Negative / Null Result ReportOpen accessMedicine
Swati Dogra , Altaf Hussain Mir , Suhail Sidiq et al. · 2025 · Asian Journal of Medical Sciences
Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP. Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice.
View details →DOI: https://doi.org/10.71152/ajms.v16i5.4484 Negative / Null Result ReportOpen accessDermatology
JI Liyue, QIU Xiaonan, WANG Xijuan et al. · 2025 · Pifu-xingbing zhenliaoxue zazhi
[Objective] To evaluate the clinical efficacy and safety of intralesional injection of heparin sodium versus carbon dioxide (CO2) laser ablation in the treatment of xanthelasma palpebrarum. [Methods] A total of 38 patients with Grade Ⅰ-Ⅲ xanthelasma and normal blood lipid levels were retrospectively enrolled, and divided into two groups based on the treatment modality: the heparin sodium group (n=20) treated with intralesional injection of heparin sodium and the CO2 laser group (n=18) treated with CO2 laser ablation. The primary and secondary outcomes were compared between the two groups, incl
View details →DOI: 10.3969/j.issn.1674-8468.2025.12.003 Negative / Null Result ReportOpen accessOtorhinolaryngology
José Ailton Oliveira Carneiro, Taiza Elaine Grespan Santos-Pontelli, José Fernando Colafêmina et al. · 2013 · Brazilian Journal of Otorhinolaryngology
Para manter o equilíbrio postural, algumas estratégias posturais são normalmente usadas. OBJETIVO: Avaliar as estratégias posturais de jovens e idosos em diferentes condições sensoriais usando um sistema de sensores eletromagnéticos tridimensionais posicionados na primeira vértebra torácica e região sacral. Também reportamos valores de oscilação postural dos jovens e idosos. MÉTODO: Estudo transversal observacional. Participaram do estudo 25 jovens e 16 idosas. O equipamento PolhemusTM com dois sensores foi usado para avaliar os parâmetros de oscilação postural (deslocamento máximo, velocidade
Negative / Null Result ReportMedicine
Kluger N · 2026 · European journal of epidemiology
The recent Swedish study by Rietz Liljedahl et al. examining melanoma riskamong tattooed individuals has prompted critical discussion regarding a potential causal linkbetween tattoos and melanoma. While concerns persist that tattoo…
View details →DOI: 10.1007/s10654-026-01370-w Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Aline Cecy Rocha de Lima, Wandrey Roberto dos Santos Brito, Luciana Cristina Coelho Pantoja Santos et al. · 2026 · Brazilian Journal of Infectious Diseases
Introduction: Fas and FasL are known modulators of cellular apoptosis in immunoregulation of the innate immune response, as well as in the elimination of defective cells, and may be associated with antiviral activity of HTLV-1 – infected cells. Understanding the immunological mechanisms involved in the progression of HTLV-1 – associated diseases may contribute to predicting the clinical prognosis of infected individuals. Objective: To evaluate mRNA expression of the apoptotic modulators FAS and FASL in patients infected with HTLV-1. Methods: A total of 54 HTLV-1 – infected individuals were eva
View details →DOI: 10.1016/j.bjid.2026.105460 Negative / Null Result ReportOpen accessTechnology
Sara Havrlišan, Martina Tokić, Štefanija Klarić et al. · 2026 · Tehnički Glasnik
This research analyses the impact of infill density and layer thickness on the tensile strength of test samples fabricated using FDM 3D printing, with a particular focus on comparing samples produced with and without an adhesion layer. A two-factor factorial experimental design was employed, consisting of two levels and three replications. The infill density (20% and 50%) and layer thickness (0.1 mm and 0.2 mm) were defined as input variables, while tensile strength served as the output variable. Statistical methods, such as ANOVA, were used to analyse the experimental data and evaluate the si
View details →DOI: 10.31803/tg-20251030095053 Negative / Null Result ReportOpen accessDentistry
Marcela Charantola Rodrigues, Rafael Francisco Lia Mondelli, Gabriela Ulian Oliveira et al. · 2013 · Journal of Applied Oral Science
Objective: To evaluate the in vitro changes on the enamel surface after a micro-abrasion treatment promoted by different products. Material and Methods: Fifty (50) fragments of bovine enamel (15 mm × 5 mm) were randomly assigned to five groups (n=10) according to the product utilized: G1 (control)= silicone polisher (TDV), G2= 37% phosphoric acid (3M/ESPE) + pumice stone (SS White), G3= Micropol (DMC Equipment), G4= Opalustre (Ultradent) and G5= Whiteness RM (FGM Dental Products). Roughness and wear were the responsible variables used to analyze these surfaces in four stages: baseline, 60 s an
View details →DOI: 10.1590/1678-7757201302117 Negative / Null Result ReportOpen accessMedicine
Chao-Lun Lai, Ching-Fen Wu, Raymond Nien-Chen Kuo et al. · 2015 · PLoS ONE
The clinical outcomes of different limus-based drug-eluting stents (DES) in a real-world setting have not been well defined. The aim of this study was to investigate the clinical outcomes of three different limus-based DES, namely sirolimus-eluting stent (SES), Endeavor zotarolimus-eluting stent (E-ZES) and everolimus-eluting stent (EES), using a national insurance claims database. We identified all patients who received implantation of single SES, E-ZES or EES between January 1, 2007 and December 31, 2009 from the National Health Insurance claims database, Taiwan. Follow-up was through Decemb
View details →DOI: 10.1371/journal.pone.0122860 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Suzana Müller, Carlos Fernando de Magalhães Francesconi, Ismael Maguilnik et al. · 2007 · Arquivos de Gastroenterologia
BACKGROUND: The cleansing of the colon for a colonoscopy exam must be complete so as to allow the visualization and inspection of the intestinal lumen. The ideal cleansing agent should be easily administered, have a low cost, and minimum collateral effects. Sodium picosulfate together with the magnesium citrate is a cathartic stimulant and mannitol is an osmotic laxative, both usually used for this purpose. AIMS: Assess the colon cleanliness comparing the use of mannitol and sodium picosulfate as well as evaluate the level of patient satisfaction, the presence of foam, pain, and abdominal dist
View details →DOI: 10.1590/s0004-28032007000300013 Negative / Null Result ReportOpen accessMedicine
Feingold KR · 2000
Abnormalities in lipid metabolism are very commonly observed in patients who are obese. Approximately 60-70% of patients with obesity are dyslipidemic. The lipid abnormalities in patients who are obese include elevated serum TG, VLDL,…
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu et al. · 2017 · BMC Musculoskeletal Disorders
Abstract Background Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. Methods Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers. They were harvested from five
View details →DOI: 10.1186/s12891-017-1749-0 Negative / Null Result ReportOpen accessVocational rehabilitation. Employment of people with disabilities
Uzair Ahmad, Babar Ali, Seema Gul et al. · 2025 · Journal Riphah College of Rehabilitation Sciences
Background: Regular physical activity has a positive impact on brain function, improves perception, and significantly influences academic achievement. Objective: This study aimed to determine the association of physical activity, motor skills, and academic performance in high school students in Hayatabad, Peshawar. Methodology: A total of 349 students were recruited using stratified random sampling from both public and private high schools within the Hayatabad region, Peshawar, Pakistan from December 2020 to May 2021. Only students in 9th and 10th grades from public and private schools who met
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Rudra Paul, Arijit Ghosh, Nilanjan Sengupta et al. · 2022 · National Journal of Physiology, Pharmacy and Pharmacology
Background: Type 2 diabetes mellitus (DM) is mainly due to multifactorial of which insulin resistance and deficiency in the incretion are two important pathophysiological factors. Vildagliptin, an oral hypoglycemic agent, acts by inhibiting dipeptidyl peptidase-4 enzyme, often uses as a first line drug along with metformin to enhance outcome. Aim and Objective: The aim of this study was to compare the effectiveness and safety of vildagliptin 50 mg twice daily dose with vildagliptin 100 mg sustained release tablet (SR) once daily in Type 2 DM patients and uncontrolled with metformin monotherapy
View details →DOI: 10.5455/njppp.2022.12.062851202217862022 Negative / Null Result ReportOpen accessMedicine
Davidović Lazar B., Kuzmanović Ilija B., Kostić Dušan M. et al. · 2002 · Srpski Arhiv za Celokupno Lekarstvo
The infection of the previously implanted vascular graft at the groin, is associated with great mortality and morbidity rate [1]. The authors present a retrospective study in which they analyzed management of infected vascular prostheses at the groin, using obturator bypass in 26 cases, and "lateral" bypass in 15 cases. The indications for obturator bypass reconstructions included: 20 infections of aorto-femoral grafts, two infected pse udoaneurysms in the groin after RTA of the superficial femoral artery, and 4 infections of iliac-femoral grafts. The indications for lateral bypass reconstruct
View details →DOI: 10.2298/sarh0202027d Negative / Null Result ReportOpen accessPhysics
Zihao Qiu, Siyu Chen, Zixin Feng et al. · 2025 · Frontiers in Physics
Futures, as significant financial derivatives, play a crucial role in financial markets by fulfilling price discovery functions and providing efficient risk hedging tools. Against the backdrop of geopolitical conflicts, market risk emerges not only from external shocks and random fluctuations but also from strategic interactions among diverse participants including hedgers, speculators, arbitrageurs, and regulators. This study integrates traditional VaR theory with machine learning methods to systematically examine risk characteristics and transmission mechanisms in the sugar futures market un
View details →DOI: 10.3389/fphy.2025.1674717 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
NING Li, ZHANG Yanyan, ZENG Jinfeng et al. · 2026 · Zhongguo shuxue zazhi
[Objective] To statistically analyze the association between blood donation intervals and the incidence of adverse reactions to blood donation based on blood donor data from Shenzhen. [Methods] Basic data and records of adverse reactions to blood donation among voluntary whole blood donors in Shenzhen from January 2017 to June 2025 were extracted. A total of 795 404 whole blood donations were recorded, including 502 743 from males and 292 661 from females, with 1 088 and 751 cases of adverse reactions, respectively. Analyses were performed using R software, including restricted cubic spline (R
View details →DOI: 10.13303/j.cjbt.issn.1004-549x.2026.03.006 Negative / Null Result ReportMedicine
Sowinska N, Ochota M, Partyka A et al. · 2026 · Animal reproduction science
The domestic cat (Felis catus) provides a valuable model for developing assisted reproductive technologies (ART) that can be applied to the conservation of endangered wild felids. A major limitation in the application of ART is the…
View details →DOI: 10.1016/j.anireprosci.2026.108147 Negative / Null Result ReportOpen accessMedicine
Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio et al. · 2022 · BMJ Open
Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD
View details →DOI: 10.1136/bmjopen-2021-060305 Negative / Null Result ReportOpen accessSurgery
Engin Kölükçü, Şahin Kılıç, Doğan Atılgan et al. · 2018 · Journal of Urological Surgery
Objective:The association of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with postoperative tumor stage and Fuhrman nuclear grade was investigated in patients with renal cell carcinoma (RCC).Materials and Methods:Data of 123 patients, who were operated due to RCC, in our clinic was analysed. NLR and PLR were evaluated in patients who were classified according to tumor stage (T1 and T2 low stage, T3 and T4 high stage) and Fuhrman nuclear grade (grade 1 and 2 low-grade, grade 3 and 4 high-grade). NLR and PLR were compared using Levene’s test between t
View details →DOI: 10.4274/jus.2133 Negative / Null Result ReportOpen accessPediatrics
LI Yue, XIE Zhiwei, TANG Yanjing, LI Benshang · 2026 · Linchuang erke zazhi
Objective Antigen escape, particularly CD19 loss, limits the efficacy of CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy in children with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). PAX5 gene variations have been shown to disrupt CD19 expression stability and increase relapse risk. This study aimed to compare the therapeutic efficacy of two CD19/CD22 dual-targeting CAR-T strategies, namely co-infusion versus bicistronic construct, in children with R/R B-ALL harboring PAX5 gene variations. Methods A retrospective analysis was conducted on the clinical dat
View details →DOI: 10.12372/jcp.2026.26e0038 Negative / Null Result ReportOpen accessDentistry
Mohammad Tavakoli, Ensiyeh Bateni, Mansour Rismanchian et al. · 2012 · Dental Research Journal
Background: The greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. Nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase biomineralization for periodontal regeneration and dental implants. Considering the fact that interaction between periodontal cells and bone graft materials are important for periodontal lesion regeneration, the present study was undertaken to investigate the genotoxicity of a novel synthesized nanoscale bioactive glass and compared it with No
View details →DOI: 10.4103/1735-3327.99831 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Pedro Davila-Piñón, Pedro Davila-Piñón, Alba Nogueira-Rodríguez et al. · 2024 · Frontiers in Oncology
BackgroundPolyDeep is a computer-aided detection and classification (CADe/x) system trained to detect and classify polyps. During colonoscopy, CADe/x systems help endoscopists to predict the histology of colonic lesions.ObjectiveTo compare the diagnostic performance of PolyDeep and expert endoscopists for the optical diagnosis of colorectal polyps on still images.MethodsPolyDeep Image Classification (PIC) is an in vitro diagnostic test study. The PIC database contains NBI images of 491 colorectal polyps with histological diagnosis. We evaluated the diagnostic performance of PolyDeep and four e
View details →DOI: 10.3389/fonc.2024.1393815 Negative / Null Result ReportOpen accessMedicine
Lara Kakabas, Krzysztof Piersiala, Aeneas Kolev et al. · 2023 · Scientific Reports
Abstract A history of allergies has been said to be associated with a lower risk of head and neck cancer compared to the general population. However, it is not known whether having an allergic sensitization influences the prognosis and advancement of cancer disease. Thus, the aim of the study was to investigate the relationship between allergic sensitization and oral cancer advancement and patient survival. Allergen-specific IgE antibodies were investigated by ImmunoCAP™ Rapid in consecutive 80 patients with oral cancer. ImmunoCAP Rapid system tests a mix of representative inhalant allergens s
View details →DOI: 10.1038/s41598-023-48879-8 Negative / Null Result Report
Chebe PC, Martens K · 2026 · Preprint
Abstract The construct of sense of place (SoP) has gained growing interdisciplinary attention for its ability to capture the intricate relationship between people and their environments, a key consideration in urban planning. Despite this…
View details →DOI: 10.21203/rs.3.rs-9766699/v1 Negative / Null Result ReportOpen accessMedicine
Alberta Simona Tinu, Doina Lucia Ghergic, Mirel Stoian et al. · 2018 · Romanian Journal of Stomatology
Objectives. We performed a retrospective observational analytical study to determine the incidence of complications in the oral cavity in a group of patients diagnosed with diabetes mellitus. Material and method. We have studied 68 diabetic patients, who have been referred to dental practices seeking specialized treatment. Patient data sheets were centralized, categorized, and statistically processed with IBM SPSS Statistics 22 and Microsoft Excel 2010 depending on: sex of patients, age, type of diabetes, time elapsed from diagnosis of diabetes, the environment of origin of the patients, the l
View details →DOI: 10.37897/rjs.2018.1.1 Negative / Null Result ReportOpen accessMedicine
Yunsur Çevik, Fatma Nur Karaarslan, Şeref Kerem Çorbacıoğlu et al. · 2022 · Eurasian Journal of Emergency Medicine
Aim:The aim of this study was to examine the relationship between immature granulocyte (IG) counts and the severity of the disease and to evaluate the effectiveness of IG in predicting the poor outcomes in polymerase chain reaction-confirmed Coronavirus disease-2019 (COVID-19) cases.Materials and Methods:The study was conducted prospectively and observationally at the emergency department. Patients were divided into three groups according to the clinical severity indicators such as mild, moderate and severe. The IG level was measured from the whole blood samples taken at the admission to the e
View details →DOI: 10.4274/eajem.galenos.2021.79836 Negative / Null Result ReportOpen accessMedicine
Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė et al. · 2017 · Acta Medica Lituanica
Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls. Materials and Methods.
View details →DOI: 10.6001/actamedica.v24i2.3487 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Hao Lu, Shikuan Li, Chengzhi Wang et al. · 2025 · BMC Gastroenterology
Abstract Objective To investigate the impact of peritoneal lavage on the incidence of intra-abdominal abscess (IAA) after laparoscopic appendectomy (LA) in adults with perforated appendicitis. Methods Clinical data from adult patients intraoperatively diagnosed with perforated appendicitis and undergoing LA at the Affiliated Hospital of Qingdao University between January 2020 and January 2025 were retrospectively analyzed. Patients were divided into a no-peritoneal lavage group and a peritoneal lavage group based on whether peritoneal lavage was performed. A total of 128 patients were included
View details →DOI: 10.1186/s12876-025-04397-7 Negative / Null Result ReportOpen accessMedicine (General)
Maria Aparecida A.O. Serra, PhD, Arlene T. Medeiros, RN, Mateus D. Torres, RN et al. · 2021 · Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: الأعراض الهضمية هي الشكاوى الأكثر شيوعا من قبل المرضى الذين يسعون للحصول على خدمات الرعاية الصحية الأولية. تهدف هذه الدراسة إلى تحديد أعراض الجهاز الهضمي وتحديد ارتباطها بنتائج التنظير المعوي العلوي لدى المرضى الذين عولجوا في مركز التنظير العام في شمال شرق البرازيل. طرق البحث: أجرينا دراسة مقطعية باستخدام بيانات ٧٥١ مريضا يعانون من أعراض الجهاز الهضمي ولديهم حاجة للتنظير المعوي العلوي. حددنا الارتباط بين هذه المتغيرات من خلال اختبار فيشر الدقيق وحسبنا نسبة الاحتمالات. النتائج: أظهرت النتائج أن ٨٣٪ من المرضى يعانون من آلام شرسوفية، ٧٢.٦٪ من الامتلاء بعد الأكل، و٧٢.٣٪ من حرق
View details →DOI: 10.1016/j.jtumed.2020.12.020 Negative / Null Result ReportOpen accessDermatology
Imran Majid, Gousia Sheikh, Farhath Kanth et al. · 2016 · Indian Journal of Dermatology
Background: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. Aim: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. Materials and Methods: A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cruris were included in the study. The enrolled patients were administered oral terbinafine 250 mg once daily for 2 weeks. All clinically cured patients were then followed up for 12 weeks to look for any rel
View details →DOI: 10.4103/0019-5154.190120 