Negative / Null Result ReportOpen accessMedicine (General)
Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro et al. · 2024 · Biomarker Insights
Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. Objective and design: This retrospective cohort study aimed to evaluate mRNA expression and promoter methylation of some homologous recombination-related genes in this neoplasm. Methods: We evaluated mRNA expression and methylation of RAD51 , ATM , ATR , BRCA1 , and BRCA2 in tumor and non-tumor frozen samples from gastrectomy specimens by RT-qPCR and MS-HRM, correlating our results with previous i
View details →DOI: 10.1177/11772719231225206 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Aves Editorial Aves Editorial · 2019 · Urology Research and Practice
Abstract Introduction: Lower urinary tract symptoms (LUTS) associated with BPH and erectile dysfunction (ED) are common problems in aging male. In this study, we aimed to determine the causes of the relationship between LUTS and ED, and the possible effects of body mass index (BMI), serum leptin, free testosterone (fT) and lipid levels on LUTS and ED etiology. Materials and Methods: Between June 2003 and February 2004, 46 patients were recruited in this study. All patients underwent physical examination including digital rectal examination, urine analysis, uroflowmetry and residual urine volum
Negative / Null Result ReportOpen accessPediatrics
Nevzat Gönder, Cansu Öztürk, Rabia Taşdemir et al. · 2025 · Children
Background: A precise radiographic evaluation of adolescent idiopathic scoliosis (AIS) is essential for effective treatment planning and follow-up. The pelvic axial rotation (PAR) and horizontal balance of the pelvis are critical factors to consider throughout the treatment and monitoring of AIS. While some previous studies have examined spinal curvature in relation to PAR direction and the direction of the major curve (DMC) in AIS patients, this study aims to explore the relationship between scoliosis morphology, pelvic axial rotation (PAR), and the direction of the major curve in patients wi
View details →DOI: 10.3390/children12080991 Negative / Null Result ReportOpen accessMedicine
Derya Koyun, Gokhan Nergizoglu, Kemal Metin Kir · 2018 · Saudi Journal of Kidney Diseases and Transplantation
The loss of muscle mass and cachexia is commonly seen in hemodialysis (HD) patients and contribute to morbidity and mortality. The exact mechanism of this fact is multifactorial and still unclear. Myostatin, a transforming growth factor-ß family ligand, is released from the skeletal and heart muscle and may be responsible for muscle degradation and atrophy. The aim of this study is evaluation of the relationship between muscle mass and serum myostatin level in chronic HD patients. One hundred and forty HD patients (79 males, 28 diabetic, mean age; 53.96 ± 13.6) were included in this cross-sect
View details →DOI: 10.4103/1319-2442.239648 Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities
Lalić Bojan R., Ranđelović Dušan J. · 2013 · Zbornik Radova Filozofskog Fakulteta u Prištini
The aim of this research was to identify relations between level of religiosity and level of contact on one side and social attitudes towards members of religious out-groups in conflict environment on the other side. This research was conducted on the sample of Christian Orthodox students in Kosovska Mitrovica (which is partially conflict environment) and the Muslims were the out-group towards whom attitudes were analyzed. Attitudes measures we used were social distance scale and semantic differential. Likert type scale was used for religiosity measure, quantity and quality of contact. Control
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Inga Marte Charlott Seuthe, Markus Ruwe, Franz Mitze et al. · 2025 · Discover Oncology
Abstract Objectives VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC. Methods The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed. Results High VCP/p97 express
View details →DOI: 10.1007/s12672-025-03839-8 Negative / Null Result ReportOpen accessVeterinary medicine
Erica Anna Gumpert Herlofson, Francesca Tavola, Karolina Siri Engdahl et al. · 2023 · Acta Veterinaria Scandinavica
Abstract Background Pre-emptive local analgesia with the use of lidocaine is practised increasingly in veterinary medicine as part of applied multimodal analgesia, despite its controversial impact on wound healing. The purpose of this prospective, randomised, double-blinded, placebo-controlled clinical study was to evaluate if preoperative subcutaneous infiltration of lidocaine has a negative impact on primary wound healing of surgical incisions. Fifty-two companion animals (3 cats and 49 dogs) were enrolled in the study. The inclusion criteria were as follows: American Society of Anaesthesiol
View details →DOI: 10.1186/s13028-023-00686-x Negative / Null Result ReportOpen accessAgriculture
Yosuke Kuroda, Kazuyuki Okazaki, Kenji Takashino et al. · 2025 · Agrosystems, Geosciences & Environment
Abstract Sugar beet (Beta vulgaris) production in Japan faces major challenges from virus yellows (VY), caused by beet leaf yellowing virus (BLYV) and transmitted by aphids. Outbreaks have reduced sugar yields, and breeding for tolerant varieties has not been conducted in Japan. This study marks the first step toward developing VY‐tolerant varieties by testing three hypotheses: (1) leaf yellowing can be induced by artificial inoculation, (2) tolerance varies among breeding materials, and (3) differences in tolerance to yellowing disease can be evaluated. From 2017 to 2020, four sugar beet mate
View details →DOI: 10.1002/agg2.70201 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Kun Wang, Yuanyuan Shen, Chen Hu et al. · 2025 · Clinical and Translational Science
ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s
View details →DOI: 10.1111/cts.70322 Negative / Null Result ReportOpen accessMedicine
Ni Luh Kadek Alit Arsani, Luh Ari Arini, Luh Yenny Armayanti et al. · 2026 · Althea Medical Journal
Background: During perimenopause, declining estrogen levels often lead to altered menstrual patterns and other age-related health concerns. Consequently, the role of physical activity warrants closer examination. This study investigated the correlation between exercise frequency and menstrual cycle characteristics in premenopausal women Methods: A cross-sectional observational study was conducted in Singaraja City, Indonesia, from July to October 2024. A total of 150 premenopausal women aged 45–50 years were recruited through random sampling. Exercise frequency was measured using the World Hea
View details →DOI: 10.15850/amj.v13n2.4594 Negative / Null Result ReportOpen accessVeterinary medicine
Kimberly Williams, Valerie MacDonald-Dickinson, Arata Matsuyama · 2024 · Journal of Feline Medicine and Surgery
Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between
View details →DOI: 10.1177/1098612x241266418 Negative / Null Result ReportOpen accessMedicine
Yayuan Deng, Hongxuan Wu, Tingning Zhao et al. · 2025 · Scientific Reports
Abstract Atmospheric dustfall is solid air pollutant, which is mainly influenced by local sources, so it has a major impact on the local environment and the health of local residents. The objective of this study was to investigate the distribution characteristics of dustfall fluxes and particle size, and the meteorological factors affected them. Atmospheric dustfall was collected in an open-pit coal mining area and surrounding areas in the arid desert area of Northwest China from March to December 2018. Dustfall fluxes was measured, particle size was measured by using graphical methods and gra
View details →DOI: 10.1038/s41598-025-94161-4 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Nicola Manta, Laura Mangiavini, Cristiana Balbino et al. · 2021 · BMC Musculoskeletal Disorders
Abstract Background Suction drainage is commonly applied after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) to reduce hematoma, swelling and to favor surgical wound healing. However, its efficacy remains controversial; thus, the purpose of this study is to evaluate drainage efficiency in the management of postoperative bleeding in TKA and UKA. Methods The cohort comprised 134 clinical records of patients affected by knee osteoarthritis (OA) who underwent either TKA or UKA. All the patients were subdivided into 2 groups: the first one with drainage and the second o
View details →DOI: 10.1186/s12891-021-04868-4 Negative / Null Result ReportOpen accessVeterinary medicine
Evangelia Maniaki, Carmen Pineda, Angie Hibbert et al. · 2024 · Frontiers in Veterinary Science
ObjectivesThis case-control study aimed to evaluate calcitonin response in naturally occurring hypercalcemia in cats and assess the relationships between calcitonin and ionized calcium (iCa) and examine relationships between calcitonin, iCa and bone turnover.MethodsHypercalcemic cats (persistently increased iCa concentration [>1.40 mmol/l]) were identified retrospectively via a medical database search; additional hypercalcemic and normocalcemic cats were recruited prospectively. Data regarding routine biochemical and urine testing, diagnostic imaging and additional blood testing were obtained.
View details →DOI: 10.3389/fvets.2024.1399942 Replication Failure
Anisatul Fauziah · 2023 · SIGNIFICANT : Journal Of Research And Multidisciplinary
Persaingan dalam lingkungan kerja saat ini semakin ketat, ini menuntut perusahaan terus menerus mengembangkan usahanya untuk dapat bersaing dengan perusahaan lain. Oleh karena itu dibutuhkan pengelola manajemen perusahaan yang biasa…
View details →DOI: 10.62668/significant.v2i02.863 Negative / Null Result ReportMedicine
A. Rezaei, Farnoush Fotovat, Ali Heidari et al. · 2026 · The Journal of prosthetic dentistry (Print)
STATEMENT OF PROBLEM Implant-supported prostheses provide a reliable method of replacing missing teeth. To avoid complications, their accurate placement is critical. Advances in static computer-aided implant surgery (sCAIS), which uses…
View details →DOI: 10.1016/j.prosdent.2025.12.026 Negative / Null Result ReportOpen accessMedicine
N. Kumar, N. Elbanhawy, S. Chalil et al. · 2021
Type of funding sources: None. Catheter ablation in patients with atrial fibrillation (AF)/atrial flutter carries a risk of thromboembolism and major bleeding. Oral anticoagulation is advised for prevention of thromboembolic complications.…
View details →DOI: 10.1093/europace/euab116.559 Negative / Null Result ReportMedicine
Enzo Berbery, Vitor de Salles Painelli, Paulo Vitor Suto Aizava et al. · 2026 · Australasian Journal on Ageing
ABSTRACT Objective The aim of this study was to investigate the effects of a moderate‐intensity multicomponent training (MCT) program on body composition, physical function, glycaemic control and lipid profiles in overweight and obese…
View details →DOI: 10.1111/ajag.70176 Negative / Null Result ReportOpen accessMedicine
Yodi Suryo Arnanto, Ruli Herman Sitanggang, Nurita Dian Kestriani Saragi Sitio · 2018 · Jurnal Anestesi Perioperatif
Informasi mengenai indikasi, tujuan, prosedur, risiko, manfaat, dan alternatif tindakan anestesi yang akan dilakukan harus disampaikan kepada pasien. Pemberian informasi dilakukan secara verbal atau lisan pada saat proses persetujuan…
View details →DOI: 10.15851/jap.v6n3.1351 Negative / Null Result ReportOpen accessMedicine
K. Lang-Illievich, C. Klivinyi, Heike Schulze-Bauer et al. · 2024 · PLoS ONE
Background Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom. Objectives This study investigated the efficacy of…
View details →DOI: 10.1371/journal.pone.0307034 Negative / Null Result ReportOpen accessMedicine
Xiaobao Liu, Wenjie Wu, Yulong Huang et al. · 2024 · PLoS ONE
Purpose This study aimed to assess the repeatability of intraocular lens (IOL) decentration measurements obtained through Pentacam, based on corneal topographic axis (CTA) and pupillary axis (PA), and to evaluate the level of agreement…
View details →DOI: 10.1371/journal.pone.0299064 Negative / Null Result ReportMedicine
N. Segal, Lauren N. Neuman, Maria C Hochstedler et al. · 2018 · The Foot
INTRODUCTION Anthropometric changes to the feet with pregnancy may increase risk for musculoskeletal disease. Customized arch-supportive orthoses to prevent anthropometric changes could potentially provide an inexpensive means to prevent…
View details →DOI: 10.1016/j.foot.2018.07.007 Negative / Null Result ReportOpen access
P. Magnus, C. Jayakumar, N. Thomas et al. · 2023 · Journal of Veterinary and Animal Sciences
Primary uterine inertia is the inherent inability of the uterus to contract and expel a fully grown foetus after the end of the gestation period, through a normal birth canal, in the absence of obstructive dystocia.There are conflicting…
View details →DOI: 10.51966/jvas.2023.54.1.7-12 Negative / Null Result ReportOpen accessMedicine
H. Shieh, C. Smithers, Thomas E. Hamilton et al. · 2018 · Frontiers in Surgery
Purpose We review outcomes of posterior tracheopexy for tracheomalacia in esophageal atresia (EA) patients, comparing primary treatment at the time of initial EA repair versus secondary treatment. Methods All EA patients who underwent…
View details →DOI: 10.3389/fsurg.2017.00080 Negative / Null Result ReportMedicine
J. Hannestad, Tiffanie Duclos, Whitney Chao et al. · 2021 · Journal of Alzheimer's Disease
Background: The plasma fraction GRF6019 shows multiple benefits on brain aging in mice, including enhanced cognition, neurogenesis, and synaptic density, as well as reduced neuroinflammation. Objective: To evaluate the safety,…
View details →DOI: 10.3233/jad-210011 Negative / Null Result ReportOpen accessComputer Science
B. Selivany, A. Yousif · 2020 · The Journal Of Duhok University
Aim : The study aimed to compare Shaping ability of WaveOne Gold, Reciproc Blue and 2Shape NiTi systems having different design and metallurgic properties. Method : Forty five extracted human single root with 10 mm root length were…
View details →DOI: 10.26682/sjuod.2020.23.2.11 Negative / Null Result ReportOpen accessMedicine
P. Subramaniam, N. Nandan · 2011 · Contemporary Clinical Dentistry
Introduction: Prevention of dental caries is one of the main strategies in contemporary pediatric dental practice. Mouth rinses are widely used as an adjunct to maintain oral hygiene. It is important for these products to be effective and…
View details →DOI: 10.4103/0976-237x.91790 Negative / Null Result ReportMedicine
C. E. Monera Lucas, J. Escolano Serrano, C. T. Tarazona Jaimes et al. · 2022 · Archivos de la Sociedad Española de Oftalmología
PURPOSE To evaluate the reproducibility in the measurement of ocular biometric parameters using a new swept-source optical coherence tomographer and its comparability with an optical low coherence reflectometry biometer. DESIGN An…
View details →DOI: 10.1016/j.oftale.2022.04.003 Negative / Null Result ReportOpen accessMedicine
J. Ortiz, M. Fernández‐Arquero, E. Urcelay et al. · 2006 · BMC Medical Genetics
BackgroundIgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Genetic and environmental factors are suspected to be involved in the development of the disease. Interleukin-10 (IL-10) is a cytokine with…
View details →DOI: 10.1186/1471-2350-7-56 Negative / Null Result ReportMedicine
C. Villanueva · 2019 · Journal of Pediatric Urology
INTRODUCTION AND OBJECTIVE The assessment of penile curvature is a key component of hypospadias surgery, as it often determines if a one- or two-stage procedure should be performed. The objective of this study was to compare unaided visual…
View details →DOI: 10.1016/j.jpurol.2019.09.020 