Replication FailureMedicine
Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice
Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…
View details →DOI: 10.23876/j.krcp.25.452 Replication FailureMedicine
Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews
Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…
View details →DOI: 10.1002/14651858.cd008626.pub4 Negative / Null Result ReportMedicine
Mehta V, Galletti C, Mathur A et al. · 2026 · Systematic reviews
Background Oral candidiasis (OC) is among the most prevalent oral infections, frequently associated with immunosuppression, denture wearing, advanced age, and excessive antibiotic use. Given the growing concerns about antifungal…
View details →DOI: 10.1186/s13643-026-03249-z Negative / Null Result ReportMedicine
Wu X, Zhang B, Yu M et al. · 2026 · Photodiagnosis and photodynamic therapy
Repeated low-level red-light therapy (RLRL) has emerged as a promising ocular photobiomodulation strategy for childhood myopia control. Published randomized trials have reported substantial reductions in axial elongation and refractive…
View details →DOI: 10.1016/j.pdpdt.2026.105554 Failed Experiment ReportMedicine
Anarna K, Fiander M, Mitra S · 2026 · The Cochrane database of systematic reviews
Rationale Preterm and low-birthweight infants are at risk of anemia due to a variety of factors, including low levels of erythropoietin. They may therefore benefit from erythropoiesis-stimulating agents (ESAs). However, controversy remains…
View details →DOI: 10.1002/14651858.cd004863.pub7 Null DatasetMedicine
He Z, Yang L, Liang Z et al. · 2026 · NPJ digital medicine
Large language models (LLMs) are being deployed in clinical settings despite an underdeveloped evidence base regarding their real-world effectiveness. This study employed systematic evidence mapping to characterize outcome measures used in…
View details →DOI: 10.1038/s41746-026-02837-6 Negative / Null Result Report
Curran T, Pymm J, Gabriel J et al. · 2026 · Preprint
Abstract Cardiac fitness and rehabilitation programs offer meaningful benefits for individuals with congenital heart disease (CHD), and newer delivery models include hybrid formats combining virtual and in-person training. We hypothesized…
View details →DOI: 10.21203/rs.3.rs-10026873/v1 Negative / Null Result ReportMedicine
Ordóñez-Riaño S, Jiménez-Leal W · 2026 · Acta psychologica
What motivates people to place trust in strangers-the sense that they ought to trust, or the feeling that they want to? Competing perspectives suggest that trust may be driven either by obligations or by desires. In two studies, we tested…
View details →DOI: 10.1016/j.actpsy.2026.107099 Negative / Null Result Report
Seymore TN, Hoffmann S, Louro P et al. · 2026 · Preprint
Fetal health is heavily dictated by the maternal environment. Inhaling airborne pollutants, like particulate matter, is associated with pregnancy complications and fetal developmental pathologies, including fetal growth restriction (FGR).…
View details →DOI: 10.64898/2026.06.16.732724 Negative / Null Result ReportMedicine
De Laet H, Nijhof AD, Wiersema JR · 2026 · Autism : the international journal of research and practice
While prevailing theories suggest social interaction difficulties are inherent to autism, the theory of the double empathy problem (DEP) proposes these difficulties arise from a mismatch between different neurotypes. The theory predicts…
View details →DOI: 10.1177/13623613261451897 Negative / Null Result Report
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 258, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
View details →DOI: 10.31234/osf.io/kq9ds_v4 Negative / Null Result Report
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
View details →DOI: 10.31234/osf.io/kq9ds_v3 Negative / Null Result Report
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
View details →DOI: 10.31234/osf.io/kq9ds_v2 Negative / Null Result ReportMedicine
Kiang M, Lepock JR, Mizrahi R et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Objectives Patients at clinical high risk (CHR) for schizophrenia experience a wide range of clinical outcomes. Given this heterogeneity, long-term prognostic biomarkers are needed. The gamma-frequency EEG auditory steady-state response…
View details →DOI: 10.1080/15622975.2026.2684757 Negative / Null Result ReportMedicine
Csigai P, Sparrow L, Maquet L et al. · 2026 · Scientific reports
Resting heart rate variability (HRV) is considered a marker of individuals' capacity to adapt to environmental demands, although direct empirical evidence remains limited. This study examined whether resting HRV predicts subjective and…
View details →DOI: 10.1038/s41598-026-52956-z Negative / Null Result ReportMedicine
Werle D, Sablottny L, Tuschen-Caffier B et al. · 2026 · Appetite
While the hierarchical model of approach-avoidance motivation suggests a heightened food-specific approach behavior for individuals with binge eating disorder (BED), empirical evidence does not confirm the postulated food approach bias.…
View details →DOI: 10.1016/j.appet.2025.108434 Negative / Null Result ReportMedicine
Flint RW Jr, Morehouse J, Chown AE et al. · 2026 · Psychological reports
Long-term reactivated memories undergo a time-dependent reconsolidation process during which they are susceptible to modulation. We report the results of an experiment examining the effect of multiple reminder treatments on reconsolidation…
View details →DOI: 10.1177/00332941261438074 Negative / Null Result ReportMedicine
Sharma A, Hanly M, Bhonagiri D · 2026 · Critical care medicine
Objectives This study aims to investigate the effect of culturally and linguistically diverse (CaLD) status on in-hospital mortality in patients admitted to ICUs with sepsis. We hypothesize that diverse cultural and ethnic backgrounds,…
View details →DOI: 10.1097/ccm.0000000000007126 Negative / Null Result ReportMedicine
van Doorslaer de Ten Ryen S, Warnier G, Antoine N et al. · 2026 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Satellite cells participate in myogenesis and contribute to skeletal muscle regeneration and hypertrophy. Amongst other stimuli, satellite cells can be activated by exercise and hypoxia. However, the cumulative effect of exercise on…
View details →DOI: 10.1096/fj.202600405rr Negative / Null Result Report
Hannibal W, Freitas-Oliveira R, Bernardes-Dias AC et al. · 2026 · Preprint
Abstract The study of species distribution has long intrigued naturalists, driven by ecological and evolutionary processes such as species interactions, climatic, and geological factors. Understanding these patterns is crucial for…
View details →DOI: 10.21203/rs.3.rs-9181042/v1 Negative / Null Result ReportMedicine
Tagami U, Imaizumi S · 2026 · Acta psychologica
Visual false pattern perception can increase in response to a lack of control. However, prior studies have manipulated control over relatively long timescales by altering participants' beliefs. We investigated whether short-timescale…
View details →DOI: 10.1016/j.actpsy.2026.106632 Negative / Null Result Report
Wójcik M, Orłowski P, Adamczyk S et al. · 2026 · Preprint
Background Contemporary research indicates that psychedelics induce notable neurophysiological changes, some lasting weeks to months after a single dose. However, most evidence derives from acute administration studies and limited…
View details →DOI: 10.64898/2026.03.30.711922 Negative / Null Result ReportMedicine
Inamura Y, Miyazaki S, Nitta J et al. · 2026 · Heart rhythm
Background A size-adjustable cryoballoon (SACB, POLARxFIT, Boston Scientific), switching between 28-mm and 31-mm diameters, was introduced for atrial fibrillation ablation; however, its efficacy and safety compared with conventional…
View details →DOI: 10.1016/j.hrthm.2026.05.037 Negative / Null Result Report
Chusyd DE, Austad SN, Brown JL et al. · 2026 · Preprint
Early-life trauma in humans, including maternal loss, is strongly associated with increased risk of chronic diseases, reduced life expectancy, and accelerated biological aging, as measured through epigenetic modifications, such as DNA…
View details →DOI: 10.64898/2026.04.03.716431 Replication FailureMedicine
Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery
Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…
View details →DOI: 10.1016/j.jpedsurg.2026.163233 Replication FailureMedicine
Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
View details →DOI: 10.1097/xcs.0000000000001749 Negative / Null Result ReportMedicine
Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
View details →DOI: 10.1007/s00421-026-06227-4 Negative / Null Result ReportMedicine
Pacheco CFO, Costa RF, Silva AEB et al. · 2026 · Forest Ecology and Management.
Mangroves face increasing threats from human degradation and extreme weather events, yet limited information exists on whether they can naturally recover after those disturbances. In this study, we attempted to fill this gap by assessing…
Negative / Null Result ReportMedicine
Antonarakis ES, Antonarakis ES, Cao Q et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This multicenter, single-arm, phase II trial evaluated the safety and efficacy of cabazitaxel and carboplatin followed by abiraterone, plus androgen deprivation therapy (ADT), in patients with high-volume metastatic…
View details →DOI: 10.1158/1078-0432.ccr-25-4823 Negative / Null Result ReportMedicine
Wanner P, Ostermair F, Cristini J et al. · 2026 · Experimental brain research
A single bout of cardiovascular exercise (CVE) can promote neuroplasticity in an intensity-dependent manner. Consequently, performing CVE immediately after encoding may enhance motor memory consolidation, with stronger effects reported for…
View details →DOI: 10.1007/s00221-026-07256-3 