Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules
Zierke L; John D; Gischke M; Trà̂n QT; Sendler M; Weiss FU; Bornscheuer UT; Ritter C · 2024 · Cell. Mol. Life Sci
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-localization are not fully…
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Metadata source: Europe PMC