A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21360 results · page 596 of 712
Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
Mousavi SS, Karimi S, Hassannia MS et al. · 2025 · Preprint
Objective Electrocardiography and blood pressure (BP) measurement are two widely used tools for diagnosis and monitoring cardiovascular diseases. While the electrocardiogram (ECG) and BP have been considered complementary modalities, there…
Rosiles T, Nguyen M, Calin-Jageman RJ et al. · 2026 · eNeuro
Forming a long-term memory requires changes in neuronal transcription. What happens, though, as the memory is forgotten? And how does the transcriptional state relate to the maintenance and recall of the long-term memory? To answer these…
Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports
Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…
Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…
McGuier M, Bragg E, Holtzheimer P et al. · 2026 · eNeuro
There is a critical need for robust and reliable preclinical models for posttraumatic stress disorder (PTSD) to better understand pathophysiological mechanisms and support the development of novel treatments. The single prolonged stress…
Salman E · 2026 · Indian journal of medical microbiology
Background The primary reason for increased lab use is inappropriate or needless test requests. Our study examined the benefits of repeated antinuclear antibody (ANA) testing and the reasons for ANA test requests in accordance with…
Watanabe K, Takahashi H, Narumi R et al. · 2025 · The journal of obstetrics and gynaecology research
Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which…
Hartady T, Sugandi SD, Viqih M · 2026 · Veterinary sciences
Poultry disease outbreaks are frequently multifactorial, involving complex interactions between infectious agents and environmental stressors. This report describes a case of avian influenza (AI) co-infection in a commercial broiler farm…
İpek Demir K, Yılmaz D, Güvenir FA et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Background and objective Adverse drug reactions (ADRs) are a serious public health problem. This study aimed to evaluate reaction characteristics and diagnostic test results in pediatric patients in whom suspected drug allergy was…
Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Cancers
Backgrounds : Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)
Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…
Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem
Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…
Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute
Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…
Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…
Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases
Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…
Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases
Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…
Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms
In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…
AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint
Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…
Witkin JM, Pandey KP, Smith JL · 2022 · Pharmacology, biochemistry, and behavior
Pharmacological modulation of glutamate has long been considered to be of immense therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for safely altering glutamate-driven excitation. Data support the…
Abdelmalek MF, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethylene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine
Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…
Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology
Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…
Hiester A, Che Y, Lusch A et al. · 2023 · European urology
Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…
Hamada S, Satomoto K, Goto K et al. · 2026 · Mutation research. Genetic toxicology and environmental mutagenesis
Objective The liver micronucleus (MN) assay is useful for detecting genotoxic hepatocarcinogens that may be missed by the erythrocyte MN assay. Because micronuclei form only in dividing cells, evaluating hepatocyte proliferation is…
Ahogni I, Avanon H, Hueha C et al. · 2025 · Preprint
Abstract Background: Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs,…
Wen CP, Tsai MK, Wen C et al. · 2026 · Gut and liver
Background/aims Colorectal cancer (CRC) risk is approximately 0.1% according to registry data, and fecal immunochemical tests (FITs) identify approximately 5% of screened individuals as positive. We evaluated whether a negative FIT result…
Ibrahim AM, Saleem A, Faisal MS et al. · 2025 · Digestive diseases and sciences
Background and aims Multitarget stool DNA (mt-sDNA) testing is a non-invasive colorectal cancer (CRC) screening tool, but false-negative results may delay diagnosis. Understanding which patients are more likely to have advanced lesions…
Kundu A, Majumder D, Das D et al. · 2026 · Cureus
Introduction Latent tuberculosis infection (LTBI) is still neglected and acts as a barrier to the tuberculosis (TB) elimination goal of the National Tuberculosis Elimination Programme (NTEP) by 2025 sustaining TB transmission, particularly…