A comparative study on the efficacy of two CD19/CD22 dual-targeting CAR-T strategies in children with relapsed/refractory B-cell acute lymphoblastic leukemia with PAX5 gene variations
LI Yue, XIE Zhiwei, TANG Yanjing, LI Benshang · 2026 · Linchuang erke zazhi
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective Antigen escape, particularly CD19 loss, limits the efficacy of CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy in children with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). PAX5 gene variations have been shown to disrupt CD19 expression stability and increase relapse risk. This study aimed to compare the therapeutic efficacy of two CD19/CD22 dual-targeting CAR-T strategies, namely co-infusion versus bicistronic construct, in children with R/R B-ALL harboring PAX5 gene variations. Methods A retrospective analysis was conducted on the clinical dat
Abstract by LI Yue, XIE Zhiwei, TANG Yanjing, LI Benshang, Linchuang erke zazhi (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.12372/jcp.2026.26e0038