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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 639 of 713

Failed Experiment ReportOpen accessMedicine

Antimicrobial activity of Nd: YAG irradiation, laser activated photodynamic therapy and passive ultrasonic irrigation on enterococcus faecalis biofilms (an ex vivo study).

El Gazar SM, El Backly RN, Lotfy WA et al. · 2026 · BMC oral health

Aim To evaluate the antimicrobial effects of Nd: YAG laser irradiation, antimicrobial photodynamic therapy (aPDT), and passive ultrasonic irrigation (PUI) in comparison with conventional irrigation with Sodium hypochlorite (NaOCl) in root…

View details →DOI: 10.1186/s12903-026-08651-6
Methods Dead-EndMedicine

Independent effects of volume and energy density manipulation on energy intake and appetite in healthy adults: A randomized, controlled, crossover study.

Hatch-McChesney A, Whitney CC, Richardson M et al. · 2024 · Appetite

Consuming enough energy to meet high energy demands can be challenging for military personnel wherein logistical constraints limit food availability. Increasing dietary energy density (ED) and/or volume density (VD) of rations may be…

View details →DOI: 10.1016/j.appet.2024.107537
Failed Experiment ReportMedicine

Evaluation of phyto-gallic acid as a potential inhibitor of Staphylococcus aureus efflux pump mediated tetracycline resistance: an in-vitro and in-silico study.

Moubayed NMS, Alsabbagh R, Smiline GAS et al. · 2025 · Natural product research

Plants contain many bioactive compounds with potent antibacterial and efflux pump inhibitory activity (EPI). In this study, gallic acid extracted from pomegranate molasses by analytical HPLC holds promise as an EPI drug for Staphylococcus…

View details →DOI: 10.1080/14786419.2024.2349810
Replication FailureMedicine

No evidence in favor of the existence of "intentional" binding.

Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance

Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…

View details →DOI: 10.1037/xhp0001204
Negative / Null Result ReportOpen accessMedicine

Antiarrhythmic Treatment in Heart Failure.

Könemann H, Güler-Eren S, Ellermann C et al. · 2024 · Current heart failure reports

Purpose of review Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches…

View details →DOI: 10.1007/s11897-023-00642-w
Negative / Null Result ReportOpen accessMedicine

Laparoscopic Salpingectomy Regulates The Expression of Endometrial Homeobox Genes ( HOXA9, HOXA10, HOXA11, HOXD10 ) and HOX Transcript Antisense Intergenic RNA in Women with Communicating Hydrosalpinx: A Prospective Study.

Zafarani F, Soleimani Mehranjani M, Ghaffari F et al. · 2024 · International journal of fertility & sterility

Background This study aimed to determine the alteration of endometrial expression levels of HOXA9/HOXA10/ HOXA11/HOXD10 genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with…

View details →DOI: 10.22074/ijfs.2024.2026081.1655
Negative / Null Result ReportOpen accessMedicine

Effectiveness of strenghtning oropharyngeal myofunctional therapy combined with cervical spine exercises in mild to moderate obstructive sleep apnoea.

Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung

Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…

View details →DOI: 10.1007/s11325-025-03487-w
Negative / Null Result ReportMedicine

Quantitative EEG for the Monitoring of Walking Recovery in Chronic Stroke Patients Receiving Action Observation Training.

Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior

The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…

View details →DOI: 10.1080/00222895.2024.2320904
Negative / Null Result ReportOpen accessMedicine

Osteoporosis independent of traditional risk factors in hyperthyroid patients in a resource-limited setting: An observational study.

Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine

Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…

View details →DOI: 10.1097/md.0000000000048715
Negative / Null Result ReportOpen accessMedicine

Safety and clinical outcomes of micro-axial intravascular flow pump compared to intra-aortic balloon pump in cardiogenic shock.

Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy

Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…

View details →DOI: 10.21037/cdt-2025-302
Negative / Null Result ReportMedicine

Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.

Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association

Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…

View details →DOI: 10.47391/jpma.9158
Negative / Null Result ReportOpen accessMedicine

Comparative Evaluation of Antimicrobial Activity and Minimum Inhibitory Concentration of Commercially Available Pediatric Dentifrices: An In Vitro Study.

Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry

Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…

View details →DOI: 10.5005/jp-journals-10005-2939
Negative / Null Result ReportMedicine

CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity.

Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine

Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…

View details →DOI: 10.1016/j.freeradbiomed.2024.08.030
Negative / Null Result ReportOpen accessMedicine

The "inverted-U" of cognitive effort across speech rates holds for simple but not complex sentence structures.

O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology

Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…

View details →DOI: 10.3389/fpsyg.2025.1685938
Negative / Null Result ReportMedicine

Bactericidal Efficacy of So-Called Sanitizers in Japan.

Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin

Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…

View details →DOI: 10.1248/bpb.b24-00439
Negative / Null Result Report

Predicting clinical outcomes of post-operative focal neurological deficits after glioma resection based on MRI characteristics: A retrospective chart review

Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint

Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…

View details →DOI: 10.21203/rs.3.rs-2616875/v1
Negative / Null Result ReportMedicine

Weight Suppression, Brain Reward Response to Food Cues, and Bulimic Behaviours: A Pilot fMRI Study.

Singh S, Jagannathan K, Childress AR et al. · 2026 · European eating disorders review : the journal of the Eating Disorders Association

Objective Weight suppression (WS), or the difference between one's highest past and current weights, may help maintain bulimia nervosa (BN) by altering reward response to food cues. This pilot study tested associations among WS, brain…

View details →DOI: 10.1002/erv.70127
Negative / Null Result ReportOpen accessMedicine

Alcohol

· 2006

The effects of maternal alcohol (ethanol) ingestion during lactation are complex and depend on the pattern of maternal drinking. With casual alcohol use (such as 1 glass of wine or beer) it is best to wait 2 to 2.5 hours per drink before…

Negative / Null Result ReportMedicine

An Exploratory Analysis of Eye-Tracking During a Virtual Reality Social Cognition Intervention for Children with Autism Spectrum Disorders.

Gámez Martínez S, Lovatón Romero G, Alcañiz Raya M et al. · 2026 · Cyberpsychology, behavior and social networking

The diagnosis of autism spectrum disorder is based on clinical judgment, as there are no clearly identified markers to determine the presence of this condition. Gaze patterns have been proposed as a potential biomarker for autism. This…

View details →DOI: 10.1177/21522715261439451
Negative / Null Result ReportMedicine

Aphantasia and visual working memory: No direct evidence of impaired visual working memory in aphantasics, either in behavioral performance or the accuracy of a multivoxel pattern classifier.

Knight KF, Milton F, Zeman A · 2026 · Neuropsychologia

Visual mental imagery and visual working memory are often thought to be closely related. After all, both have been argued to involve the temporary maintenance of visual representations in conscious awareness. We might expect, therefore,…

View details →DOI: 10.1016/j.neuropsychologia.2026.109430
Negative / Null Result ReportMedicine

Nightly sleep as a predictor of next-day arrhythmias in ambulatory adults.

Randa L, Lee C, Cheng J et al. · 2026 · Journal of electrocardiology

Background The frequency of cardiac ectopy, including premature atrial contractions (PACs), premature ventricular contractions (PVCs), non-sustained supraventricular tachycardia (SVT), and non-sustained ventricular tachycardia (NSVT), is…

View details →DOI: 10.1016/j.jelectrocard.2026.154364
Negative / Null Result ReportMedicine

A 25-year longitudinal study on dipping/nondipping tracking in the general population: the PAMELA study.

Cuspidi C, Facchetti R, Tadic M et al. · 2026 · Journal of hypertension

Background The long-term reproducibility of the nighttime blood pressure (BP) phenotypes, namely, dipping (D) and nondipping (ND) has never been described in population-based studies. We investigated this issue in the participants to the…

View details →DOI: 10.1097/hjh.0000000000004276
Negative / Null Result ReportMedicine

Associations of fear, anger, happiness, and hope with risk judgments: Revisiting appraisal-tendency framework with a replication and extensions registered report of Lerner and Keltner (2001).

Lu S, Efendić E, Feldman G · 2025 · Journal of personality and social psychology

The appraisal-tendency framework proposed that specific emotions predispose individuals to appraise future events corresponding to the core appraisal themes of the emotions. In a registered report with a U.S. American online Amazon…

View details →DOI: 10.1037/pspp0000586
Negative / Null Result ReportMedicine

Lung ultrasound score and prediction of patient outcomes in hypoxaemic intubated and mechanically ventilated critically ill: A cohort study.

Ntoumenopoulos G, Hansell L, Neindre AL et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background The extent of pulmonary aeration present on admission to the intensive care unit (ICU) as determined by the lung ultrasound score (LUSS) may be useful to predict weaning from mechanical ventilation. The aim of this study was to…

View details →DOI: 10.1016/j.aucc.2025.101495