Negative / Null Result ReportOpen accessMedicine
Pellegrino N, Eliasziw M, Fortinsky R et al. · 2026 · Scientific reports
Exposure to particulate matter is associated with adverse health outcomes such as cardiovascular and neurological diseases. However, there are few intervention studies that have examined short-term changes in air particulate exposure and…
View details →DOI: 10.1038/s41598-026-48063-8 Negative / Null Result ReportMedicine
Tlili S, Ben Mahfoudh H, Zoudji B · 2025 · Perceptual and motor skills
Generated drawing is a specific instructional approach that has been investigated in academic settings. However, in sports, tactical drawings are often presented based more on coaches' preferences than on empirical evidence. This study…
View details →DOI: 10.1177/00315125251391658 Failed Experiment ReportMedicine
Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…
View details →DOI: 10.1016/j.euroneuro.2026.112771 Negative / Null Result ReportMedicine
Scherer C, Fung V, Anzellini D et al. · 2026 · Breast cancer (Tokyo, Japan)
Background We report outcomes of patients who received intraoperative radiation therapy (IORT) using 50 kV after lumpectomy and sentinel lymph node biopsy. Methods Women with age > 45 and post-menopausal status, localized, unifocal,…
View details →DOI: 10.1007/s12282-026-01824-9 Negative / Null Result ReportMedicine
Kanthar T, Vatcharavongvan P, Prasert V · 2025 · Journal of evaluation in clinical practice
Rationale The global prevalence rate of glaucoma blindness is extremely high and is a leading cause of irreversible blindness. Despite many advancements in treatment, evaluating glaucoma blindness remains challenging due to the long time…
View details →DOI: 10.1111/jep.70341 Negative / Null Result ReportMedicine
Blin P, Danchin N, Benichou J et al. · 2026 · American journal of cardiovascular drugs : drugs, devices, and other interventions
Introduction Antiplatelet therapy with low-dose aspirin, alone or as dual antiplatelet therapy (DAPT) with a P2Y 12 inhibitor, is used in secondary prevention following myocardial infarction (MI). However, the optimal duration of DAPT is…
View details →DOI: 10.1007/s40256-025-00782-5 Negative / Null Result ReportMedicine
Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina
Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…
View details →DOI: 10.1701/4518.45175 Negative / Null Result ReportOpen accessMedicine
Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer
AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…
View details →DOI: 10.1186/s12885-026-16073-4 Negative / Null Result ReportMedicine
Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy
Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…
View details →DOI: 10.1016/j.gie.2025.12.290 Negative / Null Result ReportMedicine
Gupta Y, Baranwal M, Chudasama B · 2025 · Biotechnology journal
Despite the challenge in generating adequate immunogenicity, peptide-based vaccines offer a significant benefit in terms of improving immunity when combined with conjugates. In previous studies, three computationally designed immunogenic…
View details →DOI: 10.1002/biot.70140 Negative / Null Result ReportOpen accessMedicine
Shin L, Mentz O, Gelfand AA et al. · 2026 · Headache
Introduction There is an unmet need for safe, evidence-based pharmacologic treatments for migraine prevention in children and adolescents. Rimegepant and atogepant, calcitonin gene-related peptide receptor antagonists (gepants), have been…
View details →DOI: 10.1111/head.15087 Negative / Null Result ReportMedicine
Bartels CM, Ranganathan B, Spinner M · 2025 · Journal of the American Veterinary Medical Association
Objective To prospectively evaluate a nonporous wrap's ability to prevent inadvertent perianesthetic hypothermia (IPH) in canines undergoing ovariohysterectomy. Methods All client-owned canines and felines undergoing ovariohysterectomy…
View details →DOI: 10.2460/javma.25.06.0429 Negative / Null Result ReportMedicine
Aziz M, Leske V, Guerdile MJ et al. · 2025 · Hormone research in paediatrics
Introduction Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is a rare disorder characterized by respiratory failure, autonomic dysregulation, and endocrine abnormalities.…
View details →DOI: 10.1159/000549050 Replication FailureMedicine
Sadeghpour M, Laughter M, Rizzo SI et al. · 2026 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Background Despite evidence supporting efficacy of low-fluence Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm lasers, treatment protocols are not standardized and limited to mostly retrospective, observational,…
View details →DOI: 10.1097/dss.0000000000004846 Negative / Null Result ReportMedicine
Wu BY, Hsu CY, Cheng YH · 2026 · Archives of physical medicine and rehabilitation
Objective To evaluate the efficacy of ultrasound-guided dextrose injection (DI) therapy for chronic anterior talofibular ligament sprain. Design A randomized, single-blinded controlled trial. Setting Participants were recruited from the…
View details →DOI: 10.1016/j.apmr.2025.09.004 Negative / Null Result ReportMedicine
Greco P, Costanzi F, Listorti I et al. · 2026 · Reproductive biomedicine online
Research question Can hyaluronan-enriched transfer medium (HETM) improve reproductive outcomes in frozen single euploid blastocyst transfers after preimplantation genetic testing for aneuploidy (PGT-A)? Design Retrospective analysis of 445…
View details →DOI: 10.1016/j.rbmo.2025.105235 Negative / Null Result ReportMedicine
Zhao P, Wang X, Zhang Q et al. · 2025 · British journal of hospital medicine (London, England : 2005)
Aims/Background Growth hormone (GH) supplementation contributes to improved reproductive and pregnancy outcomes in in vitro fertilization (IVF)-embryo transfer (ET) in polycystic ovary syndrome (PCOS) women. This study aimed to explore the…
View details →DOI: 10.12968/hmed.2025.0546 Negative / Null Result ReportOpen accessMedicine
Rosa HH, Ruppel C, Trappel ND et al. · 2026 · Medicina oral, patologia oral y cirugia bucal
Background This study evaluated the efficacy of a single 15 mg preoperative sublingual dose of melatonin in reducing anxiety as the primary outcome, and its effects on psychomotor performance, postoperative sleep quality, and early…
View details →DOI: 10.4317/medoral.27846 Failed Experiment ReportOpen accessMedicine
Vaisitti F, Sobrero S, Rudella S et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery
Objectives The fissure last (FL) technique described in 1998 has the goal of minimizing postoperative airleak leaving the stapling of the fissure as the last step. The aim of this study was the reduction in airleak may be already evident…
View details →DOI: 10.1093/icvts/ivag039 Failed Experiment ReportMedicine
Graciano N, López L, Rodriguez CA et al. · 2025 · Breast cancer research and treatment
Purpose Patients with triple-negative breast cancer (TNBC) who do not achieve pathological complete response (non-pCR) after neoadjuvant chemotherapy (NACT) have a high-risk of relapse. While adjuvant capecitabine (AdjCape) has…
View details →DOI: 10.1007/s10549-025-07814-3 Negative / Null Result ReportMedicine
Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes
Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…
View details →DOI: 10.1093/ehjqcco/qcae087 Negative / Null Result Report
Nasrallah OG, Herrera MT, Nasr RW et al. · 2025 · Preprint
Abstract Background : Standardization of multi-parametric MRI (mp-MRI) prior to prostate biopsy and the incorporation of ultrasound fusion allowed precise and accurate targeted prostate biopsies. Random biopsies, still performed as…
View details →DOI: 10.21203/rs.3.rs-6950274/v1 Negative / Null Result ReportMedicine
Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons
Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…
View details →DOI: 10.1097/xcs.0000000000001473 Negative / Null Result ReportOpen accessMedicine
Asali M, Asali G · 2026 · Advances in urology
Background Partial nephrectomy represents a nephron-sparing strategy aimed at preserving renal function while balancing increased technical complexity and potential oncological considerations. Innovations in minimally invasive surgery,…
View details →DOI: 10.1155/aiu/5540611 Negative / Null Result ReportOpen accessMedicine
Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist
Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…
View details →DOI: 10.1093/oncolo/oyag177 Negative / Null Result ReportMedicine
Hara R, Watanabe S, Murase Y et al. · 2025 · Chest
Case presentation A 72-year-old man with progressive dyspnea was referred to our hospital for evaluation of diffuse lung disease. His medical history was unremarkable except for a 20-year history of smoking 20 cigarettes per day. Abnormal…
View details →DOI: 10.1016/j.chest.2025.02.024 Negative / Null Result ReportOpen accessMedicine
McDermott MM, Zhang D, Zhao L et al. · 2025 · Journal of the American Heart Association
Background Supervised treadmill exercise improves walking performance in people with lower extremity peripheral artery disease, but benefits are not immediate. This study identified the time course of attaining meaningful improvement in…
View details →DOI: 10.1161/jaha.124.040058 Negative / Null Result ReportMedicine
Humes LE, Dhar S, Singh J · 2025 · International journal of audiology
Objective To evaluate use of the Hearing Handicap Inventory for the Elderly (HHIE), and its derivatives, as hearing-aid outcome measures. Design A targeted narrative literature review identified 12 studies in the primary research…
View details →DOI: 10.1080/14992027.2025.2511218 Failed Experiment ReportOpen accessMedicine
Dalbeni A, Vicardi M, Natola LA et al. · 2026 · Oncology research
Objectives The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and…
View details →DOI: 10.32604/or.2026.073063 Failed Experiment ReportMedicine
Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →DOI: 10.1016/j.arthro.2025.03.025 