Negative / Null Result ReportMedicine
Srivastava A, Maienschein-Cline M, Pabalan A et al. · 2026 · Methods (San Diego, Calif.)
MicroRNAs (miRNAs) are promising biomarkers and therapeutic targets; however, reliable extracellular miRNA quantification by RT-qPCR depends on appropriate normalization, and no universal endogenous reference has been established. This…
View details →DOI: 10.1016/j.ymeth.2026.05.010 Negative / Null Result ReportOpen accessMedicine
Chen C, Qualls WA, Xue RD et al. · 2026 · Journal of economic entomology
The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.)…
View details →DOI: 10.1093/jee/toaf030 Methods Dead-EndMedicine
Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies
Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…
View details →DOI: 10.1016/j.jbmt.2026.03.018 Failed Experiment ReportMedicine
Gower JSE, Webster R, Westaway JAF et al. · 2026 · The Journal of infectious diseases
Background The zoonotic parasite Plasmodium knowlesi is an increasing cause of human malaria in Southeast Asia. We aimed to develop a P. knowlesi induced blood-stage malaria (IBSM) model to facilitate study of parasite biology, host…
View details →DOI: 10.1093/infdis/jiag225 Methods Dead-EndOpen accessMedicine
Pedauyé-Rueda B, Maté-Muñoz JL, Hernández-Lougedo J et al. · 2026 · Frontiers in aging
Background The Sarcopenia Optoelectronic Chair-Rise Velocity Test (SARC-T) has been proposed as an instrumented chair-rise measure related to physical function in sarcopenia; however, its test-retest measurement properties have not been…
View details →DOI: 10.3389/fragi.2026.1822206 Failed Experiment ReportMedicine
Saad R, Sekiguchi T, Takai Y et al. · 2026 · Marine environmental research
Microplastics (MPs) are ubiquitous in marine environments and readily ingested by filter-feeding organisms, yet the ecotoxicological effects of irregularly shaped MPs remain poorly understood. This study assessed the accumulation and…
View details →DOI: 10.1016/j.marenvres.2026.108135 Failed Experiment ReportMedicine
Coronado L, Muñoz-Aguilera A, Puente-Marin S et al. · 2026 · Frontiers in veterinary science
Control of classical swine fever (CSF) in endemic regions relies heavily on vaccination of breeding herds. Optimizing vaccination strategies is essential for sustainable disease control covering pigs belonging to different categories. Data…
View details →DOI: 10.3389/fvets.2026.1827278 Negative / Null Result ReportOpen accessMedicine
Buchkowski RW, Polussa A, Bradford MA · 2026 · Global change biology
Detecting changes in forest soil carbon stocks is critical for compiling national carbon budgets, yet remains challenging due to high spatial variability and relatively small temporal changes. Here, we use data from Canada's National…
View details →DOI: 10.1111/gcb.70868 Negative / Null Result ReportOpen accessMedicine
Yun YJ, Moon C, Kim KH et al. · 2026 · Journal of clinical medicine
Background : Wearable powered gait orthoses offer a clinically flexible alternative to treadmill-based robotic systems, yet evidence on different device configurations matched to the site of neuromuscular impairment remains limited.…
View details →DOI: 10.3390/jcm15103580 Negative / Null Result ReportMedicine
Li Y, Santer BD, Solomon S et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Large volcanic eruptions and intense wildfires perturb Earth's atmospheric temperature. Understanding the climate response to such natural forcings is essential for obtaining reliable estimates of its response to anthropogenic greenhouse…
View details →DOI: 10.1073/pnas.2525500123 Negative / Null Result Report
Khan D · 2026 · Preprint
Abstract How social influence is organized in a networked group determines not only the accuracy of its collective estimate but also its vulnerability to deliberate steering. For a DeGroot-with-signals model of repeated estimation, the…
View details →DOI: 10.21203/rs.3.rs-10061658/v1 Negative / Null Result Report
Paplauskas S · 2026 · Preprint
Local adaptation (LA) is expected to arise when populations evolve higher fitness in their local environment than migrants, particularly in heterogeneous environments and coevolving host–parasite systems. Such adaptation can influence…
View details →DOI: 10.22541/au.177153469.92868672/v2 Negative / Null Result ReportOpen accessMedicine
Iribarren A, Obrutu O, Maughan J et al. · 2026 · American heart journal plus : cardiology research and practice
Background Caffeine, a nonselective adenosine A2 receptor antagonist, blunts adenosine-induced coronary hyperemia. Despite recommended abstinence before adenosine stress cardiac magnetic resonance imaging (CMRi), residual caffeine may…
View details →DOI: 10.1016/j.ahjo.2025.100709 Negative / Null Result ReportMedicine
Sivanandam P, Syenina A, Chan YF et al. · 2026 · Communications medicine
Background Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown if systemically administered…
View details →DOI: 10.1038/s43856-026-01678-4 Negative / Null Result ReportOpen accessMedicine
Liu LT, Sun XS, Quan TT et al. · 2026 · Nature communications
Induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (LA-NPC); however, patients with a suboptimal response to IC, defined as detectable…
View details →DOI: 10.1038/s41467-026-71019-5 Negative / Null Result ReportOpen accessMedicine
Němá K, Kačúr P, Kozák T et al. · 2026 · Journal of functional morphology and kinesiology
Background: Operational performance in security-force settings depends on maintaining accurate motor-cognitive and shooting performance under acute physical strain. This descriptive pilot study examined pre-post performance patterns during…
View details →DOI: 10.3390/jfmk11020183 Negative / Null Result ReportOpen accessMedicine
Rasmussen CA, Mink SB, Primdahl J et al. · 2026 · Musculoskeletal care
Introduction In recent years, the Ankylosing Spondylitis Performance Index (ASPI) has emerged as a new objective measure of physical function in patients with axial spondyloarthritis (axSpA). So far, only the relative interrater…
View details →DOI: 10.1002/msc.70224 Negative / Null Result ReportOpen accessMedicine
Moabelo KC, Rauh R, Loots A et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
We evaluated the performance of the FMDV 2.1 dry RT-rtPCR prototype assay (Tetracore) to detect foot-and-mouth disease virus (FMDV) in lymph nodes. Various masses (20-100 mg) of FMDV-negative lymph node tissue were homogenized, diluted,…
View details →DOI: 10.1177/10406387261451770 Negative / Null Result ReportMedicine
Arovah NI, Kushartanti W, Ambardini RL · 2026 · Rehabilitacion
Background and objective Nonspecific low back pain (NSLBP) is a prevalent musculoskeletal condition. This study examined the immediate effects of extracorporeal shockwave therapy (ESWT), ultrasound therapy (UST), and shortwave diathermy…
View details →DOI: 10.1016/j.rh.2026.100987 Negative / Null Result Report
Kumpas G, Brewer B · 2026 · Preprint
Abstract Between 1976 and 2016, most U.S. states adopted laws authorizing or requiring police to make warrantless arrests at the scene of a domestic violence call. These laws were intended to protect victims, but they may also deter…
View details →DOI: 10.21203/rs.3.rs-9412007/v1 Negative / Null Result ReportMedicine
Cherenack EM, Larson ME, Roach ME et al. · 2026 · Brain, behavior, and immunity
Background Limited research has examined the longitudinal interplay of depression, substance use, and immune dysregulation among men with HIV. Methods We analyzed longitudinal data from 100 men who have sex with men (MSM) living with HIV…
View details →DOI: 10.1016/j.bbi.2026.106300 Negative / Null Result ReportOpen accessMedicine
Hoehne C, Rehling S, Schrenker J et al. · 2026 · Scientific reports
Preclinical simulation is essential for students to practice before clinical treatment. A low-cost 3D-printed model was developed with repositionable mobile maxillary anterior teeth to train periodontal splinting and evaluate learner…
View details →DOI: 10.1038/s41598-026-52988-5 Failed Experiment ReportOpen accessMedicine
Bolder R, King SBS, Zahn RC et al. · 2026 · Vaccines
Background/objectives RSV is a major cause of mortality in infants, and despite recent progress to prevent RSV in the very young, an RSV vaccine for this population is still highly warranted. Clinical studies in infants in the 1960s using…
View details →DOI: 10.3390/vaccines14010087 Failed Experiment Report
Noble C, Geller D, Urs N et al. · 2026 · Preprint
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…
View details →DOI: 10.64898/2026.06.16.732451 Failed Experiment ReportOpen accessMedicine
· 2006
Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…
Negative / Null Result ReportOpen accessMedicine
Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus
Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…
View details →DOI: 10.7759/cureus.109235 Negative / Null Result Report
Stein A · 2026 · Preprint
Abstract Low-dose radiation epidemiology is contested and inconclusive: confidence intervals span zero, and point estimates shift with the chosen dose range. Part of the contest is structural, not empirical. Under the linear…
View details →DOI: 10.21203/rs.3.rs-10010384/v1 Negative / Null Result ReportOpen accessMedicine
Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation
Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…
View details →DOI: 10.1186/s13102-026-01734-5 Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →DOI: 10.1097/cce.0000000000001404 Negative / Null Result Report
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
View details →DOI: 10.12688/openreseurope.21896.1 