Negative / Null Result ReportMedicine
Gandhy SU, Karzai FH, Bilusic M et al. · 2024 · European urology oncology
Background The emergence of positron emission tomography (PET) in prostate cancer is impacting clinical practice, but little is known about PET imaging as a tool to determine treatment failure in metastatic castration-resistant prostate…
View details →DOI: 10.1016/j.euo.2023.09.010 Negative / Null Result ReportOpen accessMedicine
Gagnon J, Quansah JE, Saleh G et al. · 2022 · Psychopathology
Introduction Splitting, as a defense mechanism in Kernberg's theory, plays a significant role in the development and maintenance of polarized and oscillating representations of self/other characteristics of borderline personality disorder…
View details →DOI: 10.1159/000525006 Negative / Null Result ReportOpen accessMedicine
Regel A, Sepriano A, Baraliakos X et al. · 2017 · RMD open
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism…
View details →DOI: 10.1136/rmdopen-2016-000397 Negative / Null Result ReportOpen accessMedicine
Abdelrahman KM, Hackshaw KV · 2021 · Biomedicines
Neuropathic pain affects 7-10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake…
View details →DOI: 10.3390/biomedicines9060674 Negative / Null Result ReportOpen accessMedicine
Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →DOI: 10.1111/ene.16154 Negative / Null Result ReportMedicine
Kitchin SS, Lakshmanan S, Kinninger A et al. · 2023 · The British journal of cardiology
Atrial fibrillation (AF) is a common arrhythmia associated with poor outcomes. N-3 fatty acids have been shown to provide significant cardiovascular risk reduction, but they may exacerbate the risk of AF. The pathway by which N-3 fatty…
View details →DOI: 10.5837/bjc.2023.022 Negative / Null Result ReportOpen accessMedicine
Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →DOI: 10.3390/e26110958 Negative / Null Result ReportOpen accessMedicine
Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →DOI: 10.1002/jgc4.70125 Negative / Null Result ReportMedicine
Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →DOI: 10.1097/olq.0000000000002244 Negative / Null Result ReportMedicine
Ding JJ, Chiu CF, Su YT et al. · 2025 · Pediatric research
Background Maternal hypercalcemia is a rare but potentially serious cause of late-onset neonatal hypocalcemia. Data on the clinical characteristics and outcomes of mother-baby couplets with maternal hypercalcemia and subsequent neonatal…
View details →DOI: 10.1038/s41390-025-04577-x Negative / Null Result ReportMedicine
Džafić F, Ahmetović A, Čoloman N et al. · 2026 · International archives of allergy and immunology
Introduction Allergic rhinitis (AR) is a prevalent health concern. In Europe, 20-40% of the population is affected. Diagnostic methods include skin tests, measurement of serum immunoglobulin E (IgE), nasal smear for eosinophils, and…
View details →DOI: 10.1159/000548221 Negative / Null Result ReportOpen accessMedicine
Kohan R, Gil-Campesino H, García Rodríguez IO et al. · 2026 · Emerging infectious diseases
We report 2 cases of donor-derived Strongyloides stercoralis infection in renal transplant recipients. Despite initial negative serologic testing in donor samples, retrospective testing confirmed transmission. This report underscores the…
View details →DOI: 10.3201/eid3201.251483 Failed Experiment ReportMedicine
Bae-Jump VL, Sill MW, Gehrig PA et al. · 2025 · Gynecologic oncology
Introduction We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). Methods In this phase II/III…
View details →DOI: 10.1016/j.ygyno.2025.03.003 Failed Experiment ReportMedicine
Rosell R, Karachaliou N, Codony J et al. · 2014 · Translational lung cancer research
Designing molecular targeted therapy with high specificity based on novel tumor biomarkers is a high priority in lung cancer research. Several molecular aberrations have been already identified in non-small cell lung cancer (NSCLC), with…
View details →DOI: 10.3978/j.issn.2218-6751.2014.08.10 Negative / Null Result ReportOpen accessMedicine
Le Duc W, Butler CR, Argyropoulos GPD et al. · 2025 · PLoS biology
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise…
View details →DOI: 10.1371/journal.pbio.3003033 Methods Dead-EndOpen accessMedicine
Whitty JA, Wagner AP, Kang E et al. · 2023 · The Australian & New Zealand journal of obstetrics & gynaecology
Background There is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS).…
View details →DOI: 10.1111/ajo.13677 Failed Experiment ReportMedicine
Ip EH, Saldana S, Miller KD et al. · 2021 · Cancer
Background E5103 was a study designed to evaluate the efficacy and safety of bevacizumab. It was a negative trial for the end points of invasive disease-free survival and overall survival. The current work examines the tolerability of…
View details →DOI: 10.1002/cncr.33992 Negative / Null Result ReportOpen accessMedicine
Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
View details →DOI: 10.3233/jad-215699 Negative / Null Result ReportOpen accessMedicine
Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
View details →DOI: 10.1038/s41598-025-89737-z Negative / Null Result ReportOpen accessMedicine
Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →DOI: 10.1186/s13018-023-03698-5 Replication FailureMedicine
Meyers DE, Jenei K, Chisamore TM et al. · 2021 · JAMA internal medicine
Importance Cancer drugs approved by the US Food and Drug Administration have come under scrutiny for marginal clinical benefits; however, the clinical benefits of cancer drugs recommended for reimbursement in Canada have not been…
View details →DOI: 10.1001/jamainternmed.2020.8588 Failed Experiment ReportMedicine
O'Sullivan Coyne G, Burotto M · 2014 · Expert opinion on biological therapy
Introduction Monoclonal antibodies and small molecules targeting the VEGF pathway are part of the arsenal to treat malignant tumors. Antiangiogenesis therapies has been studied in breast cancer with partial success, reflected by the…
View details →DOI: 10.1517/14712598.2014.939069 Negative / Null Result ReportOpen accessMedicine
Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →DOI: 10.3389/fonc.2018.00423 Negative / Null Result ReportMedicine
Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →DOI: 10.1016/j.jsat.2014.11.007 Negative / Null Result ReportOpen accessMedicine
Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →DOI: 10.1093/ijnp/pyy051 Failed Experiment ReportMedicine
Scheperjans F, Levo R, Bosch B et al. · 2024 · JAMA neurology
Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models. Objective To assess the safety and symptomatic efficacy of…
View details →DOI: 10.1001/jamaneurol.2024.2305 Negative / Null Result ReportMedicine
Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →DOI: 10.1016/j.visres.2021.107965 Failed Experiment ReportMedicine
Black PC, Tangen CM, Singh P et al. · 2023 · European urology
Background Although radical cystectomy (RC) is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), many patients are ineligible for surgery or elect…
View details →DOI: 10.1016/j.eururo.2023.08.004 Failed Experiment ReportMedicine
Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
Failed Experiment ReportOpen accessMedicine
Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations
Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…
View details →DOI: 10.1097/cce.0000000000000742 