Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.
Ghosh AK; Bhattacharjee A; Jayashankar U; Bogan SN; Mesecar AD · 2026 · Organic & biomolecular chemistry
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Abstract (excerpt)
We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…
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Metadata source: Europe PMC · DOI 10.1039/d5ob01897h