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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 651 of 725

Negative / Null Result ReportOpen accessMedicine

The causal association between systolic blood pressure and breast cancer: a two sample Mendelian randomization study.

Awada Z, Kazmi N, Jones HJ et al. · 2026 · BMC cancer

BACKGROUND: Breast cancer (BC) is the leading cause of cancer incidence worldwide. Observational studies have suggested that hypertension may be a risk factor for BC. We tested whether systolic blood pressure (SBP) may influence BC and BC…

View details →DOI: 10.1186/s12885-025-15513-x
Negative / Null Result ReportMedicine

AI and healthcare: surveying patient perspectives on artificial intelligence in neurosurgery.

Shah H, Ali M, Kilgallon JL et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Neurosurgery and neurosurgical care continues to evolve and to embrace technological advances. AI is used to interpret radiological studies and to distill medical information, with the potential to help guide physicians and patients in…

View details →DOI: 10.1016/j.jocn.2025.111731
Failed Experiment ReportMedicine

The Adherence Conundrum of Sleep Restriction Therapy for Insomnia.

Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research

While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…

View details →DOI: 10.1111/jsr.70339
Negative / Null Result Report

Variation of The Dose of Norepinephrine in Septic Shock Patients Treated with an IgM and IgA-Enriched Immunoglobulin Preparation: Secondary Analysis of a Prospective Multicenter Observational Study

Bixio M, Scamperle A, Quarantotto G et al. · 2026 · Preprint

Background: /Objectives: The use of IgM- and IgA-enriched intravenous immunoglobulins (eIg) in septic shock remains controversial due to the lack of high-quality evidence, despite indications from observational studies and meta-analyses…

View details →DOI: 10.20944/preprints202604.2104.v1
Negative / Null Result ReportMedicine

How Orthographic Transparency Shapes Word Learning and Retention in Monolingual and Bilingual Adults.

Clark C, Lira Calabrich S, Lallier M et al. · 2026 · Quarterly journal of experimental psychology (2006)

This study examined how orthographic characteristics relate to the learning and retention of novel written words in monolingual English and bilingual Welsh-English adults. Participants learned pseudowords designed to follow either…

View details →DOI: 10.1177/17470218261441260
Negative / Null Result ReportMedicine

Development and psychometric validation of the Kanazawa University loneliness scale for children and adolescents.

Murayama Y, Soma D, Kameya M et al. · 2026 · Discover mental health

Loneliness is a key risk factor for youth mental health; however, existing scales often fail to capture its multidimensional and relational nature. This study developed the [blinded] University Loneliness Scale (KULoS) for students in…

View details →DOI: 10.1007/s44192-026-00462-z
Negative / Null Result ReportMedicine

Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study.

Han M, Qu Y, Zeng M et al. · 2026 · Geriatric nursing (New York, N.Y.)

Background To investigate the associations of physical activity (PA) and sedentary behavior (SB) with the risk of mortality using observational and Mendelian randomization (MR) designs. Methods In a prospective cohort study based on UK…

View details →DOI: 10.1016/j.gerinurse.2026.103834
Negative / Null Result ReportMedicine

Changes in Peri-Implant Soft Tissue Dimensions Following Soft Tissue Contour Augmentation: A 3-Year Follow-Up of a Multi-Center RCT.

Jepsen K, Jepsen S, Hämmerle CHF et al. · 2026 · Clinical oral implants research

Aim To assess 3-year changes of peri-implant tissues following previous soft tissue (volume) augmentation (STA) with a volume-stable collagen matrix (VCMX) or connective tissue (SCTG) at single-implant restorations. Material and methods In…

View details →DOI: 10.1111/clr.70078
Negative / Null Result ReportMedicine

Parental care liberates juvenile growth: a common-garden test of the evolutionary benefits of care.

Eggert AK, Prang MA, Capodeanu-Nägler A et al. · 2026 · Evolution; international journal of organic evolution

Effects on juvenile growth have long been considered an important benefit of parental care, but they have rarely been tested empirically. Protection and feeding by parents might accelerate offspring growth by allowing offspring to allocate…

View details →DOI: 10.1093/evolut/qpaf223
Negative / Null Result ReportOpen accessMedicine

The association between weekend catch-up sleep and obesity in U.S. adults: A cross-sectional analysis of NHANES 2017-2020.

Zeng J, Huang D, Zhu M et al. · 2025 · Medicine

Weekend catch-up sleep (WCS) is a behavioral strategy employed to compensate for weekday sleep loss and has been reported to be associated with various metabolic outcomes. However, its association with obesity remains controversial. This…

View details →DOI: 10.1097/md.0000000000044670
Failed Experiment ReportOpen accessMedicine

Potential Causes of Shedding Aggregations in Prairie Rattlesnakes.

Martin E, Conway CJ · 2026 · Ecology and evolution

Aggregation is common across taxa and typically confers clear benefits to group members (e.g., allo-parenting, group defense, thermoregulation, access to resources). But aggregation can also be costly. The mechanisms that underpin…

View details →DOI: 10.1002/ece3.73311
Failed Experiment Report

Vitamin B12, Homocysteine, and Cognitive Function in the Older Adults Attending Tertiary Geriatric Psychiatry Centre: A Retrospective Case Notes Based Study

Huchegowda R, Harbishettar V, Sinha P et al. · 2025 · Preprint

Background Cognitive impairment in the older adult population has been linked to low Vitamin B12 levels and elevated Homocysteine levels, but evidence is not clear. This study examines the relationship between serum Vitamin B12 (B12)…

View details →DOI: 10.1101/2025.08.02.25332580
Negative / Null Result ReportMedicine

Serum ACE2 and Anti-MMR Antibody Profiles in Pediatric Patients with and without SARS-CoV-2 Infection.

Labbani-Motlagh Z, Nozarian Z, Haghi Ashtiani MT et al. · 2025 · Iranian journal of immunology : IJI

Background Coronavirus Disease 2019 (COVID-19) typically manifests with milder symptoms and lower mortality rates in children when compared to adults. Objective To investigate potential mechanisms underlying this age-related protection, we…

View details →DOI: 10.22034/iji.2025.104055.2879
Negative / Null Result ReportMedicine

A new species of hermit crab provisionally assigned to the genus Pagurus Fabricius, 1775 (Crustacea: Anomura: Paguridae) from the Ryukyu Islands, Japan.

Komai T · 2025 · Zootaxa

A new pagurid hermit crab species, Pagurus inflatus sp. nov., has been provisionally assigned to the heterogeneous genus Pagurus Fabricius, 1775. This new species is characteristic in its elongated right cheliped with a noticeably inflated…

View details →DOI: 10.11646/zootaxa.5647.1.3
Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

View details →DOI: 10.1007/s10493-025-01051-5
Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

View details →DOI: 10.4103/jpbs.jpbs_1240_25
Failed Experiment ReportMedicine

Pembrolizumab in recurrent or metastatic medullary thyroid cancer.

Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist

Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…

View details →DOI: 10.1093/oncolo/oyaf348
Failed Experiment ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor.

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

View details →DOI: 10.3168/jds.2025-26959