e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 573 of 712

Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

View details →DOI: 10.1016/j.mbplus.2025.100181
Negative / Null Result ReportMedicine

Rete ridges are decreased in dyschromic burn hypertrophic scar: A histological study.

Carney BC, Travis TE, Keyloun JW et al. · 2024 · Burns : journal of the International Society for Burn Injuries

Dyschromic hypertrophic scar (HTS) is a common sequelae of burn injury, however, its mechanism has not been elucidated. This work is a histological study of these scars with a focus on rete ridges. Rete ridges are important for normal skin…

View details →DOI: 10.1016/j.burns.2023.09.005
Negative / Null Result ReportOpen accessMedicine

Modulation of response inhibition with event-related atVNS showed EEG but no behavioral effects.

Becker LF, Sallandt GM, Rosolowsky E et al. · 2025 · Scientific reports

Response inhibition can be explained within the theory of event coding. Event file binding and reconfiguration have previously been studied in relation to various neurotransmitters. We aimed to activate the noradrenergic system through…

View details →DOI: 10.1038/s41598-025-24491-w
Negative / Null Result ReportOpen accessMedicine

Comparison of Medial Meniscus Root Repair with Two Surgical Techniques Using Medial and Lateral Tunnels: A Prospective Cohort Study.

Shahsavari Pour A, Hosseini A, Ghomashi I et al. · 2026 · The archives of bone and joint surgery

Objectives This study aimed to compare the clinical outcomes of trans-tibial pullout repair of the medial meniscus posterior root using the lateral tibial tunnel versus the conventional medial tibial tunnel. Methods In this prospective…

View details →DOI: 10.22038/abjs.2025.86673.3939
Negative / Null Result ReportOpen accessMedicine

Does the change between the native and the prosthetic posterior tibial slope influence the clinical outcomes after posterior stabilized TKA? A review of 793 knees at a minimum of 5 years follow-up.

Alhamdi H, Deroche E, Shatrov J et al. · 2025 · SICOT-J

Introduction The understanding of the influence of posterior tibial slope (PTS) on knee kinematics has increased. However, the PTS influence on clinical outcomes remains unclear. The study aimed to evaluate whether a significant change…

View details →DOI: 10.1051/sicotj/2025014
Negative / Null Result ReportOpen accessMedicine

Omega-3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization.

Lo MM, Black MN, McGlory C et al. · 2026 · Physiological reports

Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega-3 fatty acid (n-3) attenuates declines in muscle mass and…

View details →DOI: 10.14814/phy2.70736
Negative / Null Result ReportMedicine

Dynamic lactation responses to dietary crude protein oscillation in diets adequate and deficient in metabolizable protein in Holstein cows.

Erickson MG, Zanton GI, Wattiaux MA · 2023 · Journal of dairy science

Limited research has examined the interaction between dietary crude protein (CP) level and CP feeding pattern. We tested CP level (low protein [LP], 13.8%; high protein [HP], 15.5% CP, dry matter [DM] basis) and CP feeding pattern (OF =…

View details →DOI: 10.3168/jds.2023-23603
Negative / Null Result ReportMedicine

Odor-Color Associations Are Not Mediated by Concurrent Verbalization.

Speed LJ, de Valk J, Croijmans I et al. · 2023 · Cognitive science

Odor and color are strongly associated. Numerous studies demonstrate consistent odor-color associations, as well as effects of color on odor perception and language. Yet, we know little about how these associations arise. Here, we test…

View details →DOI: 10.1111/cogs.13266
Negative / Null Result ReportOpen accessMedicine

Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in Posttraumatic Stress Disorder.

Goldway N, Markovits T, Fine N et al. · 2026 · Biological psychiatry global open science

Background Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of posttraumatic stress disorder (PTSD). Despite its significance, the…

View details →DOI: 10.1016/j.bpsgos.2025.100655
Failed Experiment ReportMedicine

Dimethyl fumarate treatment of primary progressive multiple sclerosis: results of an open-label extension study.

Højsgaard Chow H, Talbot J, Lundell H et al. · 2023 · Multiple sclerosis and related disorders

Introduction Dimethyl fumarate treatment is approved in Europe for patients with relapsing-remitting multiple sclerosis (MS) and in the US for relapsing forms of MS. We recently published the results of the first randomized…

View details →DOI: 10.1016/j.msard.2022.104458
Failed Experiment ReportOpen accessMedicine

A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer.

Goel S, Jovanović B, Chu X et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Cyclin-dependent kinase 4/6 inhibitors can significantly extend survival when given in combination with endocrine therapy in patients with hormone receptor-positive metastatic breast cancer. However, their activity has been…

View details →DOI: 10.1158/1078-0432.ccr-24-2647
Failed Experiment ReportMedicine

Add-On Prostaglandin E 1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-Blind, Placebo-controlled Pilot Trial.

Buchtele N, Schörgenhofer C, Schwameis M et al. · 2022 · American journal of respiratory and critical care medicine

Rationale: Prostaglandin E 1 (alprostadil; PGE 1 ), in addition to low-dose unfractionated heparin, increases the biocompatibility of extracorporeal systems and enhances the efficacy of artificial organs without increasing bleeding risk.…

View details →DOI: 10.1164/rccm.202110-2359oc
Methods Dead-EndOpen accessMedicine

Cost-effectiveness of lurbinectedin with atezolizumab for extensive-stage small-cell lung cancer in the United States: impact of drug wastage reduction on economic outcomes.

Zhu J, Li Z, Song D et al. · 2026 · BMC health services research

Background The IMforte trial had supported lurbinectedin as a recommended first-line maintenance therapy for patients with extensive-stage small-cell lung cancer (ES-SCLC), while its cost-effectiveness remains uncertain for patients and…

View details →DOI: 10.1186/s12913-026-14653-5
Failed Experiment ReportOpen accessMedicine

TRAbectedin in adVanced rEtroperitoneal well differentiated/dedifferentiated Liposarcoma and Leiomyosarcoma (TRAVELL): results of a phase II study from the Italian Sarcoma Group.

Fabbroni C, Grignani G, Vincenzi B et al. · 2024 · ESMO open

Background This is a multicentre, single-arm, phase II study aimed at further exploring the activity of trabectedin as second-/further-line treatment in retroperitoneal leiomyosarcoma (LMS) and well-differentiated/dedifferentiated…

View details →DOI: 10.1016/j.esmoop.2024.103667
Negative / Null Result Report

The role of emotion regulation for general self-efficacy in adolescents assessed through both neurophysiological and self-reported measures

Lande NM, Ask TF, Sætren SS et al. · 2023 · Preprint

Background: Self-efficacy, the belief in one’s ability and capacity to organize and execute actions required to achieve desired results, is associated with adolescent academic achievement and reduced risk for psychopathology. Adolescent…

View details →DOI: 10.31234/osf.io/abxfn
Negative / Null Result ReportOpen accessMedicine

Do Surrogate Markers of Cardiorespiratory Fitness Predict Individual Changes in VO<sub>2peak</sub>? A Randomized Controlled Trial.

Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science

The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…

View details →DOI: 10.70252/pvyg1833
Negative / Null Result ReportOpen accessMedicine

Relationship between the stiffness of the medial gastrocnemius and spatiotemporal variables during 100-m sprint running in collegiate sprinters.

Fujii N, Takahashi K, Kawama R et al. · 2026 · PloS one

Higher stiffness of the medial gastrocnemius (MG) has been reported to be associated with faster race time in 100-m sprint running. However, the association of muscle stiffness with spatiotemporal variables (i.e., step frequency, step…

View details →DOI: 10.1371/journal.pone.0347567
Negative / Null Result ReportOpen access

Association of Polygenic Risk Scores for Neurodevelopmental Traits and Psychiatric Conditions with Incontinence and Constipation in Children and Young People

Bastiani O, Dardani C, Burrows K et al. · 2024 · Preprint

Observational studies report prospective associations of neurodevelopmental and psychiatric traits with paediatric incontinence and constipation, but unmeasured and residual confounding may limit observational measures. Here, we use a…

View details →DOI: 10.1101/2024.11.29.24318188
Negative / Null Result ReportOpen accessMedicine

Effect of wild yeast inoculation on the nutritive value, fermentation profile, and aerobic stability of rehydrated corn grain silage.

Pupo MR, Diepersloot EC, Wenzel MPR et al. · 2026 · JDS communications

Feeding spoiled silage with high yeast activity is commonly related to impaired lactation performance by dairy cows. However, rehydrated corn grain silage (RCGS) may be more prone to yeast proliferation and be greatly affected by high…

View details →DOI: 10.3168/jdsc.2025-0888
Negative / Null Result ReportOpen accessMedicine

Comparison of Jaw Function and Mental Health Between Patients With Anterior Disc Displacement With and Without Reduction.

Yao Y, Liu SS, Jin L et al. · 2025 · Clinical and experimental dental research

Objectives Anterior disc displacement with reduction (ADDWR) and without reduction (ADDWOR) are two common clinical types of temporomandibular disorders. This study compared the levels of anxiety, depression, somatization, and jaw function…

View details →DOI: 10.1002/cre2.70261
Negative / Null Result ReportOpen accessMedicine

Effects of Supervised Exercise during Neoadjuvant Chemotherapy on Tumor Response in Patients with Breast Cancer (Neo-train): A Randomized Controlled Trial.

Kjeldsted E, Ammitzbøll G, Lænkholm AV et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant…

View details →DOI: 10.1158/1078-0432.ccr-25-0416
Negative / Null Result Report

Emotional anticipation for dynamic emotional faces is not modulated by schizotypal traits: A Representational Momentum study

Grave J, Cordeiro S, De Sá Teixeira NA et al. · 2022 · Preprint

Schizotypy, a personality structure that resembles schizophrenia symptoms, is often associated with abnormal facial emotion perception. Based on the prevailing sense of threat in psychotic experiences, and the immediate perceptual history…

View details →DOI: 10.31234/osf.io/f26pg