Abandoned HypothesisMedicine
Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA
Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…
View details →DOI: 10.1016/j.tiv.2026.106274 Negative / Null Result ReportMedicine
Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology
Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…
View details →DOI: 10.1097/mcg.0000000000002341 Negative / Null Result ReportMedicine
Lu J, Huang S, Wei S et al. · 2026 · Genes
Objective: TNFSF13B , which encodes B-cell-activating factor ( BAFF ) and peptidylarginine deiminase 4 ( PADI4 ), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of…
View details →DOI: 10.3390/genes17060710 Negative / Null Result ReportMedicine
Zhang G, Zhang L, Jiang M et al. · 2026 · Clinical rheumatology
Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) have an increased risk of developing lung cancer (LC).This study investigated whether non-receipt of immunosuppressive therapy is associated with LC…
View details →DOI: 10.1007/s10067-026-08231-7 Negative / Null Result ReportOpen accessMedicine
Chavatza K, Gialouri CG, Drougkas K et al. · 2026 · RMD open
Objective To examine the role of low-dose glucocorticoids (GCs) in major relapse, hospitalisation and damage accumulation risk during maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs). Methods…
View details →DOI: 10.1136/rmdopen-2026-006935 Negative / Null Result ReportMedicine
Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology
Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…
View details →DOI: 10.1007/s10067-026-08253-1 Negative / Null Result ReportOpen accessMedicine
Hendrixson DT, Tiwari R, James P et al. · 2026 · Maternal & child nutrition
Upstream pathways influencing child growth are complex. Weight-for-age z-score (WAZ) reflects both ponderal and linear growth and can identify children at high mortality risk. Using data from a prospective cohort of 326 mother-child pairs…
View details →DOI: 10.1111/mcn.70195 Negative / Null Result ReportMedicine
Suzuki Y, Misaka T, Okochi S et al. · 2026 · Fukushima journal of medical science
Background Heart-liver metabolic crosstalk contributes to heart failure pathophysiology. Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new disease entity based on positive metabolic criteria. However,…
View details →DOI: 10.5387/fms.26-00009 Abandoned HypothesisMedicine
Bruno MT, Pagana A, Aiello T et al. · 2026 · BMC cancer
Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…
View details →DOI: 10.1186/s12885-026-16398-0 Negative / Null Result ReportMedicine
Guzman JM, Hardi FA, Peckins MK et al. · 2026 · Psychoneuroendocrinology
The hypothalamic-pituitary-adrenal (HPA) axis maintains homeostasis and responds to stressors in the environment, shaping responsivity and behavior at least partly through its effects on the brain. For example, increased cortisol levels…
View details →DOI: 10.1016/j.psyneuen.2026.107938 Negative / Null Result ReportMedicine
Frijmersum ZZ, Van Der Meij E, Huirne JA et al. · 2026 · Occupational and environmental medicine
Objectives Women's labour force participation often declines after childbirth, but the role of sick leave during pregnancy and after childbirth in sustained employment remains unclear. This study examined: (1) the association between sick…
View details →DOI: 10.1136/oemed-2025-110638 Negative / Null Result ReportMedicine
Yang L, Xu L · 2026 · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Background Postpartum falls threaten maternal and infant safety, yet evidence on postpartum women's fall-prevention knowledge, attitude, and behaviour (KAB) and their sociodemographic correlates remains limited. This study examined…
View details →DOI: 10.1080/01443615.2026.2678173 Negative / Null Result ReportMedicine
Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…
View details →DOI: 10.1111/liv.70723 Negative / Null Result ReportMedicine
Yamao S, Chiba Y, Kuniyoshi K et al. · 2026 · Ophthalmology. Retina
Purpose To evaluate surgical outcomes and identify key prognostic factors in retinal detachment associated with morning glory syndrome (MGS-RD). Design Retrospective consecutive case series. Subjects Fifteen consecutive eyes of 15 patients…
View details →DOI: 10.1016/j.oret.2026.06.011 Negative / Null Result ReportOpen accessMedicine
Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience
AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…
View details →DOI: 10.1038/s44277-026-00065-0 Negative / Null Result ReportMedicine
David P, Oliphant K, Zhou C et al. · 2026 · Pediatric research
Background Fentanyl, an opioid medication commonly given to hospitalized preterm infants, may alter gut microbiome development and subsequent neurodevelopmental outcomes. Methods We compare a cohort of preterm infants with and without…
View details →DOI: 10.1038/s41390-026-05210-1 Negative / Null Result ReportMedicine
Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes
Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…
View details →DOI: 10.1186/s13104-026-07924-1 Negative / Null Result Report
Letta S · 2026 · Preprint
Abstract Background Low back pain is a major occupational health problem among the healthcare workforce. It contributes to reduced productivity, absenteeism, and diminished quality of life. Despite its significant burden, the prevalence…
View details →DOI: 10.21203/rs.3.rs-10143847/v1 Negative / Null Result ReportOpen accessMedicine
Siddique S, Wang R, Berardi D et al. · 2026 · Cancer
Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…
View details →DOI: 10.1002/cncr.70458 Negative / Null Result ReportOpen accessMedicine
Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…
View details →DOI: 10.1212/nxi.0000000000200615 Negative / Null Result ReportMedicine
Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…
View details →DOI: 10.1111/psyg.70179 Negative / Null Result ReportOpen accessMedicine
Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research
Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…
View details →DOI: 10.1177/03000605261457776 Negative / Null Result Report
Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint
ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…
View details →DOI: 10.64898/2026.06.04.26354935 Negative / Null Result ReportMedicine
Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients
Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…
View details →DOI: 10.3390/nu18122022 Negative / Null Result ReportMedicine
Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy
Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…
View details →DOI: 10.1016/j.bjpt.2026.101593 Negative / Null Result ReportMedicine
Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…
View details →DOI: 10.3390/diagnostics16121841 Replication FailureOpen accessMedicine
Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
View details →DOI: 10.1136/bmjment-2026-302515 Negative / Null Result ReportMedicine
Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…
View details →DOI: 10.1016/j.ejvs.2026.06.019 Failed Experiment ReportMedicine
Ganesh A, Smith EE, Mostert J et al. · 2026 · Neurology
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
View details →DOI: 10.1212/wnl.0000000000218227 Replication FailureMedicine
Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
View details →DOI: 10.3390/ani16121854 