of motor vehicle injuries and fatalities, yet little is known about its impact on older adults. This group may face heightened risk due to age-related sleep issues. Using survey data from 3,411 Floridians…

View details →DOI: 10.1177/00914150261445628
Negative / Null Result ReportMedicine

Carboplatin with or without nivolumab in metastatic triple-negative breast cancer: a randomized phase II trial.

Garrido-Castro AC, Graham N, Li KX et al. · 2026 · Nature communications

This multi-institutional randomized phase II clinical trial (NCT03414684) investigated the efficacy and safety of carboplatin plus nivolumab compared to carboplatin in metastatic triple-negative breast cancer (mTNBC). The primary endpoint…

View details →DOI: 10.1038/s41467-026-73085-1