e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 640 of 713

Negative / Null Result ReportOpen accessPsychiatry

Status of Perceived Stress and Quality of Life in Adults during COVID-19 Pandemic

Subodh Kumar, Divye Kartikey, Jayeeta Biswas · 2022 · Indian Journal of Private Psychiatry

Background: The deadly second wave of coronavirus disease-2019 (COVID-19) pandemic swept through the whole of India during the month of April–May 2021. Restrictions like lockdowns and social distancing impacted the normal functioning of life. It is in this backdrop that we need to understand the perceived stress and quality of life among people. Aim and objective: The aim and objective of this study was to evaluate and study the relationship between perceived stress and quality of life among adults living in Delhi NCR, during the second wave of the COVID-19 pandemic. Materials and methods: A 1

View details →DOI: 10.5005/jp-journals-10067-0102
Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

Lower Activation in Frontal Cortex and Posterior Cingulate Cortex Observed during Sex Determination Test in Early-Stage Dementia of the Alzheimer Type

Ravi Rajmohan, Ronald C. Anderson, Dan Fang et al. · 2017 · Frontiers in Aging Neuroscience

Face-labeling refers to the ability to classify faces into social categories. This plays a critical role in human interaction as it serves to define concepts of socially acceptable interpersonal behavior. The purpose of the current study was to characterize, what, if any, impairments in face-labeling are detectable in participants with early-stage clinically diagnosed dementia of the Alzheimer type (CDDAT) through the use of the sex determination test (SDT). In the current study, four (1 female, 3 males) CDDAT and nine (4 females, 5 males) age-matched neurotypicals (NT) completed the SDT using

View details →DOI: 10.3389/fnagi.2017.00156
Negative / Null Result ReportOpen accessSports medicine

Patients’ Satisfaction Evaluation

Ebru Kaya Mutlu, Arzu Razak Özdinçler · 2014 · Orthopaedic Journal of Sports Medicine

Objectives: Although many studies were focused on the assessment of patients' satisfaction, few studies have specifically addressed this issue for knee osteoartritis. Global rating of change (GRC) scales are very commonly used in clinical research, particularly in the musculoskeletal area. The purpose of this study was to evaluate the patients’ satisfaction of the Mulligan’s Mobilization with Movement (MWM) techniques, Passive Mobilization (PM) techniques and physical therapy modalities (PTM) (superficial heat or cold, Transcutaneous Electrical Nerve Stimulation (TENS) and therapeutic ultrasou

View details →DOI: 10.1177/2325967114s00172
Negative / Null Result ReportOpen accessMedicine

The Effects of Bougie Diameters on Tissue Oxygen Levels After Sleeve Gastrectomy: A Randomized Experimental Trial

Can Konca, Ali Abbas Yılmaz, Süleyman Utku Çelik et al. · 2018 · Balkan Medical Journal

Background: Staple-line leak is the most frightening complication of laparoscopic sleeve gastrectomy and several predisposing factors such as using improper staple sizes regardless of gastric wall thickness, narrower bougie diameter and ischemia of the staple line are asserted. Aims: To evaluate the effects of different bougie diameters on tissue oxygen partial pressure at the esophagogastric junction after sleeve gastrectomy. Study Design: A randomized and controlled animal experiment with 1:1:1:1 allocation ratio. Methods: Thirty-two male Wistar Albino rats were randomly divided into 4 group

View details →DOI: 10.4274/balkanmedj.2017.0484
Failed Experiment ReportOpen accessGeriatrics

Effect of the Casein-Derived Peptide Met-Lys-Pro on Cognitive Function in Community-Dwelling Adults Without Dementia: A Randomized, Double-Blind, Placebo-Controlled Trial

Yuda N, Tanaka M, Yamauchi K et al. · 2020 · Clinical Interventions in Aging

Naoki Yuda,1 Miyuki Tanaka,1 Koji Yamauchi,1 Fumiaki Abe,1 Izumi Kakiuchi,2 Kyoko Kiyosawa,2 Mitsunaga Miyasaka,2 Naoki Sakane,3 Masahiko Nakamura4 1Food Ingredients and Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan; 2Department of Nursing, Matsumoto Junior College, Matsumoto, Nagano, Japan; 3Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan; 4Matsumoto City Hospital, Matsumoto, Nagano, JapanCorrespondence: Naoki YudaFood Ingredients and Technology Institute, Morinaga Milk Industry Co.

Failed Experiment ReportOpen accessMedicine

Results of the performance test for quality assessment of personal radiation dosimetry services including the influence of the dosimeter readout frequency

Chen-Ju Feng, Chin-Hui Wu, Yi-Hui Huang et al. · 2022 · Scientific Reports

Abstract This study was to determine the significance of factors considered for the measurement accuracy of personal dosimeter in dosimetry services such as dosimetry service, irradiation category, years of use and readout frequency. The investigation included management information questionnaire, on-site visit and blind test. The blind test with random selected personal badge was used in inter-comparison of eight dosimetry services, and the test results followed ANSI/HPS N13.11 criteria. This study also analyzed the measurement deviations if they felt in the criteria of ICRP 75 or not. One-wa

View details →DOI: 10.1038/s41598-022-23942-y
Failed Experiment ReportOpen accessMedicine

Effects of co-occurrence and intra- and interspecific interactions between Drosophila suzukii and Zaprionus indianus

Larine de Paiva Mendonça, Khalid Haddi, Wesley Augusto Conde Godoy · 2023 · PLoS ONE

In drosophilids, competition and coexistence can impact survivorship, growth, and reproductive output. Here, we evaluated direct competition between two co-occurring fruit flies, the spotted-wing drosophila Drosophila suzukii and the African fig fly Zaprionus indianus, comparing results from field collections with laboratory experiments. Field collections were conducted to evaluate co-occurrence between species. In the laboratory, different densities of eggs of each species were provided an artificial diet, and intra- and interspecific densities were evaluated regarding biological traits such

Failed Experiment ReportOpen accessMiscellaneous systems and treatments

Aerobic training versus strength exercises on muscle strength and quality of life for children with acute lymphoblastic leukemia

Doaa Mohamed, Faten Abd Alazim, Elham Salem et al. · 2020 · Bulletin of Faculty of Physical Therapy

Abstract Background The treatment for children and adolescents with acute lymphoblastic leukemia (ALL) can lead to multiple adverse effects, including poor physical capacity and muscle weakness. This study aimed to determine which is more effective, aerobic exercises or modified strength training program, on muscle strength and quality of life (QOL) for children with ALL. Results In terms of muscle strength, there was a significant difference (P 0.05) between groups on QOL. Conclusion The outcomes of the study showed that there was a significant difference in the selected group of muscles at b

View details →DOI: 10.1186/s43161-020-00007-7
Negative / Null Result ReportOpen accessMedicine (General)

Height Estimation Using Anthropometric Parameters of the Upper Limbs in the Indigenous Population of Bushehr

Nahid Jashirenezhad, Sahar Almasi Turk, Marzieh Mahmoodi et al. · 2025 · Iranian South Medical Journal

Background: Identifying individuals based on their height is of great importance, especially in cases such as accidents or burns where identifying individuals is challenging. Therefore, the aim of this study was to investigate upper extremity parameters in a population of Bushehr in a relative formulation to predict their stature using anatomical indices. Materials and Methods: The project involved men and women aged 18 to 50 who were themselves born and both they and two generations before them also lived there. The indices of arm, forearm, hand, upper extremity, and stature were measured in

Negative / Null Result ReportOpen accessBiology (General)

Age-Dependent Changes in Bone Architecture, Patterning, and Biomechanics During Skeletal Regeneration

Kevin Hoffseth, Emily Busse, Josue Jaramillo et al. · 2021 · Frontiers in Cell and Developmental Biology

Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal. The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for multi-tissue regeneration. Bone integrity relies upon a balanced remodeling between bone resorption and formation, which, when disrupted, results in changes to bone architecture and biomechanics, particularly during aging. In this study, we used recently developed techniques to evalu

View details →DOI: 10.3389/fcell.2021.749055
Negative / Null Result ReportOpen accessDentistry

Knowledge of correct prescription of radiographs among dentists in Yazd, Iran

Fatemeh Ezoddini Ardakani, Vahid Sarayesh · 2008 · Journal of Dental Research, Dental Clinics, Dental Prospects

Background and aims. While the use of X-ray is increasing, professional responsibility of dentists entitles them to have sufficient and correct knowledge of using radiographs. The aim of this study was to assess the level of knowledge of correct prescription of radiographs among dentists in Yazd, Iran. Materials and methods. This was a descriptive cross-sectional study including 134 general dentists and dental specialists. A self-administered questionnaire was used to assess their level of knowledge in various sections pertaining to prescription of radiographs. Their level of knowledge was com

Negative / Null Result ReportOpen accessSports medicine

Is the Lind or LaPrade Technique Able to Control Anterior and Rotational Laxity in Medial-Side Knee Injuries? A Controlled Laboratory Study of 18 Knees

Michel Drouineau MD, Baptiste Guegan MD, Harold Common MD et al. · 2025 · Orthopaedic Journal of Sports Medicine

Background: Reconstruction of the medial collateral ligament (MCL) and posterior oblique ligament (POL) is necessary to restore stability in chronic lesions on the medial side of the knee. The Lind technique uses a single-strand, pedicled semitendinosus tendon autograft to perform continuous reconstruction of the MCL and POL. The LaPrade technique uses 2 free grafts: 1 graft for the MCL (double-strand semitendinosus tendon graft) and 1 graft for the POL (double-strand gracilis tendon graft). Purpose: To investigate the LaPrade and Lind techniques in restraining tibial translation and rotation

View details →DOI: 10.1177/23259671251389124
Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology

Novel three-dimensional imaging system may facilitate gastric endoscopic submucosal dissection procedure: an ex vivo animal study

Naoki Akizue, Tomoaki Matsumura, Daisuke Maruoka et al. · 2018 · Endoscopy International Open

Background and study aims Endoscopic submucosal dissection (ESD) requires advanced skills to perform safely without complications. The current study evaluated the usefulness of a novel three-dimensional (3D) imaging system in ESD using porcine stomachs. Methods Four endoscopists (two trainees and two experts) performed eight ESD procedures using both 3D and 2D images. The usefulness of 3D image versus 2D image was evaluated by visibility and procedure time. In addition, occurrence of eyestrain and dizziness in 3D image was assessed. Results En bloc resection was successfully achieved, without

View details →DOI: 10.1055/a-0761-9649
Negative / Null Result ReportOpen accessTechnology

Territorial defense of the red-whiskered bulbul, Pycnonotus jocosus (Pycnonotidae), in a semi-wild habitat of the bird farm

Sunthorn Sotthibandhu · 2003 · Songklanakarin Journal of Science and Technology (SJST)

The territorial behavior of the red-whiskered bulbul, Pycnonotus jocosus, was studied in the semiwild habitat of a bird farm compound in the District of Chana, Songkhla Province, the south of Thailand. The male and female birds were bred and reared in the farm till they reached maturity following which they were released to the wild. A mating pair was later formed and their territory established in the farm area. A decoy was used to simulate a natural intruder to the defended area. Ten test stations were sited in the four cardinal points of the compass and with reference to the farmhouse. The

Negative / Null Result ReportOpen accessPublic aspects of medicine

Nanofat Injection for the Treatment of Abnormal Scar Compared with Triamcinolone Acetonide

Almas Mirza Murastomo, Agus Santoso Budi, Magda Rosalina Hutagalung et al. · 2023 · Biomolecular and Health Science Journal

Introduction: Hypertrophic and keloid scars arise from abnormal healing processes in fibrous tissue where tissue repair and regeneration control mechanisms do not work well. The standard treatment is an intralesional steroid injection with triamcinolone acetonide (TA). This method is effective, but there are some side effects include hypopigmentation and tissue atrophy. The nanofat method has been applied to various skin conditions with fewer side effects. Therefore, the use of nanofat with its regenerative properties can be expected to yield better results. This study aims to compare the decr

View details →DOI: 10.4103/bhsj.bhsj_19_23
Negative / Null Result ReportOpen accessSports medicine

Evaluation of body-self-perception of sedentary individuals aged over 30 who attended fitness center classes

Engin Gezer, Gulten Herguner, Mahmut Gulle et al. · 2014 · Türk Spor ve Egzersiz Dergisi

With this study; it was aimed to obtain multi-dimensional evaluation of body-self perception levels of sedentary individuals aged over 30 who attended fitness center classes. The population of the study was consisted of fitness centers located inHatayProvince. The sample was composed of 80 sedentary individuals (38 men and 42 women) who attended the selected fitness centers with random sampling. All of the subjects were included in the study with voluntariness principle. Pre-test and post-test method was used in order to conduct a more illustrative study. In the study; a personal information f

Negative / Null Result ReportOpen accessNursing

Assessing the psychometric properties of persian version of Zarit Burden interview among family caregivers of patients with multiple sclerosis

Hajar Haghshenas, Zeinab Jokar, Ladan Zarshenas et al. · 2023 · BMC Nursing

Abstract Background Caring for patients with multiple sclerosis (MS) imposes a great burden on caregivers and affects their lives in various aspects. This study aimed to evaluate the psychometric properties of Persian version of 22-item Zarit Burden Interview (ZBI-22) among family caregivers of patients with MS. Methods This methodological study was conducted in Fars province, southern of Iran. For this purpose, 120 family caregivers were recruited to participate in the study from January to March 2022. Zarit Burden Interview (ZBI) was translated into Persian through forward–backward method. F

View details →DOI: 10.1186/s12912-023-01260-6
Negative / Null Result ReportOpen accessAccounting. Bookkeeping

The Effect of Performance Evaluation System Dimensions on Organizational Results: A Financial Approach and Organizational Capabilities

Seyedeh Raja Ghalebi, Shokrollah Khajavai, Ali Mahmoodi · 2025 · Iranian Journal of Accounting, Auditing & Finance

The comprehensive Performance Measurement System (PMS) clearly emphasizes the managers' role by explaining strategic purposes and various dimensions of performance. The present study aims to analyze empirical evidence about the effect of managers' emphasis on a particular type of function and complexity levels of PMS on its benefits and organizational performance based on Levers of Control (LOC) and Contingency Theory (CT). The study was conducted in 46 companies active in Persian Gulf Petrochemical Holding in 2022. Results from data modeling using partial least squares structural equations in

View details →DOI: 10.22067/ijaaf.2025.45563.1471
Negative / Null Result ReportOpen accessMedicine

The Timing of the Melatonin Onset and Phase Angle to Sleep Onset in Older Adults after Uncontrolled vs. Controlled Lighting Conditions

Arturo Arrona-Palacios, Jung-Hie Lee, Charles A. Czeisler et al. · 2023 · Clocks & Sleep

The main aim of this study was to explore how melatonin onset timing and phase angle to bedtime in healthy older adults are impacted by prior light exposure. A total of 13 healthy older (ages 56–74) individuals were studied on two successive evenings. Prior to the first evening, the participants were in self-selected lighting conditions for the first 4–6 h of the day and then were in dim light (3 lux) until their scheduled bedtime. On the second day, individuals from Project A remained in the dim lighting conditions throughout the entire day but those in Project B were in more typical indoor l

View details →DOI: 10.3390/clockssleep5030026
Negative / Null Result ReportOpen accessAgriculture (General)

Índíces de conforto térmico e concentração de gases em galpões avícolas no semiárido Paraibano Indices of thermal comfort and gases concentration in broilers houses in the semiarid region, Brazil

Dermeval A. Furtado, Herlucio P. Rocha, José W. B. Nascimento et al. · 2010 · Engenharia Agrícola

Esta pesquisa teve o objetivo de determinar os índices de conforto térmico e a concentração de gases no interior de galpões avícolas e suas influencias sobre o desempenho de frangos de corte comercias, em condições de verão, na região semiárida paraibana. Utilizaram-se dois aviários, um coberto com telha de cerâmica e outro coberto com telha de fibrocimento. Observou-se que não houve diferença significativa (p > 0,05) entre a temperatura ambiente (TA), umidade relativa do ar (UR), temperatura da água de bebida (Tágua) e da cama entre os galpões, sendo que os valores médios de TA (das 8h às 17h

View details →DOI: 10.1590/s0100-69162010000600001
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

The Mechanism of Gefitinib Resistance Induced by Hepatocyte Growth Factor in Sensitive Non-small Cell Lung Cancer Cells in Vitro

Xianglan XUAN, Changshan AN, Caicun ZHOU · 2013 · Chinese Journal of Lung Cancer

Background and objective Previous studies have reported that Met might be related to gefitinib resistance in non-small cell lung cancer (NSCLC). The present study aims to explore the mechanism of hepatocyte growth factor (HGF)-induced gefitinib resistance in different gene types of sensitive NSCLC in vitro. Methods The PC-9 and H292 cell lines were chosen and induced by HGF. The cell survival was measured using MTT assay, the cell cycle distribution was measured using PI assay, and cell apoptosis with an Annexin V-PE assay, respectively. The c-Met and p-Met protein expression was determined vi

View details →DOI: 10.3779/j.issn.1009-3419.2013.01.01
Negative / Null Result ReportOpen accessDentistry

Effects of Ozone and Prophylactic Antimicrobial Applications on Shear Bond Strength of Orthodontic Brackets

Özer Alkan, Burcu Oktay Çöven, Betül Özçopur et al. · 2017 · Turkish Journal of Orthodontics

Objective:The present study aimed to evaluate the effects of ozone and prophylactic antimicrobial applications on the shear bond strengths and bond failure interfaces of orthodontic brackets.Methods:Sixty human canine teeth were randomly divided into three groups (n=20), receiving the following treatments: Group I-pumice prophylaxis (Isler Dental, Ankara, Turkey)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+Transbond XT primer and adhesive (3M Unitek, Monrovia, USA); Group II-prophylaxis paste (Topex, NJ, USA)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+ Transbon

View details →DOI: 10.5152/turkjorthod.2017.17032
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy

Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang et al. · 2020 · BMC Cancer

Abstract Background The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margin status and locoregional recurrence (LRR). Methods Our institutional prospectively maintained database was reviewed to identify patients who were treated with NACT between January 2008 and April 2018. Results Among the main partial mastectomy specimens available for analysis (n = 161), 28 had margins 2 mm. LRR occurred in 16 patients (9.9%) and distant metastases were

View details →DOI: 10.1186/s12885-020-06955-6
Negative / Null Result ReportOpen accessMicrobiology

Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns

Yuhan Xie, Gang Peng, Hongyu Zhao et al. · 2023 · Metabolites

Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as age at blood collection, birth weight, gestational age, infant sex, parent-reported ethnicity, and maternal age at deliver

View details →DOI: 10.3390/metabo14010005
Negative / Null Result ReportOpen accessAgriculture

Investigating Carbonate Distribution in Particle Size Components of Some Soils of Khuzestan Province

S. Jafari, M. Karimzadeh, A. Abdeshahi · 2021 · علوم آب و خاک

Characteristics of most soils in arid and semi-arid regions affected by carbonates. The study aimed to determine the distribution of carbonates in the size components of some soils in Khuzestan province. Upward to the bottom of Karun, Karkheh, and Jarahi rivers were studied at depths of 0-50, 50-100, and 150-100 cm. The results showed that the average amount of carbonates in the soils of the Jarahi river basin (37%) was significantly different from the amount in the soils of the other two rivers (33%). Carbonates were observed in all soil size components but the maximum was present in the clay

Negative / Null Result ReportOpen accessDentistry

Comparison Of Transfer Accuracy Among Hexed Implant Mounts, Clips Impression Copings, And Open-Tray Impression Copings at Different Implant Angulations: An In Vitro Study

Merna M. Seif, Ahmed A. Abdel Hakim, Hassan M. Abouelkheir et al. · 2025 · BMC Oral Health

Abstract Background Accurate impression registration is essential for transferring the three-dimensional (3D) implant position to the definitive cast, ensuring passivity of the final prosthesis. Various impression techniques have been developed to optimize accuracy, particularly for angulated implants. This study aimed to evaluate and compare the accuracy of open-tray impression copings, clips impression copings, and hexed implant mounts in transferring implant positions for both straight and angulated implants. Methods Five implants with different angulations (three at 0°, one at 15°, and one

View details →DOI: 10.1186/s12903-025-06304-8
Negative / Null Result ReportOpen accessMedicine

Precipitating factors of diabetic ketoacidosis in type 1 diabetes patients at a tertiary hospital: a cross-sectional study with a two-time-period comparison

Laura Emanuelle da Rosa Carlos Monteiro, Sheila Piccoli Garcia, Leonardo Grabinski Bottino et al. · 2022 · Archives of Endocrinology and Metabolism

ABSTRACT Objective: To evaluate the precipitating factors of diabetic ketoacidosis (DKA) in patients with type 1 diabetes hospitalized through the emergency department of a tertiary hospital. Materials and methods: Individuals with type 1 diabetes hospitalized for DKA from January 2005 to March 2010 (first period [P1], n = 75) and from April 2010 to January 2017 (second period [P2], n = 97) were identified through a query of electronic medical records. Data were collected by reviewing medical records. Only the first hospitalization of each participant in each period was included. Results: In P

View details →DOI: 10.20945/2359-3997000000480
Negative / Null Result Report

Absence of significant effect of nitrogen addition on soil respiration in a subtropical Chinese fir plantation

Xiang Zheng, Yingying He, Minmin Cao et al. · 2025 · Canadian Journal of Forest Research

Chinese fir ( Cunninghamia lanceolata (Lamb.) Hook) is one of the most dominant tree species in southern China. However, the effect of different nitrogen (N) levels on soil respiration in subtropical Chinese fir plantations remains…

View details →DOI: 10.1139/cjfr-2025-0011
Negative / Null Result ReportOpen accessSports medicine

Poster 231: Isolated Medial Meniscus Root Tears: A Multicenter Analysis of Prognostic Variables for Achieving Patient Acceptable Symptomatic State after Repair

Mario Hevesi MD, PhD, Alexander M. Boos, Allen Wang et al. · 2024 · Orthopaedic Journal of Sports Medicine

Objectives: Medial meniscus posterior root tears (MMPRTs) render the meniscus essentially non-functional, resulting in increased peak contact pressures, reduced forced dissipation, and increased risk of early osteoarthritis. Transtibial root repair has shown promise at restoring meniscus function and improving clinical outcomes; however, a paucity of literature exists evaluating the prognostic clinical and radiographic factors for poor outcomes following isolated meniscus root repair. The purpose of this study was to 1) describe the patient reported clinical outcomes after isolated MMPRT repai

View details →DOI: 10.1177/2325967124s00200