A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Kutumova E, Kovaleva A, Sharipov R et al. · 2024 · Preprint
The angiotensin converting enzyme (ACE) gene ( ACE ) insertion/deletion ( I/D ) polymorphism has attracted much attention in recent years, as it raises the hope of personalizing ACE inhibitor therapy to optimize its efficiency and reduce…
Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease
The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…
Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine
Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…
Zanetto A, Campello E, Spiezia L et al. · 2024 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Introduction Factor XI (FXI) is associated with thrombosis in patients without liver disease, but it alterations and prognostic value in cirrhosis are uncertain. Patients and methods We studied a prospective cohort of cirrhosis patients…
Singh T, Kumar S, Sinha S et al. · 2025 · Cureus
Background Dietary diversity is an essential component of nutritional adequacy, particularly for school-aged children who are undergoing rapid physical and cognitive development. Inadequate dietary diversity can lead to micronutrient…
Ramsburg H, Hinkle JL, MacKenzie Greenle M · 2026 · The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
Background Each year in the United States, 795,000 people are diagnosed with a new or recurrent stroke, resulting in 165,393 deaths. However, little is known about the quality of end-of-life (EOL) care in this population, including the…
Bitar G, Fishel Bartal M · 2025 · Diabetes spectrum : a publication of the American Diabetes Association
Current recommendations encourage strict intrapartum glycemic control for individuals with diabetes in pregnancy to optimize maternal and neonatal outcomes. However, established evidence is limited in providing a strong association between…
Hulsmann SC, Zaal DC, van Gestel JPJ et al. · 2026 · Pituitary
PURPOSE: Children undergoing neurosurgery for (supra)sellar tumors are at risk of developing arginine vasopressin-deficiency (AVP-D), which can cause severe sodium fluctuations and associated neurological complications, prolonged…
Siokas V, Liampas I, Aloizou AM et al. · 2023 · Journal of integrative neuroscience
Background Microglial activation is considered to assume a role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). To date, the relationship between ALS and the rs3865444 polymorphism of the cluster of differentiation 33 (CD33)…
Sala G, Castelli M, Orsetti C et al. · 2025 · Veterinary sciences
Procalcitonin (PCT), protein carbonyl content (PCC), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been proposed as promising biomarkers for detecting diseases in cattle. Their concentrations could…
Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia
Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…
Wallam S, Park J, Wu LW et al. · 2025 · Journal of gastrointestinal oncology
Background Claudin18.2 (CLDN18.2), a tight junction molecule, is a novel therapeutic target for patients with advanced gastroesophageal adenocarcinoma. Recent phase III trials demonstrated improved survival with the addition of an…
Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences
The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…
Campos A, Tuomainen J, Tuomainen O · 2023 · Preprint
This study compared cortical responses to speech in preschoolers with typical language development (TLD) and Developmental Language Disorder (DLD), and in adults. We investigated whether top-down language effects modulate speech perception…
Thapa M, Courville J, Leonhard R et al. · 2025 · Frontiers in stroke
Introduction Whole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of…
Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers
Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…
Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…
Sanchez JA, de Pedro L, López-Gallego E et al. · 2024 · Scientific reports
Many agricultural landscapes offer few resources for maintaining natural enemy populations and floral plantings have frequently been adopted to enhance biological pest control in crops. However, restored margins may harbour both pests and…
Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research
Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…
Wattacheril J, Kleinstein SE, Shea PR et al. · 2024 · Preprint
Background and Aims Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 ( PNPLA3 ) and transmembrane 6 superfamily member 2 ( TM6SF2 ) genes…
Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review
Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…
D'Marco L, Checa-Ros A, Locascio A et al. · 2025 · Frontiers in medicine
Background Several studies suggest that C-peptide (CP) is involved in regulating lipolysis, adipokine release, and other functions in the adipose tissue. On the other hand, organ-specific adipose tissues, such as the epicardial adipose…
Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics
Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…
Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls
Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…
Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology
Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…
Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine
Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…
Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open
Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…
Abdalla M · 2026 · Frontiers in medicine
Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…
O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association
Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…
Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…