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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 573 of 725

Negative / Null Result ReportOpen accessMedicine

Lessons Learned: Why Motivational Interviewing Should Be Adapted to Socio-Cultural Contexts.

Kirby C, Baldwin JA, Elwell K et al. · 2026 · Healthcare (Basel, Switzerland)

Background The literature shows inconclusive results from utilizing motivational interviewing (MI) in indigenous populations to address early childhood caries (ECC). Great Beginnings for Healthy Native Smiles (GBHNS) (NIDCR U01DE028508), a…

View details →DOI: 10.3390/healthcare14081059
Negative / Null Result ReportOpen accessMedicine

Fibrillary glomerulonephritis disease natural history and outcomes: a retrospective two centre cohort study.

Zhang Y, Baharani J, Ajayi B et al. · 2025 · BMC nephrology

Background Fibrillary glomerulonephritis (FGN) is a rare immune complex-mediated glomerulonephritis characterised by the deposition of anomalous fibrillary structures within the glomeruli. The prognosis for patients with FGN is usually…

View details →DOI: 10.1186/s12882-025-04187-z
Negative / Null Result ReportOpen accessMedicine

A Study on the Visibility and Radiological Characteristics of a Normal Appendix in Patients Undergoing Non-contrast Computed Tomography at Teaching Hospital Jaffna, Sri Lanka.

Gobishangar S, Abiharan P, Jenil A et al. · 2026 · Cureus

Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality…

View details →DOI: 10.7759/cureus.102357
Negative / Null Result ReportMedicine

Tooth wear and bruxism: A scoping review.

Bronkhorst H, Kalaykova S, Huysmans MC et al. · 2024 · Journal of dentistry

Objective This study presents a scoping review to determine the association between tooth wear and bruxism. Data A protocol was developed a priori (Open Science Framework (DOI 10.17605/OSF.IO/CS7JX)). Established scoping review methods…

View details →DOI: 10.1016/j.jdent.2024.104983
Negative / Null Result ReportMedicine

50 Hz magnetic field influences caspase-3 activity and cell cycle distribution in ionizing radiation exposed SH-SY5Y neuroblastoma cells.

Nieminen V, Martikainen MV, Kalliomäki S et al. · 2024 · International journal of radiation biology

Purpose Earlier evidence suggests that extremely low frequency magnetic fields (ELF MFs) can modify the effects of carcinogenic agents. However, the studies conducted so far with ionizing radiation as the co-exposure agent are sparse and…

View details →DOI: 10.1080/09553002.2024.2369105
Negative / Null Result ReportMedicine

Detection of Electrophysiologic Conduction After Polyethylene Glycol-Fusion Repair of Peripheral Nerve Injuries in a Porcine Model.

Gaviria M, Arave M, Phan N et al. · 2026 · Military medicine

Introduction Peripheral nerve injuries (PNIs) are associated with significant morbidity, and traditional repair techniques often result in incomplete functional recovery. Polyethylene glycol (PEG) fusion has been proposed as a technique to…

View details →DOI: 10.1093/milmed/usag235
Negative / Null Result ReportOpen accessMedicine

Persistence of protozoan parasites and <i>Escherichia coli</i> on plant tissue in soil.

McCaughan KJ, Danyluk MD, Kniel KE · 2026 · Applied and environmental microbiology

Tilling under is a method growers employ in an effort to remediate instances of widespread contamination in fields of crops, but its effectiveness with respect to specific pathogens remains poorly understood. This study had two overarching…

View details →DOI: 10.1128/aem.02467-25
Negative / Null Result ReportOpen accessMedicine

Case Report: early regression and bladder-intact survival after limited-course immunotherapy-based systemic therapy in two patients with clinically staged bulky muscle-invasive bladder cancer.

Zhang S, Zhang H, Dong X et al. · 2026 · Frontiers in immunology

Background Radical cystectomy remains a standard curative treatment for muscle-invasive bladder cancer (MIBC). Bladder preservation after systemic therapy without immediate surgery remains investigational and requires careful patient…

View details →DOI: 10.3389/fimmu.2026.1866469
Negative / Null Result ReportOpen accessMedicine

Use of dual ART in individuals with different HBV serological patterns.

Swaine T, Bhagani S · 2026 · Current opinion in HIV and AIDS

Purpose of review Two-drug regimens (2DR) for antiretroviral therapy are increasingly being recommended for people living with HIV to reduce pill burden and reduce short and long-term toxicity. The exclusion of tenofovir and lamivudine or…

View details →DOI: 10.1097/coh.0000000000001016
Negative / Null Result ReportOpen accessMedicine

Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.

Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…

View details →DOI: 10.1097/gox.0000000000007662
Negative / Null Result ReportOpen accessMedicine

Anticoagulant residues associated with an attempted rodent eradication from a subtropical coral atoll.

Antaky CC, Leinbach IL, Plissner JH et al. · 2026 · PloS one

The use of rodenticides is a primary method for eradicating rodents from islands for conservation purposes. Rodenticide residue monitoring is often incorporated into rodent eradication project planning to understand the potential effects…

View details →DOI: 10.1371/journal.pone.0344972
Replication FailureMedicine

UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity Toward <i>N</i>-Hydroxypipecolic Acid.

Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)

N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…

View details →DOI: 10.3390/life16060992
Failed Experiment ReportMedicine

Evaluation of leukocyte depletion filters for the removal of EpCAM-positive tumor cells during oncologic intraoperative blood salvage using CATUVAB<sup>®</sup>: an exploratory feasibility study.

Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology

Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…

View details →DOI: 10.1186/s12871-026-03994-7
Methods Dead-EndOpen accessMedicine

Minimum Detectable Change and Minimal Clinically Important Difference for the Box and Block Test and Fugl-Meyer Assessment in Moderate to Severe Chronic Stroke.

Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation

Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…

View details →DOI: 10.1016/j.arrct.2026.100623
Abandoned Hypothesis

Environmental Volatility Shifts Visual Search from Capture to Caution

Qiu N, Allenmark F, Chen S et al. · 2026 · Preprint

Real-world distractors occur in environments whose states change at different rates. We asked whether such volatility alters early attentional gating or instead changes the criterion for committing to a response. Observers performed an…

View details →DOI: 10.64898/2026.05.08.723763
Replication FailureMedicine

Consistent Efficacy of Vutrisiran Across Sexes in Transthyretin Cardiac Amyloidosis: Evidence from the HELIOS-B Trial.

Mansell J, Wang X, Jering KS et al. · 2026 · European journal of heart failure

Sex differences in transthyretin cardiac amyloidosis (ATTR-CM) are increasingly recognised; however, women are underrepresented in trials and sex-specific treatment effects remain incompletely understood. We evaluated sex differences in…

View details →DOI: 10.1093/ejhf/xuag208
Replication FailureOpen accessMedicine

Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness.

Zhou Y, Zhong Z, Mo H et al. · 2026 · Research and practice in thrombosis and haemostasis

Background Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity. Recent studies have…

View details →DOI: 10.1016/j.rpth.2026.103395
Replication FailureOpen accessMedicine

Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing <i>Caenorhabditis</i> species.

O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology

Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…

View details →DOI: 10.17912/micropub.biology.002151
Negative / Null Result ReportOpen accessMedicine

Serum HMGB1 and Alcohol-Related Liver Disease.

Popiolek I, Hydzik P, Ciszowski K et al. · 2026 · Journal of clinical medicine

Background/Objectives: Alcohol-related liver disease (ALD) lacks widely adopted biomarkers that reflect disease activity and severity. High-mobility group box 1 (HMGB1), a damage-associated molecular pattern, has been implicated in ALD…

View details →DOI: 10.3390/jcm15093397
Negative / Null Result ReportMedicine

In Vitro Evaluation of the Antifungal Activity and Cytotoxicity of <i>Sambucus williamsii</i> var. <i>coreana</i> Extract Against <i>Candida albicans</i> and HaCaT Cells.

Yoon HJ, Kim GC, Nam SH · 2026 · Pathogens (Basel, Switzerland)

Background Oral candidiasis is an opportunistic infection caused by Candida albicans (C. albicans) , highlighting the need to evaluate candidate substances that ensure both antifungal efficacy and mucosal safety. This study aimed to assess…

View details →DOI: 10.3390/pathogens15060635
Negative / Null Result ReportMedicine

SARS-CoV-2 spike-directed T cells and anti-receptor-binding-domain antibodies in hematological patients receiving three mRNA COVID-19 vaccine doses.

Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)

Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…

View details →DOI: 10.1016/j.eimce.2026.503146
Replication FailureMedicine

Procedure-Specific Efficacy of Tranexamic Acid in Breast Surgery: A Propensity-Score Adjusted Analysis of 5,202 Procedures.

Friedman O, Maiershon D, Paniri Y et al. · 2026 · Plastic and reconstructive surgery

Background Hematoma remains a major complication following breast surgery. While tranexamic acid (TXA) efficacy is established in reduction mammaplasty, its utility across other breast procedures remains unclear. Methods This retrospective…

View details →DOI: 10.1097/prs.0000000000013206
Methods Dead-EndMedicine

Reproducibility of a Shear Wave Elastography Procedure for Assessing the Piriformis Muscle Stiffness in a Sample of Healthy Young Adults Under Controlled Laboratory Conditions: An Intra- and Inter-Examiner Reliability Study.

Varol U, Kobylarz MD, López-Redondo M et al. · 2026 · Journal of clinical medicine

Background/Objectives : Shear wave elastography (SWE) may provide an objective method for quantifying piriformis muscle stiffness, but its clinical and research use requires evidence that the measurement procedure is reliable. This study…

View details →DOI: 10.3390/jcm15124548