A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Tungjitviboonkun S, Schulte B, Shi K et al. · 2026 · Cancer medicine
Background Chronic kidney disease (CKD) is a common comorbidity among cancer patients and may influence treatment options and outcomes. However, the independent effect of CKD in patients with hematologic malignancies remains unclear.…
George MD, Gavigan K, Venkatachalam S et al. · 2026 · ACR open rheumatology
Objective People with rheumatoid arthritis (RA) are at increased risk of serious infection, but less is known about nonserious infections. Our prospective cohort study evaluated associations between medications for RA and the risk of…
Wolfswinkel SMM, Raghoebar S, de Vet E et al. · 2026 · Applied psychology. Health and well-being
Social norm perceptions are implicit rules of conduct that describe what is normal and acceptable behavior. Changing social norm perceptions through textual and physical social norm communications can be a promising approach to changing…
Currò D, Vergani E, Nicolazzi MA et al. · 2026 · International journal of molecular sciences
Cardiovascular diseases remain the leading cause of global mortality, with heart failure (HF) representing a critical clinical endpoint. HF is traditionally classified into two distinct phenotypes based on left ventricular ejection…
Rabbi F, Gulacha P, Thabane L et al. · 2026 · Nutrition bulletin
Asthma affects over 850,000 Canadian children under 14, ranking among the top chronic childhood diseases. Prenatal dietary factors are hypothesised to influence its development. We examined associations between maternal prenatal dietary…
Kocamış Ö · 2026 · BMC ophthalmology
BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in elderly individuals. Increasing evidence indicates that systemic inflammation contributes to nAMD pathogenesis.…
Gonçalves TR, Cunha DB, Mediano MFF et al. · 2025 · BMC public health
Background Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association…
Wierzbiński P, Henzler M, Hubska J · 2022 · Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353…
Gümüş CY, Özer Y, Kaşko Arıcı Y · 2026 · Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Vitamin D deficiency is common in pediatric obesity and has been proposed to contribute to metabolic-associated fatty liver disease (MAFLD). This retrospective study aimed to evaluate serum 25-hydroxyvitamin D (25[OH]D) levels…
Barber LE, Maliniak ML, Moubadder L et al. · 2024 · JAMA network open
Importance Neighborhood deprivation has been associated with increased breast cancer mortality among White women, but findings are inconsistent among Black women, who experience different neighborhood contexts. Accounting for interactions…
Xin Y, Qian X, Yang Y · 2025 · BMC public health
Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…
Rabizadeh S, Seyedi SA, Nabipoorashrafi SA et al. · 2023 · Chronic diseases and translational medicine
Background High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it…
Lange AV, Hess E, Barón AE et al. · 2026 · Journal of palliative medicine
Background Providing and measuring goal-concordant care is a priority. Objective Determine the effect of a nurse and social worker palliative telecare team intervention on goal concordance and participants' understanding of care focus.…
Soeda K, Komaba H, Nakagawa Y et al. · 2024 · Journal of nephrology
Background Hyponatremia is implicated in pathological bone resorption and has been identified as a risk factor for bone fracture in the general population. However, there are limited data on the association between serum sodium levels and…
Lampousi AM, Zeng J, Löfvenborg JE et al. · 2026 · Diabetologia
Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whether such associations are modified by…
Bowler SA, Premeaux TA, Ratzan L et al. · 2025 · AIDS (London, England)
A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies…
Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports
This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…
Tian Y, Kim H, Ratcliffe PJ et al. · 2026 · Preprint
Oxidative post-translational modifications on the sulfhydryl group of cysteines can occur spontaneously or enzymatically. The dioxygenation of N-terminal cysteines has emerged as a new oxygen sensing paradigm, catalysed by…
Franco Vega I · 2026 · Journal of sex research
This study assessed the effects of condom types and brands on use in a free condom distribution intervention in hostales (love hotels). New policies are needed to overcome the low levels of contraceptive use in Perú. Hostales could serve…
Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals
Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…
Sundarakrishnan A, Siek B, Clarke PBS · 2026 · Behavioural brain research
The sucrose preference test is the primary measure of anhedonia in rat models of depression, but it does not specifically assess anticipatory anhedonia, a deficit commonly observed in patients. Anticipatory 50-kHz ultrasonic vocalizations…
Getman-Pickering Z, Thaler J, Davis J et al. · 2026 · Preprint
During domestication, selection has typically decreased plant resistance to herbivores and reduced beneficial relationships with microbial mutualists such as mycorrhizae. These two processes raise the question of whether reductions in…
S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology
This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…
Gonotkov MA, Safiulina VF · 2026 · Preprint
Whole-cell patch-clamp studies often fail to observe the expected effect of melatonin on the IK1 current in cardiomyocytes, which may be due to cytoplasmic dialysis and the loss of key components of the intracellular signaling system. The…
Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…
Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…
Ha SH, Kim S, Lee S et al. · 2026 · Parkinsonism & related disorders
Introduction Approximately one-third of patients with Parkinson's disease (PD) develop dementia, and anticholinergic use has been implicated as a risk factor, particularly with prolonged exposure. This study examined whether short-term…
Nygaard B, Jensen CZ, Jorsal M et al. · 2025 · European thyroid journal
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the…
Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science
We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…