Replication FailureOpen access
Panca M, Serfaty M, Satchell J et al. · 2025 · Preprint
Abstract Background : Crime has significant impact on older victims. High rates of anxiety and depression may be associated with crimes. Aims: This paper aims to evaluate the cost-effectiveness of a Victim Improvement Package (VIP) for the…
View details →DOI: 10.21203/rs.3.rs-7256160/v1 Negative / Null Result ReportMedicine
Polauke E, Stage Sø J, Carl H et al. · 2024 · Journal of environmental management
Ambitious to fulfill the European Water Framework Directive obligations, the European governments support projects to rehabilitate lakes with poor water quality. However, most lake restorations having relied on biomanipulation by fish…
View details →DOI: 10.1016/j.jenvman.2024.120570 Negative / Null Result ReportOpen accessMedicine
Li J, Zhou J, Ha Q et al. · 2026 · Frontiers in cardiovascular medicine
Objective Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired endothelium-dependent relaxation is an early manifestation of…
View details →DOI: 10.3389/fcvm.2026.1797300 Replication FailureMedicine
Shankie-Williams K, Day M, Dowland S · 2026 · Biology open
There is a critical need for novel non-hormonal contraceptives. Zinc-based intrauterine devices (IUDs) demonstrate 100% efficacy in rats, yet the mechanism remains unclear. We investigated whether zinc targets sperm, embryos, or the…
View details →DOI: 10.1242/bio.062546 Replication FailureMedicine
Zaidi S, Zoya M, Ishrat M et al. · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
The study aimed to evaluate delays in emergency department (ED) arrival among stroke patients and to identify demographic factors that contribute to these delays. It was a cross-sectional study conducted at the Department of Neurology,…
View details →DOI: 10.29271/jcpsp.2026.06.826 Replication FailureMedicine
Rowhani M, Hörmannstorfer-Fessl K, Kastner M et al. · 2026 · Respiratory medicine
Background Dry powder inhalers (DPIs) prescribed for respiratory diseases require patients to generate sufficient peak inspiratory flow (PIF) for optimal drug delivery to the airways. However, information is scarce regarding PIF of asthma…
View details →DOI: 10.1016/j.rmed.2026.108952 Replication FailureMedicine
Moss AS, Nguyen QG, Iyer P · 2026 · Clinical rheumatology
Background Patient education materials are vital to health education and, according to the American Medical Association (AMA), should not be written above a 6th grade reading level (Weiss 2003). We aim to assess American College of…
View details →DOI: 10.1007/s10067-025-07746-9 Negative / Null Result ReportMedicine
Carnes N, McAnany J, Khodr Z et al. · 2026 · Journal of attention disorders
Objective Attention-deficit/hyperactivity disorder (ADHD) can potentially disqualify individuals for military service. However, some past research suggests the performance of individuals with ADHD in military service may be comparable to…
View details →DOI: 10.1177/10870547261446718 Negative / Null Result ReportOpen accessMedicine
Heilmann F, Langsdorf LE, Schubert T · 2026 · Psychological research
This study investigated how stimulus material and effector specificity influence interference control (a form of inhibitory control) in adolescent players. Ninety-one males aged 15-18 years (28 handball players, 34 soccer players, 29…
View details →DOI: 10.1007/s00426-026-02327-0 Negative / Null Result ReportMedicine
DeBoest A, Holley C, Hickey M et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Purpose To determine the impact of pharmacist intervention with real-time continuous glucose monitors (rtCGMs) on glycated hemoglobin (HbA1c) levels and the number of pharmacist touchpoints compared to standard of care (SOC). Methods…
View details →DOI: 10.1093/ajhp/zxaf344 Negative / Null Result Report
Michelutti N, Baud A, Meyer-Jacob C et al. · 2026 · Preprint
Abstract The “top–bottom” approach in paleolimnology provides a rapid means of assessing environmental change by comparing modern surface sediments with deeper intervals assumed to pre-date major anthropogenic disturbances (ca. pre-1880).…
View details →DOI: 10.21203/rs.3.rs-9359156/v1 Negative / Null Result ReportMedicine
Phan TH, Phan MQ · 2026 · La Clinica terapeutica
Background Residual cardiovascular risk after acute myocardial infarction (AMI) is driven not only by dyslipidemia but also by systemic inflammation. High-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol…
View details →DOI: 10.7417/ct.2026.2028 Failed Experiment ReportMedicine
Zhang Z, Luo Z, Lai M et al. · 2026 · Optics express
To address the severe intersymbol interference (ISI) in high-speed optical transmission systems, this paper proposes a memory-augmented neural network equalizer (MANNE). Building upon the architecture of a traditional neural network…
View details →DOI: 10.1364/oe.588133 Negative / Null Result ReportMedicine
Xiao H, Zeng X, Pang Q et al. · 2026 · Transplant immunology
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) yield additional cardiorenal benefits beyond glycemic control. Emerging evidence suggests that SGLT2i have potential benefits in organ transplantation, though causal…
View details →DOI: 10.1016/j.trim.2026.102385 Negative / Null Result ReportMedicine
Park M, Park H, Baek IH et al. · 2026 · Journal of patient safety
Objectives Erythropoiesis-stimulating agents (ESAs), classified as long-acting or short-acting, is a primary treatment for anemia in chronic kidney disease and chemotherapy. Given ongoing safety concerns regarding cardiovascular events and…
View details →DOI: 10.1097/pts.0000000000001504 Negative / Null Result ReportMedicine
Tulsian V, Kant R, Patnaik I et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Background and objectives Helicobacter pylori infection is highly prevalent globally. Standard bismuth quadruple therapy is commonly used in India, but there are growing concerns regarding the emergence of anti-microbial resistance and…
View details →DOI: 10.1007/s12664-026-01968-8 Negative / Null Result ReportMedicine
Hong WJ, Huang JM, Liu YH et al. · 2025 · Aesthetic plastic surgery
Background The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes…
View details →DOI: 10.1007/s00266-025-05154-7 Negative / Null Result ReportMedicine
Morris JS, Rajshekhar S, Gremmo G et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Deep endometriosis (DE) is established to cause chronic pelvic pain (CPP), lower urinary tract symptoms (LUTS) and altered bowel function. Although the aim of surgical excision is often to relieve CPP, evidence suggests it could also…
View details →DOI: 10.1016/j.ejogrb.2025.114924 Negative / Null Result Report
Sit B, Sanderlin AG, Zhu CY et al. · 2025 · Preprint
Obligate intracellular bacterial pathogens cannot grow extracellularly, a trait that renders them highly understudied, but also endows them with unexpected host dependencies. Here, using the emerging obligate intracellular tickborne…
View details →DOI: 10.1101/2025.10.28.684717 Negative / Null Result ReportOpen accessMedicine
Reiter T, Dörrler AL, Hasenauer N et al. · 2026 · European journal of nuclear medicine and molecular imaging
Introduction Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial (NCT05519735) focused on molecular imaging of…
View details →DOI: 10.1007/s00259-026-07809-2 Negative / Null Result ReportMedicine
Shabbir A, Abbas G, Alharby HF et al. · 2026 · International journal of phytoremediation
Heat stress and soil arsenic (As) contamination are resulting in severe decline in crop production around the world. The present experiment aimed to assess physiological and biochemical changes induced by the combination of As and heat…
View details →DOI: 10.1080/15226514.2025.2604833 Negative / Null Result Report
Jeneson J, van den Berg-Faay A, Hooijmans M · 2025 · Preprint
We employed interleaved dynamic 1H magnetic resonance imaging (MRI) and 31P MR spectroscopy in combination with arm-cycling to investigate correlations of exercise hyperemia and muscle energetics in the triceps brachii (TB) muscle of the…
View details →DOI: 10.1101/2025.10.17.682308 Negative / Null Result Report
Jacobsen P, Cloos L, vanpaemel w et al. · 2025 · Preprint
Affective inertia – the extent to which changes in one’s affective state persist over time – isan important feature of affect dynamics. It is often examined using experience sampling studies thatcapture momentary affect multiple times per…
View details →DOI: 10.31234/osf.io/5unj7_v1 Negative / Null Result ReportOpen accessMedicine
Son AJ, Rapp E, Wiezorek A et al. · 2026 · JCI insight
Stopping and restarting GLP-1 weight-loss drugs in mice made them less effective over time and increased fat gain compared with continuous treatment.
View details →DOI: 10.1172/jci.insight.205174 Negative / Null Result ReportMedicine
Cottom JM, Verdoni TJ · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral…
View details →DOI: 10.1053/j.jfas.2025.11.010 Negative / Null Result Report
Varughese VJ, Richardson C, Pollock J et al. · 2025 · Preprint
ABSTRACT INTRODUCTION MitraClip ® (MC) placement has been extensively used as an intervention for mitral transcatheter edge-to-edge repair (mTEER) for functional mitral regurgitation (FMR). The aim of our study is to analyze the…
View details →DOI: 10.1101/2025.04.25.25326462 Negative / Null Result ReportMedicine
El-Haffaf I, Marsot A, Paillault A et al. · 2025 · Canadian journal of physiology and pharmacology
In this study, we evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. We conducted a prospective observational study in two Canadian intensive care units (ICUs) from January…
View details →DOI: 10.1139/cjpp-2025-0028 Negative / Null Result ReportOpen accessMedicine
Beijer G, Swartling M, Nielsen EI et al. · 2025 · Critical care (London, England)
Background Standard dosing regimens of meropenem and piperacillin-tazobactam frequently fail to achieve targeted plasma concentrations in critically ill patients. Extended or continuous regimens are often used to improve target attainment.…
View details →DOI: 10.1186/s13054-025-05445-0 Negative / Null Result ReportMedicine
Jang S, Kim D, Kim T et al. · 2025 · Nanotechnology
In this study, a Cleaning Endpoint Evaluation Sensor (CEES) was developed and applied to improve the monitoring accuracy and uniformity control in the cleaning processes for NF 3 -based remote plasma sources in semiconductor equipment.…
View details →DOI: 10.1088/1361-6528/adf8f6 Negative / Null Result ReportOpen accessMedicine
Wang J · 2025 · Scandinavian journal of trauma, resuscitation and emergency medicine
This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09),…
View details →DOI: 10.1186/s13049-025-01403-5 