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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21374 results · page 658 of 713

Negative / Null Result ReportMedicine

Non-Coding RNAs as Emerging Biomarkers in HPV-Associated Cervical Precancer and Cancer: Molecular Mechanisms and Clinical Perspectives.

Terrinoni M, Caputo V, Palisciano M et al. · 2026 · Genes

Background/Objectives: Cervical cancer is mainly driven by persistent infection with high-risk human papillomaviruses (HPV), particularly HPV16 and HPV18. Despite advances in cytology, HPV-DNA testing and vaccination, challenges remain in…

View details →DOI: 10.3390/genes17060714
Negative / Null Result ReportMedicine

Exosomal MALAT1 expression associated with the cardioprotective effects of carvacrol in acute doxorubicin-induced cardiac injury: Potential involvement of Nrf2/Keap1-related signaling.

Ahmadi T, Ghorbanzadeh V, Hosseinnejad E et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Doxorubicin remains an indispensable component of many chemotherapy regimens; however, its clinical use is limited by dose-dependent cardiotoxicity that may progress to dilated cardiomyopathy and heart failure. In the present study, we…

View details →DOI: 10.1016/j.biopha.2026.119606
Negative / Null Result ReportMedicine

Thyroid Autoimmunity in Polycystic Ovary Syndrome: Phenotype Distribution, HDL-Cholesterol, and Data-Driven Clusters in a Retrospective Cohort Study.

Mogoș RA, Carauleanu A, Vasilache IA et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Autoimmune thyroiditis (AIT) is often reported patients with PCOS, and may co-occur with altered metabolic risk markers. The aims of this study were to assess baseline differences according to thyroid…

View details →DOI: 10.3390/medicina62061184
Negative / Null Result ReportMedicine

Abdominal massage improves intestinal barrier function via the TLR4/MyD88/NF-κB signaling pathway in obesity-associated T2DM rats.

Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports

Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…

View details →DOI: 10.1038/s41598-026-57589-w
Negative / Null Result Report

Inflammation-Driven Epithelial Plasticity in Oral Mucosa Adjacent to Long-Term Restorative Materials: A Retrospective Histopathological and Immunohistochemical Study

Mehedinti R, Earar K, Stefanescu A et al. · 2026 · Preprint

Background: and Objectives: Long-standing contact between oral mucosa and restorative materials may be associated with adaptive epithelial and stromal remodeling. This study evaluated non-dysplastic epithelial plasticity and cumulative…

View details →DOI: 10.20944/preprints202606.1076.v1
Negative / Null Result ReportMedicine

Urate-lowering therapy adherence among gout patients in Southwest China: A cross-sectional study of determinants and regional disparities.

Tang Z, Huang C, Qiu G et al. · 2026 · Clinical rheumatology

Objective Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China. Methods A cross-sectional…

View details →DOI: 10.1007/s10067-026-08232-6
Negative / Null Result ReportMedicine

Incidence and risk factors of acute blood pressure drops during circular-array pulsed-field ablation for pulmonary vein isolation.

Hashimoto S, Ishiguchi H, Yoshiga Y et al. · 2026 · Heart rhythm

Background Data regarding acute blood pressure (BP) drops during pulsed-field ablation (PFA) for pulmonary vein isolation (PVI) are limited. Objective This study aimed to determine the incidence and risk factors of acute BP drops during…

View details →DOI: 10.1016/j.hrthm.2026.02.050
Negative / Null Result ReportMedicine

EXPRESS: Exaggerated Self-Referencing in Body Dysmorphic Disorder.

Richards-Brown M, Castiello de Obeso S, Dennison R et al. · 2026 · Quarterly journal of experimental psychology (2006)

The self-prioritisation effect demonstrates that people have a bias to learn and process self-relevant compared to other-relevant information. This tendency may provide a tool to understand how body image and perception become disrupted in…

View details →DOI: 10.1177/17470218261465670
Negative / Null Result ReportMedicine

Predictors of Ageism among Social Work Students and Practitioners in Greece: The Role of Aging Anxiety and Experiential Factors.

Micheli K, Koutra K, Markakis G · 2026 · International journal of aging & human development

This study examines whether aging anxiety (based on terror management theory) or demographic and experiential factors better explain attitudes toward older adults among social work students and professionals. Cross-sectional data were…

View details →DOI: 10.1177/00914150261456748
Negative / Null Result ReportMedicine

Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study.

Daniel N, Papadimitriou N, Chatziioannou AC et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Background and aims Recent data suggest a role for the gut microbiome in the development of hepatocellular carcinoma. We investigated associations of gut microbiome abundances and concentrations of circulating bacteria-associated…

View details →DOI: 10.1016/j.dld.2026.05.008
Negative / Null Result ReportMedicine

Ocular toxoplasmosis in Latin American and European patients: clinical characteristics, visual outcomes, and recurrence patterns.

Shamani-Aminian A, Adán A, Llorenç V · 2026 · Journal of ophthalmic inflammation and infection

Ocular toxoplasmosis is the most common cause of posterior uveitis worldwide and a major cause of visual impairment. Previous studies suggest that the disease may follow a more aggressive clinical course in patients from Latin America;…

View details →DOI: 10.1186/s12348-026-00615-9
Negative / Null Result ReportMedicine

NELA, P-POSSUM, and Paraspinal Muscle Index in risk stratification of elderly patients undergoing emergency laparotomy.

Ugur MA, Okut G, Buyuktoka RE et al. · 2026 · BMC geriatrics

Background Emergency laparotomy in older adults is associated with substantial morbidity and mortality, necessitating accurate and rapid preoperative risk stratification. Established risk models such as National Emergency Laparotomy Audit…

View details →DOI: 10.1186/s12877-026-07539-y
Negative / Null Result ReportMedicine

Thoracic radiographs in dogs with gastric dilatation-volvulus rarely affect the decision to proceed with surgery or survival to discharge: a 25-year retrospective study of 176 cases.

Lee J, DeGroot W · 2026 · Journal of the American Veterinary Medical Association

Objective To assess whether thoracic radiographs in dogs with gastric dilatation-volvulus (GDV) are associated with the decision to proceed with surgery and survival to discharge. Methods A retrospective cohort study of dogs with GDV…

View details →DOI: 10.2460/javma.25.12.0871
Negative / Null Result ReportMedicine

When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda.

Gunderson AK, Kwon T, Kumarasinghe Y et al. · 2026 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Background Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting. Methods We conducted a cross-sectional…

View details →DOI: 10.1093/trstmh/trag045
Failed Experiment ReportMedicine

Differential analysis of CACNA1C polymorphisms among patients with depression and bipolar disorder and exploration of sleep as a mediator.

Xu Z, Guo Y, Shao Y et al. · 2026 · Journal of affective disorders

Background Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this…

View details →DOI: 10.1016/j.jad.2026.122152
Negative / Null Result ReportMedicine

Treatment failure in adolescents and young people living with HIV: a cohort study.

Piran CMG, Cargnin AVE, Mori MM et al. · 2026 · Revista brasileira de enfermagem

Objectives to analyze factors associated with poor adherence and loss to follow-up among adolescents and young people living with HIV. Methods ambidirectional cohort study of 512 adolescents and young people with HIV receiving treatment at…

View details →DOI: 10.1590/0034-7167-2025-0340
Negative / Null Result ReportMedicine

Higher social vulnerability is associated with lower rates of peripheral nerve decompression surgery.

Sriram N, Muller R, Jain R et al. · 2026 · Clinical neurology and neurosurgery

Objective Surgical decompression is often needed to relieve symptoms and prevent long-term disability from compressive peripheral nerve pathologies. This study applied the Social Vulnerability Index (SVI) to characterize utilization…

View details →DOI: 10.1016/j.clineuro.2026.109545
Negative / Null Result ReportMedicine

ESR1 as a candidate gene for adolescent idiopathic scoliosis pathogenesis in North-West Indian population.

Kowra S, Singh H, Singh V et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Introduction Estrogens are crucial in the development and growth of skeletal systems. Estrogen receptor alpha (ESRα) and beta (ESRβ) are crucial regulators of estrogen response. Estrogen receptor genes (ESR1 and ESR2) have been extensively…

View details →DOI: 10.1007/s00586-026-10065-5