Failed Experiment ReportMedicine
Idris, Burhan, Hajeer et al. · 2026 · The Journal of international medical research
ObjectiveTo investigate the effect of repeated submucosal administration of injectable platelet-rich fibrin in the buccal region of the lower incisors on orthodontically induced apical root resorption in patients with moderate…
View details →DOI: 10.1177/03000605261452234 Negative / Null Result ReportMedicine
Wilcox, Campbell, Gill et al. · 2026 · The bone & joint journal
Computer navigation is capable of improving the accuracy of glenoid baseplate and screw positioning in shoulder arthroplasty, but there is very limited evidence of its effect on clinical outcomes. In Australia, there is one commonly used…
View details →DOI: 10.1302/0301-620x.108b6.bjj-2025-1772.r1 Negative / Null Result ReportMedicine
Metter, Dumoulin, Hay et al. · 2026 · Scandinavian journal of gastroenterology
Endoscopic submucosal resection (ESR) is a novel resection technique. ESR is performed with a partially insulated snare, which allows a resection close to the proper muscle layer thus resecting in the deep submucosa. This should have…
View details →DOI: 10.1080/00365521.2026.2678594 Negative / Null Result ReportMedicine
García Alcaide, Conde Villar, Pérez Alfayate et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe
To assess the impact of a tailored ergonomic lecture on postural risk among second-year endodontic residents depending on the use of no magnification, ergonomic loupes, or an operating microscope. A within-subjects, repeated measures…
View details →DOI: 10.1111/eje.70203 Negative / Null Result ReportMedicine
Qiao, Wang, Liu et al. · 2026 · BMC surgery
To evaluate the impact of sodium carboxymethyl cellulose (SCMC)-based absorbable hemostatic gauze on postoperative infectious outcomes in emergency laparoscopic appendectomy (LA) for acute appendicitis. A retrospective analysis of 184…
View details →DOI: 10.1186/s12893-026-03886-0 Negative / Null Result ReportMedicine
Herzog, Brink, Gondalia et al. · 2026 · Sports medicine (Auckland, N.Z.)
One often-stated aim of load management in elite athletes is injury reduction. However, current literature on the efficacy and effectiveness of specific load management strategies to reduce injury risk is limited. The aim of this study was…
View details →DOI: 10.1007/s40279-026-02457-w Negative / Null Result ReportMedicine
Wang, Liu, Wang et al. · 2026 · Journal of neuro-oncology
H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brainstem tumor with a median overall survival (OS) of less than one year. Radiotherapy (RT) is the standard treatment, but the survival benefit of adding…
View details →DOI: 10.1007/s11060-026-05622-3 Negative / Null Result ReportMedicine
Prasert, Praphasiri, Ditsungnoen et al. · 2026 · The Journal of infectious diseases
Antigenically drifted influenza A(H3N2) subclade K viruses have contributed substantially to influenza burden since 2025, but their clinical severity is less well described. Using sentinel surveillance data from Thailand, we found no…
View details →DOI: 10.1093/infdis/jiag283 Negative / Null Result ReportMedicine
Keskin, Erdoğan, Küçükçetin et al. · 2026 · Psychiatry research
The aim of this study was to compare serum levels of Fibroblast Growth Factor-2 (FGF-2) and Fibroblast Growth Factor-9 (FGF-9) between patients with Bipolar Disorder (BD) and healthy controls (HC), and to evaluate whether these molecules…
View details →DOI: 10.1016/j.psychres.2026.117248 Negative / Null Result ReportMedicine
Li, Zhu, Xu et al. · 2026 · Advances in therapy
This study evaluated the efficacy and safety of cipepofol vs. dexmedetomidine for long-term sedation of patients undergoing mechanical ventilation (MV) in an intensive care unit (ICU). Adult patients who required invasive MV for…
View details →DOI: 10.1007/s12325-026-03640-1 Negative / Null Result ReportMedicine
Tan, Feng, Wen et al. · 2026 · Medicine
To investigate the effect of expressive writing intervention on optimism and coping modes of newly diagnosed people with human immunodeficiency virus (HIV). A total of 84 newly diagnosed people with HIV in the care clinic of Public Health…
View details →DOI: 10.1097/md.0000000000048936 Negative / Null Result ReportMedicine
Tao, Pan, Li et al. · 2026 · BMC emergency medicine
The impact of Emergency Medical Service (EMS) on the prognosis of patients with acute ischemic stroke (AIS) remains controversial. This prospective cohort study enrolled AIS patients admitted to the emergency department of the Central…
View details →DOI: 10.1186/s12873-026-01621-9 Negative / Null Result ReportMedicine
Sood, Turnbull, De Silva et al. · 2026 · Heart, lung & circulation
Improved patient outcomes after ventricular arrhythmia (VA) ablation procedure have been found to correlate with procedures being performed in high volume centres. Whether the concentration of expertise in experienced, urban centres…
View details →DOI: 10.1016/j.hlc.2025.12.026 Negative / Null Result ReportMedicine
Cheng, Zhu, Xie et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
This study aimed to explore the association between different stroke onset types [unwitnessed stroke (UWS) vs. witnessed stroke (WS)] and clinical outcomes in patients with large ischemic stroke treated with endovascular therapy (EVT).…
View details →DOI: 10.1016/j.jocn.2026.112116 Negative / Null Result ReportMedicine
Sinsareekul, Chantarangsu, Hiran-Us · 2026 · Journal of dentistry
This retrospective study aimed to evaluate the influence of sealer extrusion on treatment outcomes using a within-tooth comparative design and to identify associated prognostic factors. A total of 126 patients who underwent nonsurgical…
View details →DOI: 10.1016/j.jdent.2026.106801 Negative / Null Result ReportMedicine
Susma, Spronken, van Nieuwkoop et al. · 2026 · Journal of virology
Cytosine-phosphate-guanine (CpG) dinucleotide motifs are the most underrepresented motifs in RNA virus genomes, including those of the influenza A viruses (IAV). Previous studies have indicated that increasing the number of CpG motifs in…
View details →DOI: 10.1128/jvi.00047-26 Negative / Null Result ReportMedicine
Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine
Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…
View details →DOI: 10.1080/13548506.2026.2694730 Negative / Null Result ReportMedicine
Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one
Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…
View details →DOI: 10.1371/journal.pone.0352429 Failed Experiment ReportMedicine
Tam, Rezaee, Abdi et al. · 2026 · Acta parasitologica
Giardiasis is a globally common protozoan disease with significant public health impact, causing diarrhea, nausea, weight loss, bloating, and abdominal pain. Current treatments face limitations including drug resistance and adverse…
View details →DOI: 10.1007/s11686-026-01311-3 Negative / Null Result ReportMedicine
Yamada, Hosokawa, Mitoma et al. · 2026 · Biological & pharmaceutical bulletin
Rheumatoid arthritis is characterized by chronic synovial inflammation and recurrent flares, which are thought to involve joint-specific inflammatory memory. Synovial fibroblasts (SFs) contribute to this process through altered responses…
View details →DOI: 10.1248/bpb.b26-00213 Replication FailureMedicine
Yang, Xu, Liu et al. · 2026 · Medicine
The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a potential composite biomarker that integrates nutritional and immune-inflammatory profiles. However, its association with rheumatoid arthritis (RA) prevalence remains…
View details →DOI: 10.1097/md.0000000000049349 Negative / Null Result ReportMedicine
Jawahir, Balqis, Lee et al. · 2026 · BMJ open
Guided by the Andersen Behavioural Model of Healthcare Utilisation, this study investigated the relationship between socioeconomic status, enabling factors and need factors in predicting hospital admission. Data were analysed from the…
View details →DOI: 10.1136/bmjopen-2025-103322 Negative / Null Result ReportMedicine
Rostami, Ashraf, Hosseininasab · 2026 · Open heart
Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer survivors. ACE inhibitors (ACEIs), angiotensin receptor blockers and beta blockers have been proposed as prophylactic therapies;…
View details →DOI: 10.1136/openhrt-2026-004062 Negative / Null Result ReportMedicine
Zuin, Chopard, Drachman et al. · 2026 · American heart journal plus : cardiology research and practice
β-Blockers have been traditionally prescribed after acute myocardial infarction (MI), but contemporary evidence in patients with preserved or mildly reduced left ventricular ejection fraction (LVEF ≥40%) have not provided…
View details →DOI: 10.1016/j.ahjo.2026.100810 Negative / Null Result ReportMedicine
Meng, Zhang, Jin et al. · 2026 · iScience
Soil aggregates are the basic structure of soil. To investigate the distribution characteristics of karst soil aggregates in southwest China and the response of their stability to long-term vegetation restoration, we took karst areas and…
View details →DOI: 10.1016/j.isci.2026.116137 Negative / Null Result ReportMedicine
Imai, Dai, Ono et al. · 2026 · Human cell
Embryo implantation is a critical and tightly regulated process essential for successful human reproduction. Although the role of endometrial receptivity is well established, the molecular mechanisms governing this process are not…
View details →DOI: 10.1007/s13577-026-01386-0 Negative / Null Result ReportMedicine
Petit, Sayah, Indelicato et al. · 2026 · Journal of neurology
Increasing evidence suggests that cognition and affect may be affected in Friedreich Ataxia (FA). To investigate the Cerebellar Cognitive Affective Syndrome (CCAS) in patients with FA and evaluate its correlations with speech and clinical…
View details →DOI: 10.1007/s00415-026-13786-1 Negative / Null Result ReportMedicine
Sun, Han, Huang et al. · 2026 · Drug design, development and therapy
To investigate the effect of end-stage kidney disease (ESKD) factor on the sedative effects of ciprofol. Elective kidney transplant recipients aged 18-64 years, with a body mass index (BMI) of 18.5-24.0 kg/m 2 , Mallampati class I or II,…
View details →DOI: 10.2147/dddt.s601965 Negative / Null Result ReportMedicine
Esmer, Hafızoğlu, Bardakçı et al. · 2026 · Journal of ovarian research
Advanced epithelial ovarian cancer (EOC) is commonly diagnosed at late stages, and despite improvements with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), prognosis remains poor. Body composition has emerged…
View details →DOI: 10.1186/s13048-025-01960-4 Negative / Null Result ReportMedicine
Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology
Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…
View details →DOI: 10.1016/j.ibmb.2026.104613 