Negative / Null Result ReportOpen accessMedicine
van der Meulen C, van de Stadt LA, Kroon FPB et al. · 2025 · Rheumatology (Oxford, England)
Objective Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain…
View details →DOI: 10.1093/rheumatology/keaf029 Negative / Null Result ReportOpen accessMedicine
Laviolle B, Locher C, Allain JS et al. · 2025 · Clinical pharmacology and therapeutics
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We…
View details →DOI: 10.1002/cpt.3535 Failed Experiment ReportOpen accessMedicine
Arter ZL, Nagasaka M · 2024 · Lung Cancer (Auckland, N.Z.)
Targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), have revolutionized the treatment landscape for EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of resistance to…
View details →DOI: 10.2147/lctt.s443099 Negative / Null Result ReportOpen accessMedicine
Ter Bruggen FFJA, Redekop WK, Stronks DL et al. · 2021 · Journal of pain research
Objective The success of neurostimulation depends partly on the amount of coverage of the neurostimulation-induced paresthesia of the painful area. This is often achieved by asking feedback from patients intraoperatively. If sedation…
View details →DOI: 10.2147/jpr.s323961 Negative / Null Result ReportOpen accessMedicine
Agostinho M, Shani A, Canaipa R et al. · 2024 · Pain reports
Introduction Within-subject variability (WSV) of pain intensity reports has been shown to predict the placebo response. The focused analgesia selection test (FAST), which allows to experimentally assess WSV of pain reports, has been used…
View details →DOI: 10.1097/pr9.0000000000001175 Negative / Null Result ReportMedicine
Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
View details →DOI: 10.1001/jama.2024.27853 Negative / Null Result ReportOpen accessMedicine
Correll CU, Durgam S, Kozauer SG et al. · 2026 · International clinical psychopharmacology
This Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of lumateperone to treat bipolar depression. Patients (18-75 years) with bipolar I or bipolar II disorder experiencing a major depressive…
View details →DOI: 10.1097/yic.0000000000000597 Negative / Null Result ReportMedicine
Seybold U · 2018 · Deutsche medizinische Wochenschrift (1946)
Vaccination practices in Germany are driven by scientific developments and a complex regulatory environment. Some important developments in 2018 are described here: Starting in 2018 only quadrivalent influenza vaccines will be used for the…
View details →DOI: 10.1055/a-0638-9282 Negative / Null Result ReportOpen accessMedicine
Bremhorst A, Mills DS, Stolzlechner L et al. · 2021 · Frontiers in psychology
The inner brow raiser is a muscle movement that increases the size of the orbital cavity, leading to the appearance of so-called 'puppy dog eyes'. In domestic dogs, this expression was suggested to be enhanced by artificial selection and…
View details →DOI: 10.3389/fpsyg.2021.568935 Negative / Null Result ReportOpen accessMedicine
Mutale W, Freeborn K, Graybill LA et al. · 2021 · The Lancet. Global health
Background Testing men for HIV during their partner's pregnancy can guide couples-based HIV prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase HIV…
View details →DOI: 10.1016/s2214-109x(21)00393-4 Failed Experiment ReportOpen accessMedicine
Chen H, Colasurdo M, Matsukawa H et al. · 2025 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →DOI: 10.1177/23969873251364973 Failed Experiment ReportMedicine
Nickel JC, Moldwin R, Hanno P et al. · 2019 · The Journal of urology
Purpose In this 12-week, randomized, double-blind, placebo controlled, multicenter, 3-arm, parallel group, phase 3 trial we assessed the effects of a novel SHIP1 activator on bladder pain and urinary symptoms in patients with interstitial…
View details →DOI: 10.1097/ju.0000000000000192 Negative / Null Result ReportOpen accessMedicine
Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
View details →DOI: 10.1016/j.invent.2026.100908 Negative / Null Result ReportMedicine
Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
View details →DOI: 10.1016/j.jpainsymman.2019.10.028 Negative / Null Result ReportMedicine
Pucha KA, Ma TC, York W et al. · 2023 · Parkinsonism & related disorders
Introduction Impaired autophagy is a pathogenic mechanism in the synucleinopathies. Sirolimus, a potent mTOR inhibitor and autophagy activator, had no beneficial effects in a randomized placebo-controlled trial in patients with multiple…
View details →DOI: 10.1016/j.parkreldis.2023.105821 Negative / Null Result ReportOpen accessMedicine
Thompson KP, Sykes J, Chandakkar P et al. · 2022 · Orphanet journal of rare diseases
Background Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel therapies for epistaxis…
View details →DOI: 10.1186/s13023-022-02539-8 Negative / Null Result ReportMedicine
Allen PM, Dedi S, Kumar D et al. · 2012 · Perception
We manipulated the accommodative response using positive and negative lenses to study any association between symptoms of pattern glare and accommodation. Two groups of eighteen young adults were selected from seventy-eight on the basis…
View details →DOI: 10.1068/p7390 Negative / Null Result ReportOpen accessMedicine
Komarow HD, Wang J, Eisch R et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems. IL-6 has been shown to promote mast cell maturation, proliferation, and…
View details →DOI: 10.1016/j.jacig.2025.100498 Negative / Null Result ReportOpen accessMedicine
Guo JY, Lin HY · 2023 · Chinese journal of traumatology = Zhonghua chuang shang za zhi
The Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) trial has many defects, and thus cannot be the terminator of recombinant thrombomodulin (rTM). On the contrary, it provides sufficient evidence for further research.…
View details →DOI: 10.1016/j.cjtee.2023.04.006 Negative / Null Result ReportMedicine
de Ruiter MB, Groot PFC, Deprez S et al. · 2023 · Neuro-oncology
Background Reducing radiation dose to the hippocampus with hippocampal avoidance prophylactic cranial irradiation (HA-PCI) is proposed to prevent cognitive decline. It has, however, not been investigated whether hippocampal atrophy is…
View details →DOI: 10.1093/neuonc/noac148 Negative / Null Result ReportMedicine
Abrams D, Montesi SB, Moore SKL et al. · 2020 · Critical care medicine
Objectives Recurring issues in clinical trial design may bias results toward the null, yielding findings inconclusive for treatment effects. This study evaluated for powering bias among high-impact critical care trials and the associated…
View details →DOI: 10.1097/ccm.0000000000004568 Negative / Null Result ReportOpen accessMedicine
Stockton S, Catalano P, Cohen SJ et al. · 2023 · The oncologist
Background Patients with advanced esophageal cancer carry poor prognoses; limited data exist to guide second-line therapy in the metastatic setting. Paclitaxel has been used yet is associated with limited efficacy. There is preclinical…
View details →DOI: 10.1093/oncolo/oyad096 Failed Experiment ReportOpen accessMedicine
Jansen D, Deleu S, Caenepeel C et al. · 2025 · Gut microbes
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for…
View details →DOI: 10.1080/19490976.2025.2499575 Failed Experiment ReportOpen accessMedicine
Limon D, Amiel A, Even Haim S et al. · 2024 · Neuro-oncology advances
Background Atypical and anaplastic meningiomas account for 20% of all meningioma cases. Solitary fibrous tumor (SFT) is a type of soft tissue sarcoma with similar attributes to meningioma. For patients with refractory or recurrent disease…
View details →DOI: 10.1093/noajnl/vdae154 Abandoned HypothesisOpen accessMedicine
Kwon SB, Megjhani M, Nametz D et al. · 2023 · Resuscitation plus
Background Despite significant progress in cardiopulmonary resuscitation and post-cardiac arrest care, favorable outcome in out-of hospital sudden cardiac arrest patients remains low. One of the main reasons for mortality in these patients…
View details →DOI: 10.1016/j.resplu.2023.100450 Negative / Null Result ReportMedicine
Gandhy SU, Karzai FH, Bilusic M et al. · 2024 · European urology oncology
Background The emergence of positron emission tomography (PET) in prostate cancer is impacting clinical practice, but little is known about PET imaging as a tool to determine treatment failure in metastatic castration-resistant prostate…
View details →DOI: 10.1016/j.euo.2023.09.010 Negative / Null Result ReportOpen accessMedicine
Gagnon J, Quansah JE, Saleh G et al. · 2022 · Psychopathology
Introduction Splitting, as a defense mechanism in Kernberg's theory, plays a significant role in the development and maintenance of polarized and oscillating representations of self/other characteristics of borderline personality disorder…
View details →DOI: 10.1159/000525006 Negative / Null Result ReportOpen accessMedicine
Imamura Y, Kiyota N, Tahara M et al. · 2024 · Cancer medicine
Background In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m 2 ) was non-inferior to 3-weekly cisplatin (100 mg/m 2 ) for postoperative high-risk head and neck cancer. We investigated how acute kidney injury (AKI), a…
View details →DOI: 10.1002/cam4.70235 Negative / Null Result ReportOpen accessMedicine
Wüst LN, Cajochen C, Lasauskaite R · 2025 · Neurobiology of sleep and circadian rhythms
A chronotype is defined as a preference for certain behaviours (e.g., sleep and wake) to occur at specific times of day. It is therefore also temporally linked with cognitive performance across the day. In an exploratory analysis, we…
View details →DOI: 10.1016/j.nbscr.2025.100125 Negative / Null Result ReportOpen accessMedicine
Metsch LR, Feaster DJ, Gooden LK et al. · 2025 · Open forum infectious diseases
Background People with HIV (PWH) who use cocaine are less likely to achieve virologic suppression ( Methods Project RETAIN recruited 360 cocaine-using PWH who were not virologically suppressed in Miami, FL, and Atlanta, GA. Patients were…
View details →DOI: 10.1093/ofid/ofaf104 