Short Note
Mehrzad Tavakolian, Hassan Asadzadeh, S. Hosseini-Almadani et al. · 2025 · KMAN Counseling and Psychology Nexus
This study aimed to investigate the effect of content-related and content-unrelated humor on academic engagement among fourth-grade male students in Tehran. A quasi-experimental research design with pretest-posttest and control group…
View details →DOI: 10.61838/kman.ec.psynexus.3.11 Negative / Null Result ReportOpen accessEngineering (General). Civil engineering (General)
Xiu-An Ye, Shu-Hong Lin, Liang-Yu Chen et al. · 2025 · Sensing and Bio-Sensing Research
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), necessitates early diagnosis for effective patient care. Despite advancements in TB diagnostics, there remains an urgent need to discover innovative non-sputum-based methods to detect Mtb-specific antigens for TB patient identification. We have developed a polymer-based electrochemical biosensor for detecting an Mtb-specific antigen, the 6-kDa early secreted antigenic target (ESAT-6), in blood. Using a gold electrode (Au), the biosensor is created by electropolymerizing poly(3,4-ethylene dioxythiophene) with carboxyl grou
View details →DOI: 10.1016/j.sbsr.2025.100816 Negative / Null Result ReportOpen accessEnvironmental sciences
Abayneh Melaku, Tesfaye Admassu Abate, Argaw Ambelu · 2025 · Environmental Health Insights
Introduction: Hand hygiene is a cornerstone of infection prevention; however, the water and infrastructure used for handwashing can themselves become sources of microbial contamination. This study assessed the water quality and sanitary conditions of hand hygiene facilities in public and private hospitals in Addis Ababa, Ethiopia. Methods: A laboratory-based cross-sectional study was conducted from May to June 2025 in 10 hospitals. Forty samples were collected, including 20 tap water samples and 20 swab samples from tap handles. A sanitary survey evaluated water supply and hand hygiene station
View details →DOI: 10.1177/11786302251389704 Negative / Null Result ReportOpen accessMedicine
Dawid Schellingerhout, Lucia G LeRoux, Brian P Hobbs et al. · 2012 · PLoS ONE
Background and purpose The purpose of our study was to utilize a molecular imaging technology based on the retrograde axonal transport mechanism (neurography), to determine if oxaliplatin-induced neurotoxicity affects retrograde axonal transport in an animal model. Materials and methods Mice (n = 8/group) were injected with a cumulative dose of 30 mg/kg oxaliplatin (sufficient to induce neurotoxicity) or dextrose control injections. Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fluorescent dye were done (15 ug/20 uL) in the left calf muscles, and in vivo flu
View details →DOI: 10.1371/journal.pone.0045776 Negative / Null Result ReportOpen accessAnimal culture
X.L. Chen, L.Z. Gong, J.X. Xu · 2013 · Animal
In this study, antioxidant capability and protective effect of probiotics on reproductive damage induced by diet oxidative stress were investigated. Thirty male Sprague-Dawley rats were randomly divided into three groups with 10 rats in each group. The control group consumed a normal standard diet (5% fat, w/w). The other two treatment groups were fed with a high-fat diet (20% fat, w/w), and a high-fat diet supplemented with 2% probiotics (w/w), respectively. At the end of the experimental period, that is, after 6 weeks, rats were killed. Activities of superoxide dismutase (SOD), glutathione p
View details →DOI: 10.1017/s1751731112001528 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Seyed Ebrahim ESKANDARI, Alireza FIROOZ, Mansour NASSIRI-KASHANI et al. · 2019 · Iranian Journal of Parasitology
Background: We aimed to evaluate the safety of SinaAmpholeish in a double-blind, randomized, phase 1 clinical trial in healthy human volunteers. Methods: The study was carried out in DermaLab of Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran in 2012. A topical Nano-liposomal formulation of 0.4% Amphotericin B was developed against Leishmania under trade name of SinaAmpholeish. In this randomized, double-blind, right-left, comparative, phase I clinical trial, in 2 steps; 7 and 20 healthy volunteers were recruited and applied Si
View details →DOI: 10.18502/ijpa.v14i2.1130 Negative / Null Result ReportOpen accessSports medicine
Raziyeh Shiri, Mahsa Abdi, Sadegh Amani Shalamzari · 2022 · فیزیولوژی ورزش و فعالیت بدنی
Purpose: One of the changes that occurs in the vascular structure of skeletal muscle during exercise to resolving stress is the process of angiogenesis that has been considered by researchers. Thus, the aim of this study was to investigate the effect of 6-week resistance training with different Time under Tension (TUT) on some serum vascular growth factors in inactive girls.Methods: 20 female volunteer students (mean age 22.3 yrs) were randomly and equally divided into two groups with different TUT of (1s – 1s) and (2s – 4s). Resistance training was performed for 6-week, three times per week,
View details →DOI: 10.52547/joeppa.15.1.97 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Qin Zhang, Qin Zhang, Qin Zhang et al. · 2022 · Frontiers in Neurology
ObjectiveVertigo is very common in children, but the specific diagnosis and characteristics are not clear. The main objective of this study was to analyze the characteristics of caloric test (CT) and video head impulse test (vHIT) in vestibular migraine of childhood (VMC), probable vestibular migraine of childhood (PVMC), and recurrent vertigo of childhood (RVC), which can provide a reference value for their clinical diagnosis.MethodsWe selected VMC, PVMC and RVC patients under 18 years of age from the outpatient Department of Otolaryngology–Head and Neck Surgery between May 2021 and August 20
View details →DOI: 10.3389/fneur.2022.1050282 Negative / Null Result ReportOpen accessOphthalmology
Almeida DRP, Chin EK, Shah SS et al. · 2016 · Clinical Ophthalmology
David RP Almeida,1 Eric K Chin,2,3 Shaival S Shah,3 Benjamin Bakall,3 Karen M Gehrs,3 H Culver Boldt,3 Stephen R Russell,3 James C Folk,3 Vinit B Mahajan3,41VitreoRetinal Surgery PA, Minneapolis, MN, 2Retina Consultants of Southern California, Riverside, CA, 3Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, 4Omics Laboratory, University of Iowa, Iowa City, IA, USABackground: The role of pars plana vitrectomy (PPV) for endophthalmitis has evolved over recent decades but the literature is lacking on comparisons between small-gauge and 20-gauge vitrectomy.Objective: To eval
Negative / Null Result ReportOpen accessMedicine (General)
MR Yeganekhah, T Dadkhahe Tehrani, MT Ziyuayinejad · 2012 · Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
Background and Objectives: Coronary angiography is the golden diagnostic test for coronary heart disease that causes various vascular complications. To prevent these complications, patients are completely restricted in bed. Changing position is considered an alteration in routine care protocols after coronary angiography, improving patients’ comfort and satisfaction that is considered in current studies. The purpose of this study is the comparing different ways of position on vascular complications after coronary angiography. Methods: This clinical trial study was carried out in post angiograp
Negative / Null Result ReportOpen accessMedicine
Hashem Heshmati, Karim darvishpour · 2015 · مجله ایرانی آموزش در علوم پزشکی
Introduction: Clinical education is one of the most important aspects of medical and paramedical students' education and has a determining role in the professional future of these students as well as other professionals in health care. So this study aimed to evaluate the effective factors in the quality of clinical education from the viewpoints of operation room and Anesthesiology students in Torbat Heydarieh University of Medical Sciences. Methods: In this descriptive cross-sectional study, a number of 115 students of operation room and Anesthesiology studying in Torbat Heydarieh university o
Failed Experiment ReportOpen accessMedicine
Jan Walleczek, Nikolaus von Stillfried, Stefan Schmidt et al. · 2025 · PLoS ONE
This metascientific project studied the replicability of Bem Experiment 1, which had claimed a precognitive effect, i.e., the ability to successfully guess the outcome of future random events (Bem. J Pers Soc Psychol. 2011;100: 407-25). The use of advanced methodologies-based on the advanced meta-experimental protocol (AMP) and transparent psi project (TPP) procedures-reduced the risk of false discoveries as a function of (i) confirmation bias, (ii) non-transparency, and (iii) intrinsic measurement bias. The combined AMP-TPP test strategy performed three replication studies with a total of 26,
View details →DOI: 10.1371/journal.pone.0335330 Failed Experiment ReportOpen accessPsychology
Smederevac Snežana, Mitrović Dušanka · 2005 · Psihologija
Jeffrey Gray has modified Eysenck's system by rotating the dimensions of extraversion and neuroticism by 45 degrees, which resulted in two new dimensions: impulsivity (behavioral approach system) and anxiety (behavioral inhibition system). The main purpose of this study was to examine psychometric properties of the BIS/BAS scale, inventory for assessment of dimensions included in Gray's theory, in order to, also, test the foundation of the Gray's constructs themselves. 476 participants were included, age 17 to 77. All subjects completed The BIS/BAS scale (Carver & White, 1994) and The Big Five
View details →DOI: 10.2298/psi0503311s Negative / Null Result ReportOpen accessMedicine
Caitlin N Jacques, Anna K Hulbert, Shelby Westenskow et al. · 2020 · PLoS ONE
BACKGROUND:Recently, it was found that 1% Phytagel plates used to conduct Arabidopsis thaliana seedling phenotypic analysis no longer reproduced previously published results. This Phytagel, which is produced in China (Phytagel C), has replace American-made Phytagel (Phytagel), which is no longer commercially available. In this study, we present the impact of Phytagel produced in the United States vs. China on seedling phenotypic analysis. As a part of this study, an alternative gelling agent has been identified that is capable of reproducing previously published seedling morphometrics. RESULTS
View details →DOI: 10.1371/journal.pone.0228515 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Julie Van, Sam E. Nielsen, C. Brock Kirwan · 2022 · NeuroImage: Reports
Common research practices in neuroimaging studies using functional magnetic resonance imaging may produce outcomes that are difficult to replicate. Results that cannot be replicated have contributed to a replication crisis in psychology, neuroscience, and other disciplines over the years. Here we replicate two previous papers in which the authors present two analysis paths for a dataset in which participants underwent fMRI while performing a recognition memory test for old and new words. Both studies found activation in the medial temporal lobe including the hippocampus, with the first demonst
View details →DOI: 10.1016/j.ynirp.2022.100135 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Shunchuan Zhang, Lauren E Springer, Han-Zhi Rao et al. · 2021 · PLoS Pathogens
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV from the site of infection. In theory, such dissemination should expose CMV to cell-mediated immunity and thus necessitate evasion of T cells and NK cells. However, this hypothesis remains untested. We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR-142-3p in the essential viral gene IE3. This virus diss
View details →DOI: 10.1371/journal.ppat.1009255 Failed Experiment ReportOpen accessImmunologic diseases. Allergy
Jessica J. Harrison, Wilson Nguyen, Mahali S. Morgan et al. · 2024 · npj Vaccines
Abstract In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current approved human and veterinary vaccines are derived from genotype (G) III JEV strains, we used the recently described insect-specific Binjari virus (BinJV) chimeric flavivirus vaccine technology to produce a JEV GIV vaccine candidate. Herein we describe the production of a chimeric virus displaying the structural prM and E proteins of a JEV GIV
View details →DOI: 10.1038/s41541-024-00903-2 Failed Experiment ReportOpen accessNeurology. Diseases of the nervous system
Baker David, Giovannoni Gavin, Jackson Samuel J · 2011 · Journal of Neuroinflammation
Abstract Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell egress from lymph organs. In addition, it is brain penetrant and has been shown to exert multiple effects on nervous system cells. Methods In this study, the impact of fingolimod and other sphingosine-1-phosphate receptor active molecules following lysophosphotidyl choline-induced demyelination was examined in the rat telencephalon reagg
View details →DOI: 10.1186/1742-2094-8-76 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lars Hausfeld, Lars Hausfeld, Niels R. Disbergen et al. · 2021 · Frontiers in Neuroscience
Numerous neuroimaging studies demonstrated that the auditory cortex tracks ongoing speech and that, in multi-speaker environments, tracking of the attended speaker is enhanced compared to the other irrelevant speakers. In contrast to speech, multi-instrument music can be appreciated by attending not only on its individual entities (i.e., segregation) but also on multiple instruments simultaneously (i.e., integration). We investigated the neural correlates of these two modes of music listening using electroencephalography (EEG) and sound envelope tracking. To this end, we presented uniquely com
View details →DOI: 10.3389/fnins.2021.635937 Negative / Null Result ReportOpen accessMedicine
Karen E Mulak, Hannah S Sarvasy, Alba Tuninetti et al. · 2021 · PLoS ONE
Adapting laboratory psycholinguistic methods to fieldwork contexts can be fraught with difficulties. However, successful implementation of such methods in the field enhances our ability to learn the true extent and limitations of human behavior. This paper reports two attempts to run word learning experiments with the small community of Nungon speakers in Towet village in the Saruwaged Mountains, Papua New Guinea. A first attempt involved running a cross-situational task in which word-object pairings were presented ambiguously in each trial, and an explicit word learning task in which pairings
View details →DOI: 10.1371/journal.pone.0257393 Negative / Null Result ReportOpen accessAstrophysics
Mohit Bhardwaj, Victoria M. Kaspi, K. W. Masui et al. · 2025 · The Astrophysical Journal
Despite hundreds of detected fast radio bursts (FRBs), the faint-end slope ( γ ) of their energy distribution remains poorly constrained, hindering understanding of whether bright, cosmological FRBs and faint, Galactic magnetar SGR 1935+2154-like bursts share a common origin. In this study, we constrain this faint-end slope, modeled with a Schechter-like distribution, by searching for potential associations between bursts from the CHIME/FRB Catalog-1 and galaxies in the Local Volume. We crossmatched CHIME/FRB Catalog-1 FRBs with 495 Local Volume galaxies within 21 Mpc, identified from the HECA
View details →DOI: 10.3847/1538-4357/aded17 Replication FailureOpen accessNuclear and particle physics. Atomic energy. Radioactivity
The CMS collaboration, A. Hayrapetyan, A. Tumasyan et al. · 2025 · Journal of High Energy Physics
Abstract Results are presented for a test of the compositeness of the heaviest charged lepton, τ, using data collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 13 TeV at the CERN LHC. The data were collected in 2016–2018 and correspond to an integrated luminosity of 138 fb −1. This analysis searches for tau lepton pair production in which one of the tau leptons is produced in an excited state and decays to a ground state tau lepton and a photon. The event selection consists of two isolated tau lepton decay candidates and a high-energy photon. The mass of
View details →DOI: 10.1007/jhep06(2025)006 Replication FailureOpen accessAstrophysics
J. Ming, M. A. Papa, H.-B. Eggenstein et al. · 2024 · The Astrophysical Journal
We perform a search for continuous nearly monochromatic gravitational waves from the central compact objects associated with the supernova remnants Vela Jr. and G347.3. Over 10 ^18 different waveforms are considered, covering signal frequencies between 20 and 1300 Hz (20 and 400 Hz) for G347.3-0.5 (Vela Jr.) and a very broad range of frequency derivatives. The data set used for this first search is from the second observing run of LIGO (O2). Thousands of volunteers donating compute cycles through the computing project Einstein@Home have made this endeavor possible. Following the Einstein@Home
View details →DOI: 10.3847/1538-4357/ad8b9e Replication FailureOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
N. V. Dmitrieva, M. V. Eidelshtein, V. V. Aginova et al. · 2019 · Сибирский онкологический журнал
The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resi
View details →DOI: 10.21294/1814-4861-2019-18-2-28-34 Methods Dead-EndOpen accessMedicine
Rukhsana Tumrani, S. Sabahat Haider, Mehvish Sana · 2024 · Pakistan Journal of Medical Research
Background: Serum electrolytes are one of the most frequently requested tests in patients from critical care settings. Methodsfor estimation of serum electrolytes include direct and indirect ion selective electrode (ISE). In case of indirect ISE, the pre-analytical dilution step can result in pseudonormonatremia or pseudohypernatremia in setting of hypoalbuminemia. Discrepancy in sodium results can lead to the misdiagnosis and mismanagement of critically ill patients. Objective: To evaluate the difference of mean serum sodium level measured by direct and indirect ISE in critically ill patients
Negative / Null Result ReportOpen access
Miftahul Jannah, Zulpikar Zulpikar, Muliani Muliani · 2021 · Acta Aquatica
Tilapia (Oreochromis niloticus) is a type of freshwater fish that is widely cultivated by Indonesians. The problem that often arises in cultivation is lack of water quality. One of the ways to improve water quality is by using aquaponics…
View details →DOI: 10.29103/aa.v8i3.3711 Replication FailureOpen accessDiseases of the digestive system. Gastroenterology
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
View details →DOI: 10.1177/17562848241309870 Negative / Null Result ReportOpen accessMedicine
Teerachate Nantakeeratipat · 2026 · Frontiers in Digital Health
BackgroundLarge Language Models (LLMs) in healthcare holds immense promise yet carries the risk of perpetuating social biases. While artificial intelligence (AI) fairness is a growing concern, a gap exists in understanding how these models perform under conditions of clinical ambiguity, a common feature in real-world practice.MethodsWe conducted a study using an ambiguity-probe methodology with a set of 42 sociodemographic personas and 15 clinical vignettes based on the 2018 classification of periodontal diseases. Ten were clear-cut scenarios with established ground truths, while five were int
View details →DOI: 10.3389/fdgth.2025.1687820 Negative / Null Result ReportOpen accessGynecology and obstetrics
Jingting Liu, Yijun Dong, Yawei Zhou et al. · 2024 · BMC Pregnancy and Childbirth
Abstract Background Observational epidemiological studies suggested that immunological dysregulation and inflammation play a significant role in the placental and renal dysfunction that leads to maternal hypertension. The immunophenotypes' possible causalities with hypertensive disease of pregnancy remain ambiguous. We performed two-sample Mendelian randomization (MR) analyses to comprehensively investigate the causal effect of immunophenotypes on hypertensive disorder of pregnancy (HDP). Methods The large-scale genome-wide association studies (GWASs) data on immunological traits was taken fro
View details →DOI: 10.1186/s12884-024-06950-w Negative / Null Result ReportOpen accessMedicine (General)
Emily Sheppard, MScPT, Michael Smyth, MSc, Todd Dow, BSc et al. · 2020 · Archives of Rehabilitation Research and Clinical Translation
Objective: To assess the effect the Pre-clerkship Residency Exploration Program (PREP) had on student career interest and improving understanding of physical medicine and rehabilitation (PMR). Design: During a 2-week program, students were exposed to a PMR elective, workshop, career presentation, and panel discussion with PMR residents. Interest and understanding were assessed using pre- and postprogram questionnaires. Setting: PREP was held at a Canadian medical school during the summer between the second and third years of undergraduate medical training. Participants: Second-year medical stu
View details →DOI: 10.1016/j.arrct.2019.100035 